141
Views
40
CrossRef citations to date
0
Altmetric
Reports

Chemoprevention of Rat Prostate Carcinogenesis by Soy Isoflavones and by Bowman-Birk Inhibitor

, , , &
Pages 184-193 | Received 03 Aug 2006, Accepted 23 Oct 2006, Published online: 05 Dec 2007

References

  • Fournier , D B , Erdman , J W Jr. and Gordon , G B . 1998 . Soy, its components, and cancer prevention: a review of the in vitro, animal, and human data. . Cancer Epidemiol Biomarkers Prev , 7 : 1055 – 1065 .
  • Sarkar , F H and Li , Y . 2003 . Soy isoflavones and cancer prevention . Cancer Invest , 21 : 817 – 818 .
  • Messina , M J . 2003 . Emerging evidence on the role of soy in reducing prostate cancer risk . Nutr Rev , 61 : 117 – 131 .
  • Sarkar , F H , Adsule , S , Padhye , S , Kulkarni , S and Li , Y . 2006 . The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. . Mini Rev Med Chem , 6 : 401 – 407 .
  • Troll , W and Wiesner , R . 1983 . Protease inhibitors: possible anticarcinogens in edible seeds . Prostate , 4 : 345 – 349 .
  • Kennedy , A R . 1995 . The evidence for soybean products as cancer preventive agents . J Nutr , 125 : 733s – 743s .
  • Kerwin , S M . 2004 . Soy saponins and the anticancer effects of soybeans and soy-based foods . Curr Med Chem Anticancer Agents , 4 : 263 – 272 .
  • Pollard , M and Luckert , P H . 1997 . Influence of isoflavones in soy protein isolates on development of induced prostate-related cancers in L-W rats . Nutr Cancer , 28 : 41 – 45 .
  • Onozawa , M , Kawamori , T , Baba , M , Fukuda , K , Toda , T , Sato , H , Ohtani , M , Akaza , H , Sugimura , T and Wakabayashi , K . 1999 . Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats . Jpn J Cancer Res , 90 : 393 – 398 .
  • LaMartiniere , C A , Cotroneo , M S , Fritz , W A , Wang , J , Mentor-Marcel , R and Elgavish , A . 2002 . Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate . J Nutr , 132 : 552S – 558S .
  • Wang , J , Eltoum , I E and LaMartiniere , C A . 2002 . Dietary genistein suppresses chemically induced prostate cancer in Lobund-Wistar rats . Cancer Lett , 186 : 11 – 18 .
  • Barnes , S . 1997 . The chemopreventive properties of soy isoflavonoids in animal models of breast cancer . Breast Cancer Res Treat , 46 : 169 – 179 .
  • Wei , H , Bowen , R , Zhang , X and Lebwohl , M . 1998 . Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice . Carcinogenesis , 19 : 1509 – 1514 .
  • S⊘rensen , I K , Kristiansen , E , Mortensen , A , Nicolaisen , G M , Wijnands , J A , van Kranen , H J and van Kreijl , C F . 1998 . The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse . Cancer Lett , 130 : 217 – 225 .
  • Tatsuta , M , Iishi , H , Baba , M , Yano , H , Uehara , H and Nakaizuma , A . 1999 . Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats . Int J Cancer , 80 : 396 – 399 .
  • Guo , J Y , Li , X , Browning , J D Jr. , Rottinghaus , G E , Lubahn , D B , Constantinou , A , Bennink , M and MacDonald , R S . 2004 . Dietary soy isoflavones and estrone protect ovariectomized ERα KO and wild-type mice from carcinogen-induced colon cancer . J Nutr , 134 : 179 – 182 .
  • Rao , C V , Wang , C X , Simi , B , Lubet , R , Kelloff , G , Steele , V and Reddy , B S . 1997 . Enhancement of experimental colon cancer by genistein . Cancer Res , 57 : 3717 – 3722 .
  • C D , Allred , K F , Ju , Y H , Clausen , L M , Doerge , D R , Schantz , S L , Korol , D L , Wallig , M A and Helferich , W G . 2004 . Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats . Carcinogenesis , 25 : 211 – 218 .
