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Reports

Cyclooxygenase-2 Promoter Activation by the Aromatic Hydrocarbon Receptor in Breast Cancer MCF-7 Cells: Repressive Effects of Conjugated Linoleic Acid

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Pages 248-257 | Received 10 Nov 2006, Accepted 08 May 2007, Published online: 05 Dec 2007

References

  • Smith , W L , De Witt , D L and Garavito , R M . 2000 . Cyclooxygenases: structural, cellular, and molecular biology . Annu Rev Biochem , 69 : 145 – 182 .
  • Brown , J R and DuBois , R N . 2004 . Cyclooxygenase as a target in lung cancer . Clin Cancer Res , 10 : 4266s – 4269s . (Pt 2)
  • Oshima , H , Oshima , M , Inaba , K and Taketo , M M . 2004 . Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice . EMBO J , 23 : 1669 – 1678 .
  • Pai , R , Soreghan , B , Szabo , I L , Pavelka , M Baatar , D . 2002 . Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy . Nat Med , 8 : 289 – 293 .
  • Chang , S H , Liu , C H , Conway , R , Han , D K Nithipatikom , K . 2004 . Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression . Proc Natl Acad Sci USA , 101 : 591 – 596 .
  • Liu , C H , Chang , S H , Narko , K , Trifan , O C Wu , M T . 2001 . Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice . J Biol Chem , 276 : 18563 – 18569 .
  • Harris , R E , Chlebowski , R T , Jackson , R D , Frid , D J Ascenseo , J L . 2003 . Women's Health Initiative: breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative . Cancer Res , 63 : 6096 – 6101 .
  • Burbach , K M , Poland , A and Bradfield , C A . 1992 . Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor . Proc Natl Acad Sci USA , 89 : 8185 – 8159 .
  • Reyes , H , Reisz-Porszasz , S and Hankinson , O . 1992 . Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor . Science , 256 : 1193 – 1195 .
  • Sogawa , K , Nakano , R , Kobayashi , A , Kikuchi , Y Ohe , N . 1995 . Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation . Proc Natl Acad Sci USA , 92 : 1936 – 1940 .
  • Ko , H P , Okino , S T , Ma , Q and Whitlock , J P Jr. 1996 . Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure . Mol Cell Biol , 16 : 430 – 436 .
  • Hockings , J K , Thorne , P A , Kemp , M Q , Morgan , S S Selmin , O . 2006 . The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen . Cancer Res , 66 : 2224 – 2232 .
  • Gozgit , J M , Nestor , K M , Fasco , M J , Pentecost , B T and Arcaro , K F . 2004 . Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells . Toxicol Appl Pharmacol , 196 : 58 – 67 .
  • Marlowe , J L , Knudsen , E S , Schwemberger , S and Puga , A . 2004 . The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression . J Biol Chem , 279 : 29013 – 29022 .
  • Romagnolo , D F , Degner , S C , Kemp , M Q , Hockings , J K and Selmin , O . 2006 . Role of dietary xenobiotic-gene interactions in carcinogenesis: protective effects of nutritional factors . Curr Nutr Food Sci , 2 : 205 – 214 .
  • Yan , Z , Subbaramaiah , K , Camilli , T , Zhang , F Tanabe , T . 2000 . Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells: evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB . J Biol Chem , 275 : 4949 – 4955 .
  • Miller , M E , Holloway , A C and Foster , W G . 2005 . Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output . Clin Exp Metastasis , 22 : 149 – 156 .
  • Puga , A , Hoffer , A , Zhou , S , Bohm , J M Leikauf , G D . 1997 . Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin . Biochem Pharmacol , 54 : 1287 – 1296 .
  • Vogel , C , Schuhmacher , U S , Degen , G H , Bolt , H M Pineau , T . 1998 . Modulation of prostaglandin H synthase-2 mRNA expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice . Arch Biochem Biophys , 351 : 265 – 271 .
  • Kraemer , S A , Arthur , K A , Denison , M S , Smith , W L and DeWitt , D L . 1996 . Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin . Arch Biochem Biophys , 330 : 319 – 328 .
  • Liu , Y , Levy , G N and Weber , W W . 1997 . Induction of human prostaglandin endoperoxide H synthase-2 (PHS-2) mRNA by TCDD . Prostaglandins , 53 : 1 – 10 .
  • Wolfle , D , Marotzki , S , Dartsch , D , Schafer , W and Marquardt , H . 2000 . Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin . Carcinogenesis , 21 : 15 – 21 .
  • Song , S , Lippman , S M , Zou , Y , Ye , X Ajani , J A . 2005 . Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression . Oncogene , 24 : 8268 – 8276 .
  • Wiese , F W , Thompson , P A and Kadlubar , F F . 2001 . Carcinogen substrate specificity of human COX-1 and COX-2 . Carcinogenesis , 22 : 5 – 10 .
  • Hooper , K , Petreas , M X , Chuvakova , T , Kazbekova , G Druz , N . 1998 . Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakstan: high levels of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in agricultural villages of southern Kazakstan . Environ Health Perspect , 106 : 797 – 806 .
