Retinol Increases β-Catenin-RXRα Binding Leading to the Increased Proteasomal Degradation of β-Catenin and RXRα

REFERENCES

• Park , E , Dillard , A , Williams , E , Wilder , E Pepper , M . 2005 . Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism . Cancer Res , 65 : 9923 – 9933 .
   PubMed Web of Science ®Google Scholar
• Park , E Y , Wilder , E T and Lane , M A . 2007 . Retinol inhibits the invasion of retinoic-acid resistant colon cancer cells in vitro and decreases matrix metalloproteinase mRNA, protein, and activity levels . Nutr Cancer , 57 : 66 – 77 .
   PubMed Web of Science ®Google Scholar
• Vogel , S , Gamble , M and Blaner , W . 1999 . Retinoids: The Biochemical and Molecular Basis of Vitamin A and Retinoid Action , Berlin : Springer-Verlag .
   Google Scholar
• Delage , B , Bairras , C , Buaud , B , Pallet , V and Cassand , P . 2005 . A high-fat diet generates alterations in nuclear receptor expression: prevention by vitamin A and links with cyclooxygenase-2 and beta-catenin . Int J Cancer , 116 : 839 – 846 .
   PubMed Web of Science ®Google Scholar
• Delage , B , Groubet , R , Pallet , V , Bairras , C Higueret , P . 2004 . Vitamin A prevents high fat diet-induced ACF development and modifies the pattern of expression of peroxisome proliferator and retinoic acid receptor mRNA . Nutr Cancer , 48 : 28 – 36 .
   PubMed Web of Science ®Google Scholar
• Chesire , D R , Ewing , C M , Gage , W R and Isaacs , W B . 2002 . In vitro evidence for complex modes of nuclear bold beta-catenin signaling during prostate growth and tumorigenesis . Oncogene , 21 : 2679 – 2694 .
   PubMedGoogle Scholar
• Peifer , M and Polakis , P . 2000 . Wnt signaling in oncogenesis and embryogenesis—a look outside the nucleus . Science , 287 : 1606 – 1609 .
   PubMed Web of Science ®Google Scholar
• Pennisi , E . 1998 . How a growth control path takes a wrong turn to cancer . Science , 281 : 1438 – 1441 .
   PubMedGoogle Scholar
• Wong , N A and Pignatelli , M . 2002 . Beta-catenin—a linchpin in colorectal carcinogenesis? . Am J Pathol , 160 : 389 – 401 .
   PubMed Web of Science ®Google Scholar
• He , T-C , Sparks , A , Rago , C , Hermeking , H Zawel , L . 1998 . Identification of c-myc as a target of the APC pathway . Science , 281 : 1509 – 1512 .
   PubMed Web of Science ®Google Scholar
• Tetsu , O and McCormick , F . 1999 . Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells . Nature , 398 : 422 – 426 .
   PubMed Web of Science ®Google Scholar
• Crawford , H , Fingleton , B , Rudolph-Owen , L , Goss , K H Rubinfeld , B . 1999 . The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors . Oncogene , 18 : 2883 – 2891 .
   PubMed Web of Science ®Google Scholar
• Xiao , J-H , Ghosn , C , Hinchman , C , Forbes , C Wang , J . 2003 . Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway . J Biol Chem , 278 : 29954 – 29962 .
   PubMed Web of Science ®Google Scholar
• Dillard , A C and Lane , M . 2007 . Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines . Mol Carcinog , 46 : 315 – 329 .
   PubMed Web of Science ®Google Scholar
• Cao , X , Liu , W , Lin , F , Li , H Kolluri , S K . 2005 . Retinoid X receptor regulates Nur77/thyroid hormone receptor 3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting . Mol Cell Biol , 24 : 9705 – 9725 .
   Google Scholar
• Ilyas , M , Tomlinson , I , Rowan , A , Pignatelli , M and Bodmer , W . 1997 . Beta-catenin mutations in cell lines established from human colorectal cancers . Proc Natl Acad Sci USA , 94 : 10330 – 10334 .
   PubMed Web of Science ®Google Scholar
• Bordonaro , M , Mariadason , J , Aslam , F , Heerdt , B and Augenlicht , L . 1999 . Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin . Cell Growth Differ , 10 : 713 – 720 .
   PubMedGoogle Scholar
• Serinsoz , E , Neusch , M , Busche , G , Wasielewski , R V Kreipe , H . 2004 . Aberrant expression of beta-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia . Br J Haematol , 126 : 313 – 319 .
   PubMed Web of Science ®Google Scholar
• Collins , F and Team , M GC . 2002 . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc Natl Acad Sci USA , 99 : 16899 – 16903 .
   PubMedGoogle Scholar
• Mangelsdorf , D , Ong , E , Dyck , J and Evans , R . 1990 . Nuclear receptor that identifies a novel retinoic acid response pathway . Nature , 345 : 224 – 229 .
   PubMed Web of Science ®Google Scholar
• Lin , X-F , Zhao , B-X , Chen , H-Z , Ye , X-F Yang , C-Y . 2004 . RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells . J Cell Sci , 117 : 5609 – 5621 .
   PubMed Web of Science ®Google Scholar
• Bush , K , Goldberg , A and Nigam , S . 1997 . Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance . J Biol Chem , 272 : 9086 – 9092 .
   PubMedGoogle Scholar
• Schmitt-Graff , A , Ertelt , V , Allgaier , H-P , Koelble , K Olschewski , M . 2003 . Cellular retiniol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival . Hepatology , 38 : 470 – 480 .
   PubMed Web of Science ®Google Scholar
• Lu , D , Cottam , H B , Corr , M and Carson , D A . 2005 . Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs . Proc Natl Acad Sci USA , 102 : 18567 – 18571 .
   PubMed Web of Science ®Google Scholar
• Steineger , H H , Arntsen , B M , Spydevold , Ø and Sørensen , H N . 1998 . Gene transcription of the retinoid X receptor a (RXRa) is regulated by fatty acids and hormones in rat hepatic cells . J Lipid Res , 39 : 744 – 754 .
   PubMed Web of Science ®Google Scholar
• Soprano , D , Qin , P and Soprano , K J . 2004 . Retinoic acid receptors and cancers . Annu Rev Nut , 24 : 201 – 221 .
   PubMed Web of Science ®Google Scholar