- Abalovich M, Levalle O, Heimes R, Scaglia H, Aranda C, Zylbersztein C, Oneto A, Aquilano D, Gutierrez S (1999): Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males. Thyroid 9:857-863.
- Ahuja MMS, Chopra IJ, Sridhar CB (1969): Sporadic cretinism and juvenile hypothyroidism. Metabolism 18:488-496.
- Amin SO, El-Sheikh AS (1977): Pituitary-testicular function changes in hypo- and hyperthyroid male rats. Acta Anat 98:121-129.
- Anasti JN, Flack MR, Froehlich J, Nelson LM, Nisula BC (1995): A potential novel mechanism for precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab 80:276-279.
- Andó S, Panno ML, Beraldi E, Tarantino G, Salerno M, Palmero S, Prati M, Fugassa E (1990): Influence of hypothyroidism on in-vitro testicular steroidogenesis in adult rats. Exp Clin Endocrinol 96:149-156.
- Andó S, Sirianni R, Forastieri P, Casaburi I, Lanzino M, Rago V, Giordano F, Giordano C, Carpino A, Pezzi V (2001): Aromatase expression in prepuberal Sertoli cells: effect of thyroid hormone. MoI Cell Endocrinol 178:11-21.
- Antony FF, Aruldhas MM, Udhayakumar RCR, Maran RRM, Govindarajulu P (1995): Inhibition of Leydig cell activity in vivo and in vitro in hypothyorid rats. J Endocrinol 144:293-300.
- Arambepola NK, Bunick D, Cooke PS (1998): Thyroid hormone and follicle-stimulating hormone regulate Müllerian-inhibiting substance messenger ribonucleic acid expression in cultured neonatal rat Sertoli cells. Endocrinology 139:4489-4495.
- Arambepola NK, Bunick D, Cooke PS (1998): Thyroid hormone effects on androgen receptor messenger RNA expression in rat Sertoli and peritubular cells. J Endocrinol 156:43-50.
- Ariyaratne HBS, Mills N, Mason JI, Mendis-Handagama SMLC (2000): Effects of thyroid hormone on Leydig cell regeneration in the adult rat following ethane dimethane sulphonate treatment. Biol Reprod 63:1115-1123.
- Baksi SN (1973): Effect of propylthiouracil-induced hypothyroidism on serum levels of luteinizing hormone and follicle-stimulating hormone in the rat. J Endocrinol 59:655-656.
- Bardi G, Bottazzi C, Demori I, Palmero S (1999): Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in prepubertal pig Sertoli cells. Eur J Endocrinol 141:637-643.
- Barker SB, Klitgaard HM (1952): Metabolism of tissue excised from thyroxine-injected rats. Am J Physiol 170:81-86.
- Becker KL, Winnacker JL, Matthews MJ, Higgins GA (1968): Gynecomastia and hyperthyroidism: an endocrine and histological investigation. J Clin Endocrinol Metab 28:277-285.
- Biswas NM, Ghosh PK, Biswas R, Ghosh D (1994): Effect of thyroidectomy, and thyroxine and a2µ -globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats. J Endocrinol 140:343-347.
- Bruder JM, Samuels MH, Bremner WJ, Ridgway EC, Wierman ME (1995): Hypothyroidisminduced macroorchidism: use of a gonadotropin-releasing hormone agonist to understand its mechanism and augment adult stature. J Clin Endocrinol Metab 80:11-16.
- Bruni JF, Marshall S, Dibbet JA, Meites J (1975): Effects of hyper- and hypothyroidism on serum LH and FSH levels in intact and gonadectomized male and female rats. Endocrinology 97:558-563.
- Buchanan CR, Stanhope R, Adlard P, Jones J, Grant DB, Preece MA (1988): Gonadotrophin, growth hormone and prolactin secretion in children with primary hypothyroidism. Clin Endocrinol 29:427-436.
- Buitrago JMG, Diez LCG (1987): Serum hormones and seminal parameters in males with thyroid disturbance. Andrologia 19:37-41.
- Bunick D, Kirby J, Hess RA, Cooke PS (1994): Developmental expression of testis messenger ribonucleic acids in the rat following propylthiouracil-induced neonatal hypothyroidism. Biol Reprod 51:706-713.
- Buzzard JJ, Morrison JR, O'Bryan MK, Song Q, Wreford NG (2000): Developmental expression of thyroid hormone receptors in the rat testis. Biol Reprod 62: 664-669.
