HPLC Analysis of Antiepileptic Drugs in Blood Samples: Microbore Separation of Fourteen Compounds

References

• Soldin , S. E. 1985 . “ Anticonvulsants ” . In Therapeutic drug monitoring and toxicology by liquid chromatography Edited by: Wong , S. H. Y. 351 New York and Basel : Marcel Dekker . in:, Ed., p.
   Google Scholar
• Evans , J. E. 1973 . Simultaneous measurement of diphenylhydantoin and phenobarbital in serum by high performance liquid chromatography. . Anal. Chem. , 45 : 2428
   Web of Science ®Google Scholar
• Albert , K. S. , Hallmark , M. R. , Carroll , M. E. and Wagner , J. G. 1973 . Quantitative separation of diphenylhydantoin and its parahydroxylated metabolites by high-performance liquid chromatography. . Res. Commun. Chem. Pathol. Pharmacol. , 6 : 845
   PubMedGoogle Scholar
• Gauchel , G. , Gauchel , F. D. and Birkofer , L. 1973 . Eine Mikromethode zur Bestimmung von Diphenylhydantoin (Phenhydan) im Blut durch Flüssigkeits-Chromatographie mit hohen Eingangsdrucken . Z. Klin. Chem. Klin. Biochem. , 11 : 35
   PubMedGoogle Scholar
• Gauchel , G. , Gauchel , F. D. and Birkofer , L. 1973 . A Micromethod for the determination of carbamazepine in blood by high speed liquid chromatography . Z. Klin. Chem. Klin. Biochem. , 11 : 459
   Google Scholar
• Eichelbaum , M. and Bertilsson , L. 1975 . Determination of carbamazepine and its epoxide metabolite in plasma by high-speed liquid chromatography . J. Chromatogr. , 103 : 135
   PubMed Web of Science ®Google Scholar
• Atwell , S. H. , Green , V. A. and Haney , W. G. 1975 . Development and evaluation of method for simultaneous determination of phenobarbital and diphenylhydantoin in plasma by high-pressure liquid chromatography . J. Pharm. Sci. , 64 : 806
   PubMed Web of Science ®Google Scholar
• Kitazawa , S. and Komuro , T. 1976 . High-speed liquid chromatographic determination of antiepileptic drugs in human plasma . Clin. Chim. Acta , 73 : 31
   PubMedGoogle Scholar
• Kabra , P. M. , Gotelli , G. , Stanfill , R. and Marton , L. J. 1976 . Simultaneous measurement of phenobarbital, diphenylhydantoin, and primidone in blood by high-pressure liquid chromatography . Clin. Chem. , 22 : 824
   PubMed Web of Science ®Google Scholar
• Westenberg , H. G. and de Zeeuw , R. A. 1976 . Rapid and sensitive liquid chromatographic determination of carbamazepine suitable for use in monitoring multiple-drug anticonvulsant therapy . J. Chromatogr. , 118 : 217
   PubMed Web of Science ®Google Scholar
• Maijub , A. G. , Stafford , D. T. and Chamberlain , R. T. 1976 . Anticonvulsant analyses by liquid chromatography . Clin. Chem. , 22 : 1208
   Google Scholar
• Adams , R. F. and Vandemark , F. L. 1976 . Simultaneous high-pressure liquid-chromatographic determination of some anticonvulsants in serum . Clin. Chem. , 22 : 25
   PubMed Web of Science ®Google Scholar
• Adams , R. F. and Schmidt , G. 1976 . Determination of less common anticonvulsants in serum using reversed-phase high-pressure liquid chromatography . Chromatogr. Newsletter , 4 : 8
   Google Scholar
• Soldin , S. J. and Hill , J. G. 1976 . Rapid micromethod for measuring anticonvulsant drugs in serum by high-performance liquid chromatography . Clin. Chem. , 22 : 856
   PubMed Web of Science ®Google Scholar
• Kabra , P. M. and Marton , L. J. 1976 . Determination of carbamazepine in blood or plasma by high-prssure liquid chromatography . Clin. Chem. , 22 : 1070
   PubMedGoogle Scholar
