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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 40, 2018 - Issue 11
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Original Research Paper

Thymoquinone protects DRG neurons from axotomy-induced cell death

ORCID Icon, , &
Pages 930-937 | Received 08 Mar 2018, Accepted 19 Jul 2018, Published online: 08 Aug 2018

References

  • Araujo-Filho HG, Quintans-Junior LJ, Barreto AS, et al. Neuroprotective effect of natural products on peripheral nerve degeneration: a systematic review. Neurochem Res. 2016;41:647–658.
  • Zhang YG, Sheng QS, Wang HK, et al. Triptolide improves nerve regeneration and functional recovery following crush injury to rat sciatic nerve. Neurosci Lett. 2014;561:198–202.
  • Chen MM, Qin J, Chen SJ, et al. Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice. J Nutr Biochem. 2017;46:57–67.
  • Lerch JK, Alexander JK, Madalena KM, et al. Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs. eNeuro. 2017;4.
  • Moy JK, Khoutorsky A, Asiedu MN, et al. The MNK-eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. J Neurosci. 2017;37:7481–7499.
  • Sullivan R, Dailey T, Duncan K, et al. Peripheral nerve injury: stem cell therapy and peripheral nerve transfer. Int J Mol Sci. 2016;17.
  • Gomez-Sanchez JA, Pilch KS, Van Der Lans M, et al. After nerve injury, lineage tracing shows that myelin and Remak Schwann cells elongate extensively and branch to form repair Schwann cells, which shorten radically on remyelination. J Neurosci. 2017;37:9086–9099.
  • Gordon T, Aw E. Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise. Eur J Neurosci. 2016;43:336–350.
  • Benito C, Davis CM, Gomez-Sanchez JA, et al. STAT3 controls the long-term survival and phenotype of repair Schwann cells during nerve regeneration. J Neurosci. 2017;37:4255–4269.
  • Alhebshi AH, Odawara A, Gotoh M, et al. Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against alpha-synuclein-induced synapse damage. Neurosci Lett. 2014;570:126–131.
  • Goyal SN, Prajapati CP, Gore PR, et al. Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin. Front Pharmacol. 2017;8:656.
  • Chen L, Li B, Chen B, et al. Thymoquinone alleviates the experimental diabetic peripheral neuropathy by modulation of inflammation. Sci Rep. 2016;6:31656.
  • Ismail M, Al-Naqeep G and Chan KW. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med. 2010;48:664–672.
  • Woo CC, Kumar AP, Sethi G, et al. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012;83:443–451.
  • Akhondian J, Kianifar H, Raoofziaee M, et al. The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Res. 2011;93:39–43.
  • Javidi S Razavi BM and Hosseinzadeh H. A review of neuropharmacology effects of Nigella sativa and its main component, thymoquinone. Phytother Res. 2016;30:1219–1229.
  • Ullah I, Badshah H, Naseer MI, et al. Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. Neuromolecular Med. 2015;17:35–46.
  • Ullah I, Ullah N, Naseer MI, et al. Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci. 2012;13:11.
  • Khan A, Vaibhav K, Javed H, et al. Attenuation of Abeta-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Mol Cell Biochem. 2012;369:55–65.
  • Radad KS, Al-Shraim MM, Moustafa MF, et al. Neuroprotective role of thymoquinone against 1-methyl-4-phenylpyridinium-induced dopaminergic cell death in primary mesencephalic cell culture. Neurosciences (Riyadh). 2015;20:10–16.
  • Cobourne-Duval MK, Taka E, Mendonca P, et al. Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFkappaB pathway signaling targets in LPS/IFNgamma-activated BV-2 microglia cells. J Neuroimmunol. 2018;320:87–97.