- Canale D, Agostini M, Giorgilli G, Caglieresi C, Scartabelli G, Nardini V, Jannini EA, Martino E, Pinchera A, Macchia E (2001): Thyroid hormone receptors in neonatal, prepubertal, and adult rat testis. J Androl 22:284-288.
- Cavaliere H, Abelin N, Medeiros-Neto G (1988): Serum levels of total testosterone and sex hormone binding globulin in hypothyroid patients and normal subjects treated with incremental doses of L-T4 or L-T3. J Androl 9:215-219.
- Chandrasekhar Y, D'Occhio MJ, Holland MK, Setchell BP (1985): Spermatogenesis, seminal characteristics and reproductive hormone levels in mature rams with induced hypothyroidism and hyperthyroidism. J Endocrinol 105:39-46.
- Chandrasekhar Y, D'Occhio MJ, Setchell BP (1986): Reproductive hormone secretion and spermatogenic function in thyroidectomized rams receiving graded doses of exogenous thyroxine. J Endocrinol 111:245-253.
- Chandrasekhar Y, Holland MK, D'Occhio MJ, Setehell BP (1985): Activity of the hypothalamo-pituitary axis and testicular development in piepubertal ram lambs with induced hypothyroidism or hyperthyroidism. Endocrinology 117:1645-1651.
- Cooke PS, Hess RA, Porcelli J, Meisami E (1991): Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology 129:244-248.
- Cooke PS, Meisami E (1991): Early hypothyroidism in rats causes increased adult testis, and reproductive organ size but does not change testosterone levels. Endocrinology 129:237-243.
- Cooke PS, Porcelli J, Hess RA (1992): Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PTU): the critical period. Biol Reprod 46:146-154.
- Chopra IJ, Tulchinsky D (1974): Status of estrogen-androgen balance in hyperthyroid men with Grave's disease. J Clin Endocrinpl Metab 38:269-277.
- Corrales Hernändez JJ, Miralles Garcia JM, Garcia Diez LC (1990): Primary hypothyroidism and human spermatogenesis. Arch Androl 25:21-27.
- Cristovao FC, Bisi H, Mendonca BB, Bianco AC, Bloise W (2002): Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. Thyroid 12: 13-18.
- Falcone M, Miyamoto T, Fierro-Renoy F, Macchia E, DeGroot LJ (1992): Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform. Endocrinology 131: 2419-2429.
- Ford HC, Cooke RR, Keightley EA, Peek CM (1992): Serum levels of free and bound testosterone in hyperthyroidism. Clin Endocrine! (Oxf) 36:187-192.
- Francavilla S, Cordeschi G, Properzi G, DiCicco L, Jannini EA, Palmero S, Fugassa E, Loras B, D'Armiento M (1991): Effect of thyroid hormone on the pre- and post-natal development of the rat testis. J Endocrinol 129:35-42.
- Fugassa E, Palmero S, Gallo G (1987): Triiodothyronine decreases the production of androgen-binding protein by rat Sertoli cells. Biochem Biophys Res Commun 143: 241-247.
- Gordon GG, Southern AL, Tochimoto S, Rand JJ, Olivo J (1969): Effect of hyperthyroidism and hypothyroidism on the metabolism of testosterone and androstenedione in man. J Clin Endocrinol Metab 29:164-170.
- Hardy MP, Kirby JD, Hess RA, Cooke PS (1993): Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 132:2417-2420.
- Hardy MP, Sharma RS, Arambepola NK, Sottas CM, Russell LD, Bunick D, Hess RA, Cooke PS (1996): Increased proliferation of Leydig cells induced by neonatal hypothyroidism in the rat. J Androl 17:231-238.
- Hess RA, Cooke PS, Bunick D, Kirby JD (1993): Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers. Endocrinology 132:2607-2613.
- Hudson RW, Edwards AL (1992): Testicular function in hyperthyroidism. J Androl 13:117-124.
- Jana NR, Bhattacharya S (1994): Binding of thyroid hormone to the goat testicular Leydig cell induces the generation of proteinaceous factor which stimulates androgen release. J Endocrinol 143:549-556.
- Jana NR, Halder S, Bhattacharya S (1996): Thyroid hormone induces a 52 kDa soluble protein in goat testis Leydig cell which stimulates androgen release. Biochim Biophys Acta 1292:209-214.
- Jannini EA, Carosa E, Rucci N, Screponi E, D'Armiento M (1999): Ontogeny and regulation of variant thyroid hormone receptor isoforms in developing rat testis. J Endocrinol Invest 22: 843-848.