• Soldin , S. J. and Hill , J. G. 1977 . Interference with column-chromatographic measurement of primidone . Clin. Chem. , 23 : 782
   PubMedGoogle Scholar
• Soldin , S. J. and Hill , J. G. 1977 . Routine dual-wavelength analysis of anticonvulsant drugs by high-performance liquid chromatography . Clin. Chem. , 23 : 2352
   PubMedGoogle Scholar
• Kabra , P. M. , Stafford , B. E. and Marton , L. J. 1977 . Simultaneous measurement of phenobarbital, phenytoin, primidone, ethosuximide, and carbamazepine in serum by high-pressure liquid chromatography . Clin. Chem. , 23 : 1284
   PubMed Web of Science ®Google Scholar
• Adams , R. F. , Schmidt , G. J. and Vandemark , F. L. 1977 . A micro method for the determination of carbamazepine and the 10, 11-epoxide metabolite in serum and urine by reverse-phase liquid chromatography . Chromatogr. Newsletter , 5 : 11
   Google Scholar
• Mihaly , G. W. , Phillips , J. A. , Louis , W. J. and Vajda , F. J. 1977 . Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine . Clin. Chem. , 23 : 2283
   PubMedGoogle Scholar
• Gaetani , E. , Laureri , C. F. , Prati , G. and Zambelloni , G. 1978 . Chromatografia liquido liquido ad alta pressione . Dosaggio diantiepilettici nel plasma. Il Farmaco, Ed. Pr. , 33 : 136
   PubMedGoogle Scholar
• Schmidt , G. J. 1978 . Evaluation of new internal standards for the analysis of carbamazepine and procainamide by liquid chromatography . Chromatogr. Newsletter , 6 : 37
   Google Scholar
• Hackett , L. P. and Dusci , L. J. 1978 . High performance liquid chromatography in clinical toxicology . Clin. Toxicol. , 13 : 551
   PubMed Web of Science ®Google Scholar
• Gonnet , C. , Porthault , M. , Bory , C. and Baltassat , P. 1978 . Microdosages du phenobarbital et de la theophylline dans les millieux biologiques par chromatographie en phase liquide . Analusis , 6 : 406
   Google Scholar
• Farinotti , R. , Pfaff , M. C. and Mahuzier , G. 1978 . Dosage simultane du phenobarbital et de l'acide valproique dans le plasma par chromatographie liquide haute performance . Ann. Biol. Clin. , 36 : 347
   PubMedGoogle Scholar
• Kabra , P. M. , McDonald , D. M. and Marton , L. J. 1978 . A simultaneous high-performance liquid chromatographic analysis of the most common anticonvulsants and their metabolites in the serum . J. Anal. Toxicol. , 2 : 127
   Web of Science ®Google Scholar
• Adams , R. F. , Schmidt , G. J. and Vandemark , F. L. 1978 . A micro liquid column chromatography procedure for twelve anticonvulsants and some of their metabolites . J. Chromatogr. , 145 : 275
   PubMedGoogle Scholar
• Helmsing , P. J. , van der Woude , J. and van Eupen , O. M. 1978 . A micromethod for simultaneous estimation of blood levels of some commonly used antiepileptic drugs . Clin. Chim. Acta , 89 : 301
   PubMedGoogle Scholar
• Kabra , P. M. , Koo , H. Y. and Marton , L. J. 1978 . Simultaneous liquid-chromatographic determination of 12 common sedatives and hynotics in serum . Clin. Chem. , 24 : 657
   PubMed Web of Science ®Google Scholar
• Slonek , J. E. , Peng , G. W. and Chiou , W. L. 1978 . Rapid and micro high-pressure liquid chromatographic determination of plasma phenytoin levels . J. Pharm. Sci. , 67 : 1462
   PubMed Web of Science ®Google Scholar
• Gupta , R. N. , Keane , P. M. and Gupta , M. L. 1979 . Valproic acid in plasma, as determined by liquid chromatography . Clin. Chem. , 25 : 1984
   PubMed Web of Science ®Google Scholar
