Geniposide ameliorates brain injury in mice with intracerebral hemorrhage by inhibiting NF-κB signaling

References

• van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 2010;9(2):167–176. doi: 10.1016/S1474-4422(09)70340-0
   PubMed Web of Science ®Google Scholar
• Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am. 2012;30(3):771–794. doi: 10.1016/j.emc.2012.06.003
   PubMed Web of Science ®Google Scholar
• Fiorella D, Zuckerman SL, Khan IS, et al. Intracerebral hemorrhage: a common and devastating disease in need of better treatment. World Neurosurg. 2015;84(4):1136–1141. doi: 10.1016/j.wneu.2015.05.063
   PubMed Web of Science ®Google Scholar
• Tao Y, Xu Y, Shen M, et al. The neuroprotection of cerebrolysin after spontaneous intracerebral hemorrhage through regulates necroptosis via Akt/GSK3β signaling pathway. Acta Cir Bras. 2021;36(10):e361002. doi: 10.1590/acb361002
   PubMed Web of Science ®Google Scholar
• Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11(8):720–731. doi: 10.1016/S1474-4422(12)70104-7
   PubMed Web of Science ®Google Scholar
• Yao Z, Bai Q, Wang G. Mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage. Oxid Med Cell Longev. 2021;2021:8815441. doi: 10.1155/2021/8815441
   PubMed Web of Science ®Google Scholar
• Zhao L, Peng F, Guan B, et al. Whether metal element-containing herbal formula angong niuhuang pill is safe for acute brain disorders? Biol Trace Elem Res. 2015;166(1):41–48. doi: 10.1007/s12011-015-0318-3
   PubMed Web of Science ®Google Scholar
• Chen S, Sun P, Zhao X, et al. Gardenia jasminoides has therapeutic effects on L‑NNA‑induced hypertension in vivo. Mol Med Rep. 2017;15(6):4360–4373. doi: 10.3892/mmr.2017.6542
   PubMed Web of Science ®Google Scholar
• Chen YC, Ho WM, Lee YS, et al. Polymorphisms in the promoters of the MMP-2 and TIMP-2 genes are associated with spontaneous deep intracerebral hemorrhage in the Taiwan population. PloS One. 2015;10(11):e0142482. doi: 10.1371/journal.pone.0142482
   PubMed Web of Science ®Google Scholar
• Fu Y, Yuan PP, Cao YG, et al. Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors. J Pharm Pharmacol. 2020b;72(12):1956–1969. doi: 10.1111/jphp.13361
   PubMed Web of Science ®Google Scholar
• Fu C, Zhang X, Lu Y, et al. Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation. Int Immunopharmacol. 2020a;84:106547. doi: 10.1016/j.intimp.2020.106547
   PubMed Web of Science ®Google Scholar
• Yuan J, Zhang J, Cao J, et al. Geniposide alleviates traumatic brain injury in rats via anti-inflammatory effect and MAPK/NF-kB inhibition. Cell Mol Neurobiol. 2020;40(4):511–520. doi: 10.1007/s10571-019-00749-6
   PubMed Web of Science ®Google Scholar
• Wen J, Yang CY, Lu J, et al. Ptprj-as1 mediates inflammatory injury after intracerebral hemorrhage by activating NF-κB pathway. Eur Rev Med Pharmacol Sci. 2018;22(9):2817–2823. doi: 10.26355/eurrev_201805_14981
   PubMed Web of Science ®Google Scholar
• Yang Y, Tan X, Xu J, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage. Biomed Pharmacother. 2020;126:110044. doi: 10.1016/j.biopha.2020.110044
   PubMed Web of Science ®Google Scholar
• Li Y, Qiu H, Yao S, et al. Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway. Int Immunopharmacol. 2021b;100:108158. doi: 10.1016/j.intimp.2021.108158
   PubMed Web of Science ®Google Scholar
