Processed Meat and Colorectal Cancer: A Review of Epidemiologic and Experimental Evidence

REFERENCES

• Cummings , J H and Bingham , S A . 1998 . Fortnightly review—diet and the prevention of cancer . British Medical Journal , 317 : 1636 – 1640 .
   PubMed Web of Science ®Google Scholar
• WCRF . 1997 . Food, nutrition and the prevention of cancer: a global perspective . WCRF and American Institute for Cancer Research , : 1 – 670 .
   Google Scholar
• Willett , W C . 2005 . Diet and cancer: an evolving picture . JAMA , 293 : 233 – 234 .
   PubMed Web of Science ®Google Scholar
• Sandhu , M S , White , I R and Mcpherson , K . 2001 . Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: a meta-analytical approach . Cancer Epidemiology Biomarkers & Prevention , 10 : 439 – 446 .
   PubMed Web of Science ®Google Scholar
• Norat , T , Lukanova , A , Ferrari , P and Riboli , E . 2002 . Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies . International Journal of Cancer , 98 : 241 – 256 .
   PubMed Web of Science ®Google Scholar
• Larsson , S C and Wolk , A . 2006 . Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies . Int J Cancer , 119 : 2657 – 2664 .
   PubMed Web of Science ®Google Scholar
• Linseisen , J , Kesse , E , Slimani , N , Bueno-De-Mesquita , H B Ocke , M C . 2002 . Meat consumption in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts: results from 24-hour dietary recalls . Public Health Nutr , 5 : 1243 – 1258 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Cross , A , Curtin , J , Zimmerman , T McNutt , S . 2005 . Development of a food frequency questionnaire module and databases for compounds in cooked and processed meats . Mol Nutr Food Res , 49 : 648 – 655 .
   PubMed Web of Science ®Google Scholar
• Pegg , R B and Shahidi , F . 2000 . Nitrite curing of meat: the N-nitrosamine problem and nitrite alternatives. The color of meat , 23 – 66 . Trumbull, CT : Food & Nutrition Press Inc. .
   Google Scholar
• Shahidi , F and Pegg , R B . 1991 . Novel synthesis of cooked cured-meat pigment . J. Food Science , 5 : 1205 – 1208 .
   Web of Science ®Google Scholar
• Jean-Blain , M . 1948 . Les aliments d'origine animale destinés à l'homme . Vigot Frères Editeurs, Paris , : 1 – 573 .
   Google Scholar
• Linseisen , J , Rohrmann , S , Norat , T , Gonzalez , C A Dorronsoro Iraeta , M . 2006 . Dietary intake of different types and characteristics of processed meat which might be associated with cancer risk—results from the 24-hour diet recalls in the European Prospective Investigation into Cancer and Nutrition (EPIC) . Public Health Nutr , 9 : 449 – 64 .
   PubMed Web of Science ®Google Scholar
• Volatier , J L and Dufour , A . 2006 . La place de la viande et des produits à base de viande comme aliments-vecteurs dans les apports nutritionnels de la population française . JSMTV, Journées Sciences du Muscle et Technologies des Viandes, 4-5 octobre 2006, Clermont-Ferrand , 11 : 55 – 60 .
   Google Scholar
• Chao , A , Thun , M J , Connell , C J , McCullough , M L Jacobs , E J . 2005 . Meat consumption and risk of colorectal cancer . Jama , 293 : 172 – 82 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Chow , W H , Kulldorff , M , Denobile , J Butler , J . 1999 . Well-done, grilled red meat increases the risk of colorectal adenomas . Cancer Research , 59 : 4320 – 4324 .
   PubMed Web of Science ®Google Scholar
• Ward , M H , Cross , A J , Divan , H , Kulldorff , M Nowell-Kadlubar , S . 2007 . Processed meat intake, CYP2A6 activity, and risk of colorectal adenoma . Carcinogenesis ,
   Web of Science ®Google Scholar
• Bingham , S and Riboli , E . 2004 . Diet and cancer—The European prospective investigation into cancer and nutrition . Nature Reviews Cancer , 4 : 206 – 215 .
