Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats

References

• Albrecht S, Hering W, Schuttler J, et al. New intravenous anesthetics. Remifentanil, S(+)-ketamine, eltanolone and target controlled infusion. Anaesthesist. 1996;45:1129–1141.
   PubMed Web of Science ®Google Scholar
• Li L, Vlisides PE. Ketamine: 50 years of modulating the mind. Front Hum Neurosci. 2016;10:612.
   PubMed Web of Science ®Google Scholar
• Poulsen MH, Andersen J, Christensen R, et al. Binding of ArgTX-636 in the NMDA receptor ion channel. J Mol Biol. 2015;427:176–189.
   PubMed Web of Science ®Google Scholar
• Rameau GA, Tukey DS, Garcin-Hosfield ED, et al. Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death. J Neurosci. 2007;27:3445–3455.
   PubMed Web of Science ®Google Scholar
• Liu L, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004;304:1021–1024.
   PubMed Web of Science ®Google Scholar
• Kudo K, Wati H, Qiao C, et al. Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats. Brain Res. 2005;1054:30–37.
   PubMed Web of Science ®Google Scholar
• Li Y, Li X, Zhao J, et al. Midazolam attenuates autophagy and apoptosis caused by ketamine by decreasing reactive oxygen species in the hippocampus of fetal rats. Neuroscience. 2018b. DOI:10.1016/j.neuroscience.2018.03.040.
   Web of Science ®Google Scholar
• Li X, Li Y, Zhao J, et al. Administration of ketamine causes autophagy and apoptosis in the rat fetal hippocampus and in PC12 cells. Front Cell Neurosci. 2018a;12:21.
   PubMed Web of Science ®Google Scholar
• Rui L. A link between protein translation and body weight. J Clin Invest. 2007;117:310–313.
   PubMed Web of Science ®Google Scholar
• Rodriguez Perez JC. The role of mTOR inhibitors in renal diseases. Nefrologia. 2011;31:251–255.
   PubMed Web of Science ®Google Scholar
• Dennis MD, Kimball SR, Jefferson LS. Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem. 2013;288:10–19.
   PubMed Web of Science ®Google Scholar
• Seo MK, McIntyre RS, Cho HY, et al. Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions. Psychopharmacology (Berl). 2016;233:2617–2627.
   PubMed Web of Science ®Google Scholar
• Mejia LA, Litterman N, Ikeuchi Y, et al. A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain. J Neurosci. 2013;33:18015–18021.
   PubMed Web of Science ®Google Scholar
• Pei JJ, Hugon J. mTOR-dependent signalling in Alzheimer’s disease. J Cell Mol Med. 2008;12:2525–2532.
   PubMed Web of Science ®Google Scholar
• Santini E, Heiman M, Greengard P, et al. Inhibition of mTOR signaling in Parkinson’s disease prevents L-DOPA-induced dyskinesia. Sci Signal. 2009;2:ra36.
   PubMed Web of Science ®Google Scholar
• Pryor WM, Biagioli M, Shahani N, et al. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease. Sci Signal. 2014;7:ra103.
   PubMed Web of Science ®Google Scholar
• Abelaira HM, Réus GZ, Ignácio ZM, et al. Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of rapamycin into prefrontal cortex. J Psychiatr Res. 2017;87:81–87.
   PubMed Web of Science ®Google Scholar
• National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals[J]. Publication No. 85-23(rev.). 1996;327:963–965
   Google Scholar
• Park SW, Lee JG, Seo MK, et al. Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. Int J Neuropsychopharmacol. 2014;17:1831–1846.
   PubMed Web of Science ®Google Scholar
• Xu JT, Zhao J-Y, Zhao X, et al. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. J Clin Invest. 2014;124:592–603.
   PubMed Web of Science ®Google Scholar
• Creeley CE. From drug-induced developmental neuroapoptosis to pediatric anesthetic neurotoxicity-where are we now?. Brain Sci. 2016;6:32.
   PubMed Web of Science ®Google Scholar
• Dong C, Anand KJ. Developmental neurotoxicity of ketamine in pediatric clinical use. Toxicol Lett. 2013;220:53–60.
   PubMed Web of Science ®Google Scholar
• Jiang S, Li X, Jin W, et al. Ketamine-induced neurotoxicity blocked by N-Methyl-d-aspartate is mediated through activation of PKC/ERK pathway in developing hippocampal neurons. Neurosci Lett. 2018;673:122–131.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Kwon JS. Effects of placing micro-implants of melatonin in striatum on oxidative stress and neuronal damage mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors. Arch Pharm Res. 1999;22:35–43.
   PubMed Web of Science ®Google Scholar
• Singh J, Kaur G. HSP70 induction and oxidative stress protection mediated by a subtoxic dose of NMDA in the retinoic acid-differentiated C6 glioma cell line. Brain Res Bull. 2006;69:37–47.
   PubMed Web of Science ®Google Scholar
• Lana D, Di Russo J, Mello T, et al. Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. Neurobiol Learn Mem. 2017;137:15–26.
