10
Views
16
CrossRef citations to date
0
Altmetric
Original Articles

A Coupled HPLC/Radioimmunoassay for Analysis of Zidovudine Metabolites in Mononuclear Cells

, , &
Pages 2261-2272 | Published online: 23 Oct 2006

References

  • Furman , PA , Fyfe , JA , St Clair , MH , Weinhold , K. , Rideout , JL , Freeman , GA , Nusinoff-Lehrman , S. , Bolognesi , DP , Broder , S. , Mitsuya , H. and Barry , DW . 1986 . Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase . Proc Natl Acad Sci USA , 83 : 8333
  • Fischl , MA , Richman , DD , Grieco , MH , Gottlieb , MS , Volberding , PA , Laskin , OL , Leedom , JM , Groopman , JE , Mildvan , D. , Schooley , RT , Jackson , GG , Durak , DT and King , D. 1987 . AZT Collaborative Working Group. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex . N Engl J Med , 317 : 185
  • Stretcher , BN , Pesce , AJ , Murray , JA , Hurtubise , PE , Vine , WH and Frame , PT . in press . Concentrations of phosphorylated zidovudine (ZDV) in patient leucocytes do not correlate with ZDV dose or plasma concentrations . Ther Drug Monit ,
  • Stretcher , BN , Pesce , AJ , Wermeling , JR and Hurtubise , PE . 1990 . In vitro measurement of phosphorylated zidovudine in peripheral blood leucocytes . Ther Drug Monit , 12 : 481
  • Balzarini , J. , Paulwels , R. , Baba , M. , Herdewijn , P. , De Clerq , E. , Broder , S. and Johns , DG . 1988 . The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-dideoxycytidine are highly dependent on the cell species . Biochem Pharmacol , 37 : 897
  • Frick , LW , Nelson , DJ , St Clair , MH , Furman , PA and Krenitsky , TA . 1988 . Effects of 3′-azido-3′-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells . Biochem Biophys Res Commun , 154 : 124
  • Avramis , VI , Markson , W. , Jackson , RL and Gomperts , E. 1989 . Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells (CEM) . AIDS , 3 : 417
  • Kuster , J. , Joos , B. , Luthy , R. and Vogt , M. 1990 . A method for determination of intracellular azidothymidine (AZT) nucleotides in vivo. Presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy . October 1990 , Atlanta, GA.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.