Renal function and neurodegenerative diseases : a two-sample Mendelian randomization study

References

• Roth GA, Abate D, Abate KH. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018 Nov 10;392(10159):1736–1788. DOI:10.1016/s0140-6736(18)32203-7 PubMed PMID: 30496103; PubMed Central PMCID: PMCPMC6227606. eng.
   PubMed Web of Science ®Google Scholar
• Bakhta K, Cecillon E, Lacombe E, et al. Alzheimer’s disease and neurodegenerative diseases in France. Lancet. 2019 Aug 10;394(10197):466–467. DOI:10.1016/s0140-6736(19)31633-2 PubMed PMID: 31402022; eng.
   PubMed Web of Science ®Google Scholar
• de Lau LM, Breteler MM. Epidemiology of parkinson’s disease. Lancet Neurol. 2006 Jun;5(6):525–535. DOI:10.1016/s1474-4422(06)70471-9 PubMed PMID: 16713924; eng.
   PubMed Web of Science ®Google Scholar
• Ascherio A, Schwarzschild MA. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol. 2016 Nov;15(12):1257–1272. DOI:10.1016/s1474-4422(16)30230-7 PubMed PMID: 27751556; eng.
   PubMed Web of Science ®Google Scholar
• Koushik NS, McArthur SF, Baird AD. Adult chronic kidney disease: neurocognition in chronic renal failure. Neuropsychol rev. 2010 Mar;20(1):33–51. DOI:10.1007/s11065-009-9110-5 PubMed PMID: 19705282; eng.
   PubMed Web of Science ®Google Scholar
• Yaffe K, Ackerson L, Kurella Tamura M, et al. Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc. 2010 Feb;58(2):338–345. DOI:10.1111/j.1532-5415.2009.02670.x PubMed PMID: 20374407; PubMed Central PMCID: PMCPMC2852884. eng.
   PubMed Web of Science ®Google Scholar
• Sarnak MJ, Tighiouart H, Scott TM, et al. Frequency of and risk factors for poor cognitive performance in hemodialysis patients. Neurology. 2013 Jan 29;80(5):471–480. DOI:10.1212/WNL.0b013e31827f0f7f PubMed PMID: 23303848; PubMed Central PMCID: PMCPMC3590049. eng.
   PubMed Web of Science ®Google Scholar
• Meléndez-Flores JD, Estrada-Bellmann I. Linking chronic kidney disease and parkinson’s disease: a literature review. Metab Brain Dis. 2021 Jan;36(1):1–12. DOI:10.1007/s11011-020-00623-1 PubMed PMID: 32990929; eng.
   PubMed Web of Science ®Google Scholar
• Oh Y-S, Kim J-S, Park H-E, et al. Association between urine protein/creatinine ratio and cognitive dysfunction in Lewy body disorders. J Neurolog Sci. 2016 Mar 15;362:258–262. 10.1016/j.jns.2016.01.061 PubMed PMID: 26944159; eng
   PubMed Web of Science ®Google Scholar
• Calabresi PA, Austin H, Racke MK, et al. Impaired renal function in progressive multiple sclerosis. Neurology. 2002 Dec 10;59(11):1799–1801. DOI:10.1212/01.wnl.0000036618.68674.7a PubMed PMID: 12473777; eng.
   PubMed Web of Science ®Google Scholar
• Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014 Sep 15;23(R1):R89–98. DOI:10.1093/hmg/ddu328 PubMed PMID: 25064373; PubMed Central PMCID: PMCPMC4170722. eng.
   PubMed Web of Science ®Google Scholar
• Haycock PC, Burgess S, Wade KH, et al. Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr. 2016 Apr;103(4):965–978. DOI:10.3945/ajcn.115.118216 PubMed PMID: 26961927; PubMed Central PMCID: PMCPMC4807699. eng.
   PubMed Web of Science ®Google Scholar
• Wuttke M, Li Y, Li M, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature genet. 2019 Jun;51(6):957–972. DOI:10.1038/s41588-019-0407-x PubMed PMID: 31152163; PubMed Central PMCID: PMCPMC6698888. eng.
   PubMed Web of Science ®Google Scholar
• Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007 Sep;81(3):559–575. DOI:10.1086/519795 PubMed PMID: 17701901; PubMed Central PMCID: PMCPMC1950838. eng.