- Jannini EA, Dolci S, Ulisse S, Nikodem VM (1994): Developmental regulation of the thyroid hormone receptor a1- mRNA expression in the rat testis. MoI Endocrinol 8:89-96.
- Jannini EA, Olivieri M, Francavilla S, Gulino A, Ziparo E, D'Armiento M (1990): Ontogenesis of the nuclear 3,5,3'-triiodothyronine receptor in the rat testis. Endocrinology 126: 2521-2526.
- Jannini EA, Ulisse S, D'Armiento M (1995): Thyroid hormone and male gonadal function. Endocr Rev 16:443-459.
- Kalland GA, Vera A, Peterson M, Swerdloff RS (1978): Reproductive hormonal axis of the male rat in experimental hypothyroidism. Endocrinology 102:476-484.
- Kidd SG, Glass AR, Vigensky RA (1979): The hypothalamic-pituitary-testicular axis in thyrotoxicosis. J Clin Endocrinol Metab 48:798-802.
- Kirby JD, Arambepola N, Porkka-Heiskanen T, Kirby YK, Rhoads ML, Nitta H, Jetton AE, Iwamoto G, Jackson GL, Turek FW, Cooke PS (1997): Neonatal hypothyroidism permanently alters follicle-stimulating hormone and luteinizing hormone production in the male rat. Endocrinology 138:2713-2721.
- Kirby JD, Jetton AE, Cooke PS, Hess RA, Bunick D, Ackland JF, Turek FW, Schwartz NB (1992): Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat. Endocrinology 131:559-565.
- Kumar BJ, Khurana ML, Ammini AC, Karmarkar MG, Ahuja MM (1990): Reproductive endocrine functions in men with primary hypothyroidism: effect of thyroxine replacement. Horm Res 34:215-218.
- Lazar MA (1993): Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev 14:184-193.
- Longcope C (1996): The male and female reproductive systems in thyrotoxicosis and hypothyroidism. In: Werner and Ingbar's the Thyroid: A Fundamental and Clinical Text. Braverman LE, Utiger RD (eds). New York: Lippincott-Raven, pp 671-677, 849-852.
- Lovejoy JC, Smith SR, Bray GA, Veldhuis JD, Rood JC, Tulley R (1997): Effects of experimentally induced mild hyperthyroidism on growth hormone and insulin secretion and sex steroid levels in healthy young men. Metabolism 46:1424-1428.
- Macchia E, Nakai A, Janiga A, Sakurai A, Fisfalen ME, Gardner P, Soltani K, DeGroot LJ (1990): Characterization of site-specific polyclonal antibodies to c-erbA peptides recognizing human thyroid hormone receptors «1, «2, and â and native 3,5,3'-triiodothyronine receptor, and study of tissue distribution of the antigen. Endocrinology 126:3232-3239.
- Manna PR, Kero J, Tena-Sempere M, Pakarinen P, Stocco DM, Huhtaniemi IT (2001): Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function. Endocrinology 142:319-331.
- Manna PR, Roy P, Clark BJ, Stocco DM, Huhtaniemi IT (2001): Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in the regulation of murine Leydig cell steroidogenesis. J Steroid Biochem MoI Biol 76:167-177.
- Manna PR, Tena-Sempere M, Huhtaniemi IT (1999): Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse Leydig tumor cells: involvement of the steroidogenic acute regulatory (StAR) protein. J Biol Chem 274:5909-5918.
- Maqsood M (1950): The role of the thyroid in sexual development in the male. Nature 166:692.
- Maqsood M (1954): Role of thyroid on maturity and fertility in the male. Fertil Steril 5:383-401.
- Maran RRM, Aruldhas MM (2002): Adverse effects of neonatal hypothyroidism on Wistar rat spermatogenesis. Endocr Res 28:141-154.
- Maran RRM, Aruldhas MM, Udhayakumar RCR, Subramanian S, Rajendiran G, Antony FF, Arunakaran J, Govindarajulu P (1998): Impact of altered thyroid hormone status on prostatic glycosidases. Int J Androl 21:121-128.
- Maran RRM, Arunakaran J, Aruldhas MM (2000): T3 directly stimulates basal and modulates LU induced testosterone and oestradiol production by rat Leydig cells in vitro. Endocr J 47: 417-428.
- Maran RRM, Arunakaran J, Aruldhas MM (2001): Prolactin and Leydig cells: biphasic effects of prolactin on LH-, T3-, and GH-induced testosterone/oestradiol secretion by Leydig cells in pubertal rats. Int J Androl 24: 48-55.
