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Orignal Articles

Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial

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Pages 643-651 | Received 31 May 2007, Accepted 17 Jan 2008, Published online: 12 Sep 2008

REFERENCES

  • The Research Group for Population-based Cancer Registration in Japan . 2004 . Cancer incidence and incidence rates in Japan in 1999: Estimates based on data from 11 population-based cancer registries . Jpn J Clin Oncol , 34 : 352 – 356 .
  • Mizushima , Y , Yuhki , N , Hosokawa , M and Kobayashi , H . 1982 . Diminution of cyclophosphamide-induced suppression of antitumor immunity by an immunomodulator PS-K and combined therapeutic effects of PS-K and cyclophosphamide on transplanted tumor in rats . Cancer Res , 42 : 5176 – 5180 .
  • Nishioka , Y , Hirao , M , Robbins , P D , Lotze , M T and Tahara , H . 1999 . Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin12 . Cancer Res , 59 : 4035 – 4041 .
  • Akiyama , J , Kawamura , T , Gotohda , E , Yamada , Y Hosokawa , M . 1997 . Immunochemotherapy of transplanted KMT-17 tumor in WKA rats by combination of cyclophosphamide and immunostimulatory protein-bound polysaccharide isolated from basidiomycetes . Cancer Res , 37 : 3042 – 3045 .
  • Nakazato , H , Koike , A , Saji , S , Ogawa , N and Sakamoto , J . 1994 . Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer . Lancet , 343 : 1122 – 1126 .
  • Milner , J A . 2000 . Functional foods: the US perspective . Am J Clin Nutr , 71 : 1654S – 1659S .
  • Roberfroid MB . 2000 . Concepts and strategy of functional food science: the European perspective . Am J Clin Nutr , 71 : 1660S – 1664S .
  • Matsui , Y , Uhara , J , Satoi , S , Kaibori , M Yanada , H . 2002 . Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study . J Hepatol , 37 : 78 – 86 .
  • Banchereau , J and Steinman , R M . 1998 . Dendritic cells and the control of immunity . Nature , 392 : 245 – 252 .
  • Nestle , F O , Alijagic , S , Gilliet , M , Sun , Y Grabbe , S . 1998 . Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells . Nat Med , 4 : 328 – 332 .
  • Schuler-Thurner , B , Schultz , E S , Berger , T G , Weinlich , G Ebner , S . 2002 . Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells . J Exp Med , 195 : 1279 – 1288 .
  • Ito , T , Inaba , M , Inaba , K , Toki , J Sogo , S . 1999 . A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells . J Immunol , 163 : 1409 – 1419 .
  • Toyokawa , H , Inaba , M , Takai , S , Satoi , S Beuth , J . 2002 . Enhancement of circulating dendritic cell activity by immunomodulators (OK432 and KP-40) . Anticancer Res , 22 : 2137 – 2145 .
  • Yanagimoto , H , Takai , S , Satoi , S , Toyokawa , H Takahashi , K . 2005 . Impaired function of circulating dendritic cells in patients with pancreatic cancer . Clin Immunol , 114 : 52 – 60 .
  • Takahashi , K , Toyokawa , H , Takai , S , Satoi , S Yanagimoto , H . 2006 . Surgical influence of pancreatectomy on the function and count of circulating dendritic cells in patients with pancreatic cancer . Cancer Immunol Immunother , 55 : 775 – 784 .
  • Terakawa , N , Satoi , S , Takai , S , Yanagimoto , H Takahashi , K . 2006 . Clinical monitoring of innate cellular immunity of monocytes/macrophages by tumor necrosis factor alpha productivity in whole blood stimulated by lipopolysaccharide in patients with pancreatic cancer . Pancreas , 33 : 31 – 37 .
  • Suzuki , K , Koyama , T , Kobayashi , S , Kobayashi , K Inagaki , K . 2002 . Novel method for detection of ex vivo tumor necrosis factor alpha production by monocytes . J Clin Lab Anal , 16 : 273 – 278 .
  • Matsushita , K , Kuramitsu , Y , Ohiro , Y , Obara , M Kobayashi , M . 1998 . Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma . Anticancer Drugs , 9 : 343 – 350 .
  • Agett , P J , Alexander , J , Alles , M , Anderson , P A Antonie , J M . 1999 . Scientific concepts of functional foods in Europe consensus document . Br J Nutr , 81 : S1 – S27 .
  • O'Doherty , U , Peng , M , Gezelter , S , Swiggard , W J Betjes , M . 1994 . Human blood contents two subsets of dendritic cells, one immunologically mature and the other immature . Immunology , 82 : 487 – 493 .
  • Raoul , J L , Guyader , D , Bretagne , J F , Heautot , J F Duvauferrier , R . 1997 . Prospective randomized trial of chemoembolization versus intra-arterial injection of 131I-labeled-iodized oil in the treatment of hepatocellular carcinoma . Hepatology , 26 : 1156 – 1161 .
  • Majno , P E , Adam , R , Bismuth , H , Castaing , D Ariche , A . 1997 . Influence of preoperative transarterial lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis . Ann Surg , 226 : 688 – 703 .
  • Castellano , L , Calandra , M , Blanco , C V and De Sio , I . 1997 . Predictive factors of survival and intrahepatic recurrence of hepatocellular carcinoma in cirrhosis after percutaneous ethanol injection: analysis of 71 patients . J Hepatol , 27 : 862 – 870 .
  • Ebara , M , Ohto , M , Sugiura , N , Kita , K Yoshikawa , M . 1990 . Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Study of 95 patients . J Gastroenterol Hepatol , 5 : 616 – 626 .
  • Ito , T , Amakawa , R , Inaba , M , Ikehara , S Inaba , K . 2001 . Differential regulation of human blood dendritic cell subsets by IFNs . J Immunol , 166 : 2961 – 2969 .
  • Jang SW . 2002 . The hematoimmunologic effect of AHCC for Korean patients with various cancers . Biotherapy , 16 : 560 – 564 .
  • Uno , K , Kosuna , K , Sun , B , Fujii , H , Wakame , K Chikamaru , S . 2000 . Active hexose correlated compound (AHCC) improves immunological parameters and performance status of patients with solid tumors . Biotherapy , 14 : 303 – 307 .
  • Nozoe , T , Korenaga , D , Ohga , T , Futatsugi , M and Maehara , Y . 2003 . Suppression of the phytohemagglutinin response to lymphocytes is an independent prognosticator in patients with squamous cell carcinoma of the esophagus . Ann Thorac Surg , 76 : 260 – 265 .
  • Farinas , M C , Rodriguez-Valverde , V , Zarrabeitia , M T , Parra-Blanco , J A and Sanz-Ortiz , J . 1991 . Contribution of monocytes to the decreased lymphoproliferative response to phytohemagglutinin in patients with lung cancer . Cancer , 68 : 1279 – 1284 .
  • Bauernhofer , T , Kuss , I , Henderson , B , Baum , A S and Whiteside , T L . 2003 . Preferential apoptosis of CD56dim natural killer cell subset in patients with cancer . Eur J Immunol , 33 : 119 – 124 .
  • Rissoan , M C , Soumelis , V , Kadowaki , N , Grouard , G Briere , F . 1999 . Reciprocal control of T helper cell and dendritic cell differentiation . Science , 283 : 1183 – 1186 .
  • Kamiyama , Y , Matsui , Y , Kawaguchi , Y , Kosuna , K Wakame , K . 2000 . Active hexose correlated compound (AHCC) . Biotherapy , 14 : 959 – 964 .

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