Lack of association between MTHFR A1298C variant and Alzheimer’s disease: evidence from a systematic review and cumulative meta-analysis

References

• Alzheimer’s Association. 2012 Alzheimer’s disease facts and figures. Alzheimers Dement. 2012;8:131–168.
   PubMed Web of Science ®Google Scholar
• Mayeux R, Stern Y. Epidemiology of Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2:a006239.
   PubMed Web of Science ®Google Scholar
• Alzheimer’s Association. 2014 Alzheimer’s disease facts and figures. Alzheimers Dement. 2014;10:e47–e92.
   PubMed Web of Science ®Google Scholar
• Baumgart M, Snyder HM, Carrillo MC, et al. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement. 2015;11:718–726.10.1016/j.jalz.2015.05.016
   PubMed Web of Science ®Google Scholar
• Querfurth HW, LaFerla FM. Alzheimer’s disease. N Engl J Med. 2010;362:329–344. 10.1016/j.bbadis.2015.12.023
   PubMed Web of Science ®Google Scholar
• Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov. 2011;10:698–712.
   PubMed Web of Science ®Google Scholar
• Hooper C, Lovestone S, Sainz-Fuertes R. Alzheimer’s disease, diagnosis and the need for biomarkers. Biomark Insights. 2008;3:317–323.
   PubMedGoogle Scholar
• Cross DS, Ivacic LC, Stefanski EL, et al. Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. BMC Genet. 2010;11:51.10.1186/1756-0500-7-194
   PubMed Web of Science ®Google Scholar
• McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:263–269.10.1016/j.jalz.2011.03.005
   PubMed Web of Science ®Google Scholar
• Bekris LM, Yu CE, Bird TD, et al. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 2010;23:213–227.10.1177/0891988710383571
   PubMed Web of Science ®Google Scholar
• Alonso Vilatela ME, López-López M, Yescas-Gómez P. Genetics of Alzheimer’s disease. Arch Med Res. 2012;43:622–631.10.1016/j.arcmed.2012.10.017
   PubMed Web of Science ®Google Scholar
• Lambert JC, Amouyel P. Genetic heterogeneity of Alzheimer’s disease: complexity and advances. Psychoneuroendocrinology. 2007;32(Suppl 1):S62–S70.10.1016/j.psyneuen.2007.05.015
   PubMed Web of Science ®Google Scholar
• Gao Y, Tan MS, Wang HF, et al. ZCWPW1 is associated with late-onset Alzheimer’s disease in Han Chinese: a replication study and meta-analyses. Oncotarget. 2016;7:20305–20311.
   PubMed Web of Science ®Google Scholar
• Li Y, Song D, Jiang Y, et al. CR1 rs3818361 polymorphism contributes to Alzheimer’s disease susceptibility in Chinese population. Mol Neurobiol. 2016;53:4054–4059.10.1007/s12035-015-9343-7
   PubMed Web of Science ®Google Scholar
• Wang M, Yang J, Su J. Relationship between the polymorphism in exon 5 of BACE1 gene and Alzheimer’s disease. Aging Clin Exp Res. 2016; [ Epub ahead of print]. DOI:10.1007/s40520-016-0539-0
   Web of Science ®Google Scholar
• Mansouri L, Fekih-Mrissa N, Klai S, et al. Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer’s disease. Clin Neurol Neurosurg. 2013;115:1693–1696.
   PubMed Web of Science ®Google Scholar
• Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification. Nat Genet. 1994;7:551.
   PubMed Web of Science ®Google Scholar
• Nishiyama M, Kato Y, Hashimoto M, et al. Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia – an epidemiological study using the polymerase chain reaction (PCR) method. J Epidemiol. 2000;10:163–172.
   PubMedGoogle Scholar
• Silva VC, Ramos FJ, Freitas EM, et al. Alzheimer’s disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms. Arq Neuropsiquiatr. 2006;64:941–945.10.1590/S0004-282X2006000600010
   PubMed Web of Science ®Google Scholar
• Andreassi MG, Botto N, Cocci F, et al. Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease. Hum Genet. 2003;112:171–177.