   PubMed Web of Science ®Google Scholar
• Norat , T and Riboli , E . 2001 . Meat consumption and colorectal cancer: a review of epidemiologic evidence . Nutrition Reviews , 59 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Oba , S , Shimizu , N , Nagata , C , Shimizu , H Kametani , M . 2006 . The relationship between the consumption of meat, fat, and coffee and the risk of colon cancer: a prospective study in Japan . Cancer Lett , 244 : 260 – 7 .
   PubMed Web of Science ®Google Scholar
• Fung , T , Hu , F B , Fuchs , C , Giovannucci , E Hunter , D J . 2003 . Major dietary patterns and the risk of colorectal cancer in women . Archives of Internal Medicine , 163 : 309 – 314 .
   PubMed Web of Science ®Google Scholar
• Dixon , L B , Balder , H F , Virtanen , M J , Rashidkhani , B Mannisto , S . 2004 . Dietary patterns associated with colon and rectal cancer: results from the Dietary Patterns and Cancer (DIETSCAN) Project . Am J Clin Nutr , 80 : 1003 – 1011 .
   PubMed Web of Science ®Google Scholar
• Kesse , E , Clavel-Chapelon , F and Boutron-Ruault , M C . 2006 . Dietary patterns and risk of colorectal tumors: a cohort of French women of the National Education System (E3N) . Am J Epidemiol , 164 : 1085 – 93 .
   PubMed Web of Science ®Google Scholar
• Chiu , B CH , Ji , B T , Dai , Q , Gridley , G Mclaughlin , J K . 2003 . Dietary factors and risk of colon cancer in shanghai, china . Cancer Epidemiology Biomarkers & Prevention , 12 : 201 – 208 .
   PubMed Web of Science ®Google Scholar
• Chiu , B C and Gapstur , S M . 2004 . Changes in diet during adult life and risk of colorectal adenomas . Nutr Cancer , 49 : 49 – 58 .
   PubMed Web of Science ®Google Scholar
• Nkondjock , A and Ghadirian , P . 2005 . Associated nutritional risk of breast and colon cancers: a population-based case-control study in Montreal, Canada . Cancer Lett , 223 : 85 – 91 .
   PubMed Web of Science ®Google Scholar
• Murtaugh , M A , Ma , K N , Sweeney , C , Caan , B J and Slattery , M L . 2004 . Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women . Journal of Nutrition , 134 : 776 – 784 .
   PubMed Web of Science ®Google Scholar
• Kimura , Y , Kono , S , Toyomura , K , Nagano , J Mizoue , T . 2007 . Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study . Cancer Sci , 98 : 590 – 7 .
   PubMed Web of Science ®Google Scholar
• Hu , J , Morrison , H , Mery , L , DesMeules , M and Macleod , M . 2007 . Diet and vitamin or mineral supplementation and risk of colon cancer by subsite in Canada . Eur J Cancer Prev , 16 : 275 – 291 .
   PubMed Web of Science ®Google Scholar
• Willett , W C . 2001 . Diet and cancer: one view at the start of the millenium . Cancer Epidemiology Biomarkers & Prevention , 10 : 3 – 8 .
   PubMed Web of Science ®Google Scholar
• Bruce , W R . 1987 . Recent hypotheses for the origin of colon cancer . Cancer Res , 47 : 4237 – 4242 .
   PubMed Web of Science ®Google Scholar
• Lapre , J A , Devries , H T , Koeman , J H and Vandermeer , R . 1993 . The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat . Cancer Research , 53 : 784 – 789 .
   PubMed Web of Science ®Google Scholar
• Reddy , B S , Narisawa , T and Weisburger , J H . 1976 . Effect of a diet with high levels of protein and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine . J Natl Cancer Int , 57 : 567 – 569 .