   PubMed Web of Science ®Google Scholar
• Hemani G, Zheng J, Elsworth B, et al. The MR-base platform supports systematic causal inference across the human phenome. Elife. 2018 May 30;7. DOI:10.7554/eLife.34408 PubMed PMID: 29846171; PubMed Central PMCID: PMCPMC5976434. eng
   PubMed Web of Science ®Google Scholar
• Davies NM, Holmes MV, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018 Jul 12;362:k601. 10.1136/bmj.k601 Clinical research ed PubMed PMID: 30002074; PubMed Central PMCID: PMCPMC6041728 interests and declare that we have no competing interests. eng.
   PubMed Web of Science ®Google Scholar
• Schwartzentruber J, Cooper S, Liu JZ, et al. Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new alzheimer’s disease risk genes. Nature genet. 2021 Mar;53(3):392–402. DOI:10.1038/s41588-020-00776-w PubMed PMID: 33589840; PubMed Central PMCID: PMCPMC7610386. eng.
   PubMed Web of Science ®Google Scholar
• Marioni RE, Harris SE, Zhang Q, et al. GWAS on family history of alzheimer’s disease. Transl Psychiatry. 2018 May 18;8(1):99. DOI:10.1038/s41398-018-0150-6 PubMed PMID: 29777097; PubMed Central PMCID: PMCPMC5959890. eng.
   PubMed Web of Science ®Google Scholar
• Nalls MA, Blauwendraat C, Vallerga CL, et al. Identification of novel risk loci, causal insights, and heritable risk for parkinson’s disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 2019 Dec;18(12):1091–1102. DOI:10.1016/s1474-4422(19)30320-5 PubMed PMID: 31701892; PubMed Central PMCID: PMCPMC8422160. eng.
   PubMed Web of Science ®Google Scholar
• Chia R, Sabir MS, Bandres-Ciga S, et al. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature genet. 2021 Mar;53(3):294–303. DOI:10.1038/s41588-021-00785-3 PubMed PMID: 33589841; PubMed Central PMCID: PMCPMC7946812. eng.
   PubMed Web of Science ®Google Scholar
• Ferrari R, Hernandez DG, Nalls MA, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol. 2014 Jul;13(7):686–699. DOI:10.1016/s1474-4422(14)70065-1 PubMed PMID: 24943344; PubMed Central PMCID: PMCPMC4112126. eng.
   PubMed Web of Science ®Google Scholar
• Nicolas A, Kenna KP, Renton AE, et al. Genome-wide analyses identify kif5a as a novel als gene. Neuron. 2018 Mar 21;97(6):1268–1283.e6. DOI:10.1016/j.neuron.2018.02.027 PubMed PMID: 29566793; PubMed Central PMCID: PMCPMC5867896. eng.
   PubMed Web of Science ®Google Scholar
• Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019Sep27;365(6460) 10.1126/science.aav7188 PubMed PMID: 31604244; PubMed Central PMCID: PMCPMC7241648. eng.
   Web of Science ®Google Scholar
• Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017 Nov 21;318(19):1925–1926. DOI:10.1001/jama.2017.17219 PubMed PMID: 29164242; eng.
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression. Int J Epidemiol. 2015 Apr;44(2):512–525. DOI:10.1093/ije/dyv080 PubMed PMID: 26050253; PubMed Central PMCID: PMCPMC4469799. eng.
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016 May;40(4):304–314. DOI:10.1002/gepi.21965 PubMed PMID: 27061298; PubMed Central PMCID: PMCPMC4849733. eng.
   PubMed Web of Science ®Google Scholar
• Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017 Dec 1;46(6):1985–1998. DOI:10.1093/ije/dyx102 PubMed PMID: 29040600; PubMed Central PMCID: PMCPMC5837715. eng.
   PubMed Web of Science ®Google Scholar
• Hailpern SM, Melamed ML, Cohen HW, et al. Moderate chronic kidney disease and cognitive function in adults 20 to 59 years of age: third National Health and Nutrition Examination Survey (NHANES III). J Am Soc Nephrol. 2007 Jul;18(7):2205–2213. DOI:10.1681/asn.2006101165 PubMed PMID: 17554148; eng.
   PubMed Web of Science ®Google Scholar
• Seliger SL, Siscovick DS, Stehman-Breen CO, et al. Moderate renal impairment and risk of dementia among older adults: the cardiovascular health cognition study. J Am Soc Nephrol. 2004 Jul;15(7):1904–1911. DOI:10.1097/01.asn.0000131529.60019.fa PubMed PMID: 15213280; eng.
   PubMed Web of Science ®Google Scholar
• Drew DA, Weiner DE, Sarnak MJ. Cognitive Impairment in CKD: pathophysiology, management, and prevention. Am J Kidney Dis. 2019 Dec;74(6):782–790. DOI:10.1053/j.ajkd.2019.05.017 PubMed PMID: 31378643; PubMed Central PMCID: PMCPMC7038648. eng.
