226
Views
50
CrossRef citations to date
0
Altmetric
Reports

In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing MiceFootnote*

, &
Pages 235-244 | Received 29 Jan 2007, Accepted 07 May 2007, Published online: 25 Mar 2008

REFERENCES

  • Abdullaev , F I , Rivera-Luna , R , Roitenburd-Belacortu , V and Espinosa-Aguirre , J . 2000 . Pattern of childhood cancer mortality in Mexico . Arch Med Res , 31 : 526 – 531 .
  • Marty , M , Mignot , L , Gisselbrecht , G , Morvan , F Gorins , A . 1985 . Teratogenic and mutagenic risks of radiotherapy: when and how to prescribe contraception . Contracept Fertil Sex (Paris) , 13 ( 1Suppl ) : 181 – 186 .
  • Mills , K H , Greally , J F , Temperley , I J and Mullins , G M . 1980 . Haematological and immune suppressive effects of total body irradiation in the rat . Ir J Med Sci , 149 : 201 – 208 .
  • Sanderson , B J , Ferguson , L R and Denny , W A . 1996 . Mutagenic and carcinogenic properties of platinum-based anticancer drugs . Mutat Res , 355 : 59 – 70 .
  • Santin , A D , Hermonat , P L , Ravaggi , A , Bellone , S Roman , J . 2000 . Effects of concurrent cisplatinum administration during radiotherapy vs. radiotherapy alone on the immune function of patients with cancer of the uterine cervix . Int J Radiat Oncol Biol Phys , 48 : 997 – 1006 .
  • Lee , E and Surh , Y J . 1998 . Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol . Cancer Lett , 134 : 163 – 168 .
  • Lamm , D L and Riggs , D R . 2000 . The potential application of Allium sativum (garlic) for the treatment of bladder cancer . Urol Clin North Am , 27 : 157 – 162 . xi
  • Fleischauer , A T , Poole , C and Arab , L . 2000 . Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers . Am J Clin Nutr , 72 : 1047 – 1052 .
  • Sigounas , G , Anagnostou , A and Steiner , M . 1997 . dl-alpha-tocopherol induces apoptosis in erythroleukemia, prostate, and breast cancer cells . Nutr Cancer , 28 : 30 – 35 .
  • Halicka , D , Ardelt , B , Juan , G , Mittelman , A and Chen , S . 1997 . Apoptosis and cell cycle effects induced by extracts of the Chinese herbal preparation PC SPES . Int J Oncol , 11 : 437 – 448 .
  • Hattori , T S , Komatsu , N , Shichijo , S and Itoh , K . 2004 . Protein-bound polysaccharide K induced apoptosis of the human Burkitt lymphoma cell line, Namalwa . Biomed Pharmacother , 58 : 226 – 230 .
  • Ghoneum , M and Gollapudi , S . 2004 . Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro . Anticancer Res , 24 : 1455 – 1463 .
  • Ghoneum , M , Hamilton , J , Brown , J and Gollapudi , S . 2005 . Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro . Anticancer Res , 25 : 981 – 989 .
  • Ghoneum , M and Gollapudi , S . 2005 . Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro . Anticancer Res , 25 : 859 – 870 .
  • Ghoneum , M . 1998 . Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran . Biochem Biophys Res Commun , 243 : 25 – 29 .
  • Ghoneum , M and Abedi , S . 2004 . Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran) . J Pharm Pharmacol , 56 : 1581 – 1588 .
  • Ghoneum , M . 1998 . Enhancement of human natural killer cell activity by modified arabinoxylane from rice bran (MGN-3) . Int J Immunother , 14 : 89 – 99 .
  • Ghoneum , M and Brown , J . 1999 . “ NK immunorestoration of cancer patients by MGN-3, a modified arabinoxylan rice bran (study of 32 patients followed for up to 4 years) ” . In Anti-aging Medical Therapeutics, Volume III , Edited by: Klatz , R and Goldman , R . 217 – 226 . Marina del Rey, CA : Health Quest Publications .
  • Ghoneum , M and Jewett , A . 2000 . Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro . Cancer Detect Prev , 24 : 314 – 324 .
  • Ghoneum , M and Matsuura , M . 2004 . Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran) . Int J Immunopathol Pharmacol , 17 : 283 – 292 .
  • Ghoneum , M and Gollapudi , S . 2003 . Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis . Cancer Lett , 201 : 41 – 49 .
