The Use of Trazodone for Insomnia and Other Sleep Disturbances

References

• AbdelFattah, M. R., Jung, S. W., Greenspan, M. A., Padilla, M., & Enciso, R. (2020). Efficacy of antidepressants in the treatment of obstructive sleep apnea compared to placebo. A systematic review with meta-analyses. Sleep & Breathing, 24(2), 443–453. https://doi.org/10.1007/s11325-019-01954-9
   PubMed Web of Science ®Google Scholar
• Alimoradi, Z., Jafari, E., Broström, A., Ohayon, M. M., Lin, C. Y., Griffiths, M. D., Blom, K., Jernelöv, S., Kaldo, V., & Pakpour, A. H. (2022). Effects of cognitive behavioral therapy for insomnia (CBT-I) on quality of life: A systematic review and meta-analysis. Sleep Medicine Reviews, 64, 101646. https://doi.org/10.1016/j.smrv.2022.101646
   PubMed Web of Science ®Google Scholar
• Aurora, R. N., Zak, R. S., Auerbach, S. H., Casey, K. R., Chowdhuri, S., Karippot, A., Maganti, R. K., Ramar, K., Kristo, D. A., Bista, S. R., Lamm, C. I., & Morgenthaler, T. I. (2010). Best practice guide for the treatment of nightmare disorder in adults. Journal of Clinical Sleep Medicine, 6(4), 389–401.
   PubMed Web of Science ®Google Scholar
• Camargos, E. F., Pandolfi, M. B., Freitas, M. P. D., Quintas, J. L., Lima, J. d O., Miranda, L. C., Pimentel, W., & Medeiros-Souza, P. (2011). Trazodone for the treatment of sleep disorders in dementia: An open-label, observational and review study. Arquivos de Neuro-Psiquiatria, 69(1), 44–49. https://doi.org/10.1590/s0004-282x2011000100010
   PubMed Web of Science ®Google Scholar
• Chen, A., Copeli, F., Metzger, E., Cloutier, A., & Osser, D. N. (2021). The psychopharmacology algorithm project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia. Psychiatry Research, 295, 113641. https://doi.org/10.1016/j.psychres.2020.113641
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., Chen, C. L., & Yu, C. C. (2021). Trazodone improves obstructive sleep apnea after ischemic stroke: A randomized, double-blind, placebo-controlled, crossover pilot study. Journal of Neurology, 268(8), 2951–2960. https://doi.org/10.1007/s00415-021-10480-2
   PubMed Web of Science ®Google Scholar
• Chung, K. F., Lee, C. T., Yeung, W. F., Chan, M. S., Chung, E. W., & Lin, W. L. (2018). Sleep hygiene education as a treatment of insomnia: A systematic review and meta-analysis. Family Practice, 35(4), 365–375. https://doi.org/10.1093/fampra/cmx122
   PubMed Web of Science ®Google Scholar
• De Crescenzo, F., D'Alò, G. L., Ostinelli, E. G., Ciabattini, M., Di Franco, V., Watanabe, N., Kurtulmus, A., Tomlinson, A., Mitrova, Z., Foti, F., Del Giovane, C., Quested, D. J., Cowen, P. J., Barbui, C., Amato, L., Efthimiou, O., & Cipriani, A. (2022). Comparative ­effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: A systematic review and network meta-analysis. Lancet, 400(10347), 170–184. https://doi.org/10.1016/S0140-6736(22)00878-9
   PubMed Web of Science ®Google Scholar