  • Yang , Y , Zhou , Z T and Ge , J P . 2006 . Effect of genistein on DMBA-induced oral carcinogenesis in hamster . Carcinogenesis , 27 : 578 – 583 .
  • Bektic , J , Guggenberger , R , Eder , I E , Pelzer , A E , Berger , A P , Bartsch , G and Klocker , H . 2005 . Molecular effects of the isflavonoid genistein in prostate cancer . Clin Prostate Cancer , 4 : 124 – 129 .
  • Rimbach , G , De Pascual-Teresa , S , Ewins , B A , Matsugo , S , Uchida , Y , Minihane , A M , Turner , R , VafeiAdou , K and Weinberg , P D . 2003 . Antioxidant and free radical scavenging activity of isoflavone metabolites . Xenobiotica , 33 : 913 – 925 .
  • Rufer , C E and Kulling , S E . 2006 . Antioxidant activity of isoflavones and their major metabolites using different in vitro assays . J Agric Food Chem , 54 : 2926 – 2931 .
  • Lee , J S . Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats . Life Sci , in press
  • Raschke , M , Rowland , I R , Magee , P J and Pool-Zobel , B L . Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress . Carcinogenesis , in press
  • Dalu , A , Haskell , J F , Coward , L and LaMartiniere , C A . 1998 . Genistein, a component of soy, inhibits the expression of the EGF and ErbB2/Neu receptors in the rat dorsolateral prostate . Prostate , 37 : 36 – 42 .
  • LaMartiniere , C A , Zhang , J X and Cotroneo , M S . 1998 . Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity . Am J Clin Nutr , 68 : 1400S – 1405S .
  • LaMartiniere , C A . 2000 . Protection against breast cancer with genistein: a component of soy . Am J Clin Nutr , 71 : 1705S – 1707S .
  • Hwang , J T , Park , I J , Shin , J I , Lee , Y K , Lee , S K , Baik , H W , Ha , J and Park , O J . 2005 . Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase . Biochem Biophys Res Commun , 38 : 694 – 699 .
  • Su , S J , Yeh , T M , Chuang , W J , Ho , C L , Chang , K L , Cheng , H L , Liu , H S , Cheng , H L , Hsu , P Y and Chow , N H . 2005 . The novel targets for anti-angiogenesis of genistein on human cancer cells . Biochem Pharmacol , 69 : 307 – 318 .
  • Singh , A V , Franke , A A , Blackburn , G L and Zhou , J R . 2006 . Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis . Cancer Res , 66 : 1851 – 1858 .
  • Busby , M G , Jeffcoat , A R , Bloedon , L T , Koch , M A , Black , T , Dix , K J , Heizer , W D , Thomas , B F , Hill , J M , Crowell , J A and Zeisel , S H . 2002 . Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men . Am J Clin Nutr , 75 : 126 – 136 .
  • Takimoto , C H , Glover , K , Huang , X , Hayes , S A , Gallot , L , Quinn , M , Jovanovic , B D , Shapiro , A , Hernandez , L , Goetz , A , Llorens , V , Lieberman , R , Crowell , J A , Poisson , B A and Bergan , R C . 2003 . Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer . Cancer Epidemiol Biomarkers Prev , 12 : 1213 – 1221 .
  • Ullmann , U , Oberwittle , H , Grossmann , M and Riegger , C . 2005a . Repeated oral once daily intake of increasing doses of the novel synthetic genistein product Bonistein in healthy volunteers . Planta Med , 71 : 891 – 896 .
  • Ullmann , U , Metzner , J , Frank , T , Cohn , W and Riegger , C . 2005b . Safety, tolerability, and pharmacokinetics of single ascending doses of synthetic genistein (Bonistein) in healthy volunteers . Adv Ther , 22 : 65 – 78 .
  • Kennedy , A R . 1998 . The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent . Amer J Clin Nutr , 68 : 1406s – 1412s .
  • Kennedy , A R , Szuhaz , B F , Newberne , P M and Billings , P C . 1993 . Preparation and production of a cancer chemopreventive agent, Bowman-Birk Inhibitor Concentrate . Nutr. Cancer , 19 : 281 – 302 .
  • Weed , H G , McGandy , R B and Kennedy , A R . 1985 . Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor . Carcinogenesis , 6 : 1239 – 1241 .
