Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke

References

• Donkor ES. Stroke in the 21(st) century: a snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018;2018:3238165.
   PubMed Web of Science ®Google Scholar
• Hackenberg KAM, Hanggi D, Etminan N. Unruptured intracranial aneurysms. Stroke. 2018;49(9):2268–2275.
   PubMedGoogle Scholar
• Yunoki M, KANDA T, SUZUKI K, et al. Ischemic tolerance of the brain and spinal cord: a review. Neurol Med Chir (Tokyo). 2017;57(11):590–600. .
   PubMed Web of Science ®Google Scholar
• Toman NG, Grande AW, Low WC. Neural repair in stroke. Cell Transplant. 2019;28(9–10):1123–1126.
   PubMed Web of Science ®Google Scholar
• McLauchlan D, Robertson NP. Stem cells in the treatment of central nervous system disease. J Neurol. 2018;265(4):984–986.
   PubMed Web of Science ®Google Scholar
• Ren H, Sang Y, Zhang F, et al. Comparative analysis of human mesenchymal stem cells from umbilical cord, dental pulp, and menstrual blood as sources for cell therapy. Stem Cells Int. 2016;2016:3516574.
   PubMed Web of Science ®Google Scholar
• Mitchell KE, Weiss ML, Mitchell BM, et al. Matrix cells from Wharton’s jelly form neurons and glia. Stem Cells. 2003;21(1):50–60.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Park JS. Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages. Dev Reprod. 2017;21(1):1–10.
   PubMedGoogle Scholar
• Hocum Stone LL, Xiao F, Rotschafer J, et al. Amelioration of ischemic brain injury in rats with human umbilical cord blood stem cells: mechanisms of action. Cell Transplant. 2016;25(8):1473–1488. .
   PubMed Web of Science ®Google Scholar
• Yasuhara T, Kawauchi S, Kin K, Morimoto, et al., Cell therapy for central nervous system disorders: current obstacles to progress. CNS Neurosci Ther. 2020;26(6):595–602.
   PubMed Web of Science ®Google Scholar
• Yoo SW, Chang D-Y, Lee H-S, et al. Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-beta. Neurobiol Dis. 2013;58:249–257.
   PubMed Web of Science ®Google Scholar
• Bronckaers A, Hilkens P, Martens W, et al. Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis. Pharmacol Ther. 2014;143(2):181–196.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yu S, Tuazon J, et al. Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism. Neural Regen Res. 2019;14(4):597–604.
   PubMed Web of Science ®Google Scholar
• Hsuan YC, Lin C-H, Chang C-P, et al. Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke. Brain Behav. 2016;6(10):e00526.
   PubMed Web of Science ®Google Scholar
• Wicks SE, Londot H, Zhang B, et al. Effect of intrastriatal mesenchymal stromal cell injection on progression of a murine model of Krabbe disease. Behav Brain Res. 2011;225(2):415–425.
   PubMed Web of Science ®Google Scholar
• Rossignol J, Fink K, Davis K, et al. Transplants of adult mesenchymal and neural stem cells provide neuroprotection and behavioral sparing in a transgenic rat model of Huntington’s disease. Stem Cells. 2014;32(2):500–509.
   PubMed Web of Science ®Google Scholar
• Lin Y-C, Ko T-L, Shih Y-H, et al. Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. Stroke. 2011;42(7):2045–2053.
   PubMed Web of Science ®Google Scholar
• Weiss ML, Medicetty S, Bledsoe AR, et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson’s disease. Stem Cells. 2006;24(3):781–792.
   PubMed Web of Science ®Google Scholar
• Dennis JE, Merriam A, Awadallah A, et al. A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse. J Bone Miner Res. 1999;14(5):700–709.
   PubMed Web of Science ®Google Scholar
• Jaiswal N, Haynesworth SE, Caplan AI, et al. Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997;64(2):295–312.
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson CR, Emson PC. AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods. 1980;3(2):129–149.
   PubMed Web of Science ®Google Scholar
• Braida D, Pegorini S, Arcidiacono MV, et al. Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils. Neurosci Lett. 2003;346(1–2):61–64.
   PubMed Web of Science ®Google Scholar
• Lin Y, Zhang J-C, Fu J, et al. Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation. J Cereb Blood Flow Metab. 2013;33(2):253–262.
   PubMed Web of Science ®Google Scholar
• Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84–91.
   PubMed Web of Science ®Google Scholar
• Zhou J, Zuo Y, Wan X, et al. Solution-processed and high-performance organic solar cells using small molecules with a benzodithiophene unit. J Am Chem Soc. 2013;135(23):8484–8487. .
   PubMed Web of Science ®Google Scholar
• Swanson RA, Morton MT, Tsao-Wu G, et al. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10(2):290–293.
   PubMed Web of Science ®Google Scholar
• Khaksar S, Bigdeli MR. Anti-excitotoxic effects of cannabidiol are partly mediated by enhancement of NCX2 and NCX3 expression in animal model of cerebral ischemia. Eur J Pharmacol. 2017;794:270–279.
   PubMed Web of Science ®Google Scholar
• Bigdeli MR, Hajizadeh S, Froozandeh M, et al. Prolonged and intermittent normobaric hyperoxia induce different degrees of ischemic tolerance in rat brain tissue. Brain Res. 2007;1152:228–233.