   PubMed Web of Science ®Google Scholar
• Bull , A W , Soulier , B K , Wilson , P S , Hayden , M T and Nigro , N D . 1979 . Promotion of azoxymethane-induced intestinal cancer by high-fat diet in rats . Cancer research , 39 : 4956 – 4959 .
   PubMed Web of Science ®Google Scholar
• Pence , B C , Butler , M J , Dunn , D M , Miller , M F Zhao , C . 1995 . Non-promoting effects of lean beef in the rat colon carcinogenesis model . Carcinogenesis , 16 : 1157 – 1160 .
   PubMed Web of Science ®Google Scholar
• Nauss , K M , Locniskar , M and Newberne , P M . 1983 . Effect of alteration in the quality and quantity of dietary fat on DMH-induced colon tumorigenesis in rats . Cancer Research , 43 : 4083 – 4090 .
   PubMed Web of Science ®Google Scholar
• Nutter , R L , Gridley , D S , Kettering , J D , Goude , A G and Slater , J M . 1983 . BALB/c mice fed milk or beef protein: differences in response to 1,2-dimethylhydrazine carcinogenesis . J Natl Cancer Inst , 71 : 867 – 874 .
   PubMedGoogle Scholar
• Clinton , S K , Imrey , P B , Mangian , H J , Nandkumar , S and Visek , W J . 1992 . The combined effects of dietary fat, protein, and energy intake on azoxymethane-induced intestinal and renal carcinogenesis . Cancer Research , 52 : 857 – 865 .
   PubMed Web of Science ®Google Scholar
• Sesink , A LA , Termont , D SML , Kleibeuker , J H and Vandermeer , R . 2000 . Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium . Carcinogenesis , 21 : 1909 – 1915 .
   PubMed Web of Science ®Google Scholar
• Khil , J and Gallaher , D D . 2004 . Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colon . Nutrition and Cancer , 50 : 55 – 62 .
   PubMed Web of Science ®Google Scholar
• Zhao , L P , Kushi , L H , Klein , R D and Prentice , R L . 1991 . Quantitative Review of Studies of Dietary Fat and Rat Colon Carcinoma . Nutrition and Cancer , 15 : 169 – 177 .
   PubMed Web of Science ®Google Scholar
• Azuma , N , Suda , H , Iwasaki , H , Yamagata , N Saeki , T . 2000 . Antitumorigenic effects of several food proteins in a rat model with colon cancer and their reverse correlation with plasma bile acid concentration . Journal of Nutritional Science and Vitaminology , 46 : 91 – 96 .
   PubMed Web of Science ®Google Scholar
• Gallaher , D D and Chen , C L . 1995 . Beef tallow, but not corn bran or soybean polysaccharide, reduces large intestinal and fecal bile acid concentrations in rats . Nutrition and Cancer , 23 : 63 – 75 .
   PubMed Web of Science ®Google Scholar
• Suzuki , K , Suzuki , K and Mitsuoka , T . 1992 . Effect of low-fat, high-fat, and fiber-supplemented high-fat diets on colon cancer risk factors in feces of healthy subjects . Nutrition and Cancer , 18 : 63 – 71 .
   PubMed Web of Science ®Google Scholar
• Kumar , S P , Roy , S J , Tokumo , K and Reddy , B S . 1990 . Effect of different levels of caloric restriction on azoxymethane induced colon carcinogenesis in male F344 rats . Cancer Research , 50 : 5761 – 5766 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Rothman , N , Salmon , C P , Knize , M G Brown , E D . 1998 . Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings . Food and Chemical Toxicology , 36 : 279 – 287 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Knize , M G , Salmon , C P , Brown , E D Rhodes , D . 1998 . Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness . Food Chem Toxicol , 36 : 289 – 97 .
   PubMed Web of Science ®Google Scholar
• Phillips , D H . 1999 . Polycyclic aromatic hydrocarbons in the diet . Mutat Res , 443 : 139 – 47 .
   PubMed Web of Science ®Google Scholar
• Lakshmi , V M , Clapper , M L , Chang , W C and Zenser , T V . 2005 . Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline . Chem Res Toxicol , 18 : 528 – 535 .