• Sutheimer , C. , Fretthold , D. and Sunshine , I. 1979 . The determination of valproic acid in plasma using reversed-phase liquid chromatography . Chromatogr. Newsletter , 7 : 1
   Google Scholar
• Johnston , C. K. and Lester , G. H. 1979 . A simple procedure for the determination of carbamazepin in plasma by high pressure-liquid chromatography . Ann. Clin. Biochem. , 16 : 213
   PubMedGoogle Scholar
• Astier , A. and Plat , M. M. 1979 . Micro determination simultanee de la carbamazepine plasmatique et de son metabolite 10, 11-epoxy par chromatographie liquide haute performance. Application a la pharmacocinetique de l'epoxy-10,11 carbamazepine . Lyon Medical , 242 : 551
   Google Scholar
• Freeman , D. J. and Rawal , N. 1979 . Serum anticonvulsant monitoring by liquid chromatography with a methanolic mobile phase . Clin. Chem. , 25 : 810
   PubMed Web of Science ®Google Scholar
• Pesh-Imam , M. , Fretthold , D. W. , Sunshine , I. , Kumar , S. , Terrentine , S. and Willis , C. E. 1979 . High pressure liquid chromatography for simultaneous analysis of anticonvulsants: Comparison with EMIT system . Ther. Drug Monit. , 1 : 289
   PubMed Web of Science ®Google Scholar
• Astier , A. , Maury , M. and Barbizet , J. 1979 . Simultaneous, rapid high-performance liquid chromatographic microanalysis of plasma carbamazepine and its 10,11-epoxide metabolite . Applications to pharmacokinetic studies in humans. J. Chromatogr. , 164 : 235
   Google Scholar
• Farinotti , R. and Mahuzier , G. 1979 . Simultaneous determination of six anticonvulsants in serum by high performance liquid chromatography . J. Liquid Chromatogr. , 2 : 345
   Web of Science ®Google Scholar
• Mahuzier , G. , Farinotti , R. and Pfaff-Dessalles , M. C. 1979 . Application de la chromatographie en phase liquide a la determination simultanee des anticonvulsivants dans le plasma . Analusis , 7 : 360
   Google Scholar
• Hodnett , C. N. and Eberhardt , R. D. 1979 . Optimization of the determination of drugs by high-pressure liquid chromatography (HPLC) . J. Anal. Toxicol. , 3 : 187
   Google Scholar
• Williams , R. C. and Viola , J. L. 1979 . Application of an automated extractor/concentrator to the analysis of anticonvulsant drugs in blood serum by high-performance liquid chromatography . J. Chromatogr. , 185 : 505
   PubMedGoogle Scholar
• Perchalski , R. J. , Bruni , J. , Wilder , B. J. and Willmore , L. J. 1979 . Simultaneous determination of the anticonvulsants, cinromide (3-bromo-N-ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography . J. Chromatogr. , 163 : 187
   PubMedGoogle Scholar
• Draper , P. , Shapcott , D. and Lemieux , B. 1979 . Single column high pressure liquid chromatographic determination of drugs in blood . Clin. Biochem. , 12 : 52
   PubMedGoogle Scholar
• Bernardo , M. 1979 . Improved sample preparation for measuring anticonvulsant drugs in serum by “high-performance” liquid chromatography . Clin. Chem. , 25 : 1861
   PubMed Web of Science ®Google Scholar
• Mathies , J. C. and Austin , M. A. 1980 . Modified acetonitrile protein-precipitation method of sample preparation for drug assay by liquid chromatography . Clin. Chem. , 26 : 1760
   PubMedGoogle Scholar
• Stafford , B. E. , Kabra , P. M. and Marton , L. J. 1980 . Some comments on anticonvulsant-drug monitoring by liquid chromatography . Clin. Chem. , 26 : 1366
   PubMedGoogle Scholar
• Soldin , S. J. 1980 . High performance liquid chromatographic analysis of anti-convulsant drugs using radial compression columns . Clin. Biochem. , 13 : 99
