Ursodeoxycholic Acid Suppresses Cox-2 Expression in Colon Cancer: Roles of Ras, p38, and CCAAT/Enhancer-Binding Protein

REFERENCES

• Potter , J D , Slattery , M L , Bostick , R M and Gapstur , S M . 1993 . Colon cancer: A review of the epidemiology . Epidemiol Rev , 15 : 499 – 545 .
   PubMed Web of Science ®Google Scholar
• Lipkin , M , Reddy , B , Newmark , H and Lamprecht , S A . 1999 . Dietary factors in human colorectal cancer . Annu Rev Nutr , 19 : 545 – 586 .
   PubMed Web of Science ®Google Scholar
• Reddy , B S . 1992 . Dietary fat and colon cancer: animal model studies . Lipids , 27 : 807 – 813 .
   PubMed Web of Science ®Google Scholar
• Reddy , B S and Wynder , E L . 1977 . Metabolic epidemiology of colon cancer: fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps . Cancer , 39 : 2533 – 2539 .
   PubMed Web of Science ®Google Scholar
• Weisburger , J H , Reddy , B S , Barnes , W S and Wynder , E L . 1983 . Bile acids, but not neutral sterols, are tumor promoters in the colon in man and in rodents . Environ Health Perspect , 50 : 101 – 107 .
   PubMed Web of Science ®Google Scholar
• Nagengast , F M , Grubben , M J and van Munster , I P . 1995 . Role of bile acids in colorectal carcinogenesis . Eur J Cancer , 31A : 1067 – 1070 .
   PubMed Web of Science ®Google Scholar
• Chaplin , M F . 1998 . Bile acids, fibre and colon cancer: the story unfolds . J R Soc Health , 118 : 53 – 61 .
   PubMedGoogle Scholar
• Bayerdorffer , E , Mannes , G A , Richter , W O , Ochsenkuhn , T Wiebecke , B . 1993 . Increased serum deoxycholic acid levels in men with colorectal adenomas . Gastroenterology , 104 : 145 – 151 .
   PubMed Web of Science ®Google Scholar
• Earnest , D L , Holubec , H , Wali , R K , Jolley , C S Bissonnette , M . 1994 . Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid . Cancer Res , 54 : 5071 – 5074 .
   PubMed Web of Science ®Google Scholar
• Wali , R K , Stoiber , D , Nguyen , L , Hart , J Sitrin , M D . 2002 . Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development . Cancer Epidemiol Biomarkers Prev , 11 : 1316 – 1321 .
   PubMed Web of Science ®Google Scholar
• Beuers , U , Boyer , J L and Paumgartner , G . 1998 . Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications . Hepatology , 28 : 1449 – 1453 .
   PubMed Web of Science ®Google Scholar
• Khare , S , Cerda , S , Wali , R K , von Lintig , F C Tretiakova , M . 2003 . Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer . Cancer Res , 63 : 3517 – 3523 .
   PubMedGoogle Scholar
• Wali , R , Khare , S , Tretiakova , M , Cohen , G Nguyen , L . 2002 . Ursodeoxycholic acid and F6-D3 inhibit aberrant crypt proliferation in the rat AOM model of colon cancer: roles of cyclin D1 and E-cadherin . Cancer Epidemiol Biomarkers Prev , 11 : 1653 – 1662 .
   PubMed Web of Science ®Google Scholar
• DuBois , R N . 2003 . Cyclooxygenase-2 and colorectal cancer . Prog Exp Tumor Res , 37 : 124 – 137 .
   PubMedGoogle Scholar
• Wang , D , Mann , J R and DuBois , R N . 2005 . The role of prostaglandins and other eicosanoids in the gastrointestinal tract . Gastroenterology , 128 : 1445 – 1461 .
   PubMed Web of Science ®Google Scholar
• Eberhart , C E , Coffey , R J , Radhika , A , Giardiello , F M Ferrenbach , S . 1994 . Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas . Gastroenterology , 107 : 1183 – 1188 .
   PubMed Web of Science ®Google Scholar
• DuBois , R N , Radhika , A , Reddy , B S and Entingh , A J . 1996 . Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors . Gastroenterology , 110 : 1259 – 1262 .
   PubMed Web of Science ®Google Scholar
• Bissonnette , M , Khare , S , von Lintig , F C , Wali , R K Nguyen , L . 2000 . Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1 . Cancer Res , 60 : 4602 – 4609 .