• Zhang B, Chang HS, Hu KL, et al. Combination of geniposide and eleutheroside B exerts antidepressant-like effect on lipopolysaccharide-induced depression mice model. Chin J Integr Med. 2021a;27(7):534–541. doi: 10.1007/s11655-019-3051-5
   PubMed Web of Science ®Google Scholar
• Hu X, Zhang X, Jin G, et al. Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways. Fundam Clin Pharmacol. 2017;31(1):54–63. doi: 10.1111/fcp.12231
   PubMed Web of Science ®Google Scholar
• Zhang Z, Li Y, Shen P, et al. Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage. Int Immunopharmacol. 2017;49:168–177. doi: 10.1016/j.intimp.2017.05.033
   PubMed Web of Science ®Google Scholar
• Li H, Wang Y, Wang B, et al. Baicalin and geniposide inhibit polarization and inflammatory injury of OGD/R-Treated microglia by suppressing the 5-LOX/LTB4 pathway. Neurochem Res. 2021a;46(7):1844–1858. doi: 10.1007/s11064-021-03305-1
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang Y, Wang J, et al. Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. Prog Neurobiol. 2014;115:25–44. doi: 10.1016/j.pneurobio.2013.11.003
   PubMed Web of Science ®Google Scholar
• Xi Z, Xu C, Chen X, et al. Protocatechuic acid suppresses microglia activation and facilitates M1 to M2 phenotype switching in intracerebral hemorrhage mice. J Stroke Cerebrovasc Dis. 2021;30(6):105765. doi: 10.1016/j.jstrokecerebrovasdis.2021.105765
   PubMed Web of Science ®Google Scholar
• Yu B, Shen Y, Qiao J, et al. Geniposide attenuates Staphylococcus aureus-induced pneumonia in mice by inhibiting NF-κB activation. Microb Pathog. 2017;112:117–121. doi: 10.1016/j.micpath.2017.09.050
   PubMed Web of Science ®Google Scholar
• Zhang Z, Song Y, Li F, et al. Inhibiting nuclear factor-κB at different stages after intracerebral hemorrhage can influence the hemorrhage-induced brain injury in experimental models in vivo. Brain Res Bull. 2020;155:159–165. doi: 10.1016/j.brainresbull.2019.12.010
   PubMed Web of Science ®Google Scholar
• Chen J, Li Y, Wang L, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32(4):1005–1011. doi: 10.1161/01.STR.32.4.1005
   PubMed Web of Science ®Google Scholar
• Han X, Zhao X, Lan X, et al. 20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis. J Cereb Blood Flow Metab. 2019;39(8):1531–1543. doi: 10.1177/0271678X18762645
   PubMed Web of Science ®Google Scholar
• Leclerc JL, Santiago-Moreno J, Dang A, et al. Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2018;38(6):1032–1046. doi: 10.1177/0271678X16679170
   PubMed Web of Science ®Google Scholar
• Yang Q, Zhuang X, Peng F, et al. Relationship of plasma matrix metalloproteinase-9 and hematoma expansion in acute hypertensive cerebral hemorrhage. Int J Neurosci. 2016;126(3):213–218. doi: 10.3109/00207454.2015.1007372
   PubMed Web of Science ®Google Scholar
• Hostettler IC, Seiffge DJ, Werring DJ. Intracerebral hemorrhage: an update on diagnosis and treatment. Expert Rev Neurother. 2019;19(7):679–694. doi: 10.1080/14737175.2019.1623671
   PubMed Web of Science ®Google Scholar
• Wang J, Li D, Hou J, et al. Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition. Mol Med Rep. 2018;17:3186–3193. doi: 10.3892/mmr.2017.8221
   PubMed Web of Science ®Google Scholar
• Gao C, Liu Y, Jiang Y, et al. Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced Alzheimer rat model. Brain Pathol. 2014;24(3):261–269. doi: 10.1111/bpa.12116
   PubMed Web of Science ®Google Scholar