  • Kennedy , A R , Beazer-Barclay , Y , Kinzler , K W and Newberne , P M . 1996 . Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor . Cancer Res , 56 : 679 – 682 .
  • von Hofe , E , Newberne , P M and Kennedy , A R . 1992 . Inhibition of N-nitrosomethylbenzyl-amine-induced esophageal neoplasms by the Bowman-Birk protease inhibitor . Carcinogenesis , 12 : 2147 – 2150 .
  • St. Clair , W H , Billings , P C , Carew , J A , Keller-McGandy , C , Newberne , P and Kennedy , A R . 1990 . Suppression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk protease inhibitor . Cancer Res , 50 : 580 – 586 .
  • Witschi , H and Kennedy , A R . 1989 . Modulation of lung tumor development in mice with the soybean–derived Bowman-Birk protease inhibitor . Carcinogenesis , 10 : 2275 – 2277 .
  • Messadi , D V , Billings , P , Shklar , G and Kennedy , A R . 1986 . Inhibition of oral carcinogenesis by a protease inhibitor . J Natl Cancer Inst , 76 : 447 – 452 .
  • Kennedy , A R , Billings , P C , Maki , P A and Newberne , P . 1993 . Effects of various preparations of dietary protease inhibitors on oral carcinogenesis in hamsters induced by DMBA . Nutr Cancer , 19 : 191 – 200 .
  • Wan , X S , Ware , J H , Zhang , L , Newberne , P M , Evans , S M , Clark , L C and Kennedy , A R . 1999 . Treatment with soybean-derived Bowman-Birk inhibitor increases serum prostate-specific antigen concentration while suppressing growth of human prostate cancer xenografts in nude mice . Prostate , 41 : 243 – 252 .
  • Kobayashi , H , Fukuda , Y , Yoshida , R , Kanada , Y , Nishiyama , S , Suzuki , M , Kanayama , N and Terao , T . 2004 . Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental, and peritoneal disseminated metastasis in mouse model . Int J Cancer , 112 : 519 – 524 .
  • Armstrong , W B , Wan , X S , Kennedy , A R , Taylor , T H and Meyskens , F L Jr. 2003 . Development of the Bowman-Birk inhibitor for oral cancer chemoprevention and analysis of Neu immunohistochemical staining intensity with Bowman-Birk inhibitor concentrate treatment . Laryngoscope , 113 : 1687 – 1702 .
  • Malkowicz , S B , McKenna , W G , Vaughn , D J , Wan , X S , Propert , K J , Rockwell , K , Marks , S H , Wein , A J and Kennedy , A R . 2001 . Effects of Bowman-Birk inhibitor concentrate (BBIC) in patients with benign prostatic hyperplasia . Prostate , 48 : 16 – 28 .
  • Yavelow , J , Collins , M , Birk , Y , Troll , W and Kennedy , A R . 1985 . Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro . Proc Natl Acad Sci (USA) , 82 : 5395 – 5399 .
  • St. Clair , W H . 1991 . Suppression of 3-methylcholanthrene-induced cellular transformation by timed administration of the Bowman-Birk protease inhibitor . Carcinogenesis , 12 : 935 – 937 .
  • Su , L N , Toscano , W A Jr. and Kennedy , A R . 1991 . Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C . Biochem Biophys Res Commun , 176 : 18 – 24 .
  • Kennedy , A R and Wan , X S . 2002 . Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells . Prostate , 50 : 125 – 133 .
  • Chen , Y W , Huang , S C , Lin-Shiau , S Y and Lin , J K . 2005 . Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1 . Carcinogenesis , 26 : 1296 – 1306 .
  • Clark , D A , Day , R , Seidah , N , Moody , T W , Cuttitta , F and Davis , T P . 1993 . Protease inhibitors suppress in vitro growth of human small cell lung cancer . Peptides , 14 : 1021 – 1028 .
  • Sun , X Y , Donald , S P and Phang , J M . 2001 . Testosterone and prostate specific antigen stimulate generation of reactive oxygen species in prostate cancer cells . Carcinogenesis , 22 : 1775 – 1780 .
  • Dittman , K , Virsik-Kopp , P , Mayer , C , Rave-Frank , M and Rodemann , H P . 2003 . Bowman-Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes . Int J Radiat Biol , 79 : 801 – 808 .