  • Quanhong , L , Caili , F , Yukui , R , Guanghui , H and Tongyi , C . 2005 . Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats . Plant Foods Hum Nutr , 60 : 13 – 16 .
  • Tribukait , B , Moberger , G and Zetterberg , A . 1975 . “ Methodological aspects of rapid flow cytofluorometry for DNA analysis of human urinary bladder cells ” . In Pulse-Cytophotometry, Part I , 50 – 60 . Ghent, , Belgium : European press, Medicon .
  • Itoh , K , Suzuki , R , Umezu , Y , Hanaumi , K and Kumagai , K . 1982 . Studies of murine large granular lymphocytes: II. tissue, strain, and age distributions of LGL and LAL . J Immunol , 129 : 395 – 405 .
  • Segura , J A , Barbero , L G and Marquez , J . 2000 . Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation . Immunol Lett , 74 : 111 – 115 .
  • Piemonti , L , Zerbi , A and Di Carlo , V . 2003 . Strategies for tumor immune escape . Drugs Today (Barc) , 39 : 701 – 724 .
  • Queiroz , M L , Valadares , M C , Bincoletto , C and Dieamant , G C . 2004 . Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties . Immunopharmacol Immunotoxicol , 26 : 511 – 525 .
  • Herberman , R B . 1981 . Natural killer (NK) cells and their possible roles in resistance against disease . Clin Immunol Rev , 1 : 1 – 65 .
  • Roder , J C and Pross , H F . 1982 . The biology of the human natural killer cell . J Clin Immunol , 2 : 249 – 263 .
  • Contasta , I , Berghella , A M , Pellegrini , P and Adorno , D . 2003 . Passage from normal mucosa to adenoma and colon cancer: alteration of normal sCD30 mechanisms regulating TH1/TH2 cell functions . Cancer Biother Radiopharm , 18 : 549 – 557 .
  • Baron , S , Tyring , S K , Fleischmann , W R Jr , Coppenhaver , D H Niesel , D W . 1991 . The interferons. Mechanisms of action and clinical applications . JAMA , 266 : 1375 – 1383 .
  • Cha , S S , Kim , M S , Choi , Y H , Sung , B J Shin , N K . 1999 . 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity . Immunity , 11 : 253 – 261 .
  • Borish , L C and Steinke , J W . 2003 . 2. Cytokines and chemokines . J Allergy Clin Immunol , 111 ( 2 Suppl ) : S460 – S475 .
  • Nishiguchi , S , Kuroki , T , Nakatani , S , Morimoto , H Takeda , T . 1995 . Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis . Lancet , 346 : 1051 – 1055 .
  • Yoshida , H , Shiratori , Y , Moriyama , M , Arakawa , Y Ide , T . 1999 . Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of hepatocarcinogenesis by interferon therapy . Ann Intern Med , 131 : 174 – 181 .
  • Kashiwagi , K , Furusyo , N , Kubo , N , Nakashima , H Nomura , H . 2003 . A prospective comparison of the effect of interferon-alpha and interferon-beta treatment in patients with chronic hepatitis C on the incidence of hepatocellular carcinoma development . J Infect Chemother , 9 : 333 – 340 .
  • Biron , C A , Nguyen , K B , Pien , G C , Cousens , L P and Salazar-Mather , T P . 1999 . Natural killer cells in antiviral defense: function and regulation by innate cytokines . Annu Rev Immunol , 17 : 189 – 220 .
  • von Hoegen , P . 1995 . Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes . Immunol Lett , 47 : 157 – 162 .
  • Hiroishi , K , Tuting , T and Lotze , M T . 2000 . IFN-alpha-expressing tumor cells enhance generation and promote survival of tumor-specific CTLs . J Immunol , 164 : 567 – 572 .
  • Ohzato , H , Monden , M , Yoshizaki , K , Ogata , A Nishimoto , N . 1993 . Systemic production of interleukin-6 following acute inflammation . Biochem Biophys Res Commun , 197 : 1556 – 1562 .
  • Kawakami , Y , Hayashi , J , Ueno , K , Ohmiya , M Kishihara , Y . 1997 . Elevation of serum soluble interleukin-2 receptor levels in patients with hepatitis C virus infection . Fukuoka Igaku Zasshi , 88 : 274 – 282 .
  • Furusyo , N , Hayashi , J , Ohmiya , M , Sawayama , Y Kawakami , Y . 1999 . Differences between interferon-alpha and -beta treatment for patients with chronic hepatitis C virus infection . Dig Dis Sci , 44 : 608 – 617 .
