Dietary Berries and Ellagic Acid Diminish Estrogen-Mediated Mammary Tumorigenesis ∈ ACI rats

REFERENCES

• American Cancer Society . 2007 . Breast Cancer Facts and Figures-2007 , Atlanta, GA : American Cancer Society .
   Google Scholar
• Silverstein , M J , Poller , D N , Waisman , J R , Colburn , W J Barth , A . 1995 . Prognostic classification of breast ductal carcinoma-in-situ . Lancet , 345 : 1154 – 1157 .
   PubMed Web of Science ®Google Scholar
• Lippman , M E , Krueger , K A , Eckert , S , Sashegyi , A Walls , E L . 2001 . Indicators of lifetime estrogen exposure: effect on breast cancer incidence and interaction with raloxifene therapy in the multiple outcomes of raloxifene evaluation study participants . J Clin Oncol , 19 : 3111 – 3116 .
   PubMed Web of Science ®Google Scholar
• Verheul , H A , Coelingh-Bennink , H J , Kenemans , P , Atsma , W J Burger , C W . 2000 . Effects of estrogens and hormone replacement therapy on breast cancer risk and on efficacy of breast cancer therapies . Maturitas , 36 : 1 – 17 .
   PubMed Web of Science ®Google Scholar
• Dunning , W F , Curtis , M R and Segaloff , A . 1953 . Strain differences in response to estrone and the induction of mammary gland, adrenal, and bladder cancer in rats . Cancer Res , 13 : 147 – 152 .
   PubMed Web of Science ®Google Scholar
• Gullino , P M , Pettigrew , H M and Grantham , F H . 1975 . N-nitrosomethylurea as mammary gland carcinogen in rats . J Natl Cancer Inst , 54 : 401 – 414 .
   PubMed Web of Science ®Google Scholar
• Huggins , C , Briziarelli , G and Sutton , H Jr . 1959 . Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors . J Exp Med , 109 : 25 – 42 .
   PubMed Web of Science ®Google Scholar
• Shepel , L A and Gould , M N . 1999 . The genetic components of susceptibility to breast cancer in the rat . Prog Exp Tumor Res , 35 : 158 – 169 .
   PubMedGoogle Scholar
• Thompson , H J , Adlakha , H and Singh , M . 1992 . Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea . Carcinogenesis , 13 : 1535 – 1539 .
   PubMed Web of Science ®Google Scholar
• Adamovic , T , Roshani , L , Chen , L , Schaffer , B S Helou , K . 2007 . Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor development . Genes Chromosomes Cancer , 46 : 459 – 469 .
   PubMed Web of Science ®Google Scholar
• Li , J J , Papa , D , Davis , M F , Weroha , S J Aldaz , C M . 2002 . Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer . Mol Carcinog , 33 : 56 – 65 .
   PubMed Web of Science ®Google Scholar
• Li , J J , Weroha , S J , Lingle , W L , Papa , D Salisbury , J L . 2004 . Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability and breast cancer in female ACI rats . Proc Natl Acad Sci U S A , 101 : 18123 – 18128 .
   PubMed Web of Science ®Google Scholar
• Schaffer , B S , Lachel , C M , Pennington , K L , Murrin , C R Strecker , T E . 2006 . Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross . Cancer Res , 66 : 7793 – 7800 .
   PubMed Web of Science ®Google Scholar
• Gould , K A , Tochacek , M , Schaffer , B S , Reindl , T M Murrin , C R . 2004 . Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18 . Genetics , 168 : 2113 – 2125 .
   PubMed Web of Science ®Google Scholar
• Strecker , T E , Spady , T J , Schaffer , B S , Gould , K A Kaufman , A E . 2005 . Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains . Genetics , 169 : 2189 – 2197 .
   PubMed Web of Science ®Google Scholar
• Ravoori , S , Vadhanam , M V , Sahoo , S , Srinivasan , C and Gupta , R C . 2007 . Mammary tumor induction in ACI rats exposed to low levels of 17ß-estradiol . Int J Oncol , 31 : 113 – 120 .
   PubMed Web of Science ®Google Scholar
• Weroha , S J , Li , S A , Tawfik , O and Li , J J . 2006 . Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats . Carcinogenesis , 27 : 491 – 498 .