- Maran RRM, Arunakaran J, Jeyaraj DA, Ravichandran K, Ravisankar B, Aruldhas MM (2000): Transient neonatal hypothyroidism alters plasma and testicular sex steroid concentration in puberal rats. Endocr Res 26:411-429.
- Maran RRM, Priyadarsini D, Udhayakumar RCR, Arunakaran J, Aruldhas MM (2001): Differential effect of hyperthyroidism on rat epididymal glycosidases. Int J Androl 24:206-215.
- Maran RRM, Ravichandran K, Arunakaran J, Aruldhas MM (2001): Impact of neonatal hypothyroidism on Leydig cell number, plasma, and testicular interstitial fluid sex steroids concentration. Endocr Res 27:119-141.
- Maran RRM, Ravisankar B, Ravichandran K, Valli G, Arunakaran J, Aruldhas MM (1999): Impact of neonatal onset hypothyroidism on Sertoli cell number, plasma and testicular interstitial fluid androgen binding protein concentration. Endocr Res 25:307-322.
- Maran RRM, Sivakumar R, Arunakaran J, Ravisankar B, Ravichandran K, Sidharthan V, Jeyaraj DA, Aruldhas MM (1999): Duration-dependent effect of transient neonatal hypothyroidism on Sertoli and germ cell number, and plasma and testicular interstitial fluid androgen binding protein concentration. Endocr Res 25:323-340.
- Maran RRM, Sivakumar R, Ravisankar B, Valli G, Ravichandran K, Arunakaran J, Aruldhas MM (2000): Growth hormone directly stimulates testosterone and oestradiol secretion by rat Leydig cells in vitro and modulates the effects of LH and T3. Endocr J 47:111-118.
- Mendis-Handagama SMLC, Ariyaratne HBS, Teunissen van Manen KR, Haupt RL (1998): Differentiation of adult Leydig cells in the neonatal rat testis is arrested by hypothyroidism. Biol Reprod 59:351-357
- Mendis-Handagama SMLC, Sharma OP (1994): Effects of neonatal administration of the reversible goitrogen propylthiouracil on the testis interstitium in adult rats. J Reprod Fertil 100:85-92.
- Minetti CASA, Su PY, Valle LBS, Oliveira-Filho RM (1986): Testicular function in prolactintreated hypothyroid rats. In: Frontiers in Thyroidology, Vol. 2. Proceedings of the 9th International Thyroid Congress, September 1-6, 1985, Sao-Paulo. Medeiros-Neto G, Gaitan E (eds). New York: Plenum, pp 1231-1234.
- Oppenheimer JH, Schwartz HL, Surks MI (1974): Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain, spleen and testis. Endocrinology 95:897-903.
- Palmero S, Benahmed M, Morera AM, Trucchi P, Fugassa E (1992): Identification of nuclear tri-iodothyronine receptors in Sertoli cells from immature piglet testes. J Mol Endocrinol 9: 55-59.
- Palmero S, DeMarco P, Fugassa E (1995): Thyroid hormone receptor beta mRNA expression in Sertoli cells isolated from prepubertal testis. J MoI Endocrinol 14:131-134.
- Palmero S, DeMarchis M, Gallo G, Fugassa E (1989): Thyroid hormone affects the development of Sertoli cell function in the rat. J Endocrinol 123:105-111.
- Palmero S, DeMarco P, Trucchi P, Prati M, Fugassa E (1991): Nuclear triiodothyronine receptors in the testis of the growing rat are regulated by the thyroid status. Boll Soc Ital Biol Sper 67:501-508.
- Palmero S, Maggiani S, Fugassa E (1988): Nuclear triiodothyronine receptors in rat Sertoli cells. MoI Cell Endocrinol 58:253-256.
- Palmero S, Prati M, DeMarco P, Trucchi P, Fugassa E (1993): Thyroidal regulation of nuclear tri-iodothyronine receptors in the developing rat testis. J Endocrinol 136:277-282.
- Palmero S, Prati M, Barreca A, Minuto F, Giordano G, Fugassa E (1990): Thyroid hormone stimulates the production of insulin-like growth factor I (IGF-I) by immature rat Sertoli cells. MoI Cell Endocrinol 68:61-65.
- Panno ML, Beraldi E, Pezzi V, Salerno M, DeLuca G, Lanzino M, LePera M, Sisci D, Prati M, Palmero S, Bolla E, Fugassa E, Ando S (1994): Influence of thyroid hormone on androgen metabolism in peripuberal rat Sertoli cells. J Endocrinol 140:349-355.