   PubMed Web of Science ®Google Scholar
• Gerhardsson-DeVerdier , M G , Hagman , U , Peters , R K , Steineck , G and Overvik , E . 1991 . Meat, cooking methods and colorectal cancer-A case-referent study in Stockholm . International Journal of Cancer , 49 : 520 – 525 .
   PubMed Web of Science ®Google Scholar
• LeMarchand , L , Hankin , J H , Wilkens , L R , Pierce , L M Franke , A . 2001 . Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1a2 phenotypes in increasing colorectal cancer risk . Cancer Epidemiology Biomarkers & Prevention , 10 : 1259 – 1266 .
   PubMed Web of Science ®Google Scholar
• Sinha , R , Kulldorff , M , Gunter , M J , Strickland , P and Rothman , N . 2005 . Dietary benzo[a]pyrene intake and risk of colorectal adenoma . Cancer Epidemiol Biomarkers Prev , 14 : 2030 – 2034 .
   PubMed Web of Science ®Google Scholar
• Gunter , M J , Probst-Hensch , N M , Cortessis , V K , Kulldorff , M Haile , R W . 2005 . Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study . Carcinogenesis , 26 : 637 – 42 .
   PubMed Web of Science ®Google Scholar
• Sugimura , T , Wakabayashi , K , Nakagama , H and Nagao , M . 2004 . Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish . Cancer Sci , 95 : 290 – 299 .
   PubMed Web of Science ®Google Scholar
• Schwabn , C E , Huber , W W , Parzefall , W , Hietsch , G Kassie , F . 2000 . Search for compoiunds that inhibit the genotoxic anc carcinogenic effects of heterocyclic aromatic amines . Crit Rev Toxicol , 30 : 1 – 69 .
   PubMed Web of Science ®Google Scholar
• Stavric , B . 1994 . Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review . Food and Chemical Toxicology , 32 : 977 – 994 .
   PubMed Web of Science ®Google Scholar
• Pence , B C , Landers , M , Dunn , D M , Shen , C L and Miller , M F . 1998 . Feeding of a well-cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in 1,2-dimethylhydrazine-treated rats . Nutrition and Cancer , 30 : 220 – 226 .
   PubMed Web of Science ®Google Scholar
• Tudek , B , Bird , R P and Bruce , W R . 1989 . Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods . Cancer Research , 49 : 1236 – 1240 .
   PubMed Web of Science ®Google Scholar
• Oneill , I K , Goldberg , M T , Elghissassi , F and Rojasmoreno , M . 1991 . Dietary Fibre, Fat and Beef Modulation of Colonic Nuclear Aberrations and Microcapsule-Trapped Gastrointestinal Metabolites of Benzo < a > pyrene-Treated C57/B6 Mice Consuming Human Diets . Carcinogenesis , 12 : 175 – 180 .
   PubMed Web of Science ®Google Scholar
• Alexandrov , K , Rojas , M , Kadlubar , F F , Lang , N P and Bartsch , H . 1996 . Evidence of anti-benzo[a]pyrene diolepoxide-DNA adduct formation in human colon mucosa . Carcinogenesis , 17 : 2081 – 3 .
   PubMed Web of Science ®Google Scholar
• Nowell , S Coles , B . 2002 . Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk . Mutation Research , 506–507 : 205 – 214 .
   PubMed Web of Science ®Google Scholar
• Sinha , R . 2002 . An epidemiologic appreach to studying heterocyclic amines . Mutation Research , 506–507 : 197 – 204 .
   PubMed Web of Science ®Google Scholar
• Lijinsky , W . 1999 . N-nitroso compounds in the diet . Mutation Research , 443 : 129 – 138 .
   PubMed Web of Science ®Google Scholar
• Knekt , P , Jarvinen , R , Dich , J and Hakulinen , T . 1999 . Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and n-nitroso compounds: a follow-up study . International Journal of Cancer , 80 : 852 – 856 .