• Dietrich, S. K., Francis-Jimenez, C. M., Knibbs, M. D., Umali, I. L., & Truglio-Londrigan, M. (2016). Effectiveness of sleep education programs to improve sleep hygiene and/or sleep quality in college students: A systematic review. JBI Database of Systematic Reviews and Implementation Reports, 14(9), 108–134. https://doi.org/10.11124/JBISRIR-2016-003088
   PubMedGoogle Scholar
• Everitt, H., Baldwin, D. S., Stuart, B., Lipinska, G., Mayers, A., Malizia, A. L., Manson, C. C., & Wilson, S. (2018). Antidepressants for ­insomnia in adults. The Cochrane Database of Systematic Reviews, 5(5), CD010753. https://doi.org/10.1002/14651858.CD010753.pub2
   PubMed Web of Science ®Google Scholar
• Gonçalo, A. M. G., & Vieira-Coelho, M. A. (2021). The effects of trazodone on human cognition: A systematic review. European Journal of Clinical Pharmacology, 77(11), 1623–1637. https://doi.org/10.1007/s00228-021-03161-6
   PubMed Web of Science ®Google Scholar
• Goyal, P., Kattula, D., Rao, R., Bhad, R., Mishra, A. K., & Dhawan, A. (2023). Trazodone for sleep disturbance in opioid dependent patients maintained on buprenorphine: A double blind, placebo-controlled trial. Drug and Alcohol Dependence, 250, 110891. https://doi.org/10.1016/j.drugalcdep.2023.110891
   PubMed Web of Science ®Google Scholar
• Gupta, M. A., & Simpson, F. C. (2015). Obstructive sleep apnea and psychiatric disorders: A systematic review. Journal of Clinical Sleep Medicine, 11(2), 165–175. https://doi.org/10.5664/jcsm.4466
   PubMed Web of Science ®Google Scholar
• Hadi, F., Agah, E., Tavanbakhsh, S., Mirsepassi, Z., Mousavi, S. V., Talachi, N., Tafakhori, A., & Aghamollaii, V. (2022). Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson’s disease and sleep disorders: A randomized, double-blind trial. Neurological Sciences, 43(10), 6141–6148. https://doi.org/10.1007/s10072-022-06188-4
   PubMed Web of Science ®Google Scholar
• Haria, M., Fitton, A., & McTavish, D. (1994). Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs & Aging, 4(4), 331–355. https://doi.org/10.2165/00002512-199404040-00006
   PubMed Web of Science ®Google Scholar
• Hertenstein, E., Trinca, E., Wunderlin, M., Schneider, C. L., Züst, M. A., Fehér, K. D., Su, T., Straten, A. V., Berger, T., Baglioni, C., Johann, A., Spiegelhalder, K., Riemann, D., Feige, B., & Nissen, C. (2022). Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis. Sleep Medicine Reviews, 62, 101597. https://doi.org/10.1016/j.smrv.2022.101597
   PubMed Web of Science ®Google Scholar
• Hwang, T., Shah, T., & Sadeghi-Nejad, H. (2021). A review of antipsychotics and priapism. Sexual Medicine Reviews, 9(3), 464–471. https://doi.org/10.1016/j.sxmr.2020.10.003
   PubMed Web of Science ®Google Scholar
• Jaffer, K. Y., Chang, T., Vanle, B., Dang, J., Steiner, A. J., Loera, N., Abdelmesseh, M., Danovitch, I., & Ishak, W. W. (2017). Trazodone for insomnia: A systematic review. Innovations in Clinical Neuroscience, 14(7–8), 24–34.
