Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF-κB signaling pathway in mice

References

• Finsen B, Owens T. Innate immune responses in central nervous system inflammation. FEBS Lett. 2011;585(23):3806–3812.
   PubMed Web of Science ®Google Scholar
• Kettenmann H, Hanisch UK, Noda M, et al. Physiology of microglia. Physiol Rev. 2011;91(2):461–553.
   PubMed Web of Science ®Google Scholar
• Elmore MR, Lee RJ, West BL, et al. Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation. PLoS One. 2015;10(4):e0122912.
   PubMed Web of Science ®Google Scholar
• Frank-Cannon TC, Alto LT, McAlpine FE, et al. Does neuroinflammation fan the flame in neurodegenerative diseases. Mol Neurodegener. 2009;4:47.
   PubMed Web of Science ®Google Scholar
• Noh H, Jeon J, Seo H. Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain. Neurochem Int. 2014;69:35–40.
   PubMed Web of Science ®Google Scholar
• Badshah H, Ali T, Kim MO. Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway. Sci Rep. 2016;6:24493.
   PubMed Web of Science ®Google Scholar
• Rahimifard M, Maqbool F, Moeini-Nodeh S, et al. Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation. Ageing Res Rev. 2017;36:11–19.
   PubMed Web of Science ®Google Scholar
• Malgorzata-Miller G, Heinbockel L, Brandenburg K, et al. Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications. Sci Rep. 2016;6:34221.
   PubMed Web of Science ®Google Scholar
• Bossù P, Cutuli D, Palladino I, et al. A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18. J Neuroinflammation. 2012;9:101.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Hou L, Song JL, et al. Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models. Neuroscience. 2014;257:20–30.
   PubMed Web of Science ®Google Scholar
• Guerreiro RJ, Santana I, Brás JM, et al. Peripheral inflammatory cytokines as biomarkers in Alzheimer’s disease and mild cognitive impairment. Neurodegener Dis. 2007;4(6):406–412.
   PubMed Web of Science ®Google Scholar
• Shin JH, Lee YA, Lee JK, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012;122(5):952–961.
   PubMed Web of Science ®Google Scholar
• Yulug B, Kilic U, Kilic E, et al. Rifampicin attenuates brain damage in focal ischemia. Brain Res. 2004;996(1):76–80.
   PubMed Web of Science ®Google Scholar
• Marija M. Rifampicin: an immunosuppressant. Lancet. 1971;2(7730):930–931.
   PubMed Web of Science ®Google Scholar
• Bellahsène A, Forsgren A. Effect of rifampin on the immune response in mice. Infect Immun. 1980;27(1):15–20.
   PubMed Web of Science ®Google Scholar
• Nau R, Wellmer A, Soto A, et al. Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis. J Infect Dis. 1999;179(6):1557–1560.
   PubMed Web of Science ®Google Scholar
• Tsiskarishvili NV, Tsiskarishvili NI. [The anti-tubercular drugs in the treatment of psoriasis]. Georgian Med News. 2009;174:25–28.
   Google Scholar
• Namazi H. Practice pearl: a novel use of rifampicin for treatment of carpal tunnel syndrome. J Pain. 2008;9(4):380–381.
   PubMed Web of Science ®Google Scholar
• Ma K, Chen X, Chen JC, et al. Rifampicin attenuates experimental autoimmune encephalomyelitis by inhibiting pathogenic Th17 cells responses. J Neurochem. 2016;139(6):1151–1162.
   PubMed Web of Science ®Google Scholar
• Ali AE, Mahdy HM, Elsherbiny DM, et al. Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: impact on oxidative, inflammatory and apoptotic machineries. Biochem Pharmacol. 2018;156:431–443.
   PubMed Web of Science ®Google Scholar
• Hu YD, Pang W, He CC, et al. The cognitive impairment induced by zinc deficiency in rats aged 0∼2 months related to BDNF DNA methylation changes in the hippocampus. Nutr Neurosci. 2017;20(9):519–525.
   PubMed Web of Science ®Google Scholar
• Micale V, Cristino L, Tamburella A, et al. Enhanced cognitive performance of dopamine D3 receptor “knock-out” mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. Pharmacol Res. 2010;61(6):531–536.
   PubMed Web of Science ®Google Scholar
• Matsuura K, Kabuto H, Makino H, et al. Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion. J Neurosci Methods. 1997;73(1):45–48.
   PubMed Web of Science ®Google Scholar
• Hernández-Romero MC, Delgado-Cortés MJ, Sarmiento M, et al. Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system. Neurotoxicology. 2012;33(3):347–360.
   PubMed Web of Science ®Google Scholar
• Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci. 2004;75(6):639–653.