   PubMed Web of Science ®Google Scholar
• Bingham , S A , Pignatelli , B , Pollock , J RA , Ellul , A Malaveille , C . 1996 . Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer? . Carcinogenesis , 17 : 515 – 523 .
   PubMed Web of Science ®Google Scholar
• Macfarlane , G T and Cummings , J H . 1991 . “ The colonic flora, fermentation, and large bowel digestive function ” . In Large Intestine : Physiology, Pathophysiology, and Disease 51 – 92 .
   Google Scholar
• Cross , A J , Pollock , J RA and Bingham , S A . 2003 . Haem, not protein or inorganic iron, is responsible for endogenous intestinal n-nitrosation arising from red meat . Cancer Research , 63 : 2358 – 2360 .
   PubMed Web of Science ®Google Scholar
• Lunn , J C , Kuhnle , G , Mai , V , Frankenfeld , C Shuker , D E . 2006 . The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract . Carcinogenesis ,
   PubMed Web of Science ®Google Scholar
• Cross , A J and Sinha , R . 2004 . Meat-related mutagens/carcinogens in the etiology of colorectal cancer . Environmental and Molecular Mutagenesis , 44 : 44 – 55 .
   PubMed Web of Science ®Google Scholar
• Parnaud , G , Pignatelli , B , Peiffer , G , Tache , S and Corpet , D E . 2000 . Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats . Nutrition and Cancer , 38 : 74 – 80 .
   PubMed Web of Science ®Google Scholar
• Haorah , J , Zhou , L , Wang , X J , Xu , G P and Mirvish , S S . 2001 . Determination of total N-nitroso compounds and their precursors in frankfurters, fresh meat, dried salted fish, sauces, tobacco, and tobacco smoke particulates . Journal of Agricultural and Food Chemistry , 49 : 6068 – 6078 .
   PubMed Web of Science ®Google Scholar
• Mirvish , S S , Haorah , J , Zhou , L , Hartman , M Morris , C R . 2003 . N-nitroso compounds in the gastrointestinal tract of rats and in the feces of mice with induced colitis or fed hot dogs or beef . Carcinogenesis , 24 : 595 – 603 .
   PubMed Web of Science ®Google Scholar
• Zhou , L , Haorah , J , Perini , F , Carmella , S G Shibamoto , T . 2006 . Partial purification from hot dogs of N-nitroso compound precursors and their mutagenicity after nitrosation . J Agric Food Chem , 54 : 5679 – 5687 .
   PubMed Web of Science ®Google Scholar
• Lewin , M H , Bailey , N , Bandaletova , T , Bowman , R Cross , A J . 2006 . Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk . Cancer Res , 66 : 1859 – 1865 .
   PubMed Web of Science ®Google Scholar
• Hughes , R , Cross , A J , Pollock , J RA and Bingham , S . 2001 . Dose-dependent effect of dietary meat on endogenous colonic n-nitrosation . Carcinogenesis , 22 : 199 – 202 .
   PubMed Web of Science ®Google Scholar
• Bingham , S A , Hughes , R and Cross , A J . 2002 . Effect of white versus red meat on endogenous N-nitrosation in the human colon and further evidence of a dose response . J. Nutr , 132 : 3522S – 3525S .
   PubMed Web of Science ®Google Scholar
• Lee , D H , Anderson , K E , Harnack , L J , Folsom , A R and Jacobs , D R Jr. 2004 . Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study . J Natl Cancer Inst , 96 : 403 – 7 .
   PubMed Web of Science ®Google Scholar
• Larsson , S C , Rafter , J , Holmberg , L , Bergkvist , L and Wolk , A . 2005 . Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: the Swedish Mammography Cohort . Int J Cancer , 113 : 829 – 34 .
   PubMed Web of Science ®Google Scholar
• Sesink , A LA , Termont , D SML , Kleibeuker , J H and Vandermeer , R . 1999 . Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme . Cancer Research , 59 : 5704 – 5709 .
