HPLC Separation of Geometric Isomers of Carbamyl Peptides

References

• De Vita , V. , Carbone , P. , Owens , A. , Gold , G. L. , Krant , M. J. and Edmonson , J. 1965 . Clinical trials with 1,3-bis-(2-chloroethyl)-1-nitrosourea NCS-409962 . Cancer Res. , 25 : 1876
   PubMed Web of Science ®Google Scholar
• Carter , S. K. , Schabel , F. M. , Broder , L. E. and Johnston , T. P. 1972 . 1,3-Bis (2-chloroethyl)-1-nitrosourea (BCNU) and other nitroso ureas in cancer treatment: A review . Adv. Cancer Res. , 16 : 273
   PubMedGoogle Scholar
• Levin , V. A. and Wilson , C. B. 1976 . Nitrosourea chemotherapy for primary malignant gliomas . Cancer Treat. Rep. , 60 : 719
   Google Scholar
• May , H. E. , Boose , R. and Reed , D. J. 1975 . Microsomal mono-oxygenation of the carcinostatic 1-(2-chloroethyl)-3-cyclo-hexyl-1-nitrosourea. Synthesis and identification of cis and trans monohydroxylated products . Biochemistry , 14 : 4723
   Google Scholar
• Desiderio , D. M. and Cunningham , M. D. 1981 . TEAF buffer for HPLC-FDMS of oligopeptides . J. Liq. Chromatog. , 4 : 721
   Web of Science ®Google Scholar
• May , H. E. , Tanzer , F. S. , Fridland , G. H. , Wakelyn , C. and Desiderio , D. M. 1982 . High performance liquid chromatography and proteolytic enzyme characterization of peptides in tooth pulp extracts . J. Liq. Chromatog. , 5 : 2135
   Web of Science ®Google Scholar
• Cheng , C. J. , Fujimura , S. , Grunberger , D. and Weinstein , I. B. 1972 . Interaction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea with nucleic acids and proteins in vivo in vitro . Cancer Res. , 32 : 22
   Google Scholar
• May , H. E. , Boose , R. and Reed , D. J. 1975 . Microsomal monooxygenation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea . Biochemistry , 14 : 4723
   Google Scholar
• Reed , D. J. and May , H. E. Formation of alkylation and carbamylation intermediates and cytochrome P-450 catalyzed mono-oxygenation of the 2-chloroethyl nitrosoureas CCNU and Methyl-CCNU, pp 680–687 in Microsomes and Drug Oxidation . Third International Symposium . 1976 , Berlin. N. Y. : Pergamon Press .
   Google Scholar
• Baril , B. B. , Baril , E. F. , Laszlo , J. and Wheeler , G. P. 1975 . Inhibition of rat liver DNA polymerase by nitrosoureas and isocyanates . Cancer Res. , 35 : 1
   Google Scholar
• Chuang , R. Y. , Laszlo , J. and Keller , P. 1976 . Effects of nitrosoureas on human DNA polymerase activities from acute and chronic granulocytic leukemia, Biochim . Biophys. Acta , 425 : 463
   Google Scholar
• Fornace , A. J. , Kohn , K. W. and Kann , H. E. 1978 . Inhibition of the ligase step of excision repair by 2-chloroethyl isocyanate, a decomposition product of 1,3-bis-(2-chloroethyl)-1-nitrosourea . Cancer Res. , 38 : 1064
   Google Scholar
• Babson , J. R. and Reed , D. J. 1978 . Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates . Biochem. Biophys. Res. Commun. , 83 : 754
   PubMedGoogle Scholar
• Brown , W. E. and Wold , F. 1973 . Alkyl isocyanates as active-site-specific reagents for serine proteases . Reaction properties., Biochemistry , 12 : 828
   PubMed Web of Science ®Google Scholar
• Babson , J. R. , Reed , D. J. and Sinkey , M. A. 1977 . Active site specific inactivation of chymotrypsin by cyclohexyl isocyanate formed during degradation of carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea . Biochemistry , 16 : 1584
   PubMed Web of Science ®Google Scholar
• Brodie , A. E. , Babson , J. R. and Reed , D. J. 1980 . Inhibition of tubulin polymerization by nitrosourea-derived isocyanates . Biochem. Pharm. , 29 : 652
   Google Scholar
• Wheeler , G. P. , Johnston , T. P. , Bowden , B. J. , McCaleb , G. S. , Hill , D. L. and Montgomery , J. A. 1977 . Comparison of the properties of metabolites of CCNU . Biochem. Pharm. , 26 : 2331
   Google Scholar
• May , H. E. , Kohlhepp , S. J. , Boose , R. B. and Reed , D. J. 1979 . Synthesis and identification of products derived from the metabolism of the carcinostatic 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by rat liver microsomes . Cancer Res. , 39 : 762
   PubMedGoogle Scholar