   PubMed Web of Science ®Google Scholar
• Block , G , Patterson , B and Subar , A . 1992 . Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence . Nutr Cancer , 18 : 1 – 29 .
   PubMed Web of Science ®Google Scholar
• Hercberg , S . 2005 . The history of beta-carotene and cancers: from observational to intervention studies. What lessons can be drawn for future research on polyphenols? . Am J Clin Nutr , 81 ( 1Suppl ) : 218S – 222S .
   PubMed Web of Science ®Google Scholar
• Forman , M R , Hursting , S D , Umar , A and Barrett , J C . 2004 . Nutrition and cancer prevention: a multidisciplinary perspective on human trials . Annu Rev Nutr , 24 : 23 – 54 .
   Web of Science ®Google Scholar
• United States Department of Agriculture . Recommended Dietary Intakes http://fnic.nal.usda.gov/nal_display/index.php?info_center=4&tax_level=3&tax_subject=256&topic_id=1342&level3_id=5140&level4_id=0&level5_id=0&placement_default=0 June 20, 2007
   Google Scholar
• Blumberg , J and Block , G . 1994 . The alpha-tocopherol, beta-carotene cancer prevention study in Finland . Nutr Rev , 52 : 242 – 245 .
   PubMed Web of Science ®Google Scholar
• Block , G . 1995 . Are clinical trials really the answer? . Am J Clin Nutr , 62 ( 6Suppl ) : 1517S – 1520S .
   PubMedGoogle Scholar
• Meyskens , F L Jr and Szabo , E . 2005 . Diet and cancer: the disconnect between epidemiology and randomized clinical trials . Cancer Epidemiol Biomarkers Prev , 14 : 1366 – 1369 .
   PubMed Web of Science ®Google Scholar
• Daniel , E M , Krupnick , A S , Heur , Y , Blinzler , J A Nims , R W . 1989 . Extraction, stability and quantitation of ellagic acid in various fruits and nuts . J Food compos Anal , : 2338 – 2349 .
   Google Scholar
• Oregon Berry Comission . Berry Health Brochures http://www.oregon-berries.com/
   Google Scholar
• United States Department of Agriculture . USDA National Nurtient Database http://www.nal.usda.gov/fnic/foodcomp
   Google Scholar
• Wu , X , Beecher , G R , Holden , J M , Haytowitz , D B Gebhardt , S E . 2006 . Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption . J Agric Food Chem , 54 : 4069 – 4075 .
   PubMed Web of Science ®Google Scholar
• Maas , J , Galletta , G and Stoner , G D . 1991 . Ellagic acid, an anticarcinogen in fruits, especially strawberries . Hort Science , 26 : 10 – 14 .
   Google Scholar
• Aggarwal , B B and Shishodia , S . 2006 . Molecular targets of dietary agents for prevention and therapy of cancer . Biochem Pharmacol , 71 : 1397 – 1421 .
   PubMed Web of Science ®Google Scholar
• Stoner , G D and Mukhtar , H . 1995 . Polyphenols as cancer chemopreventive agents . J Cell Biochem , 22 ( Suppl ) : 169 – 180 .
   Google Scholar
• Larrosa , M , Tomas-Barberan , F A and Espin , J C . 2006 . The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway . J Nutr Biochem , 17 : 611 – 625 .
   PubMed Web of Science ®Google Scholar
• Harris , G K , Gupta , A , Nines , R G , Kresty , L A Habib , S G . 2001 . Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2′-deoxyguanosine levels in the Fischer 344 rat . Nutr Cancer , 40 : 125 – 133 .
   PubMed Web of Science ®Google Scholar
• Kresty , L A , Morse , M A , Morgan , C , Carlton , P S Lu , J . 2001 . Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries . Cancer Res , 61 : 6112 – 6119 .
   PubMed Web of Science ®Google Scholar
• Stoner , G D , Chen , T , Kresty , L A , Aziz , R M Reinemann , T . 2006 . Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms . Nutr Cancer , 54 : 33 – 46 .
   PubMed Web of Science ®Google Scholar
• Lau , F C , Shukitt-Hale , B and Joseph , J A . 2005 . The beneficial effects of fruit polyphenols on brain aging . Neurobiol Aging , 26 ( 1Suppl ) : 128 – 132 .