   PubMed Web of Science ®Google Scholar
• Sawa , T , Akaike , T , Kida , K , Fukushima , Y Takagi , K . 1998 . Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis . Cancer Epidemiology Biomarkers & Prevention , 7 : 1007 – 1012 .
   PubMed Web of Science ®Google Scholar
• Van Lieshout , E MM , Van Doesburg , W and Van der Meer , R . 2004 . Real-time P CR of host DNA in feces to study differential exfoliation of colonocytes between rats and humans . Scandinavian Journal of Gastroenterology , 39 : 852 – 857 .
   PubMed Web of Science ®Google Scholar
• Pierre , F , Tache , S , Petit , C R , Van der Meer , R and Corpet , D E . 2003 . Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats . Carcinogenesis , 24 : 1683 – 1690 .
   PubMed Web of Science ®Google Scholar
• Pierre , F , Freeman , A , Tache , S , Van der Meer , R and Corpet , D E . 2004 . Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons . Journal of Nutrition , 134 : 2711 – 2716 .
   PubMed Web of Science ®Google Scholar
• Pierre , F , Peiro , G , Tache , S , Cross , A J Bingham , S A . 2006 . New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic Acid . Cancer Epidemiol Biomarkers Prev , 15 : 2274 – 2279 .
   PubMed Web of Science ®Google Scholar
• Leuratti , C , Watson , M A , Deag , E J , Welch , A Singh , R . 2002 . Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas . Cancer Epidemiol Biomarkers Prev , 11 : 267 – 273 .
   PubMed Web of Science ®Google Scholar
• Glei , M , Klenow , S , Sauer , J , Wegewitz , U Richter , K . 2006 . Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes . Mutat Res , 594 : 162 – 171 .
   PubMed Web of Science ®Google Scholar
• Stevanovic , M , Cadez , P , Zlender , B and Filipic , M . 2000 . Genotoxicity testing of cooked cured meat pigment (CCMP) and meat emulsion coagulates prepared with CCMP . J Food Prot , 63 : 945 – 952 .
   PubMed Web of Science ®Google Scholar
• Visek , W J and Clinton , S K . 1991 . Dietary Protein and Cancer . Cancer and Nutrition , 7 : 103 – 124 .
   Google Scholar
• Corpet , D E , Yin , Y , Zhang , X M , Remesy , C Stamp , D . 1995 . Colonic protein fermentation and promotion of colon carcinogenesis by thermolyzed casein . Nutrition and Cancer - an International Journal , 23 : 271 – 281 .
   PubMed Web of Science ®Google Scholar
• Clinton , S K , Bostwick , D G , Olson , L M , Mangian , H J and Visek , W J . 1988 . Effect of ammonium acetate and sodium cholate on n-methyl-n'-nitro-n-nitrosoguanidine induced colon carcinogenesis of rats . Cancer research , 48 : 3035 – 3039 .
   PubMed Web of Science ®Google Scholar
• Duranton , B , Freund , J N , Galluser , M , Schleiffer , R Gosse , F . 1999 . Promotion of intestinal carcinogenesis by dietary methionine . Carcinogenesis , 20 : 493 – 497 .
   PubMed Web of Science ®Google Scholar
• Belobrajdic , D P , Mcintosh , G H and Owens , J A . 2003 . Whey proteins protect more than red meat against azoxymethane induced ACF in wistar rats . Cancer Letters , 198 : 43 – 51 .
   PubMed Web of Science ®Google Scholar
• Parnaud , G and Corpet , D E . 1997 . Colorectal cancer: controversial role of meat consumption . Bulletin du Cancer , 84 : 899 – 911 .
   PubMed Web of Science ®Google Scholar
• Le Leu , R K , Brown , I L , Hu , Y , Morita , T Esterman , A . 2007 . Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats . Carcinogenesis , 28 : 240 – 245 .
