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Original Articles

Obesity Accelerates Mouse Mammary Tumor Growth in the Absence of Ovarian Hormones

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Pages 534-541 | Received 05 Apr 2007, Accepted 29 Sep 2007, Published online: 26 Jun 2008

REFERENCES

  • American Cancer Society . 2006 . Cancer Facts and Figures 2006 , Atlanta, GA : American Cancer Society .
  • American Cancer Society . 2007 . Breast Cancer Facts and Figures 2005–2006 , Atlanta, GA : American Cancer Society .
  • McTiernan , A . 2003 . Behavioral risk factors in breast cancer: can risk be modified? . Oncologist , 8 : 326 – 334 .
  • Calle , E E , Rodriguez , C , Walker-Thurmond , K and Thun , M J . 2003 . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults . N Engl J Med , 348 : 1625 – 1638 .
  • Bianchini , F , Kaaks , R and Vainio , H . 2002 . Overweight, obesity, and cancer risk . Lancet Oncol , 3 : 565 – 574 .
  • Petrelli , J M , Calle , E E , Rodriguez , C and Thun , M J . 2002 . Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women . Cancer Causes Control , 13 : 325 – 332 .
  • National Center for Health Statistics . 2002 . Health, United States, 2005 with Chartbook on Trends in the Health of Americans
  • Hakkak , R , Holley , A W , Macleod , S L , Simpson , P M Fuchs , G J . 2005 . Obesity promotes 7,12-dimethylbenz(a) anthracene-induced mammary tumor development in female zucker rats . Breast Cancer Res , 7 : R627 – R633 .
  • Kritchevsky , D . 1997 . Caloric restriction and experimental mammary carcinogenesis . Breast Cancer Res Treat , 46 : 161 – 167 .
  • Hursting , S D , Lavigne , J A , Berrigan , D , Perkins , S N and Barrett , J C . 2003 . Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans . Annu Rev Med , 54 : 131 – 152 .
  • Zhu , Z , Jiang , W , McGinley , J , Wolfe , P and Thompson , H J . 2005 . Effects of dietary energy repletion and IGF-1 infusion on the inhibition of mammary carcinogenesis by dietary energy restriction . Mol Carcinog , 42 : 170 – 176 .
  • Dirx , M J , Zeegers , M P Dagnelie , P C . 2003 . Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis . Int J Cancer , 106 : 766 – 770 .
  • Calle , E E and Kaaks , R . 2004 . Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms . Nat Rev Cancer , 4 : 579 – 591 .
  • Wolf , I , Sadetzki , S , Catane , R , Karasik , A and Kaufman , B . 2005 . Diabetes mellitus and breast cancer . Lancet Oncol , 6 : 103 – 111 .
  • Hu , X , Juneja , S C , Maihle , N J and Cleary , M P . 2002 . Leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development . J Natl Cancer Inst , 94 : 1704 – 1711 .
  • Xu , H , Barnes , G T , Yang , Q , Tan , G Yang , D . 2003 . Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance . J Clin Invest , 112 : 1821 – 1830 .
  • Nunez , N P , Jelovac , D , Macedo , L , Berrigan , D Perkins , S N . 2004 . Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer . Clin Cancer Res , 10 : 5375 – 5380 .
  • Wu , Y , Yakar , S Zhao , L . 2002 . Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors . Cancer Res , 62 : 1030 – 1035 .
  • Michels , K B and Ekbom , A . 2004 . Caloric restriction and incidence of breast cancer . JAMA , 10 : 1226 – 1230 .
  • Lujan , M E , Krzemien , A A , Reid , R L and Van Vugt , D A . 2005 . Caloric restriction inhibits steroid-induced gonadotropin surges in ovariectomized rhesus monkeys . Endocrine , 27 : 25 – 31 .
  • Mai , V , Colbert , L H , Berrigan , D , Perkins , S N Pfeiffer , R . 2003 . Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms . Cancer Res , 63 : 1752 – 1755 .
  • Dunn , S E , Kari , F W , French , J , Leininger , J R Travlos , G . 1997 . Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice . Cancer Res , 57 : 4667 – 4672 .
  • Hursting , S D , Switzer , B R , French , J E and Kari , F W . 1993 . The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats . Cancer Res , 53 : 2750 – 2757 .
  • Nunez , N P , Carpenter , C L , Perkins , S N , Berrigan , D Jaque , S V . 2007 . Extreme obesity reduces bone mineral density: complementary evidence from mice and women . Obesity Res , 15 : 1980 – 1987 .
