Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

REFERENCES

• Alter , M J , Kruszon-Moran , D , Nainan , O V , McQuillan , G M Gao , F . 1999 . The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 . N Engl J Med , 341 : 556 – 562 .
   PubMed Web of Science ®Google Scholar
• Ikeda , K , Saitoh , S , Suzuki , Y , Kobayashi , M Tsubota , A . 1998 . Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients . J Hepatol , 28 : 930 – 938 .
   PubMed Web of Science ®Google Scholar
• Davis , G L , Albright , J E , Cook , S F and Rosenberg , D M . 2003 . Projecting future complications of chronic hepatitis C in the United States . Liver Transpl , 9 : 331 – 338 .
   PubMed Web of Science ®Google Scholar
• Giovannucci , E . 2002 . A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer . Exp Biol Med , 227 : 852 – 859 .
   PubMed Web of Science ®Google Scholar
• Schmitz , H H , Poor , C L , Wellman , R B and Erdman , J W Jr. 1991 . Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue . J Nutr , 121 : 1613 – 1621 .
   PubMed Web of Science ®Google Scholar
• Moxley , C , Schwartz , S J , Craft , N , DeGroff , V Giovannucci , E . . Blood Lycopene Concentrations Increase in Healthy Adults Consuming Standard Servings of Processed Tomato Products Daily . Presented at AICR . Sept. 2–3 , Washington, DC.
   Google Scholar
• Fuhrman , B , Elis , A and Aviram , M . 1997 . Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages . Biochem Biophysics Res Commun , 233 : 658 – 662 .
   PubMed Web of Science ®Google Scholar
• Burton , G W and Ingold , K U . 1984 . Beta-carotene: an unusual type of lipid antioxidant . Science , 224 : 569 – 573 .
   PubMed Web of Science ®Google Scholar
• Conn , P F , Schlach , W and Truscott , T G . 1991 . The singlet oxygen and carotenoid interaction . J Photochem Photobiol , 11 : 41 – 47 .
   Google Scholar
• DiMascio , P , Kaiser , S and Sies , H . 1989 . Lycopene as the most efficient biological carotenoid singlet oxygen quencher . Arch Biochem Biophys , 274 : 1 – 7 .
   PubMed Web of Science ®Google Scholar
• Woodall , A A , Britton , G and Jackson , M J . 1997 . Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability . Biochim Biophys Acta , 1336 : 575 – 586 .
   PubMed Web of Science ®Google Scholar
• Kim , Y , DiSilvestro , R and Clinton , S . 2004 . Effects of lycopene-beadlet or tomato-powder feeding on carbon tetrachloride-induced hepatotoxicity in rats . Phytomedicine , 11 : 152 – 156 .
   PubMed Web of Science ®Google Scholar
• Koike , K . 2005 . Hepatitis c as a metabolic disease: implication for the pathogenesis of NASH . Hepatology Research , 33 : 145 – 150 .
   PubMed Web of Science ®Google Scholar
• Bureau , C , Bernad , J , Chaouche , N , Orfila , C Beraud , M . 2001 . Non-structural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase . J Biol Chem , 276 : 23077 – 23083 .
   PubMed Web of Science ®Google Scholar
• Pieczenik , S R and Neustadt , J . 2007 . Mitochondrial dysfunction and molecular pathways of disease . Exp Mol Pathol , 83 : 84 – 92 .
   PubMed Web of Science ®Google Scholar
• Mihm , S S , Fayyazi , A and Ramadori , G . 1997 . Hepatic expression of inducible nitric oxide synthase transcripts in chronic hepatitis C virus infection: relation to hepatic viral load and liver injury . Hepatology , 26 : 451 – 458 .
   PubMed Web of Science ®Google Scholar
• Bonkovsky , H , Banner , B F and Rothman , A L . 1997 . Iron and chronic viral hepatitis . Hepatology , 25 : 759 – 768 .
   PubMed Web of Science ®Google Scholar
• Aust , S D , Morehouse , L A and Thomas , C E . 1985 . Role of metals in oxygen radical reactions . Free Radic Biol Med , 1 : 3 – 25 .
   Google Scholar
• Hayasshi , H , Takikawa , T , Nishimura , N , Yano , M Isomura , T . 1994 . Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron . Am J Gastroenterol , 89 : 986 – 988 .
