Remote ischemic postconditioning protects the brain from focal ischemia/reperfusion injury by inhibiting autophagy through the mTOR/p70S6K pathway

References

• Donnan GA, Fisher M, Macleod M, et al. Stroke. Lancet. 2008;371:1612–1623.10.1016/S0140-6736(08)60694-7
   PubMed Web of Science ®Google Scholar
• Alexandrov AV. Current and future recanalization strategies for acute ischemic stroke. J Internal Med. 2010;267:209–219.10.1111/jim.2010.267.issue-2
   Google Scholar
• Cheng Z, li L, Mo X, et al. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. Int J Mol Med. 2014;34:957–966.10.3892/ijmm.2014.1873
   PubMed Web of Science ®Google Scholar
• Peng B, Guo QL, He ZJ, et al. Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway. Brain Res. 2012;1445:92–102.10.1016/j.brainres.2012.01.033
   PubMed Web of Science ®Google Scholar
• Qi Z, Dong W, Shi W, et al. Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke. Transl Stroke Res. 2015;6:198–206.10.1007/s12975-015-0393-y
   PubMed Web of Science ®Google Scholar
• Zhou Y, Fathali N, Lekic T, et al. Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. Stroke. 2011;42:439–444.10.1161/STROKEAHA.110.592162
   PubMed Web of Science ®Google Scholar
• Ren C, Yan Z, Wei D, et al. Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res. 2009;1288:88–94.10.1016/j.brainres.2009.07.029
   PubMed Web of Science ®Google Scholar
• Carrasco-Chinchilla F, Munoz-Garcia AJ, Dominguez-Franco A, et al. Remote ischaemic postconditioning: does it protect against ischaemic damage in percutaneous coronary revascularisation? Randomised placebo-controlled clinical trial Heart. 2013;99:1431–1437.
   PubMed Web of Science ®Google Scholar
• Zhong H, Gao Z, Chen M, et al. Cardioprotective effect of remote ischemic postconditioning on children undergoing cardiac surgery: a randomized controlled trial. Pediatr Anesth. 2013;23:726–733.10.1111/pan.12181
   PubMed Web of Science ®Google Scholar
• Hong DM, Lee EH, Kim HJ, et al. Does remote ischaemic preconditioning with postconditioning improve clinical outcomes of patients undergoing cardiac surgery? Remote Ischaemic Preconditioning with Postconditioning Outcome Trial. Eur Heart J. 2014;35:176–183.10.1093/eurheartj/eht346
   PubMed Web of Science ®Google Scholar
• Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis. 2008;32:329–339.10.1016/j.nbd.2008.07.022
   PubMed Web of Science ®Google Scholar
• Tian F, Deguchi K, Yamashita T, et al. In vivo imaging of autophagy in a mouse stroke model. Autophagy. 2010;6:1107–1114.10.4161/auto.6.8.13427
   PubMed Web of Science ®Google Scholar
• Wang JY, Xia Q, Chu KT, et al. Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. J Neuropathol Exp Neurol. 2011;70:314–322.10.1097/NEN.0b013e31821352bd
   PubMed Web of Science ®Google Scholar
• Sheng R, Zhang LS, Han R, et al. Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy. 2010;6:482–494.10.4161/auto.6.4.11737
   PubMed Web of Science ®Google Scholar
• Gao L, Jiang T, Guo J, et al. Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PloS One. 2012;7:1–13.
   Web of Science ®Google Scholar
• Wang J, Han D, Sun M, et al. Cerebral ischemic postconditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model. Mol Med Rep. 2016;14:4162–4172.10.3892/mmr.2016.5747
   PubMed Web of Science ®Google Scholar
• Su J, Zhang T, Wang K, et al. Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats. Neurochem Res. 2014;39:2068–2077.10.1007/s11064-014-1396-x
   PubMed Web of Science ®Google Scholar
• Qi ZF, Luo YM, Liu XR, et al. AKT/GSK3beta-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model. CNS Neurosci Ther. 2012;18:965–973.10.1111/cns.2012.18.issue-12
   PubMed Web of Science ®Google Scholar
• Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91.10.1161/01.STR.20.1.84
   PubMed Web of Science ®Google Scholar
• Liu R, Yuan H, Yuan F, et al. Neuroprotection targeting ischemic penumbra and beyond for the treatment of ischemic stroke. Neurol Res. 2012;34:331–337.10.1179/1743132812Y.0000000020
   PubMed Web of Science ®Google Scholar
• Gladstone DJ, Black SE, Hakim AM, et al. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke. 2002;33:2123–2136.10.1161/01.STR.0000025518.34157.51
   PubMed Web of Science ®Google Scholar
• Gao X, Ren C, Zhao H. Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning. J Neurosci Res. 2008;86:2505–2511.10.1002/jnr.v86:11
   PubMed Web of Science ®Google Scholar
• Joo SP, Xie W, Xiong X, et al. Ischemic postconditioning protects against focal cerebral ischemia by inhibiting brain inflammation while attenuating peripheral lymphopenia in mice. Neuroscience. 2013;243:149–157.10.1016/j.neuroscience.2013.03.062
   PubMed Web of Science ®Google Scholar
• Pignataro G, Meller R, Inoue K, et al. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008;28:232–241.10.1038/sj.jcbfm.9600559
   PubMed Web of Science ®Google Scholar
• Yu L, Fan SJ, Liu L, et al. Effect of ischemic postconditioning on cerebral edema and the AQP4 expression following hypoxic-eschemic brain damage in neonatal rats. World J Pediatr. 2015;11:165–170.10.1007/s12519-014-0519-4
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhou S, Wang Y, et al. A feasible strategy for focal cerebral ischemia-reperfusion injury: remote ischemic postconditioning. Neural Regener Res. 2014;9:1460–1463.
   PubMed Web of Science ®Google Scholar
• Li S, Hu X, Zhang M, et al. Remote ischemic post-conditioning improves neurological function by AQP4 down-regulation in astrocytes. Behav Brain Res. 2015;289:1–8.10.1016/j.bbr.2015.04.024
   PubMed Web of Science ®Google Scholar
• Cui DR, Wang L, Jiang W, et al. Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-kappaB/p53 signaling pathway. Neuroscience. 2013;246:117–132.10.1016/j.neuroscience.2013.04.054
   PubMed Web of Science ®Google Scholar
• Yuan Y, Guo Q, Ye Z, et al. Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. Brain Res. 2010;1367:85–93.
   PubMed Web of Science ®Google Scholar
• Prasad SS, Russell M, Nowakowska M. Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K–Akt pathways. J Mol Neurosci. 2011;43:428–442.10.1007/s12031-010-9461-7
   PubMed Web of Science ®Google Scholar
• Mehrjerdi FZ, Aboutaleb N, Habibey R, et al. Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice. Brain Res. 2013;1526:8.
   Web of Science ®Google Scholar