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Original Articles

Positive Association Between DNA Strand Breaks in Peripheral Blood Mononuclear Cells and Polyunsaturated Fatty Acids in Red Blood Cells From Women

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Pages 21-28 | Received 22 Dec 2006, Accepted 20 Feb 2007, Published online: 05 Dec 2007

References

  • Das , U N . 2000 . Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? . Prostaglandins Leukot Essent Fatty Acids , 63 : 351 – 362 .
  • Psota , T L , Gebauer , S K and Kris-Etherton , P . 2006 . Dietary omega-3 fatty acid intake and cardiovascular risk . Am J Cardiol , 98 : 3i – 18i .
  • Larsson , S C , Kumlin , M , Ingelman-Sundberg , M and Wolk , A . 2004 . Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms . Am J Clin Nutr , 79 : 935 – 945 .
  • Bankson , D D , Kestin , M and Rifai , N . 1993 . Role of free radicals in cancer and atherosclerosis . Clin Lab Med , 13 : 463 – 480 .
  • Vaca , C E , Wilhelm , J and Harms-Ringdahl , M . 1988 . Interaction of lipid peroxidation products with DNA: a review . Mutat Res , 195 : 137 – 149 .
  • Bartsch , H , Nair , J and Owen , R W . 1999 . Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers . Carcinogenesis , 20 : 2209 – 2218 .
  • Ray , G and Husain , S A . 2002 . Oxidants, antioxidants and carcinogenesis . Indian J Exp Biol , 40 : 1213 – 1232 .
  • Weinstein , I BL . 1988 . The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment—twenty-seventh G.H.A. Clowes memorial award lecture . Cancer Res , 48 : 4135 – 4143 .
  • Nair , J , Vaca , C E , Velic , I , Mutanen , M Valsta , L M . 1997 . High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects . Cancer Epidemiol Biomarkers Prev , 6 : 597 – 601 .
  • Fang , J L , Vaca , C E , Valsta , L M and Mutanen , M . 1996 . Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition . Carcinogenesis , 17 : 1035 – 1040 .
  • Jenkinson , A M , Collins , A R , Duthie , S J , Wahle , K W and Duthie , G G . 1999 . The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes . FASEB J , 13 : 2138 – 2142 .
  • Thomson , C A , Giuliano , A R , Shaw , J W , Rock , C L Ritenbaugh , C K . 2005 . Diet and biomarkers of oxidative damage in women previously treated for breast cancer . Nutr Cancer , 51 : 146 – 154 .
  • de Kok , T M , Zwingman , I , Moonen , E J , Schilderman , P A Rhijnsburger , E . 2003 . Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid . Food Chem Toxicol , 41 : 351 – 358 .
  • de Kok , T M , ten Vaarwerk , F , Zwingman , I , van Maanen , J M and Kleinjans , J C . 1994 . Peroxidation of linoleic, arachidonic and oleic acid in relation to the induction of oxidative DNA damage and cytogenetic effects . Carcinogenesis , 15 : 1399 – 1404 .
  • Elmadfa , I and Park , E . 1999 . Impact of diets with corn oil or olive/sunflower oils on DNA damage in healthy young men . Eur J Nutr , 38 : 286 – 292 .
  • Rhodes , L E , Shahbakhti , H , Azurdia , R M , Moison , R M Steenwinkel , M J . 2003 . Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans: an assessment of early genotoxic markers . Carcinogenesis , 24 : 919 – 925 .
  • Shoji , H , Franke , C , Campoy , C , Rivero , M Demmelmair , H . 2006 . Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy . Free Radic Res , 40 : 379 – 384 .
  • Kikugawa , K , Yasuhara , Y , Ando , K , Koyama , K Hiramoto , K . 2003 . Effect of supplementation of n-3 polyunsaturated fatty acids on oxidative stress-induced DNA damage of rat hepatocytes . Biol Pharm Bull , 26 : 1239 – 1244 .
  • Bancroft , L K , Lupton , J R , Davidson , L A , Taddeo , S S Murphy , M E . 2003 . Dietary fish oil reduces oxidative DNA damage in rat colonocytes . Free Radic Biol Med , 35 : 149 – 159 .
  • Hong , M Y , Chapkin , R S , Morris , J S , Wang , N Carroll , R J . 2001 . Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model . Carcinogenesis , 22 : 1831 – 1835 .
  • Umegaki , K , Hashimoto , M , Yamasaki , H , Fujii , Y Yoshimura , M . 2001 . Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins . Free Radic Res , 34 : 427 – 435 .
  • Glatz , J F , Soffers , A E and Katan , M B . 1989 . Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man . Am J Clin Nutr , 49 : 269 – 276 .
  • Thorlaksdottir , A Y , Skuladottir , G V , Petursdottir , A L , Tryggvadottir , L Ogmundsdottir , H M . 2006 . Positive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women . Lipids , 41 : 119 – 125 .
  • Singh , N P , Mc Coy , M T , Tice , R R and Schneider , E L . 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp Cell Res , 175 : 184 – 191 .