   PubMed Web of Science ®Google Scholar
• Reddy , B S , Hirose , Y , Lubet , R , Steele , V Kelloff , G . 2000 . Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis . Cancer Res , 60 : 293 – 297 .
   PubMed Web of Science ®Google Scholar
• Marsh , K A , Stamp , G W and Kirkland , S C . 1993 . Isolation and characterization of multiple cell types from a single human colonic carcinoma: tumorigenicity of these cell types in a xenograft system . J Pathol , 170 : 441 – 450 .
   PubMedGoogle Scholar
• Gabbay , R A , Sutherland , C , Gnudi , L , Kahn , B B O'Brien , R M . 1996 . Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway . J Biol Chem , 271 : 1890 – 1897 .
   PubMedGoogle Scholar
• Cohen , G , Mustafi , R , Chumsangsri , A , Little , N Nathanson , J . 2006 . Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci . Cancer Res , 66 : 5656 – 5664 .
   PubMed Web of Science ®Google Scholar
• Giulietti , A , Overbergh , L , Valckx , D , Decallonne , B Bouillon , R . 2001 . An overview of real-time quantitative PCR: applications to quantify cytokine gene expression . Methods , 25 : 386 – 401 .
   PubMed Web of Science ®Google Scholar
• Inoue , H , Yokoyama , C , Hara , S , Tone , Y and Tanabe , T . 1995 . Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells: involvement of both nuclear factor for interleukin-6 expression site and cAMP response element . J Biol Chem , 270 : 24965 – 24971 .
   PubMed Web of Science ®Google Scholar
• Chen , A , Davis , B H , Bissonnette , M , Scaglione-Sewell , B and Brasitus , T A . 1999 . 1,25-Dihydroxyvitamin D3 stimulates activator protein-1-dependent Caco-2 Cell Differentiation . J Biol Chem , 274 : 35505 – 35513 .
   PubMed Web of Science ®Google Scholar
• Poli , V . 1998 . The role of C/EBP isoforms in the control of inflammatory and native immunity functions . J Biol Chem , 273 : 29279 – 29282 .
   PubMed Web of Science ®Google Scholar
• Shao , J , Sheng , H , Inoue , H , Morrow , J D and DuBois , R N . 2000 . Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells . J Biol Chem , 275 : 33951 – 33956 .
   PubMed Web of Science ®Google Scholar
• Zhu , Y , Hua , P , Rafiq , S , Waffner , E J Duffey , M E . 2002 . Ca2+- and PKC-dependent stimulation of PGE2 synthesis by deoxycholic acid in human colonic fibroblasts . Am J Physiol Gastrointest Liver Physiol , 283 : G503 – G510 .
   PubMedGoogle Scholar
• Glinghammar , B , Inoue , H and Rafter , J J . 2002 . Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1 . Carcinogenesis , 23 : 839 – 845 .
   PubMed Web of Science ®Google Scholar
• Cummings , J H , Wiggins , H S , Jenkins , D J , Houston , H Jivraj , T . 1978 . Influence of diets high and low in animal fat on bowel habit, gastrointestinal transit time, fecal microflora, bile acid, and fat excretion . J Clin Invest , 61 : 953 – 963 .
   PubMed Web of Science ®Google Scholar
• van Gorkom , B A , van der Meer , R , van Boersma-Ek , W , Termont , D S de Vries , E G . 2002 . Changes in bile acid composition and effect on cytolytic activity of fecal water by ursodeoxycholic acid administration: a placebo-controlled cross-over intervention trial in healthy volunteers . Scand J Gastroenterol , 37 : 965 – 971 .
   PubMedGoogle Scholar
• Stewart , S and Guan , K L . 2000 . The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation . J Biol Chem , 275 : 8854 – 8862 .
   PubMedGoogle Scholar
• Glinghammar , B and Rafter , J . 2001 . Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells . Gastroenterology , 120 : 401 – 410 .
   PubMed Web of Science ®Google Scholar
• Dudley , D T , Pang , L , Decker , S J , Bridges , A J and Saltiel , A R . 1995 . A synthetic inhibitor of the mitogen-activated protein kinase cascade . Proc Natl Acad Sci U S A , 92 : 7686 – 7689 .
   PubMed Web of Science ®Google Scholar
• Lee , J C , Laydon , J T , McDonnell , P C , Gallagher , T F Kumar , S . 1994 . A protein kinase involved in the regulation of inflammatory cytokine biosynthesis . Nature , 372 : 739 – 746 .