   PubMed Web of Science ®Google Scholar
• Fernández-López D, Faustino J, Daneman R, et al. Blood–brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci. 2012;32(28):9588–9600.
   PubMed Web of Science ®Google Scholar
• Karahuseyinoglu S, Cinar O, Kilic E, et al. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells. 2007;25(2):319–331.
   PubMed Web of Science ®Google Scholar
• Ma S, Zhong D, Chen H, et al. The immunomodulatory effect of bone marrow stromal cells (BMSCs) on interleukin (IL)-23/IL-17-mediated ischemic stroke in mice. J Neuroimmunol. 2013;257(1–2):28–35.
   PubMed Web of Science ®Google Scholar
• Lin W, Hsuan YC-Y, Lin M-T, et al. Human umbilical cord mesenchymal stem cells preserve adult newborn neurons and reduce neurological injury after cerebral ischemia by reducing the number of hypertrophic microglia/macrophages. Cell Transplant. 2017;26(11):1798–1810.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang L-M, Chen -W-W, et al. Neural differentiation of human Wharton’s jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats. Neural Regen Res. 2017;12(7):1103–1110.
   PubMed Web of Science ®Google Scholar
• Li X, Huang M, Zhao R, et al. Intravenously delivered allogeneic mesenchymal stem cells bidirectionally regulate inflammation and induce neurotrophic effects in distal middle cerebral artery occlusion Rats within the first 7 days after stroke. Cell Physiol Biochem. 2018;46(5):1951–1970.
   PubMedGoogle Scholar
• Cheng Q, Zhang Z, Zhang S, et al. Human umbilical cord mesenchymal stem cells protect against ischemic brain injury in mouse by regulating peripheral immunoinflammation. Brain Res. 2015;1594:293–304.
   PubMed Web of Science ®Google Scholar
• Zhou X, Gu J, Gu Y, et al. Human umbilical cord-derived mesenchymal stem cells improve learning and memory function in hypoxic-ischemic brain-damaged Rats via an IL-8-mediated secretion mechanism rather than differentiation pattern induction. Cell Physiol Biochem. 2015;35(6):2383–2401.
   PubMedGoogle Scholar
• Guan Y, Li X, Yu W, et al. Intravenous transplantation of mesenchymal stem cells reduces the number of infiltrated Ly6C(+) cells but enhances the proportions positive for BDNF, TNF-1alpha, and IL-1beta in the infarct cortices of dMCAO Rats. Stem Cells Int. 2018;2018:9207678.
   PubMed Web of Science ®Google Scholar
• Chen J, Crawford R, Chen C, et al. The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue Eng Part B Rev. 2013;19(6):516–528.
   PubMed Web of Science ®Google Scholar
• Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145.
   PubMed Web of Science ®Google Scholar
• Wang F, Tang H, et al. Transplanting mesenchymal stem cells for treatment of ischemic stroke. Cell Transplant. 2018;27(12):1825–1834.
   PubMed Web of Science ®Google Scholar
• Tsai MJ, Tsai S-K, Hu B-R, et al. Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats. J Biomed Sci. 2014;21:5.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Kim KS, Park IH, et al. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One. 2007;2(1):e156.
   PubMed Web of Science ®Google Scholar
• Davis SM, Pennypacker KR. Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke. Neurochem Int. 2017;107:23–32.
   PubMed Web of Science ®Google Scholar
• Huang P, Gebhart N, Richelson E, et al. Mechanism of mesenchymal stem cell-induced neuron recovery and anti-inflammation. Cytotherapy. 2014;16(10):1336–1344.
   PubMed Web of Science ®Google Scholar
• Pan W, P. Stone K, Hsuchou H, et al. Cytokine signaling modulates blood-brain barrier function. Curr Pharm Des. 2011;17(33):3729–3740.
   PubMed Web of Science ®Google Scholar
• Wei ZZ, Gu X, Ferdinand A, et al. Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. Cell Transplant. 2015;24(3):391–402.
   PubMed Web of Science ®Google Scholar
• Namioka T, Namioka A, Sasaki, et al., Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction. J Neurosurg. 2018;131(4):1289–1296.
   Web of Science ®Google Scholar
• Cheng Z, Wang L, Qu M, et al. Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice. J Neuroinflammation. 2018;15(1):135.
   PubMedGoogle Scholar
• George PM, Steinberg GK. Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron. 2015;87(2):297–309.
   PubMed Web of Science ®Google Scholar
• Wu S, Yuan R, Wang Y, et al. Early prediction of malignant brain edema after ischemic stroke. Stroke. 2018;49(12):2918–2927. .
   PubMed Web of Science ®Google Scholar
• Galieva LR, Mukhamedshina YO, Arkhipova SS, et al. Human umbilical cord blood cell transplantation in neuroregenerative strategies. Front Pharmacol. 2017;8:628.
   PubMed Web of Science ®Google Scholar
• Turnbull MT, Zubair AC, Meschia JF, et al. Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research. NPJ Regen Med. 2019;4:10.
   PubMed Web of Science ®Google Scholar