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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 40, 2018 - Issue 7
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Original Research Paper

Morphine reduces mouse microglial engulfment induced by lipopolysaccharide and interferon-γ via δ opioid receptor and p38 mitogen-activated protein kinase

ORCID Icon, , &
Pages 602-608 | Received 02 Jan 2018, Accepted 11 Mar 2018, Published online: 27 Mar 2018

References

  • Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 2007;10(11):1387–1394.10.1038/nn1997
  • Ninkovic J, Roy S. Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms. Am J Pathol. 2012;180(3):1068–1079.10.1016/j.ajpath.2011.11.034
  • Brown GC, Neher JJ. Microglial phagocytosis of live neurons. Nat Rev Neurosci. 2014;15(4):209–216.10.1038/nrn3710
  • Sierra A, Abiega O, Shahraz A, et al. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Front Cell Neurosci. 2013;7:6.
  • van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012;67(3):280–293.10.1111/j.1365-2044.2011.07008.x
  • Katayama T, Kobayashi H, Okamura T, et al. Accumulating microglia phagocytose injured neurons in hippocampal slice cultures: involvement of p38 MAP kinase. PLoS ONE. 2012;7(7):e40813.10.1371/journal.pone.0040813
  • Tanaka T, Ueno M, Yamashita T. Engulfment of axon debris by microglia requires p38 MAPK activity. J Biol Chem. 2009;284(32):21626–21636.10.1074/jbc.M109.005603
  • Kim JA, Li L, Zuo Z. Delayed treatment with isoflurane attenuates lipopolysaccharide and interferon gamma-induced activation and injury of mouse microglial cells. Anesthesiology. 2009;111(3):566–573.10.1097/ALN.0b013e3181af5b3d
  • Vallieres N, Berard JL, David S, et al. Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord. Glia. 2006;53(1):103–113.10.1002/(ISSN)1098-1136
  • Welters ID, Menzebach A, Goumon Y, et al. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu(3) opiate receptor-dependent mechanism. J Neuroimmunol. 2000;111(1–2):139–145.10.1016/S0165-5728(00)00401-X
  • Shirzad H, Shahrani M, Rafieian-Kopaei M. Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo. Int Immunopharmacol. 2009;9(7–8):968–970.10.1016/j.intimp.2009.04.002
  • Chang MC, Fan SZ, Hsiao PN, et al. Influence of morphine on host immunity. Acta Anaesthesiol Taiwan. 2011;49(3):105–108.10.1016/j.aat.2011.08.003
  • Tomassini N, Renaud FL, Roy S, et al. Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages. J Neuroimmunol. 2003;136(1–2):9–16.10.1016/S0165-5728(02)00463-0
  • Husted TL, Govindaswami M, Oeltgen PR, et al. A delta2-opioid agonist inhibits p38 MAPK and suppresses activation of murine macrophages. J Surg Res. 2005;128(1):45–49.10.1016/j.jss.2005.04.003
  • Sowa G, Gekker G, Lipovsky MM, et al. Inhibition of swine microglial cell phagocytosis of cryptococcus neoformans by femtomolar concentrations of morphine. Biochem Pharmacol. 1997;53(6):823–828.10.1016/S0006-2952(97)00006-3
  • Fridman WH. Fc receptors and immunoglobulin binding factors. FASEB J. 1991;5(12):2684–2690.10.1096/fasebj.5.12.1916092

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