   PubMed Web of Science ®Google Scholar
• Yi , W , Fischer , J , Krewer , G and Akoh , C C . 2005 . Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis . J Agric Food Chem , 53 : 7320 – 7329 .
   PubMed Web of Science ®Google Scholar
• Seeram , N P , Adams , L S , Henning , S M , Niu , Y Zhang , Y . 2005 . In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice . J Nutr Biochem , 16 : 360 – 367 .
   PubMed Web of Science ®Google Scholar
• Mandal , S and Stoner , G D . 1990 . Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid . Carcinogenesis , 11 : 55 – 61 .
   PubMed Web of Science ®Google Scholar
• Shull , J D , Spady , T J , Snyder , M C , Johansson , S L and Pennington , K L . 1997 . Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma . Carcinogenesis , 18 : 1595 – 1601 .
   PubMed Web of Science ®Google Scholar
• Hampton , T . 2005 . Clinical trials point to complexities of chemoprevention for cancer . JAMA , 294 : 29 – 31 .
   PubMed Web of Science ®Google Scholar
• Wada , L and Ou , B . 2002 . Antioxidant activity and phenolic content of Oregon caneberries . J Agric Food Chem , 50 : 3495 – 3500 .
   PubMed Web of Science ®Google Scholar
• Wang , S Y and Lin , H S . 2000 . Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage . J Agric Food Chem , 48 : 140 – 146 .
   PubMed Web of Science ®Google Scholar
• Chen , T , Hwang , H , Rose , M E , Nines , R G and Stoner , G D . 2006 . Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun . Cancer Res , 66 : 2853 – 2859 .
   PubMed Web of Science ®Google Scholar
• Hecht , S S , Huang , C , Stoner , G D , Li , J Kenney , P M . 2006 . Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity . Carcinogenesis , 27 : 1617 – 1626 .
   PubMed Web of Science ®Google Scholar
• Han , D H , Lee , M J and Kim , J H . 2006 . Antioxidant and apoptosis-inducing activities of ellagic acid . Anticancer Res , 26 : 3601 – 3606 .
   PubMed Web of Science ®Google Scholar
• Seeram , N P , Adams , L S , Zhang , Y , Lee , R Sand , D . 2006 . Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro . J Agric Food Chem , 54 : 9329 – 9339 .
   PubMed Web of Science ®Google Scholar
• Hirose , M , Akagi , K , Hasegawa , R , Yaono , M Satoh , T . 1995 . Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats . Carcinogenesis , 16 : 217 – 221 .
   PubMed Web of Science ®Google Scholar
• Singletary , K and Liao , C H . 1989 . Ellagic acid effects on the carcinogenicity, DNA-binding and metabolism of 7,12-dimethylbenz(a)anthracene (DMBA) . In Vivo , 3 : 173 – 175 .
   PubMedGoogle Scholar
• Larrosa , M , Gonzalez-Sarrias , A , Garcia-Conesa , M T , Tomas-Barberan , F A and Espin , J C . 2006 . Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities . J Agric Food Chem , 54 : 1611 – 1620 .
   PubMed Web of Science ®Google Scholar
• Schmitt , E and Stopper , H . 2001 . Estrogenic activity of naturally occurring anthocyanidins . Nutr Cancer , 41 : 145 – 149 .
   PubMed Web of Science ®Google Scholar
• Carlton , P S , Kresty , L A , Siglin , J C , Morse , M A Lu , J . 2001 . Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries . Carcinogenesis , 22 : 441 – 446 .
   PubMed Web of Science ®Google Scholar
• Li , S A , Weroha , S J , Tawfik , O and Li , J J . 2002 . Prevention of solely estrogen-induced mammary tumors in female aci rats by tamoxifen: evidence for estrogen receptor mediation . J Endocrinol , 175 : 297 – 305 .
   PubMed Web of Science ®Google Scholar
• Mesia-Vela , S , Sanchez , R I , Reuhl , K R , Conney , A H and Kauffman , F C . 2006 . Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish rat . J Pharmacol Exp Ther , 317 : 590 – 597 .
   PubMed Web of Science ®Google Scholar