   PubMed Web of Science ®Google Scholar
• Moon IS, Lee HJ, Park IS. Dendritic eIF4E-binding protein 1 (eIF4E-BP1) mRNA is upregulated by neuronal activation. J Korean Med Sci. 2012;27:1241–1247.
   PubMed Web of Science ®Google Scholar
• Yu P, Laird AD, Du X, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014;13:1078–1091.
   PubMed Web of Science ®Google Scholar
• Fingar DC, Salama S, Tsou C, et al. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002;16:1472–1487.
   PubMed Web of Science ®Google Scholar
• Xiong F, Dong P, Liu M, et al. Tomato FK506 binding protein 12KD (FKBP12) mediates the interaction between rapamycin and target of rapamycin (TOR). Front Plant Sci. 2016;7:1746.
   PubMed Web of Science ®Google Scholar
• Shao JL, Wan X-H, Chen Y, et al. H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. J Mol Neurosci. 2011;43:453–460.
   PubMed Web of Science ®Google Scholar
• Ding K, Wang H, Wu Y, et al. Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis. J Surg Res. 2015;194:239–247.
   PubMed Web of Science ®Google Scholar
• Lossi L, Cocito C, Alasia S, et al. Ex vivo imaging of active caspase 3 by a FRET-based molecular probe demonstrates the cellular dynamics and localization of the protease in cerebellar granule cells and its regulation by the apoptosis-inhibiting protein survivin. Mol Neurodegener. 2016;11:34.
   PubMed Web of Science ®Google Scholar
• Zuo D, Lin L, Liu Y, et al. Baicalin attenuates ketamine-induced neurotoxicity in the developing rats: involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways. Neurotox Res. 2016;30:159–172.
   PubMed Web of Science ®Google Scholar
• Xie N, Wang C, Wu C, et al. Mdivi-1 protects epileptic hippocampal neurons from apoptosis via inhibiting oxidative stress and endoplasmic reticulum stress in vitro. Neurochem Res. 2016;41:1335–1342.
   PubMed Web of Science ®Google Scholar
• Rodrigo R, Fernandez-Gajardo R, Gutierrez R, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities CNS. Neurol Disord Drug Targets. 2013;12:698–714.
   PubMed Web of Science ®Google Scholar
• Gomes P, Simão S, Silva E, et al. Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure. Oxid Med Cell Longev. 2009;2:138–145.
   PubMed Web of Science ®Google Scholar
• Spirlandeli AL, Deminice R, Jordao AA. Plasma malondialdehyde as biomarker of lipid peroxidation: effects of acute exercise. Int J Sports Med. 2014;35:14–18.
   PubMed Web of Science ®Google Scholar
• Flores-Mateo G, Carrillo-Santisteve P, Elosua R, et al. Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies. Am J Epidemiol. 2009;170:135–147.
   PubMed Web of Science ®Google Scholar
• Felix LM, Vidal AM, Serafim C, et al. Ketamine induction of p53-dependent apoptosis and oxidative stress in zebrafish (Danio rerio) embryos. Chemosphere. 2018;201:730–739.
   PubMed Web of Science ®Google Scholar
• Yan J, Huang Y, Lu Y, et al. Repeated administration of ketamine can induce hippocampal neurodegeneration and long-term cognitive impairment via the ROS/HIF-1alpha pathway in developing rats. Cell Physiol Biochem. 2014;33:1715–1732.
   PubMed Web of Science ®Google Scholar
• Zhao D, Yang J, Yang L. Insights for oxidative stress and mTOR signaling in myocardial ischemia/reperfusion injury under diabetes. Oxid Med Cell Longev. 2017;2017:6437467.
   PubMed Web of Science ®Google Scholar
• Li J, Shin S, Sun Y, et al. mTORC1-driven tumor cells are highly sensitive to therapeutic targeting by antagonists of oxidative stress. Cancer Res. 2016;76:4816–4827.
   PubMed Web of Science ®Google Scholar
• Faghiri Z, Bazan NG. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp Eye Res. 2010;90:718–725.
   PubMed Web of Science ®Google Scholar
• Jiang J, Jiang J, Zuo Y, et al. Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease. Int J Mol Med. 2013;31:825–832.
   PubMed Web of Science ®Google Scholar
• Ullah I, Park HY, Kim MO. Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons. CNS Neurosci Ther. 2014;20:327–338.
   PubMed Web of Science ®Google Scholar
• Slikker W, Xu Z, Wang C. Application of a systems biology approach to developmental neurotoxicology. Reprod Toxicol. 2005;19:305–319.
   PubMed Web of Science ®Google Scholar
• MacMillan D, Currie S, Bradley KN, et al. In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005;118:5443–5451.
   PubMed Web of Science ®Google Scholar
• Kaftan E, Marks AR, Ehrlich BE. Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circ Res. 1996;78:990–997.
   PubMed Web of Science ®Google Scholar