   PubMed Web of Science ®Google Scholar
• Rydzewski , R. S. , Gadsden , R. H. and Phelps , C. A. 1980 . Simultaneous rapid HPLC determination of anticonvulsant drugs in plasma and correlation with EMIT . Ann. Clin. Lab. Sci. , 10 : 89
   PubMedGoogle Scholar
• Couri , D. , del Villar , C. S. and Toy-Manning , P. 1980 . Simultaneous quantitative assay of phenobarbital, phenytoin, and p-hydroxydiphenylhydantoin by HPLC and a comparison with EMIT(R) . J. Anal. Toxicol. , 4 : 227
   PubMedGoogle Scholar
• Sawchuk , R. J. and Cartier , L. L. 1980 . Liquid-chromatographic method for simultaneous determination of phenytoin and 5-(4-hydroxyphenyl) -5-phenylhydantoin in plasma and urine . Clin. Chem. , 26 : 835
   PubMedGoogle Scholar
• Kraak , J. C. , Smedes , F. and Meijer , J. W. A. 1980 . Application of on-column concentration of deproteinized serum to the HPLC determination of anticonvulsants . Chromatographia , 13 : 673
   Google Scholar
• Dolan , J. W. , van der Wal , S. , Bannister , S. J. and Snyder , L. R. 1980 . On-line liquid-chromatographic analysis for drugs in serum with the technicon “FAST-LC” system: Performance data to theophylline and for four commonly used anticonvulsants and their metabolites . Clin. Chem. , 26 : 871
   PubMedGoogle Scholar
• Christofides , J. A. and Fry , D. E. 1980 . Measurement of anticonvulsants in serum by reversed-phase ion-pair liquid chromatography . Clin. Chem. , 26 : 499
   PubMedGoogle Scholar
• Chu , S. Y. , Oliveras , L. and Deyasi , S. 1980 . Extraction procedure for measuring anticonvulsant drugs by liquid chromatography . Clin. Chem. , 26 : 521
   PubMed Web of Science ®Google Scholar
• MacKichan , J. J. 1980 . Simultaneous liquid chromatographic analysis for carbamazepine and carbamazepine 10,11-epoxide in plasma and saliva by use of double internal standardization . J. Chromatogr. , 181 : 373
   PubMed Web of Science ®Google Scholar
• Alric , R. , Cociglio , M. , Blayac , J. P. and Puech , R. 1981 . Performance evaluation of a reversed-phase, high-performance liquid chromatographic assay of valproic acid involving a “solvent demixing” extraction procedure and precolumn derivatisation . J. Chromatogr. , 224 : 289
   Web of Science ®Google Scholar
• Schmit , J. M. , Rigaut , P. , Daldoss , C. , Renaudeau , C. and Meunier , J. 1981 . Interet des dosages plasmatiques des medicaments anticonvulsants . Feuillets Biol. , 22 : 115
   Google Scholar
• Cisse , H. , Farinotti , R. , Kirkiacharian , S. and Dauphin , A. 1981 . Dosage de l'acide dipropylacetique dans le plasma par chromatographie en phase liquide et detection spectrofluorimetrique . J. Chromatogr. , 225 : 509
   PubMedGoogle Scholar
• Soldin , S. J. and Walter , M. 1981 . Improved HPLC analysis for anticonvulsant drugs employing radial compression columns . Clin. Biochem. , 14 : 161
   PubMedGoogle Scholar
• Schmit , J. M. , Cloitre , B. , Rigaut , P. , Aucouturier , P. and Meunier , J. 1981 . Determination du phenobarbital, de la phenytoine et de la carbamazepine par chromatographie en phase liquide . Analusis , 9 : 70
   Google Scholar
• Quattrone , A. J. and Putnam , R. S. 1981 . A single liquid-chromatographic procedure for therapeutic monitoring of theophylline, actaminophen, or ethosuximide . Clin. Chem. , 27 : 129
   PubMed Web of Science ®Google Scholar
• Salvesen , B. and Lyngbakken , E. 1981 . Assay of common anticonvulsant drugs simultaneously present in human sera by HPLC compared to GLC . Medd. Norsk Farm. Selsk. , 43 : 45