   PubMed Web of Science ®Google Scholar
• Anello G, Guéant-Rodríguez RM, Bosco P, et al. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer’s disease. NeuroReport. 2004;15:859–861.10.1097/00001756-200404090-00025
   PubMed Web of Science ®Google Scholar
• Wakutani Y, Kowa H, Kusumi M, et al. Genetic analysis of vascular factors in Alzheimer’s disease. Ann N Y Acad Sci. 2002;977:232–238.10.1111/nyas.2002.977.issue-1
   PubMed Web of Science ®Google Scholar
• Ravaglia G, Forti P, Maioli F, et al. Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects. Arch Gerontol Geriatr Suppl. 2004;9:339–348.10.1016/j.archger.2004.04.044
   Google Scholar
• Bosco P. Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2004;75:1036–1038.10.1136/jnnp.2003.025866
   PubMed Web of Science ®Google Scholar
• Mansoori N, Tripathi M, Luthra K, et al. MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer’s and vascular dementia and their epistatic interaction. Neurobiol Aging. 2012;33:1003.e1–1003.e8.
   Web of Science ®Google Scholar
• Giedraitis V, Kilander L, Degerman-Gunnarsson M, et al. Genetic analysis of Alzheimer’s disease in the Uppsala Longitudinal Study of Adult Men. Dement Geriatr Cogn Disord. 2009;27:59–68.10.1159/000191203
   PubMed Web of Science ®Google Scholar
• Linnebank M, Linnebank A, Jeub M, et al. Lack of genetic dispositions to hyperhomocysteinemia in Alzheimer disease. Am J Med Genet A. 2004;131A:101–102.10.1002/ajmg.a.30295
   Web of Science ®Google Scholar
• Dorszewska J, Florczak J, Rozycka A, et al. Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer’s and Parkinson’s diseases. Acta Neurobiol Exp (Wars). 2007;67:113–129.
   PubMed Web of Science ®Google Scholar
• Crow JF. Hardy, Weinberg and language impediments. Genetics. 1999;152:821–825.
   PubMed Web of Science ®Google Scholar
• Ziegler A, Van Steen K, Wellek S. Investigating Hardy–Weinberg equilibrium in case-control or cohort studies or meta-analysis. Breast Cancer Res Tr. 2011;128:197–201.10.1007/s10549-010-1295-z
   PubMed Web of Science ®Google Scholar
• Wells G, Shea B, O’connell D, et al. The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [ Internet]. [ cited 2017 Jan 22]. Available from: www.ohri.ca/programs/clinical_epidemiology/oxford.htm
   Google Scholar
• Copas J, Shi JQ. Meta-analysis, funnel plots and sensitivity analysis. Biostatistics (Oxford, England). 2000;1:247–262.10.1093/biostatistics/1.3.247
   PubMedGoogle Scholar
• Bagos PG, Nikolopoulos GK. Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology. J Clin Epidemiol. 2009;62:1037–1044.10.1016/j.jclinepi.2008.12.008
   PubMed Web of Science ®Google Scholar
• Muellerleile P, Mullen B. Sufficiency and stability of evidence for public health interventions using cumulative meta-analysis. Am J Public Health. 2006;96:515–522.10.2105/AJPH.2003.036343
   PubMed Web of Science ®Google Scholar
• Peters JL, Sutton AJ, Jones DR, et al. Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. J Clin Epidemiol. 2008;61:991–996.10.1016/j.jclinepi.2007.11.010
   PubMed Web of Science ®Google Scholar
• Bird TD. Genetic factors in Alzheimer’s disease. N Engl J Med. 2005;352:862–864.10.1016/j.gene.2015.03.014
   PubMed Web of Science ®Google Scholar
• Bertram L, McQueen MB, Mullin K, et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007;39:17–23.10.1038/ng1934
   PubMed Web of Science ®Google Scholar
• Ballard C, Gauthier S, Corbett A, et al. Alzheimer’s disease. Lancet. 2011;377:1019–1031.10.1016/S0140-6736(10)61349-9
   PubMed Web of Science ®Google Scholar
• Chan KY, Wang W, Wu JJ, et al. Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis. Lancet. 2013;381:2016–2023.10.1016/S0140-6736(13)60221-4
   PubMed Web of Science ®Google Scholar
• Bredesen DE. Inhalational Alzheimer’s disease: an unrecognized – and treatable – epidemic. Aging. 2016;8:304–313.
   PubMedGoogle Scholar
• Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol. 2011;7:137–152.
   PubMed Web of Science ®Google Scholar