- Panno ML, Salerno M, Lanzino M, DeLuca G, Maggiolini M, Straface SV, Prati M, Palmero S, Bolla E, Fugassa E, Ando S (1995): Follow up study on the effects of thyroid hormone administration on androgen metabolism of peripubertal rat Sertoli cells. Eur J Endocrinol 132:236-241.
- Parkinson TJ, Douthwaite JA, Follett BK (1995): Responses of prepubertal and mature rams to thyroidectomy. J Reprod Fertil 104:51-56.
- Ridgway EC, Maloof F, Longcope C (1982): Androgen and oestrogen dynamics in hyperthyroidism. J Endocrinol 95:105-115.
- Santos A, Freake HC, Rosenberg ME, Schwartz HL, Oppenheimer JH (1988): Triiodothyronine nuclear binding capacity in rat tissues correlates with a 6.0 kilobase (kb) and not a 2.6 kb messenger ribonucleic acid hybridization signal generated by a human c-erbA probe. MoI Endocrinol 2:992-998.
- Same DH, Refetoff S, Rosenfield RL, Farriaux JP (1988): Sex hormone-binding globulin in the diagnosis of peripheral tissue resistance to thyroid hormone: the value of changes after short term triiodothyronine administration. J Clin Endocrinol Metab 66: 740-747.
- Skinner MK (1991): Cell-cell interactions in the testis. Endocr Rev 12:45-77.
- Southern AL, Olivo J, Gordon GG, Vittek J, Brener J, Rafii F (1974): The conversion of androgens to estrogens in hyperthyroidism. J Clin Endocrinol Metab 38:207-214.
- Stradtman EW (1993): Thyroid dysfunction and ovulatory disorders. In: Text book of Reproductive Medicine. Carr BR, Blackwell RE (eds). Norwalk, CT: Appleton, pp 297-321.
- Tagami T, Nakamura H, Sasaki S, Imura H (1990): Characterization of interaction between nuclear T3 receptors and antiserum against cellular-erb A peptide. Endocrinology 126:1105-1111.
- Tagami T, Nakamura H, Sasaki S, Miyoshi Y, Imura H (1993): Estimation of the protein content of thyroid hormone receptor a and ßl in rat tissues by Western blotting. Endocrinology 132: 275-279.
- Tagami T, Nakamura H, Sasaki S, Mori T, Yoshioka H, Yoshida H, Imura H (1990): Immunohistochemical localization of nuclear 3,5,3'-triiodothyronine receptor proteins in rat tissues studied with antiserum against C-ERB A/T3 receptor. Endocrinology 127:1727-1734.
- Teerds KJ, DeRooij DG, DeJong FH, VanHaaster LH (1998): Development of the adult-type Leydig cell population in the rat is affected by neonatal thyroid hormone levels. Biol Reprod 59:344-350.
- Ulisse S, Jannini EA, Carosa E, Piersanti D, Graziano FM, D'Armiento M (1994): Inhibition of aromatase activity in rat Sertoli cells by thyroid hormone. J Endocrinol 140:431-436.
- Valenti S, Guido R, Fazzuoli L, Barreca A, Giusti M, Giordano G (1997): Decreased steroidogenesis and cAMP production in vitro by Leydig cells isolated from rats made hypothyroid during adulthood. Int J Androl 20:279-286.
- Valle LBS, Oliveira-Filho RM, Romaldini JH, Lara PF (1985): Pituitary-testicular axis abnormalities in immature male hypothyroid rats. J Steroid Biochem 23:253-257.
- VanHaaster LH, DeJong FH, Docter R, DeRooij DG (1992): The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat. Endocrinology 131:1574-1576.
- VanHaaster LH, DeJong FH, Docter R, DeRooij DG (1993): High neonatal triiodothyronine levels reduce the period of Sertoli cell proliferation and accelerate tubular lumen formation in the rat testis, and increase serum inhibin levels. Endocrinology 133:755-760.
- Velazquez EM, Bellabarba AG (1997): Effects of thyroid status on pituitary gonadotropin and testicular reserve in men. Arch Androl 38:85-92.
- Vilchez-Martinez JA (1973): Study of the pituitary-testicular axis in hypothyroid adult male rats. J Reprod Fertil 35:123-126.
- Wortsman J, Rosner W, Dufau ML (1987): Abnormal testicular function in men with primary hypothyroidism. Am J Med 82:207-212.
THYROID HORMONES: THEIR ROLE IN TESTICULAR STEROIDOGENESIS
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