• Lv C, Liu X, Liu H, et al. Geniposide attenuates mitochondrial dysfunction and memory deficits in APP/PS1 transgenic mice. Curr Alzheimer Res. 2014;11(6):580–587. doi: 10.2174/1567205011666140618095925
   PubMed Web of Science ®Google Scholar
• Lan X, Han X, Li Q, et al. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain Behav Immun. 2017;61:326–339. doi: 10.1016/j.bbi.2016.12.012
   PubMed Web of Science ®Google Scholar
• Zhu H, Pan Y, Jiang Y, et al. Activation of the Hippo/TAZ pathway is required for menstrual stem cells to suppress myofibroblast and inhibit transforming growth factor β signaling in human endometrial stromal cells. Hum Reprod. 2019;34(4):635–645. doi: 10.1093/humrep/dez001
   PubMed Web of Science ®Google Scholar
• Pan T, Shi X, Chen H, et al. Geniposide suppresses interleukin-1β-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-κB signaling pathway. Inflammation. 2018;41(2):390–399. doi: 10.1007/s10753-017-0694-2
   PubMed Web of Science ®Google Scholar
• Mai C, Qiu L, Zeng Y, et al. Lactobacillus casei Strain Shirota enhances the ability of geniposide to activate SIRT1 and decrease inflammation and oxidative stress in septic mice. Front Physiol. 2021;12:678838. doi: 10.3389/fphys.2021.678838
   PubMed Web of Science ®Google Scholar
• Tu Y, Li L, Zhu L, et al. Geniposide attenuates hyperglycemia-induced oxidative stress and inflammation by activating the Nrf2 signaling pathway in experimental diabetic retinopathy. Oxid Med Cell Longev. 2021;2021:9247947. doi: 10.1155/2021/9247947
   PubMed Web of Science ®Google Scholar
• Li F, Li W, Li X, et al. Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells. J Ethnopharmacol. 2016;185:77–86. doi: 10.1016/j.jep.2016.03.025
   PubMed Web of Science ®Google Scholar
• Wei F, Cui Y, Guo X, et al. Correlations of inflammatory factors, CCCK-18, MMP-9 and D-Dimer with APACHE II score and prognosis of patients with acute cerebral hemorrhage. Minerva Med. 2020;114(2):162–168. doi: 10.23736/S0026-4806.20.06685-9
   PubMedGoogle Scholar
• Qian Y, Song JL, Sun P, et al. Lactobacillus casei Strain Shirota enhances the in vitro antiproliferative effect of geniposide in human oral squamous carcinoma HSC-3 cells. Molecules. 2018;23(5):1069. doi: 10.3390/molecules23051069
   PubMed Web of Science ®Google Scholar
• Ma J, Ding Y. RETRACTED: geniposide suppresses growth, migration and invasion of MKN45 cells by down-regulation of lncRNA HULC. Exp Mol Pathol. 2018;105(3):252–259. doi: 10.1016/j.yexmp.2018.08.011
   PubMed Web of Science ®Google Scholar
• Cai L, Mu YR, Liu MM, et al. Penta-acetyl geniposide suppresses migration, invasion, and Inflammation of TNF-α-stimulated rheumatoid arthritis fibroblast-like synoviocytes involving Wnt/β-catenin signaling pathway. Inflammation. 2021;44(6):2232–2245. doi: 10.1007/s10753-021-01495-y
   PubMed Web of Science ®Google Scholar
• Li C, Wang X, Cheng F, et al. Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system. Eur J Pharmacol. 2019;854:224–231. doi: 10.1016/j.ejphar.2019.04.021
   PubMed Web of Science ®Google Scholar
• Hu X, Tao C, Gan Q, et al. Oxidative stress in intracerebral hemorrhage: sources, mechanisms, and therapeutic targets. Oxid Med Cell Longev. 2016;2016:3215391. doi: 10.1155/2016/3215391
   PubMed Web of Science ®Google Scholar
• Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci. 2003;24(9):471–478. doi: 10.1016/S0165-6147(03)00233-5
   PubMed Web of Science ®Google Scholar