  • Fiorentino , D F , Zlotnik , A , Vieira , P , Mosmann , T R Howard , M . 1991 . IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells . J Immunol , 146 : 3444 – 3451 .
  • Fiorentino , D F , Bond , M W and Mosmann , T R . 1989 . Two types of mouse T helper cell: IV. th2 clones secrete a factor that inhibits cytokine production by Th1 clones . J Exp Med , 170 : 2081 – 2095 .
  • Hsu , D H , de Waal Malefyt , R , Fiorentino , D F , Dang , M N Vieira , P . 1990 . Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1 . Science , 250 : 830 – 832 .
  • Hsu , D H , Moore , K W and Spits , H . 1992 . Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity . Int Immunol , 4 : 563 – 569 .
  • Whiteside , T L and Herberman , R B . 1995 . The role of natural killer cells in immune surveillance of cancer . Curr Opin Immunol , 7 : 704 – 710 .
  • Herberman , R B . 2002 . Cancer immunotherapy with natural killer cells . Semin Oncol , 29 ( 7Suppl ) : 27 – 30 .
  • Wu , J and Lanier , L L . 2003 . Natural killer cells and cancer . Adv Cancer Res , 90 : 27 – 56 .
  • Arase , H , Arase , N and Saito , T . 1995 . Fas-mediated cytotoxicity by freshly isolated natural killer cells . J Exp Med , 181 : 1235 – 1238 .
  • Velthuis , J H , Gavric , Z , de Bont , H J and Nagelkerke , J F . 2005 . Impaired activation of caspases and prevention of mitochondrial dysfunction in the metastatic colon carcinoma CC531s-m2 cell line . Biochem Pharmacol , 69 : 463 – 471 .
  • Walczak , H and Krammer , P H . 2000 . The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems . Exp Cell Res , 256 : 58 – 66 .
  • Takahara , K and Sano , K . 2004 . The life prolongation and QOL improvement effect of rice bran arabinoxylan derivative (MGN-3, BioBran) for progressive cancer . Clin Pharmcol Ther , 14 : 267 – 271 .
  • Meurs , E F , Galabru , J , Barber , G N , Katze , M G and Hovanessian , A G . 1993 . Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase . Proc Natl Acad Sci USA , 90 : 232 – 236 .
  • Yano , H , Iemura , A , Haramaki , M , Ogasawara , S Takayama , A . 1999 . Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines . Hepatology , 29 : 1708 – 1717 .
  • Murphy , D , Detjen , K M , Welzel , M , Wiedenmann , B and Rosewicz , S . 2001 . Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases . Hepatology , 33 : 346 – 356 .
  • Suk , K , Kim , Y H , Chang , I , Kim , J Y Choi , Y H . 2001 . IFNalpha sensitizes ME-180 human cervical cancer cells to TNFalpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation . FEBS Lett , 495 : 66 – 70 .
  • Sasagawa , T , Hlaing , M and Akaike , T . 2000 . Synergistic induction of apoptosis in murine hepatoma Hepa1-6 cells by IFN-gamma and TNF-alpha . Biochem Biophys Res Commun , 272 : 674 – 680 .
  • Konjevic , G , Jovic , V , Jurisic , V , Radulovic , S Jelic , S . 2003 . IL-2-mediated augmentation of NK-cell activity and activation antigen expression on NK- and T-cell subsets in patients with metastatic melanoma treated with interferon-alpha and DTIC . Clin Exp Metastasis , 20 : 647 – 655 .
  • Smyth , M J , Taniguchi , M and Street , S E . 2000 . The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent . J Immunol , 165 : 2665 – 2670 .
  • Carson , W E , Fehniger , T A , Haldar , S , Eckhert , K Lindemann , M J . 1997 . A potential role for interleukin-15 in the regulation of human natural killer cell survival . J Clin Invest , 99 : 937 – 943 .
  • Allavena , P , Giardina , G , Sen , S , Colella , G Broggini , M . 1998 . IFN-beta partially counteracts inhibition of natural killer activity induced by some antitumor agents . J Interferon Cytokine Res , 18 : 87 – 93 .
  • Appasamy , R , Bryant , J , Hassanein , T , Van Thiel , D H and Whiteside , T L . 1994 . Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C . Clin Immunol Immunopathol , 73 : 350 – 357 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.