   PubMed Web of Science ®Google Scholar
• Bugnicourt J-M, Godefroy O, Chillon J-M, et al. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. J Am Soc Nephrol. 2013 Feb;24(3):353–363. DOI:10.1681/asn.2012050536 PubMed PMID: 23291474; eng.
   PubMed Web of Science ®Google Scholar
• Berger I, Wu S, Masson P, et al. Cognition in chronic kidney disease: a systematic review and meta-analysis. BMC Med. 2016 Dec 14;14(1):206. DOI:10.1186/s12916-016-0745-9 PubMed PMID: 27964726; PubMed Central PMCID: PMCPMC5155375. eng.
   PubMed Web of Science ®Google Scholar
• Kurella Tamura M, Chertow GM, Depner TA, et al. Metabolic profiling of impaired cognitive function in patients receiving dialysis. J Am Soc Nephrol. 2016 Dec;27(12):3780–3787. DOI:10.1681/asn.2016010039 PubMed PMID: 27444566; PubMed Central PMCID: PMCPMC5118491. eng.
   PubMed Web of Science ®Google Scholar
• Daugirdas JT. Pathophysiology of dialysis hypotension: an update. Am J Kidney Dis. 2001 Oct;38(4 Suppl 4):S11–7. DOI:10.1053/ajkd.2001.28090 PubMed PMID: 11602456; eng.
   PubMed Web of Science ®Google Scholar
• Mizumasa T, Hirakata H, Yoshimitsu T, et al. Dialysis-related hypotension as a cause of progressive frontal lobe atrophy in chronic hemodialysis patients: a 3-year prospective study. Nephron Clin Pract. 2004;97(1):c23–30. DOI:10.1159/000077592 PubMed PMID: 15153764; eng.
   PubMedGoogle Scholar
• Singh-Manoux A, Oumarou-Ibrahim A, Machado-Fragua MD, et al. Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study. Age Ageing. 2022 Jan 6;51(1). DOI:10.1093/ageing/afab259 PubMed PMID: 35061870; PubMed Central PMCID: PMCPMC8782607. eng.
   PubMed Web of Science ®Google Scholar
• Wu J-J, Weng S-C, Liang C-K, et al. Effects of kidney function, serum albumin and hemoglobin on dementia severity in the oldest old people with newly diagnosed alzheimer’s disease in a residential aged care facility: a cross-sectional study. BMC Geriatr. 2020 Oct 7;20(1):391. DOI:10.1186/s12877-020-01789-0 PubMed PMID: 33028210; PubMed Central PMCID: PMCPMC7541276. eng.
   PubMed Web of Science ®Google Scholar
• Huang Z-H, Chen H-C, Chou Y-C, et al. Does nephrotic syndrome without chronic kidney disease increase the risk of parkinson’s disease and secondary parkinsonism? A nationwide population-based study in Taiwan. BMJ Open. 2018 Jul 7;8(7):e020821. DOI:10.1136/bmjopen-2017-020821 PubMed PMID: 29982207; PubMed Central PMCID: PMCPMC6045768. eng.
   PubMed Web of Science ®Google Scholar
• Li YC. Renoprotective effects of vitamin D analogs. Kidney Int. 2010 Jul;78(2):134–139. DOI:10.1038/ki.2009.175 PubMed PMID: 19471320; eng.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Sun L, Wang Y, et al. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 2008 Jan;73(2):163–171. DOI:10.1038/sj.ki.5002572 PubMed PMID: 17928826; eng.
   PubMed Web of Science ®Google Scholar
• Babitt JL, Lin HY. Mechanisms of anemia in CKD. J Am Soc Nephrol. 2012 Oct;23(10):1631–1634. DOI:10.1681/asn.2011111078 PubMed PMID: 22935483; PubMed Central PMCID: PMCPMC3458456. eng.
   PubMed Web of Science ®Google Scholar
• Suzuki N, Yamamoto M. Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. Pflugers Archiv : European J Physiol. 2016 Jan;468(1):3–12. DOI:10.1007/s00424-015-1740-2 PubMed PMID: 26452589; eng.
   PubMed Web of Science ®Google Scholar
• Erbaş O, Çınar BP, Solmaz V, et al. The neuroprotective effect of erythropoietin on experimental Parkinson model in rats. Neuropeptides 2015 Feb;49:1–5. DOI:10.1016/j.npep.2014.10.003 PubMed PMID: 25464888; eng.
   PubMed Web of Science ®Google Scholar