  • Sharma , S , Ghoddoussi , M , Gao , P , Kelloff , G J , Steele , V E and Kopelovich , L . 2001 . A quantitative angiogenesis model for efficacy testing of chemopreventive agents . Anticancer Res , 21 : 3829 – 3837 .
  • McCormick , D L , Rao , K VN , Dooley , L , Steele , V E , Lubet , R A , Kelloff , G J and Bosland , M C . 1998 . Influence of N-methyl-N-nitrosourea, testosterone, and N-(4-hydroxyphenyl)-all-trans-retinamide on prostate cancer induction in Wistar-Unilever (WU) rats . Cancer Res , 58 : 3282 – 3288 .
  • McCormick , D L and Rao , K VN . 1999 . Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever (WU) rat . Europ Urol , 35 : 464 – 467 .
  • Bosland , M C . 1992 . “ Age-related lesions in the male accessory sex glands and penis of the rat ” . In Monographs on Pathology of the Aging Rat , Edited by: Mohr , U . vol. 1 , 443 – 467 . Washington, DC : ILSI Press .
  • Peto , R , Pike , M C , Armitage , P , Breslow , N E , Cox , D R , Howard , S V , Mantel , N , McPherson , K , Peto , J and Smith , P G . 1977 . Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples . Brit J Cancer , 35 : 1 – 39 .
  • Rao , K V , Johnson , W D , Bosland , M C , Lubet , R A , Steele , V E , Kelloff , G J and McCormick , D L . 1999 . Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone . Cancer Res , 59 : 3084 – 3089 .
  • McCormick , D L , Rao , K VN , Steele , V E , Lubet , R A , Kelloff , G J and Bosland , M C . 1999 . Chemoprevention of rat prostate carcinogenesis by 9-cis-retinoic acid . Cancer Res , 59 : 521 – 524 .
  • Franke , A A , Custer , L J , Wang , W and Shi , C Y . 1998 . HPLC analysis of isoflavonoids and other phenolic agents from foods and human fluids . Proc Soc Exp Biol Med , 217 : 263 – 273 .
  • Su , S J , Yeh , T M , Lei , H Y and Chow , N H . 2000 . The potential of soybean foods as a chemoprevention approach for human urinary tract cancer . Clin Cancer Res , 6 : 230 – 236 .
  • Constantinou , A I , Lantvit , D , Hawthorne , M , Xu , X , van Breemen , R B and Pezzuto , J M . 2001 . Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats . Nutr Cancer , 41 : 75 – 81 .
  • Kato , K , Takahashi , S , Cui , L , Toda , T , Suzuki , S , Futakuchi , M , Sugiura , S and Shirai , T . 2000 . Suppressive effect of dietary genistin and daidzin on rat prostate carcinogenesis . Jpn J Cancer Res , 91 : 786 – 791 .
  • Hedlund , T E , van Bokhoven , A , Johannes , W U , Nordeen , S K and Ogden , L G . 2006 . Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro . Prostate , 66 : 557 – 566 .
  • Pollard , M and Wolter , W . 2000 . Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet . Prostate , 45 : 101 – 105 .
  • Pollard , M , Wolter , W and Sun , L . 2000 . Prevention of induced prostate-related cancer by soy protein isolate/isoflavone-supplemented diet in Lobund-Wistar rats . In vivo , 14 : 289 – 392 .
  • Hikosaka , A , Asamoto , M , Hokaiwado , N , Kato , K , Kuzutani , K , Kohri , K and Shirai , T . 2004 . Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) . Carcinogenesis , 25 : 381 – 387 .
  • Aronson , W J , Tymchuk , C N , Elashoff , R M , McBride , W H , McLean , C , Wang , H and Heber , D . 1999 . Decreased growth of human prostate LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavones . Nutr Cancer , 35 : 130 – 136 .
  • Rice , L , Samedi , V G , Medrano , T A , Sweeney , C A , Baker , H V , Stenstrom , A , Furman , J and Shiverick , K T . 2002 . Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts . Prostate , 52 : 201 – 212 .
  • Cohen , L A , Zhao , Z , Pittman , B and Scimeca , J . 2003 . Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors . Prostate , 54 : 169 – 180 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.