   Google Scholar
• Furlanut , M. , Delucca , M. G. , Dilberis , G. and Barnaba , A. 1981 . Rapid and sensitive high-pressure liquid chromatographic method for monitoring carbamazepine levels in serum . Br. J. Clin. Pharmacol. , 11 : 393
   PubMedGoogle Scholar
• Dungan , S. M. , Powers , N. E. , Klienman , N. and Scheeler , P. L. 1981 . Anticonvulsant analysis by liquid chromatography: Reverse-phase u-Bondapack C-18 and Radial Pak A systems compared . J. Chromatogr. Sci. , 18 : 23
   Google Scholar
• Conlan , A. M. , Tabor , K. J. and Lesko , L. J. 1981 . Liquid chromatography of anticonvulsants in an inappropriately drawn (lipemic) serum sample . Clin. Chem. , 27 : 513
   PubMedGoogle Scholar
• George , R. C. 1981 . Improved sample treatment before liquid-chromatographic determination of anticonvulsants in serum . Clin. Chem. , 27 : 198
   PubMedGoogle Scholar
• Rambeck , B. , Riedmann , M. and Meijer , J. W. A. 1981 . Systematic method development in liquid chromatography applied to the determination of antiepileptic drugs . Ther. Drug Monit. , 3 : 377
   PubMedGoogle Scholar
• Riedmann , M. , Rambeck , B. and Meijer , J. W. A. 1981 . Quantitative simultaneous determination of eight common antiepileptic drugs and metabolites by liquid chromatography . Ther. Drug Monit. , 3 : 397
   PubMedGoogle Scholar
• Kinberger , B. , Wahrgren , P. and Holmen , A. 1981 . Determination of ethosuximide, phenobarbital, carbamazepine, carbamazepine epoxide and phenytoin in serum by high-performance liquid chromatography using radially compressed columns and an aqueous methanolic mobile phase . Anal. Letters , 14 : 1419
   Web of Science ®Google Scholar
• Ehrental , W. and Rochel , M. 1982 . Kontrolle der Valproinsäure-Therapie durch Serumspiegelbestimmungen mit HPLC oder EMIT und durch gleichzeitige Bestimmung klinisch-chemischer Parameter . Arzneim.-Forsch./Drug Res. , 32 : 449
   PubMedGoogle Scholar
• Kline , W. F. , Enagonio , D. P. , Reeder , D. J. and May , W. E. 1982 . Liquid chromatographic determination of valproic acid in human serum . J. Liquid Chromatogr. , 5 : 1697
   Web of Science ®Google Scholar
• Szabo , G. K. and Browne , T. R. 1982 . Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum . Clin. Chem. , 28 : 100
   PubMedGoogle Scholar
• Kinberger , B. and Holmen , A. 1982 . Analysis for carbamazepine and phenytoin in serum with a high speed liquid chromatography system (Perkin-Elmer) . Clin. Chem. , 28 : 718
   PubMedGoogle Scholar
• Sawchuk , R. J. and Cartier , L. L. 1982 . Simultaneous liquid-chromatographic determination of carbamazepine and its epoxide metabolite in plasma . Clin. Chem. , 28 : 2127
   PubMed Web of Science ®Google Scholar
• Elyas , A. A. , Ratnaraj , N. , Goldberg , V. D. and Lascelles , P. T. 1982 . Routine monitoring of carbamazepine and carbamazepine-10,11-epoxide in plasma by high-performance liquid chromatography using 10-methoxy carbamazepine as internal standard . J. Chromatogr. , 231 : 93
   PubMed Web of Science ®Google Scholar
• Moody , J. P. and Allan , S. M. 1983 . Measurement of valproic acid in serum as the 4-bromophenacyl ester by high-performance liquid chromatography . Clin. Chim. Acta , 127 : 263
   PubMed Web of Science ®Google Scholar
• Riggenmann , H. J. and Juergens , U. 1983 . HPLC-Analyse von Antiepileptika mit Säulenschalttechnik . LaborPraxis , 3 March(.