   PubMed Web of Science ®Google Scholar
• Lasa , M , Mahtani , K R , Finch , A , Brewer , G Saklatvala , J . 2000 . Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade . Mol Cell Biol , 20 : 4265 – 4274 .
   PubMedGoogle Scholar
• Ridley , S H , Dean , J L , Sarsfield , S J , Brook , M Clark , A R . 1998 . A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA . FEBS Lett , 439 : 75 – 80 .
   PubMed Web of Science ®Google Scholar
• Dean , J L , Brook , M , Clark , A R and Saklatvala , J . 1999 . p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes . J Biol Chem , 274 : 264 – 269 .
   PubMed Web of Science ®Google Scholar
• Faour , W H , He , Y , He , Q W , de Ladurantaye , M Quintero , M . 2001 . Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts . J Biol Chem , 276 : 31720 – 31731 .
   PubMed Web of Science ®Google Scholar
• Guan , Z , Buckman , S Y , Pentland , A P , Templeton , D J and Morrison , A R . 1998 . Induction of cyclooxygenase-2 by the activated MEKK1 — > SEK1/MKK4 — > p38 mitogen-activated protein kinase pathway . J Biol Chem , 273 : 12901 – 12908 .
   PubMed Web of Science ®Google Scholar
• Bamba , H , Ota , S , Kato , A , Adachi , A Itoyama , S . 1999 . High expression of cyclooxygenase-2 in macrophages of human colonic adenoma . Int J Cancer , 83 : 470 – 475 .
   PubMedGoogle Scholar
• Nakajima , T , Kinoshita , S , Sasagawa , T , Sasaki , K Naruto , M . 1993 . Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6 . Proc Natl Acad Sci U S A , 90 : 2207 – 2211 .
   PubMed Web of Science ®Google Scholar
• Eisinger , A L , Nadauld , L D , Shelton , D N , Peterson , P W Phelps , R A . 2006 . The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid . J Biol Chem , 281 : 20474 – 20482 .
   PubMedGoogle Scholar
• Gauthier , M L , Pickering , C R , Miller , C J , Fordyce , C A Chew , K L . 2005 . p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue . Cancer Res , 65 : 1792 – 1799 .
   PubMedGoogle Scholar
• Solomon , S D , McMurray , J J , Pfeffer , M A , Wittes , J Fowler , R . 2005 . Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention . N Engl J Med , 352 : 1071 – 1080 .
   PubMed Web of Science ®Google Scholar
• Tung , B Y , Emond , M J , Haggitt , R C , Bronner , M P Kimmey , M B . 2001 . Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis . Ann Intern Med , 134 : 89 – 95 .
   PubMed Web of Science ®Google Scholar
• Pardi , D S , Loftus , E V Jr , Kremers , W K , Keach , J and Lindor , K D . 2003 . Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis . Gastroenterology , 124 : 889 – 893 .
   PubMed Web of Science ®Google Scholar
• Alberts , D S , Martinez , M E , Hess , L M , Einspahr , J G Green , S B . 2005 . Phase I II trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence . J Natl Cancer Inst , 97 : 846 – 853 .
   PubMed Web of Science ®Google Scholar
• Narisawa , T , Fukaura , Y , Takeba , N and Nakai , K . 2002 . Chemoprevention of N-methylnitrosourea-induced colon carcinogenesis by ursodeoxycholic acid-5-aminosalicylic acid conjugate in F344 rats . Jpn J Cancer Res , 93 : 143 – 150 .
   PubMedGoogle Scholar
• Jacoby , R F , Cole , C E , Hawk , E T and Lubet , R A . 2004 . Ursodeoxycholate/sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis. . Gastroenterology , 127 : 838 – 844 .
   PubMedGoogle Scholar
• Rodrigues , C M , Kren , B T , Steer , C J and Setchell , K D . 1995 . The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation . Gastroenterology , 109 : 1835 – 1844 .
   PubMed Web of Science ®Google Scholar
• Setchell , K Da and Brown , N D . 2004 . The new non-absorbed bile acid, ursodeoxycholic acid-disulfate (SUDCA) is a potent chemopreventive agent in the azoxymethane rat model of chemical induced colorectal cancer . Gastroenterology , 126 : A-26
   Google Scholar