   PubMedGoogle Scholar
• Jayaram, G., & Rao, P. (2005). Safety of trazodone as a sleep agent for inpatients. Psychosomatics, 46(4), 367–369. https://doi.org/10.1176/appi.psy.46.4.367
   PubMed Web of Science ®Google Scholar
• Kearns, B., Cooper, K., Orr, M., Essat, M., Hamilton, J., & Cantrell, A. (2022). The incidence and costs of adverse events associated with ­antidepressants: Results from a systematic review, network meta-analysis and multi-country economic model. Neuropsychiatric Disease and Treatment, 18, 1133–1143. https://doi.org/10.2147/NDT.S356414
   PubMed Web of Science ®Google Scholar
• La, A. L., Walsh, C. M., Neylan, T. C., Vossel, K. A., Yaffe, K., Krystal, A. D., Miller, B. L., & Karageorgiou, E. (2019). Long-term trazodone use and cognition: A potential therapeutic role for slow-wave sleep enhancers. Journal of Alzheimer’s Disease, 67(3), 911–921. https://doi.org/10.3233/JAD-181145
   PubMed Web of Science ®Google Scholar
• McCleery, J., & Sharpley, A. L. (2020). Pharmacotherapies for sleep disturbances in dementia. The Cochrane Database of Systematic Reviews, 11(11), CD009178. https://doi.org/10.1002/14651858.CD009178.pub4
   PubMedGoogle Scholar
• Mendelson, W. B. (2005). A review of the evidence for the efficacy and safety of trazodone in insomnia. The Journal of Clinical Psychiatry, 66(4), 469–476. https://doi.org/10.4088/jcp.v66n0409
   PubMed Web of Science ®Google Scholar
• Micromedex (2024). Trazodone hydrochloride. Merative Micromedex. Retrieved May 3, 2024, from https://www.micromedexsolutions.com/micromedex2/librarian
   Google Scholar
• Myles, H., Myles, N., Antic, N. A., Adams, R., Chandratilleke, M., Liu, D., Mercer, J., Vakulin, A., Vincent, A., Wittert, G., & Galletly, C. (2016). Obstructive sleep apnea and schizophrenia: A systematic ­review to inform clinical practice. Schizophrenia Research, 170(1), 222–225. https://doi.org/10.1016/j.schres.2015.11.014
   PubMed Web of Science ®Google Scholar
• Nobre, M. L., Sarmento, A. C. A., de Oliveira, P. F., Wanderley, F. F., Diniz Júnior, J., & Gonçalves, A. K. (2024). Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis. Clinics, 79, 100330. https://doi.org/10.1016/j.clinsp.2024.100330
   PubMed Web of Science ®Google Scholar
• Pochiero, I., Gorini, M., Comandini, A., Calisti, F., Loreto, G. D., Cattaneo, A., Knight, T., Anastassopoulos, K. P., Patel, R., Baik, R., & Bruni, O. (2022). Real-world characteristics and treatment patterns of patients with insomnia prescribed trazodone in the United States. Clinical Therapeutics, 44(8), 1093–1105. https://doi.org/10.1016/j.clinthera.2022.07.004
   PubMed Web of Science ®Google Scholar
• Puzantian, T., & Carlat, D. J. (2024). Medication fact book for psychiatric practice (7th ed.). Carlat Publishing, LLC.
   Google Scholar
• Rezaee, M. E., & Gross, M. S. (2020). Are we overstating the risk of priapism with oral phosphodiesterase type 5 inhibitors? The Journal of Sexual Medicine, 17(8), 1579–1582. https://doi.org/10.1016/j.jsxm.2020.05.019
   PubMed Web of Science ®Google Scholar
• Roy, A. N., & Smith, M. (2010). Prevalence and cost of insomnia in a state Medicaid fee-for-service population based on diagnostic codes and prescription utilization. Sleep Medicine, 11(5), 462–469. https://doi.org/10.1016/j.sleep.2009.09.012
   PubMed Web of Science ®Google Scholar
• Ruxton, K., Woodman, R. J., & Mangoni, A. A. (2015). Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis. British Journal of Clinical Pharmacology, 80(2), 209–220. https://doi.org/10.1111/bcp.12617
   PubMed Web of Science ®Google Scholar
• Sateia, M. J., Buysse, D. J., Krystal, A. D., Neubauer, D. N., & Heald, J. L. (2017). Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: An American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine, 13(2), 307–349. https://doi.org/10.5664/jcsm.6470
   PubMed Web of Science ®Google Scholar
• Scher, M., Krieger, J. N., & Juergens, S. (1983). Trazodone and priapism. The American Journal of Psychiatry, 140(10), 1362–1363. https://doi.org/10.1176/ajp.140.10.1362
   PubMed Web of Science ®Google Scholar
• Stahl, S. M. (2024). Prescriber’s guide: Stahl’s essential psychopharmacology (8th ed.). Cambridge University Press.