   Google Scholar
• Haroon , Y. and Keith , D. A. 1983 . High-performance liquid chromatography of anticonvulsants-micro-assay for phenytoin and phenobarbital . J. Chromatogr. , 276 : 445
   PubMedGoogle Scholar
• Neels , H. M. , Totte , J. A. , Verkerk , R. M. , Vlietinck , A. J. and Scharpe , S. L. 1983 . Simultaneous high performance liquid-chromatographic determination of carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone and phenylethylmalonamide in plasma . J. Clin. Chem. Clin. Biochem. , 21 : 295
   PubMedGoogle Scholar
• Greenblatt , D. J. , Matlis , R. and Abernethy , D. R. 1983 . Improved liquid chromatographic analysis of phenytoin and salicylate using radial compression separation . J. Chromatogr. , 275 : 450
   PubMed Web of Science ®Google Scholar
• Turnell , D. C. , Trevor , S. C. and Cooper , J. D. H. 1983 . A rapid procedure for the simultaneous estimation of the anticonvulsant drugs, ethosuximide, phenobarbitone, phenytoin, and carbamazepine in serum using high-pressure liquid chromatography . Ann. Clin. Biochem. , 20 : 37
   PubMedGoogle Scholar
• Kabra , P. M. , Nelson , M. A. and Marton , L. J. 1983 . Simultaneous very fast liquid-chromatographic analysis of ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine in serum . Clin. Chem. , 29 : 473
   PubMed Web of Science ®Google Scholar
• Kushida , K. , Chiba , K. and Ishizaki , T. 1983 . Simultaneous liquid chromatographic determination of chloramphenicol and anti-epileptic drugs (phenobarbital, phenytoin, carbamazepine, and primidone) in plasma . Ther. Drug Monit. , 5 : 127
   PubMedGoogle Scholar
• Stout , S. A. and DeVane , C. L. 1984 . Tissue assay of phenobarbital, phenytoin and p-hydroxyphenytoin by high-performance liquid chromatography . J. Chromatogr. , 285 : 500
   PubMed Web of Science ®Google Scholar
• Nakamura , M. , Kondo , K. , Nishioka , R. and Kawai , S. 1984 . Improved procedure for the high-performance liquid chromatographuc determination of valproic acid in serum as its phenacylester . J. Chromatogr. , 310 : 450
   PubMed Web of Science ®Google Scholar
• Chan , E. M. and Chan , S. C. 1984 . Screening for acidic and neutral drugs by high performance liquid chromatography in postmortem blood . J. Anal. Toxicol. , 8 : 173
   PubMed Web of Science ®Google Scholar
• Ou , C. N. and Rognerud , C. L. 1984 . Simultaneous measurement of ethosuximide, primidone, phenobarbital, phenytoin, carbamazepine, and their bioactive metabolites by liquid chromatography . Clin. Chem. , 30 : 1667
   PubMedGoogle Scholar
• Kumps , A. 1984 . Simultaneous HPLC determination of oxcarbazepine, carbamazepine and their metabolites in serum . J. Liquid Chromatogr. , 7 : 1235
   Web of Science ®Google Scholar
• Juergens , U. 1984 . Routine determination of eight common antiepileptic drugs and metabolites by high-performance liquid chromatography using a column-switching system for direct injection of serum samples . J. Chromatogr. , 310 : 97
   PubMed Web of Science ®Google Scholar
• Nazareth , A. , Jaramillo , L. , Karger , B. L. , Giese , R. W. and Snyder , L. R. 1984 . Automated analysis of antiepileptic drugs in serum by column-switching high-performance liquid chromatography . J. Chromatogr. , 309 : 357
   PubMedGoogle Scholar