  • Peng L, Liu A, Shen Y, et al. Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-kappaB pathway. Oncol Rep. 2013;29:571–578.
  • Geuna S, Raimondo S, Fregnan F, et al. In vitro models for peripheral nerve regeneration. Eur J Neurosci. 2016;43:287–296.
  • Ozturk G, Cengiz N, Erdogan E, et al. Two distinct types of dying back axonal degeneration in vitro. Neuropathol Appl Neurobiol. 2013;39:362–376.
  • Cengiz N, Ozturk G, Erdogan E, et al. Consequences of neurite transection in vitro. J Neurotrauma. 2012;29:2465–2474.
  • Alhebshi AH, Gotoh M and Suzuki I. Thymoquinone protects cultured rat primary neurons against amyloid beta-induced neurotoxicity. Biochem Biophys Res Commun. 2013;433:362–367.
  • Gordon T, Borschel GH. The use of the rat as a model for studying peripheral nerve regeneration and sprouting after complete and partial nerve injuries. Exp Neurol. 2017;287:331–347.
  • Üstün R, Oğuz EK. Degenerative effect of Ankaferd Blood Stopper® on mice peripheral sensory neurons in vitro. Folia Neuropathologica. 2018;56:67–74.
  • Wang H, Zhu H, Guo Q, et al. Overlapping mechanisms of peripheral nerve regeneration and angiogenesis following sciatic nerve transection. Front Cell Neurosci. 2017;11.
  • Borlongan CV. Remyelinating the transected peripheral nerve by fabricated Schwann cells derived from bone marrow. Exp Neurol. 2010;225:243–245.
  • Ma M, Ferguson TA, Schoch KM, et al. Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration. Neurobiol Dis. 2013;56:34–46.
  • Uncini A, Kuwabara S. Nodopathies of the peripheral nerve: an emerging concept. J Neurol Neurosurg Psychiatry. 2015;86:1186–1195.
  • Wong KM Babetto E and Beirowski B. Axon degeneration: make the Schwann cell great again. Neural Regen Res. 2017;12:518–524.
  • Ismail N, Ismail M, Mazlan M, et al. Thymoquinone prevents beta-amyloid neurotoxicity in primary cultured cerebellar granule neurons. Cell Mol Neurobiol. 2013;33:1159–1169.
  • Fouad IA, Sharaf NM, Abdelghany RM, et al. Neuromodulatory effect of thymoquinone in attenuating glutamate-mediated neurotoxicity targeting the amyloidogenic and apoptotic pathways. Front Neurol. 2018;9:236.
  • Kanter M. Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure. J Mol Histol. 2011;42:39–46.
  • Erkut A, Cure MC, Kalkan Y, et al. Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury. Eur Rev Med Pharmaco. 2016;20:1192–1202.
  • Sereflican M, Yurttas V, Ozyalvacli G, et al. The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model. Am J Otolaryng. 2016;37:407–415.
  • Gokce EC, Kahveci R, Gokce A, et al. Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis. J Neurosurg Spine. 2016;24:949–959.
  • Ebrahimi SS, Oryan S, Izadpanah E, et al. Thymoquinone exerts neuroprotective effect in animal model of Parkinson’s disease. Toxicol Lett. 2017;276:108–114.
  • Cobourne-Duval MK, Taka E, Mendonca P, et al. The antioxidant effects of thymoquinone in activated BV-2 murine microglial cells. Neurochem Res. 2016;41:3227–3238.
  • Velagapudi R, Kumar A, Bhatia HS, et al. Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling. Int Immunopharmacol. 2017;48:17–29.
  • De Luca AC, Faroni A, Reid AJ. Dorsal root ganglia neurons and differentiated adipose-derived stem cells: an in vitro co-culture model to study peripheral nerve regeneration. J Vis Exp. 2015.
  • Zhang Z, Yu B, Gu Y, et al. Fibroblast-derived tenascin-C promotes Schwann cell migration through beta1-integrin dependent pathway during peripheral nerve regeneration. Glia. 2016;64:374–385.
  • Bin Sayeed MS, Shams T, Fahim Hossain S, et al. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol. 2014;152:156–162.

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