   Google Scholar
• Sys, J., Van Cleynenbreugel, S., Deschodt, M., Van der Linden, L., & Tournoy, J. (2020). Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: A systematic literature review. European Journal of Clinical Pharmacology, 76(3), 363–381. https://doi.org/10.1007/s00228-019-02812-z
   PubMed Web of Science ®Google Scholar
• Tanimukai, H., Murai, T., Okazaki, N., Matsuda, Y., Okamoto, Y., Kabeshita, Y., Ohno, Y., & Tsuneto, S. (2013). An observational study of insomnia and nightmare treated with trazodone in patients with advanced cancer. The American Journal of Hospice & Palliative Care, 30(4), 359–362. https://doi.org/10.1177/1049909112452334
   PubMed Web of Science ®Google Scholar
• Taylor, D. M., Barnes, T. R., & Young, A. H. (2021). The Maudsley prescribing guidelines in psychiatry. John Wiley & Sons, Inc. https://doi.org/10.1002/9781119870203
   Google Scholar
• Thompson, J. W., Ware, M. R., & Blashfield, R. K. (1990). Psychotropic medication and priapism: A comprehensive review. The Journal of Clinical Psychiatry, 51(10), 430–433.
   PubMed Web of Science ®Google Scholar
• Trauer, J. M., Qian, M. Y., Doyle, J. S., Rajaratnam, S. M., & Cunnington, D. (2015). Cognitive behavioral therapy for chronic insomnia: A systematic review and meta-analysis. Annals of Internal Medicine, 163(3), 191–204. https://doi.org/10.7326/M14-2841
   PubMed Web of Science ®Google Scholar
• UpToDate (2019). Trazodone: Drug information. UpToDate. Retrieved May 3, 2024, from https://www.uptodate.com/contents/trazodone-drug-information
   Google Scholar
• Wang, J., Liu, S., Zhao, C., Han, H., Chen, X., Tao, J., & Lu, Z. (2020). Effects of trazodone on sleep quality and cognitive function in arteriosclerotic cerebral small vessel disease comorbid with chronic insomnia. Frontiers in Psychiatry, 11, 620. https://doi.org/10.3389/fpsyt.2020.00620
   PubMed Web of Science ®Google Scholar
• Warner, M. D., Dorn, M. R., & Peabody, C. A. (2001). Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. Pharmacopsychiatry, 34(4), 128–131. https://doi.org/10.1055/s-2001-15871
   PubMed Web of Science ®Google Scholar
• Wilson, S., Anderson, K., Baldwin, D., Dijk, D. J., Espie, A., Espie, C., Gringras, P., Krystal, A., Nutt, D., Selsick, H., & Sharpley, A. (2019). British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update. Journal of Psychopharmacology, 33(8), 923–947. https://doi.org/10.1177/0269881119855343
   PubMed Web of Science ®Google Scholar
• Yi, X. Y., Ni, S. F., Ghadami, M. R., Meng, H. Q., Chen, M. Y., Kuang, L., Zhang, Y. Q., Zhang, L., & Zhou, X. Y. (2018). Trazodone for the treatment of insomnia: A meta-analysis of randomized placebo-controlled trials. Sleep Medicine, 45, 25–32. https://doi.org/10.1016/j.sleep.2018.01.010
   PubMed Web of Science ®Google Scholar
• Zheng, Y., Lv, T., Wu, J., & Lyu, Y. (2022). Trazodone changed the polysomnographic sleep architecture in insomnia disorder: A systematic review and meta-analysis. Scientific Reports, 12(1), 14453. https://doi.org/10.1038/s41598-022-18776-7
   PubMed Web of Science ®Google Scholar