  • Weiss , J , Papke , O , Bignert , A , Jensen , S Greyerz , E . 2003 . Concentrations of dioxins and other organochlorines (PCBs, DDTs, HCHs) in human milk from Seveso, Milan and a Lombardian rural area in Italy: a study performed 25 years after the heavy dioxin exposure in Seveso . Acta Paediatr , 92 : 467 – 472 .
  • Romagnolo , D , Annab , L A , Thompson , T E , Risinger , J I Terry , L A . 1998 . Estrogen upregulation of BRCA1 expression with no effect on localization . Mol Carcinog , 22 : 102 – 109 .
  • Kemp , M Q , Jeffy , B D and Romagnolo , D F . 2003 . Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells . J Nutr , 133 : 3670 – 3677 .
  • Degner , S C , Kemp , M Q , Bowden , G T and Romagnolo , D F . 2006 . Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cells . J Nutr , 136 : 421 – 427 .
  • Zhu , Y , Saunders , M , Yeh , H , Deng , W-G and Wu , K K . 2002 . Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins . J Biol Chem , 277 : 6923 – 6928 .
  • Sherratt , P J , McLellan , L I and Hayes , J D . 2003 . Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents . Biochem Pharmacol , 66 : 51 – 61 .
  • Vogel , C , Boerboom , A M , Baechle , C , El-Bahay , C Kahl , R . 2000 . Regulation of prostglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway . Carcinogenesis , 21 : 2267 – 2274 .
  • Yu , Y , Correll , P H and Vanden Heuvel , J P . 2002 . Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism . Biochim Biophys Acta , 1581 : 89 – 99 .
  • Li , G , Barnes , D , Butz , D , Bjorling , D and Cook , M E . 2005 . 10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo . J Lipid Res , 46 : 2134 – 2142 .
  • Hwang , D M , Kundu , J K , Shin , J W , Lee , J C Lee , H J . 2007 . cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt . Carcinogenesis , 28 : 363 – 371 .
  • Ip , C , Singh , M , Thompson , H J and Scimeca , J A . 1994 . Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat . Cancer Res , 54 : 1212 – 1215 .
  • Piskorska-Pliszczynska , J , Keys , B , Safe , S and Newman , M S . 1986 . The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons . Toxicol Lett , 34 : 67 – 74 .
  • Nazare , J A , de la Perriere , A B , Bonnet , F , Desage , M Peyrat , J . 2007 . Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects . Br J Nutr , 97 : 273 – 280 .
  • Belury , M A . 2002 . Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action . Annu Rev Nutr , 22 : 505 – 531 .
  • Lu , Y F , Santostefano , M , Cunningham , B D , Threadgill , M D and Safe , S . 1995 . Identification of 3′-methoxy-4′-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells . Arch Biochem Biophys , 316 : 470 – 477 .
  • Casper , R F , Quesne , M , Rogers , I M , Shirota , T Jolivet , A . 1999 . Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity . Mol Pharmacol , 56 : 784 – 790 .
  • Martey , C A , Baglole , C J , Gasiewicz , T A , Sime , P J and Phipps , R P . 2005 . The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts . Am J Physiol Lung Cell Mol Physiol , 289 : L391 – 399 .
  • Yang , F and Bleich , D . 2004 . Transcriptional regulation of cyclooxygenase-2 gene in pancreatic beta-cells . J Biol Chem , 279 : 35403 – 35411 .
  • Denison , M S and Nagy , S R . 2003 . Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals . Annu Rev Pharmacol Toxicol , 43 : 309 – 334 .
  • Robertson , R W , Zhang , L , Pasco , D S and Fagan , J B . 1994 . Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence—a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription . Nucleic Acids Res , 22 : 1741 – 1749 .
  • Hankinson , O . 2005 . Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor . Arch Biochem Biophys , 433 : 379 – 386 .
  • Ma , D W , Field , C J and Clandinin , M T . 2002 . An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells . Nutr Cancer , 44 : 203 – 212 .
  • Pariza , M W and Hargraves , W A . 1985 . A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene . Carcinogenesis , 6 : 591 – 593 .
  • Belury , M A , Nickel , K P , Bird , C E and Wu , Y . 1996 . Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion . Nutr Cancer , 26 : 149 – 157 .
  • Delescluse , C , Lemaire , G , de Sousa , G and Rahmani , R . 2000 . Is CYP1A1 induction always related to AHR signaling pathway? . Toxicology , 153 : 73 – 82 .
  • Song , H J , Sneddon , A A , Barker , P A , Bestwick , C Choe , S N . 2004 . Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells . Nutr Cancer , 49 : 100 – 108 .
  • Kim , E J , Kang , I J , Cho , H J , Kim , W K Ha , Y L . 2003 . Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells . J Nutr , 133 : 2675 – 2681 .
  • Chen , Z H , Hurh , Y J , Na , H K , Kim , J H Chun , Y J . 2004 . Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells . Carcinogenesis , 25 : 2005 – 2013 .

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