   PubMed Web of Science ®Google Scholar
• Choi , J and Ou , J H . 2006 . Mechanisms of liver injury and oxidative stress in the pathogenesis of hepatitis C virus . Am J Physiol, Gastrointestinal Liver Physiol , 290 : 847 – 851 .
   PubMed Web of Science ®Google Scholar
• Yadav , D , Hertan , H I , Schweitzer , P , Norkus , E P and Pitchumoni , C S . 2002 . Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C . Am J Gastroenterol , 97 : 2634 – 2639 .
   PubMed Web of Science ®Google Scholar
• Yamamoto , Y , Yamashita , S , Fujisawa , A , Kokura , S and Yoshikawa , T . 1998 . Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants . Biochem Biophys Res Commun , 247 : 166 – 170 .
   PubMed Web of Science ®Google Scholar
• Rocchi , E , Casalgrandi , G , Ronzoni , A , Rosa , M C Cioni , G . 2001 . Antioxidant liposoluble vitamins and carotenoids in chronic hepatitis . Eur J Intern Med , 12 : 116 – 121 .
   PubMedGoogle Scholar
• Di Bisceglie , A M . 2000 . Natural history of hepatitis C: its impact on clinical management . Hepatology , 31 : 1014 – 1018 .
   PubMed Web of Science ®Google Scholar
• Moriya , K , Yotsuyanagi , H , Shintani , Y , Fujie , H Ishibashi , K . 1997 . Hepatitis C virus core protein induces hepatic steatosis in transgenic mice . J Gen Virol , 78 : 1527 – 1531 .
   PubMed Web of Science ®Google Scholar
• Rosser , B G and Gores , G J . 1995 . Liver cell necrosis: cellular mechanisms and clinical implications . Gastroenterology , 108 : 252 – 275 .
   PubMed Web of Science ®Google Scholar
• Houglum , K , Venkatarmani , A , Lyche , K and Chojkier , M . 1997 . A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C . Gastroenterology , 113 : 1069 – 1073 .
   PubMed Web of Science ®Google Scholar
• Poli , G and Parola , M . 1997 . Oxidative damage and fibrogenesis . Free Radic Biol Med , 22 : 287 – 305 .
   PubMed Web of Science ®Google Scholar
• Melhem , A , Stern , M , Shibolet , O , Israeli , E Ackerman , Z . 2005 . Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial . J Clin Gastroenterol , 39 : 737 – 742 .
   PubMed Web of Science ®Google Scholar
• Von Herbay , A , Stahl , W , Niederau , C and Sies , H . 1997 . Vitamin E improves the aminotransferase status of patients suffering from viral Hepatitis C: a randomized, double-blind, placebo-controlled study . Free Rad Res , 27 : 599 – 605 .
   PubMed Web of Science ®Google Scholar
• Mahmood , S , Yamada , G , Niiyama , G , Kawanaka , M Togawa , K . 2003 . Effect of vitamin E on serum aminotransferasse and thioredoxin levels in patients with viral hepatitis C . Free Radic Res , 37 : 781 – 785 .
   PubMed Web of Science ®Google Scholar
• Ideo , G , Bellobuono , A , Tempini , S , Mondazzi , L Riroldi , A . 1999 . Antioxidant drugs combined with alpha-interferon on chronic hepatitis C not responsive to alpha-interferon alone: a randomized multi-center study . Eur J Gastroenterol Hepatol , 11 : 1203 – 1207 .
   PubMed Web of Science ®Google Scholar
• Beloqui , O , Prieto , J , Suarez , M , Gil , B Qian , C H . 1993 . N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: a pilot study . J Interferon Res , 13 : 279 – 282 .
   PubMedGoogle Scholar
• Kageyama , F , Kobayashi , Y , Kawasaki , T , Toyokuni , S Uchida , K . 2000 . Successful interferon theraly reverses enhanced heoatic iron accumulation and lipid peroxidation in chronic hepatitis C . Am J Gastroenterol , 95 : 1041 – 1050 .
   PubMed Web of Science ®Google Scholar
• Harrison , S A , Brunt , E M , Qazi , R A , Oliver , D A Neuschwander-Tetri , B A . 2005 . Effect of significant histologic steatosis or steatohepatitis on response to antiviral therapy in patients with chronic hepatitis C . Clin Gastroenterol Hepatol , 3 : 604 – 609 .