  • Maguire , J L , Stell , B M , Rafizadeh , M and Mody , I . 2005 . Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety . Nat Neurosci , 6 : 797 – 804 .
  • Berrigan , D , Lavigne , J A , Perkins , S N , Nagy , T R Barrett , J C . 2005 . Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention . In Vivo , 19 : 667 – 674 .
  • Chumlea , W C , Guo , S S , Kuczmarski , R J , Flegal , K M Johnson , C L . 2002 . Body composition estimates from NHANES III bioelectrical impedance data . Int J Obes Relat Metab Disord , 26 : 1596 – 1609 .
  • Ruhl , C E and Everhart , J E . 2002 . Relationship of serum leptin concentration with bone mineral density in the United States population . J Bone Miner Res , 17 : 1896 – 1903 .
  • Zhang , X , Podsypanina , K , Huang , S , Mohsin , S K Chamness , G C . 2005 . Estrogen receptor positivity in mammary tumors of MMTV-Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations . Oncogene , 24 : 4220 – 4231 .
  • Li , Y , Hively , W P and Varmus , H E . 2000 . Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer . Oncogene , 19 : 1002 – 1009 .
  • Rosner , A , Miyoshi , K , Landesman-Bollag , E , Xu , X Seldin , D C . 2002 . Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors . Am J Pathol , 161 : 1087 – 1097 .
  • Yue , W , Wang , J P , Li , Y , Bocchinfuso , W P Korach , K S . 2005 . Tamoxifen versus aromatase inhibitors for breast cancer prevention . Clin Cancer Res , 11 : 925s – 930s .
  • Normanno , N , Di Maio , M , De Maio , E , DeLuca , A de Matteis , A . 2005 . Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer . Endocr Relat Cancer , 12 : 721 – 747 .
  • Althuis , M D , Fergenbaum , J H , Garcia-Closas , M , Brinton , L A Madigan , M P . 2004 . Etiology of hormone receptor–defined breast cancer: a systematic review of the literature . Cancer Epidemiol Biomarkers Prev , 13 : 1558 – 1568 .
  • Varticovski , L , Hollingshead , M G Carter , J P . 2007 . Establishment and characterization of transplantable, genetically engineered mouse breast cancer models for standardized preclinical drug testing . Clin Cancer Res , Forthcoming
  • Haslam , S Z , Osuch , J R , Raafat , A M and Hofseth , L J . 2002 . Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model . J Mammary Gland Biol Neoplasia , 7 : 93 – 105 .
  • Samsioe , G . 1995 . The menopause revisited . Int J Gynaecol Obstet , 51 : 1 – 13 .
  • Lemieux , C , Picard , F , Labrie , F , Richard , D and Deshaies , Y . 2003 . The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity . Obes Res , 11 : 477 – 490 .
  • Patel , A C , Nunez , N P , Perkins , S N , Barrett , J C and Hursting , S D . 2004 . Effects of energy balance on cancer in genetically altered mice . J Nutr , 134 : 3394S – 3398S .
  • Furstenberger , G and Senn , H J . 2002 . Insulin-like growth factors and cancer . Lancet Oncol , 3 : 298 – 302 .
  • Moschos , S J and Mantzoros , C S . 2002 . The role of the IGF system in cancer: from basic to clinical studies and clinical applications . Oncology , 63 : 317 – 332 .
  • Hankinson , S E , Willett , W C , Colditz , G A , Hunter , D J Michaud , D S . 1998 . Circulating concentrations of insulin-like growth factor-I and risk of breast cancer . Lancet , 351 : 1393 – 1396 .
  • Proietto , J and Thorburn , A W . 2003 . The therapeutic potential of leptin . Expert Opin Investig Drugs , 12 : 373 – 378 .
  • Shaw , D I , Hall , W L and Williams , C M . 2005 . Metabolic syndrome: what is it and what are the implications? . Proc Nutr Soc , 64 : 349 – 357 .
  • Kahn , B B and Flier , J S . 2000 . Obesity and insulin resistance . J Clin Invest , 106 : 473 – 481 .
  • Nunez , N P , Oh , W J , Rozenberg , J , Perella , C Anver , M . 2006 . Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation . Cancer Res , 66 : 5469 – 5476 .
  • Moitra , J , Mason , M M , Olive , M , Krylov , D Gavrilova , O . 1998 . Life without white fat: a transgenic mouse . Genes Dev , 12 : 3168 – 3181 .

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