Electrical stimulation of cerebellar fastigial nucleus protects against cerebral ischemic injury by PPARγ upregulation

References

• Lopez AD , Mathers CD , Ezzati M , et al . Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747–1757.10.1016/S0140-6736(06)68770-9
   PubMed Web of Science ®Google Scholar
• Chang TH , Szabo E . Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. Cancer Res. 2000;60:1129–1138.
   PubMed Web of Science ®Google Scholar
• Lehrke M , Lazar MA . The many faces of PPARgamma. Cell. 2005;123:993–999.10.1016/j.cell.2005.11.026
   PubMed Web of Science ®Google Scholar
• Hong S , Xin Y , HaiQin W , et al . The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus. Neurochem Int. 2013;63:405–412.10.1016/j.neuint.2013.07.010
   PubMed Web of Science ®Google Scholar
• Reis DJ , Berger SB , Underwood MD , Khayata M . Electrical stimulation of cerebellar fastigial nucleus reduces ischemic infarction elicited by middle cerebral artery occlusion in rat. J Cereb Blood Flow Metab. 1991;11:810–818.10.1038/jcbfm.1991.139
   PubMed Web of Science ®Google Scholar
• Yamamoto S , Golanov EV , Reis DJ . Reductions in focal ischemic infarctions elicited from cerebellar fastigial nucleus do not result from elevations in cerebral. J Cereb Blood Flow Metab. 1993;13:1020–1024.10.1038/jcbfm.1993.128
   PubMed Web of Science ®Google Scholar
• Zhang F , Iadecola C . Fastigial stimulation increases ischemic blood flow and reduces brain damage after focal ischemia. J Cereb Blood Flow Metab. 1993;13:1013–1019.10.1038/jcbfm.1993.127
   PubMed Web of Science ®Google Scholar
• Zhou P , Qian L , Glickstein SB , et al . Electrical stimulation of cerebellar fastigial nucleus protects rat brain, in vitro, from staurosporine-induced apoptosis. J Neurochem. 2000;79:328–338.
   Web of Science ®Google Scholar
• Galea E , Golanov EV , Feinstein DL , et al . Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia. Am J Physiol. 1998;274:H2035–H2045.
   PubMedGoogle Scholar
• Tang Weiju , Dong Weiwei , Xie Peng , et al . The effect of pre-condition cerebella fastigial nucleus electrical stimulation within and beyond the time window of thrombolytic on ischemic stroke in the rats. PLOS ONE. 2015;10:e0128447.10.1371/journal.pone.0128447
   PubMed Web of Science ®Google Scholar
• Belayev L , Alonso OF , Busto R , et al . Middle cerebral artery occlusion in the rat by intraluminal suture: neurological and pathological evaluation of an improved model. Stroke. 1996;27:1616–1623.10.1161/01.STR.27.9.1616
   PubMed Web of Science ®Google Scholar
• Liu B , Li J , Li L , et al . Electrical stimulation of cerebellar fastigial nucleus promotes the expression of growth arrest and DNA damage inducible gene β and motor function recovery in cerebral ischemia/reperfusion rats. Neurosci Lett. 2012;520:110–114.10.1016/j.neulet.2012.05.044
   PubMed Web of Science ®Google Scholar
• Hunter AJ , Hatcher J , Virley D , et al . Functional assessments in mice and rats after focal stroke. Neuropharmacology. 2000;39:806–816.10.1016/S0028-3908(99)00262-2
   PubMed Web of Science ®Google Scholar
• Ou Z , Zhao X , Labiche LA , et al . Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2-mediated protection of brain after experimental cerebral ischemia in rat. Brain Res. 2006;1096:196–203.10.1016/j.brainres.2006.04.062
   PubMed Web of Science ®Google Scholar
• Victor NA , Wanderi EW , Gamboa J , et al . Altered PPARgamma expression and activation after transient focal ischemia in rats. Eur J Neurosci. 2006;24:1653–1663.10.1111/ejn.2006.24.issue-6
   PubMed Web of Science ®Google Scholar
• Zhao Y , Patzer A , Herdegen T , et al . Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J. 2006;20:1162–1175.10.1096/fj.05-5007com
   PubMed Web of Science ®Google Scholar
• Zuhayra M , Zhao Y , Von Forstner C , et al . Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat. Neuropathol Appl Neurobiol. 2011;37:738–752.10.1111/nan.2011.37.issue-7
   PubMed Web of Science ®Google Scholar
• Sun Hong , Xiong Wanfen , Arrick Denise M , et al . Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: possible role of PPARγ. PLoS ONE. 2012;7:e41716.10.1371/journal.pone.0041716
   PubMed Web of Science ®Google Scholar
• Kapadia R , Yi JH , Vemuganti R . Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci. 2008;13:1813–1826.10.2741/2802
   PubMed Web of Science ®Google Scholar
• Sieber MW , Claus RA , Witte OW , et al . Attenuated inflammatory response in aged mice brains following stroke. PLoS ONE. 2011;6:e26288.10.1371/journal.pone.0026288
   PubMed Web of Science ®Google Scholar
• Chan SJ , Wong WS , Wong PT , et al . Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia. Br J Pharmacol. 2010;161:668–679.10.1111/j.1476-5381.2010.00906.x
   PubMed Web of Science ®Google Scholar
• Yasuda Y , Shimoda T , Uno K , et al . Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats. J Neuroinflammation. 2011;8:70.10.1186/1742-2094-8-70
   PubMed Web of Science ®Google Scholar
• Legos JJ , Barone FC . Update on pharmacological strategies for stroke: prevention, acute intervention and regeneration. Curr Opin Investig Drugs. 2003;4:847–858.
   PubMedGoogle Scholar
• Mitsios N , Gaffney J , Krupinski J , et al . Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue. Cell Biochem Biophys. 2007;47:73–85.10.1385/CBB:47:1:73
   PubMed Web of Science ®Google Scholar
• Zhao X , Strong R , Zhang J , et al . Neuronal PPARγ deficiency increases susceptibility to brain damage after cerebral ischemia. J Neurosci. 2009;29:6186–6195.10.1523/JNEUROSCI.5857-08.2009
   PubMed Web of Science ®Google Scholar