   PubMed Web of Science ®Google Scholar
• Volkmann , X , Cornberg , M , Wedemeyer , H , Lehner , F Manns , M P . 2006 . Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection . Hepatology , 43 : 1311 – 1316 .
   PubMed Web of Science ®Google Scholar
• Yoshida , H , Shiratori , Y , Moriyama , M , Arakawa , Y Ide , T . 1999 . Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and non cirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of hepatogenesis by interferon therapy . Ann Intern Med , 131 : 174 – 181 .
   PubMed Web of Science ®Google Scholar
• Moriya , K , Fujie , H , Shintani , Y , Yotsuyanagi , H , Tsutsumi , T Ishibashi , K . 1998 . The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice . Nat Med , 4 : 1065 – 1067 .
   PubMed Web of Science ®Google Scholar
• Nishikawa , M , Nishiguchi , S , Shiomi , S , Tamori , A Koh , N . 2001 . Somatic mutation of mitochondrial DNA in cancerous and non-cancerous liver tissue in individuals with hepatocellular carcinoma . Cancer Res , 61 : 1843 – 1845 .
   PubMed Web of Science ®Google Scholar
• Levrero , M . 2006 . Viral hepatitis and liver cancer: the case of hepatitis C . Oncogene , 25 : 3834 – 3847 .
   PubMed Web of Science ®Google Scholar
• McGlynn , K A , Tsao , L , Hsing , A W , Devesa , S S and Fraumeni , J F Jr. 2001 . International trends and patterns of primary liver cancer . Int J Cancer , 94 : 290 – 296 .
   PubMed Web of Science ®Google Scholar
• El-Serag , H B . 2004 . Hepatocellular carcinoma: recent trends in the United States . Gastroenterology , 127 : S27 – S34 .
   PubMed Web of Science ®Google Scholar
• Parkin , D M , Bray , F I and Devesa , S S . 2001 . Cancer burden in the year 2000: the global picture . Eur J Cancer , 37 : S4 – S66 .
   PubMed Web of Science ®Google Scholar
• American Cancer Society . 2004 . Cancer Facts and Figures—2004 , Vol. 60 , Atlanta, GA : American Cancer Society .
   Google Scholar
• Di Bisceglie , A M , Lyra , A C , Schwartz , M , Reddy , R K Martin , P . 2003 . Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status . Am J Gastroenterology , 98 : 2060 – 2063 .
   PubMed Web of Science ®Google Scholar
• Hossain , M Z , Wilkens , L R , Mehta , P P , Loewenstein , W and Bertram , J S . 1989 . Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation . Carcinogenesis , 10 : 1743 – 1748 .
   PubMed Web of Science ®Google Scholar
• Bertram , J S , Pung , A , Churley , M , Kappock , T J IV Wilkins , L R . 1991 . Diverse carotenoids protect against chemically induced neoplastic transformation . Carcinogenesis , 12 : 671 – 678 .
   PubMed Web of Science ®Google Scholar
• Levy , J , Bosin , E , Feldman , B , Giat , Y Miinster , A . 1995 . Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene . Nutr Cancer , 24 : 257 – 266 .
   PubMed Web of Science ®Google Scholar
• Rajah , R , Valentinis , B and Cohen , P . 1997 . Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta-1 on programmed cell death through a p53- and IGF-independent mechanism . J Biol Chem , 272 : 12181 – 12188 .
   PubMed Web of Science ®Google Scholar
• Mehta , P , Bertram , J S and Loewenstein , W R . 1989 . The actions of retinoids on cellular growth correlate with their actions on gap junctional communication . Cell Biol , 108 : 1053 – 1065 .
   PubMed Web of Science ®Google Scholar
• Gius , D , Botero , A , Shah , S and Curry , H A . 1999 . Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1 . Toxicol Lett , 106 : 93 – 106 .
   PubMed Web of Science ®Google Scholar
• Riso , P , Pinder , A , Santangelo , A and Porrini , M . 1999 . Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? . Am J Clin Nutr , 69 : 712 – 718 .