  • Collins , A. R. , Dusinska , M. , Gedik , C. M. and Stetina , R . 1996 . Oxidative damage to DNA: do we have a reliable biomarker? . Environmental Health Perspectives , 104 : 465 – 469 .
  • Collins , A R , Ma , A G and Duthie , S J . 1995 . The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells . Mutat Res , 336 : 69 – 77 .
  • Rose , H G and Oklander , M . 1965 . Improved procedure for the extraction of lipids from human erythrocytes . J Lipid Res , 63 : 428 – 431 .
  • Rice-Evans , C and Miller , N J . 1994 . Total antioxidant status in plasma and body fluids . Methods Enzymol , 234 : 279 – 293 .
  • Su , Q , Rowley , K G and O'Dea , K . 1999 . Stability of individual carotenoids, retinol and tocopherols in human plasma during exposure to light and after extraction . J Chromatogr B Biomed Sci Appl , 729 : 191 – 198 .
  • Farquhar , J W and Ahrens , E H Jr . 1963 . Effects of dietary fats on human erythrocyte fatty acid patterns . J Clin Invest , 42 : 675 – 685 .
  • Dougherty , R M , Galli , C , Ferro-Luzzi , A and Iacono , J M . 1987 . Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA . Am J Clin Nutr , 45 : 443 – 455 .
  • Brown , A J , Pang , E and Roberts , D C . 1991 . Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption . Prostaglandins Leukot Essent Fatty Acids , 44 : 103 – 106 .
  • Vidgren , H M , Agren , J J , Schwab , U , Rissanen , T Hanninen , O . 1997 . Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men . Lipids , 32 : 697 – 705 .
  • Duthie , S J , Ma , A , Ross , M A and Collins , A R . 1996 . Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes . Cancer Res , 56 : 1291 – 1295 .
  • Speit , G and Hartmann , A . 1995 . The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay) . Mutagenesis , 10 : 555 – 559 .
  • Blount , B C , Mack , M M , Wehr , C M , MacGregor , J T Hiatt , R A . 1997 . Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage . Proc Natl Acad Sci USA , 94 : 3290 – 3295 .
  • Steingrimsdottir , L , Thorgeirsdottir , H and Olafsdottir , A . 2002 . The Diet of Icelanders, Dietary Survey of the Icelandic Nutrition Council 2002, Main findings , Reykjavik, Iceland : Icelandic Nutrition Council .
  • Moller , P , Vogel , U , Pedersen , A , Dragsted , L O Sandstrom , B . 2003 . No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers . Cancer Epidemiol Biomarkers Prev , 12 : 1016 – 1022 .
  • Pool-Zobel , B L , Bub , A , Muller , H , Wollowski , I and Rechkemmer , G . 1997 . Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods . Carcinogenesis , 18 : 1847 – 1850 .
  • Riso , P , Visioli , F , Erba , D , Testolin , G and Porrini , M . 2004 . Lycopene and vitamin C concentrations increase in plasma and lymphocytes after tomato intake: effects on cellular antioxidant protection . Eur J Clin Nutr , 58 : 1350 – 1358 .
  • Collins , A R , Harrington , V , Drew , J and Melvin , R . 2003 . Nutritional modulation of DNA repair in a human intervention study . Carcinogenesis , 24 : 511 – 515 .
  • Collins , A R , Olmedilla , B , Southon , S , Granado , F and Duthie , S J . 1998 . Serum carotenoids and oxidative DNA damage in human lymphocytes . Carcinogenesis , 19 : 2159 – 2162 .
  • Porrini , M , Riso , P , Brusamolino , A , Berti , C Guarnieri , S . 2005 . Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection . Br J Nutr , 93 : 93 – 99 .
  • Giovannelli , L , Saieva , C , Masala , G , Testa , G Salvini , S . 2002 . Nutritional and lifestyle determinants of DNA oxidative damage: a study in a Mediterranean population . Carcinogenesis , 23 : 1483 – 1489 .
  • Hininger , I , Chollat-Namy , A , Sauvaigo , S , Osman , M Faure , H . 2004 . Assessment of DNA damage by comet assay on frozen total blood: method and evaluation in smokers and non-smokers . Mutat Res , 558 : 75 – 80 .
  • Panayiotidis , M and Collins , A R . 1997 . Ex vivo assessment of lymphocyte antioxidant status using the comet assay . Free Radic Res , 27 : 533 – 537 .
  • Kopjar , N , Zeljezic , D and Garaj-Vrhovac , V . 2006 . Evaluation of DNA damage in white blood cells of healthy human volunteers using the alkaline comet assay and the chromosome aberration test . Acta Biochim Pol , 53 : 321 – 336 .
  • Hoffmann , H and Speit , G . 2005 . Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test . Mutat Res , 581 : 105 – 114 .
  • Speit , G , Witton-Davies , T , Heepchantree , W , Trenz , K and Hoffmann , H . 2003 . Investigations on the effect of cigarette smoking in the comet assay . Mutat Res , 542 : 33 – 42 .
  • Moller , P , Knudsen , L E , Loft , S and Wallin , H . 2000 . The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors . Cancer Epidemiol Biomarkers Prev , 9 : 1005 – 1015 .

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