   PubMed Web of Science ®Google Scholar
• Osada , K , Hoshina , S , Nakamura , S and Sugano , M . 2000 . Cholesterol oxidation in meat products and its regulation by supplementation of sodium nitrite and apple polyphenol before processing . J Agric Food Chem , 48 : 3823 – 3829 .
   PubMed Web of Science ®Google Scholar
• ElSohemy , A , Kendall , C WC , Rao , A V , Archer , M C and Bruce , W R . 1996 . Dietary cholesterol inhibits the development of aberrant crypt foci in the colon . Nutrition and Cancer , 25 : 111 – 117 .
   PubMed Web of Science ®Google Scholar
• Kendall , C W , Koo , M , Sokoloff , E and Rao , A V . 1992 . Effect of dietary oxidized cholesterol on azoxymethane-induced colonic preneoplasia in mice . Cancer Letters , 66 : 241 – 248 .
   PubMed Web of Science ®Google Scholar
• Tsugane , S . 2005 . Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence . Cancer Sci , 96 : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Parnaud , G , Peiffer , G , Tache , S and Corpet , D E . 1998 . Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis . Nutrition and Cancer , 32 : 165 – 173 .
   PubMed Web of Science ®Google Scholar
• Masaoka , Y , Watanabe , H , Katoh , O , Ito , A and Dohi , K . 1998 . Effects of miso and NaCl on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats . Nutrition and Cancer , 32 : 25 – 28 .
   PubMed Web of Science ®Google Scholar
• Vainio , H and Weiderpass , E . 2006 . Fruit and vegetables in cancer prevention . Nutr Cancer , 54 : 111 – 142 .
   PubMed Web of Science ®Google Scholar
• Beresford , S A , Johnson , K C , Ritenbaugh , C , Lasser , N L Snetselaar , L G . 2006 . Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial . Jama , 295 : 643 – 654 .
   PubMed Web of Science ®Google Scholar
• Schatzkin , A , Lanza , E , Corle , D , Lance , P Iber , F . 2000 . Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas . New England Journal of Medicine , 342 : 1149 – 1155 .
   PubMed Web of Science ®Google Scholar
• Pischon , T , Lahmann , P H , Boeing , H , Friedenreich , C Norat , T . 2006 . Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC) . J Natl Cancer Inst , 98 : 920 – 931 .
   PubMed Web of Science ®Google Scholar
• Friedenreich , C , Norat , T , Steindorf , K , Boutron-Ruault , M C Pischon , T . 2006 . Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition . Cancer Epidemiol Biomarkers Prev , 15 : 2398 – 2407 .
   PubMed Web of Science ®Google Scholar
• Lutz , W K . 1999 . Carcinogens in the diet vs. overnutrition-individual dietary habits, malnutrition, and genetic susceptibility modify carcinogenic potency and cancer risk . Mutation Research , 443 : 251 – 258 .
   PubMed Web of Science ®Google Scholar
• McKeown-Eyssen , G . 1994 . Epidemiology of colorectal cancer revisited : are serum triglycerides and/or plasma glucose associated with risk ? . Cancer Epidemiol. Biomarkers & Prevention , 3 : 687 – 695 .
   PubMed Web of Science ®Google Scholar
• Bruce , W R , Giacca , A and Medline , A . 2000 . Possible mechanisms relating diet and risk of colon cancer . Cancer Epidemiology Biomarkers & Prevention , 9 : 1271 – 1279 .
   PubMed Web of Science ®Google Scholar
• Gunter , M J and Leitzmann , M F . 2006 . Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes . J Nutr Biochem , 17 : 145 – 156 .
   PubMed Web of Science ®Google Scholar
• Pierre , F , Santarelli , R , Taché , S , Guéraud , F and Corpet , D E . 2007 . Beef meat promotion of dimethyldydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium . Br J Nutr , 22 : 1 – 7 .
   Google Scholar
• World Cancer Research Fund/American Institute for Cancer Research . 2007 . Food, nutrition, physical activity, and the prevention of cancer: a global perspective , Washington, DC : AICR .
   Google Scholar