   PubMed Web of Science ®Google Scholar
• Rao , A V , Fleshner , N and Agarwal , S . 1999 . Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study . Nutr Cancer , 33 : 159 – 164 .
   PubMed Web of Science ®Google Scholar
• Siler , U , Barella , L , Spitzer , V , Scnorr , J Lein , M . 2004 . Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model . FASEB J , 18 : 1019 – 1021 .
   PubMed Web of Science ®Google Scholar
• Hazai , E , Bikadi , Z , Zsila , S and Lockwood , S F . 2006 . Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyl, and selected oxidative metabolites with 5-lipoxygenase . Biorg Medicinal Chem , 14 : 6859 – 6867 .
   PubMed Web of Science ®Google Scholar
• Jewell , C and O'Brien , N M . 1999 . Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat . Br J Nutr , 81 : 235 – 242 .
   PubMed Web of Science ®Google Scholar
• Chew , B P and Park , J S . 2004 . Carotenoid action on the immune response . J Nutr , 134 : 257S – 261S .
   PubMed Web of Science ®Google Scholar
• Brienholt , V , Lauridsen , S T , Daneehvar , B and Jakobeen , J . 2004 . Dose-responses effects of lycopene on selected drug metabolizing and antioxidant enzymes in rat . Cancer Lett , 154 : 201 – 210 .
   Google Scholar
• Park , Y O , Hwang , E S and Moon , T W . 2005 . The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells . Biofactors , 23 : 129 – 139 .
   PubMed Web of Science ®Google Scholar
• Hwang , E S and Lee , H J . 2006 . Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK-Hep1 human hepatoma cells . Exp Biol Med (Maywood) , 231 : 322 – 327 .
   PubMed Web of Science ®Google Scholar
• Reddy , L , Odhav , B and Bhoola , K . 2006 . Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage . Biol Chem , 387 : 87 – 93 .
   PubMed Web of Science ®Google Scholar
• Yu , M W , Chiu , Y H , Chiang , Y C , Chen , C H Lee , T H . 1999 . Plasma carotenoids, glutathione S-transferase M1 and T1 genetic polymorphisms, and risk of hepatocellular carcinoma: independent and interactive effects . Am J Epidemiol , 149 : 621 – 629 .
   PubMed Web of Science ®Google Scholar
• Watanabe , S , Kitade , Y , Masaki , T , Nishioka , M Satoh , K . 2001 . Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer . Nutr Cancer , 39 : 96 – 101 .
   PubMed Web of Science ®Google Scholar
• Takagi , H , Kakizaki , S , Sohara , N , Sato , K Tsukioka , G . 2003 . Pilot clinical trial of the use of alpha-tocopherol for the prevention of hepatocellular carcinoma in patients with liver cirrhosis . Int J Vitam Nutr Res , 73 : 411 – 415 .
   PubMed Web of Science ®Google Scholar
• Yu , M , Chiang , Y , Lien , J and Chen , C . 1997 . Plasma antioxidant vitamins, chronic hepatitis B virus infection and urinary aflatoxin B1-DNA adducts in healthy males . Carcinogenesis , 18 : 1189 – 1194 .
   PubMed Web of Science ®Google Scholar
• Nishino , H . 2007 . Prevention of hepatocellular carcinoma in chronic viral hepatitis patients with cirrhosis by carotenoid mixture: recent results . Cancer Res , 174 : 67 – 71 .
   Google Scholar
• Astorg , P , Gradelet , S , Berger , R and Suschetet , M . 1997 . Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat . Nutr Cancer , 29 : 60 – 68 .
   PubMed Web of Science ®Google Scholar
• Gradlet , S , LeBon , A M , Bergès , R , Suschetet , M and Astorg , P . 1998 . Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism . Carcinogenesis , 19 : 403 – 411 .
   PubMed Web of Science ®Google Scholar
• Sedjo , R L , Papenfuss , M R , Craft , N E and Giuliano , A R . 2003 . Effect of plasma micronutrients on clearance of oncogenic HPV infection . Cancer Causes Control , 14 : 319 – 326 .
   PubMed Web of Science ®Google Scholar
• Beck , M A , Levander , O A and Handy , J . 2003 . Selenium deficiency and viral infection . J Nutr , 133 : 1463s – 1467s .
   PubMed Web of Science ®Google Scholar