   PubMed Web of Science ®Google Scholar
• Aïd S, Bosetti F. Targeting cyclooxygenases-1 and −2 in neuroinflammation: therapeutic implications. Biochimie. 2011;93(1):46–51.
   PubMed Web of Science ®Google Scholar
• Laird MH, Rhee SH, Perkins DJ, et al. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol. 2009;85(6):966–977.
   PubMed Web of Science ®Google Scholar
• Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649–683.
   PubMed Web of Science ®Google Scholar
• Atreya I, Atreya R, Neurath MF. NF-kappaB in inflammatory bowel disease. J Intern Med. 2008;263(6):591–596.
   PubMed Web of Science ®Google Scholar
• Chui DH, Tabira T, Izumi S, et al. Decreased beta-amyloid and increased abnormal Tau deposition in the brain of aged patients with leprosy. Am J Pathol. 1994;145(4):771–775.
   PubMed Web of Science ®Google Scholar
• Qosa H, Abuznait AH, Hill RA, et al. Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer’s disease. J Alzheimers Dis. 2012;31(1):151–165.
   PubMed Web of Science ®Google Scholar
• Ubhi K, Rockenstein E, Mante M, et al. Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy. Neuroreport. 2008;19(13):1271–1276.
   PubMed Web of Science ®Google Scholar
• Kilic U, Kilic E, Lingor P, et al. Rifampicin inhibits neurodegeneration in the optic nerve transection model in vivo and after 1-methyl-4-phenylpyridinium intoxication in vitro. Acta Neuropathol. 2004;108(1):65–68.
   PubMed Web of Science ®Google Scholar
• Bi W, Zhu L, Jing X, et al. Parkinson’s disease. Neurol Sci. 2013;34(2):137–141.
   PubMed Web of Science ®Google Scholar
• Allison DJ, Ditor DS. The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflammation. 2014;11:151.
   PubMed Web of Science ®Google Scholar
• Kaur P, Sodhi RK. Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: role of pregnane X receptors. Neuroscience. 2015;288:24–36.
   PubMed Web of Science ®Google Scholar
• Zhao J, Bi W, Xiao S, et al. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep. 2019;9(1):5790.
   PubMed Web of Science ®Google Scholar
• Richwine AF, Godbout JP, Berg BM, et al. Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production. Brain Behav Immun. 2005;19(6):512–520.
   PubMed Web of Science ®Google Scholar
• Bettcher BM, Kramer JH. Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase. 2013;19(2):182–200.
   PubMed Web of Science ®Google Scholar
• Zhao WX, Zhang JH, Cao JB, et al. Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity. J Neuroinflammation. 2017;14(1):17.
   PubMed Web of Science ®Google Scholar
• Lana D, Ugolini F, Nosi D, et al. Alterations in the Interplay between neurons, astrocytes and microglia in the rat dentate gyrus in experimental models of neurodegeneration. Front Aging Neurosci. 2017;9:296.
   PubMed Web of Science ®Google Scholar
• Fukushima S, Furube E, Itoh M, et al. Robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single LPS stimulation. J Neuroimmunol. 2015;285:31–40.
   PubMed Web of Science ®Google Scholar
• Herrera AJ, Tomás-Camardiel M, Venero JL, et al. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. J Neural Transm (Vienna). 2005;112(1):111–119.
   PubMed Web of Science ®Google Scholar
• Kloss CU, Bohatschek M, Kreutzberg GW, et al. Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture. Exp Neurol. 2001;168(1):32–46.
   PubMed Web of Science ®Google Scholar
• Koedel U, Merbt UM, Schmidt C, et al. Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses. Am J Pathol. 2007;171(1):200–213.
   PubMed Web of Science ®Google Scholar
• Tamassia N, Le Moigne V, Calzetti F, et al. The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4. J Immunol. 2007;178(11):7344–7356.
   PubMed Web of Science ®Google Scholar
• Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004;16(1):3–9.
   PubMed Web of Science ®Google Scholar
• Wang X, Grace PM, Pham MN, et al. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb J. 2013;27(7):2713–2722.
   PubMed Web of Science ®Google Scholar
• Simon PS, Sharman SK, Lu C, et al. The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription. BMC Cancer. 2015;15:770.
   PubMed Web of Science ®Google Scholar
• Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009;27:693–733.
   PubMed Web of Science ®Google Scholar
• Zhang W, Wei Q. Calcineurin stimulates the expression of inflammatory factors in RAW 264.7 cells by interacting with proteasome subunit alpha type 6. Biochem Biophys Res Commun. 2011;407(4):668–673.
   PubMed Web of Science ®Google Scholar
• Bi W, Jing X, Zhu L, et al. Inhibition of 26S protease regulatory subunit 7 (MSS1) suppresses neuroinflammation. PLoS One. 2012;7(5):e36142.
   PubMed Web of Science ®Google Scholar