• Tang J, Liu J, Zhou C, et al. Role of NADPH oxidase in the brain injury of intracerebral hemorrhage. J Neurochem. 2005;94(5):1342–1350. doi: 10.1111/j.1471-4159.2005.03292.x
   PubMed Web of Science ®Google Scholar
• Yang L, Bi L, Jin L, et al. Geniposide ameliorates liver fibrosis through reducing oxidative stress and inflammatory respose, inhibiting apoptosis and modulating overall metabolism. Front Pharmacol. 2021;12:772635. doi: 10.3389/fphar.2021.772635
   PubMed Web of Science ®Google Scholar
• He T, Shen H, Zhu J, et al. Geniposide attenuates cadmium‑induced oxidative stress injury via Nrf2 signaling in osteoblasts. Mol Med Rep. 2019;20:1499–1508. doi: 10.3892/mmr.2019.10396
   PubMed Web of Science ®Google Scholar
• Zou T, Sugimoto K, Zhang J, et al. Geniposide alleviates oxidative stress of mice with depression-like behaviors by upregulating Six3os1. Front Cell Dev Biol. 2020;8:553728. doi: 10.3389/fcell.2020.553728
   PubMed Web of Science ®Google Scholar
• Zhao C, Lv C, Li H, et al. Geniposide protects primary cortical neurons against oligomeric Aβ1-42-induced neurotoxicity through a mitochondrial pathway. PloS One. 2016;11(4):e0152551. doi: 10.1371/journal.pone.0152551
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chen Y, Wu J, et al. Activation of dopamine D2 receptor suppresses neuroinflammation through αB-Crystalline by inhibition of NF-κB nuclear translocation in experimental ICH mice model. Stroke. 2015;46(9):2637–2646. doi: 10.1161/STROKEAHA.115.009792
   PubMed Web of Science ®Google Scholar
• Liu DL, Zhao LX, Zhang S, et al. Peroxiredoxin 1-mediated activation of TLR4/NF-κB pathway contributes to neuroinflammatory injury in intracerebral hemorrhage. Int Immunopharmacol. 2016;41:82–89. doi: 10.1016/j.intimp.2016.10.025
   PubMed Web of Science ®Google Scholar
• Li F, Chen Y, Li Y, et al. Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway. Eur J Pharmacol. 2020;886:173449. doi: 10.1016/j.ejphar.2020.173449
   PubMed Web of Science ®Google Scholar
• Liu S, Zheng M, Li Y, et al. The protective effect of geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway. Psychopharmacol (Berl). 2020;237(2):465–477. doi: 10.1007/s00213-019-05379-w
   PubMed Web of Science ®Google Scholar
• Jiang JY, Liu DJ, Liu MX. The protective effect of NF-κB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis. Scand J Gastroenterol. 2021;56(10):1131–1139. doi: 10.1080/00365521.2021.1953130
   PubMed Web of Science ®Google Scholar
• Sui A, Chen X, Demetriades AM, et al. Inhibiting NF-κB signaling activation reduces retinal neovascularization by promoting a polarization shift in macrophages. Invest Ophthalmol Vis Sci. 2020;61(6):4. doi: 10.1167/iovs.61.6.4
   PubMed Web of Science ®Google Scholar
• Zhang CQ, Yi S, Chen BB, et al. mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats. Int J Neurosci. 2021b;131(10):994–1003. doi: 10.1080/00207454.2020.1766460
   PubMed Web of Science ®Google Scholar
• Zeng J, Zheng S, Chen Y, et al. Puerarin attenuates intracerebral hemorrhage-induced early brain injury possibly by PI3K/Akt signal activation-mediated suppression of NF-κB pathway. J Cell Mol Med. 2021;25(16):7809–7824. doi: 10.1111/jcmm.16679
   PubMed Web of Science ®Google Scholar
• Wang BF, Cui ZW, Zhong ZH, et al. Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression. Acta Pharmacol Sin. 2015;36(8):939–948. doi: 10.1038/aps.2015.47
   PubMed Web of Science ®Google Scholar