• Kuhnz , W. and Nau , H. 1984 . Automated high-pressure liquid chromatographic assay for antiepileptic drugs and their major metabolites by direct injection in serum samples . Ther. Drug Monit. , 6 : 478
   PubMed Web of Science ®Google Scholar
• Bistue , C. , Jarry , C. and Brachet-Liermain , A. 1984 . Extraction automatique et dosage par chromatographie liquide haute performance des medicaments anti-epileptiques . Ann. Pharm. Francaises , 42 : 569
   PubMedGoogle Scholar
• Chan , K. , Lok , S. and Teoh , R. 1984 . The simultaneous determination of five anti-epileptic drugs in plasma by high performance liquid chromatography . Meth. and Find. Exptl. Clin. Pharmacol. , 6 : 701
   PubMedGoogle Scholar
• Grasela , D. M. and Rocci , M. L. 1984 . Liquid chromatographic microassay for carbamazepine and its 10,11-epoxide in plasma . J. Pharm. Sci. , 73 : 1874
   PubMedGoogle Scholar
• Cornelis , J. and Chaillet , F. 1984 . Determination simultanee par chromatographie liquide haute performance de huit antiepileptiques et sedatifs dans le plasma . Ann. Biol. Clin. , 42 : 295
   PubMedGoogle Scholar
• Soto-Otero , R. and Sierra-Marcuno , G. 1984 . Improved simultaneous liquid-chromatographic determination of antiepileptic drugs in plasma . Clin. Chem. , 30 : 817
   PubMed Web of Science ®Google Scholar
• Wad , N. 1984 . Simultaneous determination of eleven antiepileptic compounds in serum by high-performance liquid chromatography . J. Chromatogr. , 305 : 127
   PubMed Web of Science ®Google Scholar
• Gerson , B. , Bell , F. , Chan , S. , Broussard , L. A. , Stearns , F. M. , Dalrymple , R. and Frings , C. S. 1984 . Antiepileptic agents-primidone, phenobarbital, phenytoin, and carbamazepine by reversed-phase liquid chromatography . Clin. Chem. , 30 : 105
   PubMed Web of Science ®Google Scholar
• Nicot , G. , Lachatre , G. , Valette , J. P. , Merle , L. and Nouaille , Y. 1984 . Dosage plasmatique du phenobarbital, pentobarbital et penthiobarbital par chromatographie liquide a haute performance . Therapie , 39 : 361
   PubMed Web of Science ®Google Scholar
• Chan , K. 1985 . Simultaneous determination of carbamazepine and its epoxide metabolite in plasma and urine by high-performance liquid chromatography . J. Chromatogr. , 342 : 341
   PubMed Web of Science ®Google Scholar
• Willems , H. J. J. , van der Horst , A. , de Goede , P. N. F. C. and Haakmeester , G. J. 1985 . Determination of some anticonvulsants, antiarrhythmics, benzodiazepines, xanthines, paracetamol and chloramphenicol by reversed phase HPLC . Pharm. Week-blad Sci. Ed. , 7 : 150
   PubMedGoogle Scholar
• Soto-Otero , R. , Mendez-Alvarez , E. and Sierra-Marcuno , G. 1985 . High performance liquid chromatographic procedure for the simultaneous determination of theophylline, caffeine and phenobarbital in neonates . J. Clin. Chem. Clin. Biochem. , 23 : 303
   PubMedGoogle Scholar
• Kushida , K. and Ishizaki , T. 1985 . Concurrent determination of valproic acid with other antiepileptic drugs by high-performance liquid chromatography . J. Chromatogr. , 338 : 131
   PubMed Web of Science ®Google Scholar
• Wad , N. 1985 . Rapid extraction method for ethosuximide and other antiepileptics in serum for determination by high-performance liquid chromatography . J. Chromatogr. , 338 : 460
   PubMedGoogle Scholar
• Kumps , A. , Genin-Ramakers , J. and Mardens , Y. 1985 . Simultaneous determination of anticonvulsant drugs and metabolites in plasma by high-performance liquid chromatography . J. Chromatogr. , 342 : 469
   PubMed Web of Science ®Google Scholar
• Rambeck , B. 1979 . Pharmacological interactions of mesuximide with phenobarbital and phenytoin in hospitalized epileptic patients . Epilepsia , 20 : 147
   PubMedGoogle Scholar
• Dijkhuis , I. and Vervloet , E. 1974 . Rapid determination of the antiepileptic drug di-n-propylacetic acid in serum . Pharm. Weekblad , 109 : 42
   Google Scholar
• Meijer , J. W. A. 1975 . “ Report on Worksheets collected after WODADIBOF I (Workshop on the determination of anti-epileptic drugs in body fluids) ” . In Clinical pharmacology of antiepileptic drugs Edited by: Schneider , H. , Janz , D. , Gardner-Thorpe , C. , Meinardi , H. and Shewin , A. L. 286 Berlin /Heidelberg/New York : Springer-Verlag . in:, Eds., p.
   Google Scholar
• Juergens , U. , May , T. , Hillenkoetter , K. and Rambeck , B. 1984 . Systematic comparison of three basic methods of sample pretreatment for high-performance liquid chromatographic analysis of antiepileptic drugs using gas chromatography as a reference method . Ther. Drug Monit. , 6 : 334
   PubMedGoogle Scholar
• Roth , W. , Beschke , K. , Jauch , R. , Zimmer , A. and Koss , W. 1981 . Fully automated high-performance liquid chromatography-A new chromatograph for pharmacokinetic drug monitoring by direct injection of body fluids . J. Chromatogr. , 222 : 13
   PubMed Web of Science ®Google Scholar
• Ito , T. , Yamaguchi , T. , Miyazaki , H. , Sekine , Y. , Shimizu , M. , Ishida , S. , Yagi , K. , Kakegawa , N. , Seino , M. and Wada , T. 1982 . Pharmacokinetic studies of AD-810, a new antiepileptic compound-Phase I trials . Arzneim.-Forsch./Drug Res. , 32 : 1581
   PubMed Web of Science ®Google Scholar
• Wagner , J. G. , Sackellares , J. C. , Donofrio , P. D. , Berent , S. and Sakmar , E. 1984 . Nonlinear pharmacokinetics of CI-912 in adult epileptic patients . Ther. Drug Monit. , 6 : 277
   PubMedGoogle Scholar
• Theisohn , M. and Heimann , G. 1982 . Disposition of the antiepileptic oxcarbazepine and its metabolites in healthy volunteers . Eur. J. Clin. Pharmacol. , 22 : 545
   PubMed Web of Science ®Google Scholar
• Menge , G. and Dubois , J. P. 1983 . Determination of oxcarbazepine in human plasma by high-performance liquid chromatography . J. Chromatogr. , 275 : 189
   PubMedGoogle Scholar
• Noirfalise , A. and Collinge , A. 1983 . Quantitative determination of oxcarbazepine . J. Chromatogr. , 274 : 417
   PubMedGoogle Scholar
• Kuepfer , A. , James , R. , Carr , K. and Branch , R. 1982 . Analysis of hydroxylated and demethylated metabolites of mephenytoin in man and laboratory animals using gas-liquid chromatography and high-performance liquid chromatography . J. Chromatogr. , 232 : 93
   PubMedGoogle Scholar
• Juergens , U. 1985 . Simultaneous determination of zonisamide (CI-912) and nine other antiepileptic drugs and metabolites in serum by high-performance liquid chromatography. Poster on the 16th Epilepsy International Congress, Hamburg, September
   Google Scholar