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Original Articles

Quercetin Induces Oxidative Stress and Potentiates the Apoptotic Action of 2-Methoxyestradiol in Human Hepatoma Cells

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Pages 735-745 | Received 22 Jun 2008, Accepted 02 Feb 2009, Published online: 03 Sep 2009

REFERENCES

  • Vital Statistic: Taipei T, ROC . 2005 . Department of Health, Executive Yuan . Health statistics of the Republic of China ,
  • Tang , Z Y . 2001 . Hepatocellular carcinoma—cause, treatment, and metastasis . World J Gastroenterol , 7 : 445 – 454 .
  • Fotsis , T , Zhang , Y , Pepper , M S , Adlercreutz , H Montesano , R . 1994 . The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth . Nature , 368 : 237 – 239 .
  • Lin , H L , Liu , T Y , Wu , C W and Chi , C W . 2001 . 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells . Cancer , 92 : 500 – 509 .
  • Qadan , L R , Perez-Stable , C M , Anderson , C , D'Ippolito , G Herron , A . 2001 . 2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer . Biochem Biophys Res Commun , 285 : 1259 – 1266 .
  • Huang , P , Feng , L , Oldham , E A , Keating , M J and Plunkett , W . 2000 . Superoxide dismutase as a target for the selective killing of cancer cells . Nature , 407 : 390 – 395 .
  • Lui , W Y , Lin , H L , Chau , G Y , Liu , T Y and Chi , C W . 2000 . Male predominance in hepatocellular carcinoma: new insight and a possible therapeutic alternative . Med Hypotheses , 55 : 348 – 350 .
  • Lin , H L , Liu , T Y , Chau , G Y , Lui , W Y and Chi , C W . 2000 . Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species . Cancer , 89 : 983 – 994 .
  • Scharf , G , Prustomersky , S , Knasmuller , S , Schulte-Hermann , R and Huber , W W . 2003 . Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2 . Nutr Cancer , 45 : 74 – 83 .
  • Ramos , A M and Aller , P . 2008 . Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines . Biochem Pharmacol , 75 : 1912 – 1923 .
  • Kang , T B and Liang , N C . 1997 . Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells . Biochem Pharmacol , 54 : 1013 – 1018 .
  • Mouria , M , Gukovskaya , A S , Jung , Y , Buechler , P Hines , O J . 2002 . Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis . Int J Cancer , 98 : 761 – 769 .
  • Wei , Y Q , Zhao , X , Kariya , Y , Fukata , H Teshigawara , K . 1994 . Induction of apoptosis by quercetin: involvement of heat shock protein . Cancer Res , 54 : 4952 – 4957 .
  • Chang , Y F , Chi , C W and Wang , J J . 2006 . Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells . Nutr Cancer , 55 : 201 – 209 .
  • Carter , W O , Narayanan , P K and Robinson , J P . 1994 . Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells . J Leukoc Biol , 55 : 253 – 258 .
  • Reers , M , Smith , T W and Chen , L B . 1991 . J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential . Biochemistry , 30 : 4480 – 4486 .
  • Heerdt , B G , Houston , M A , Anthony , G M and Augenlicht , L H . 1998 . Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells . Cancer Res , 58 : 2869 – 2875 .
  • Hileman , E O , Liu , J , Albitar , M , Keating , M J and Huang , P . 2004 . Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity . Cancer Chemother Pharmacol , 53 : 209 – 219 .
  • Gao , N , Rahmani , M , Dent , P and Grant , S . 2005 . 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process . Oncogene , 24 : 3797 – 3809 .
  • She , M R , Li , J G , Guo , K Y , Lin , W Du , X . 2007 . Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol . Acta Pharmacol Sin , 28 : 1037 – 1044 .
  • Basini , G , Santini , S E and Grasselli , F . 2006 . 2-Methoxyestradiol inhibits superoxide anion generation while it enhances superoxide dismutase activity in swine granulosa cells . Ann NY Acad Sci , 1091 : 34 – 40 .
  • Lambert , C , Thews , O , Biesalski , H K , Vaupel , P Kelleher , D K . 2002 . 2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment . Eur J Med Res , 7 : 404 – 414 .
  • Golab , J , Nowis , D , Skrzycki , M , Czeczot , H Baranczyk-Kuzma , A . 2003 . Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor . J Biol Chem , 278 : 407 – 414 .
  • Pani , G , Colavitti , R , Bedogni , B , Fusco , S Ferraro , D . 2004 . Mitochondrial superoxide dismutase: a promising target for new anticancer therapies . Curr Med Chem , 11 : 1299 – 1308 .
  • Kachadourian , R , Liochev , S I , Cabelli , D E , Patel , M N Fridovich , I . 2001 . 2-methoxyestradiol does not inhibit superoxide dismutase . Arch Biochem Biophys , 392 : 349 – 353 .
  • Metodiewa , D , Jaiswal , A K , Cenas , N , Dickancaite , E and Segura-Aguilar , J . 1999 . Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product . Free Radic Biol Med , 26 : 107 – 116 .
  • Thangasamy , T , Sittadjody , S , Lanza-Jacoby , S , Wachsberger , P R Limesand , K H . 2007 . Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase . Nutr Cancer , 59 : 258 – 268 .
  • Irani , K , Xia , Y , Zweier , J L , Sollott , S J Der , C J . 1997 . Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts . Science , 275 : 1649 – 1652 .
  • Huang , R P , Peng , A , Golard , A , Hossain , M Z Huang , R . 2001 . Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor . Mol Carcinog , 30 : 209 – 217 .
  • Sundaresan , M , Yu , Z X , Ferrans , V J , Irani , K and Finkel , T . 1995 . Requirement for generation of H2O2 for platelet-derived growth factor signal transduction . Science , 270 : 296 – 299 .
  • Brenner , C and Grimm , S . 2006 . The permeability transition pore complex in cancer cell death . Oncogene , 25 : 4744 – 4756 .
  • Orrenius , S . 2007 . Reactive oxygen species in mitochondria-mediated cell death . Drug Metab Rev , 39 : 443 – 455 .
  • Kuhar , M , Sen , S and Singh , N . 2006 . Role of mitochondria in quercetin-enhanced chemotherapeutic response in human non-small cell lung carcinoma H-520 cells . Anticancer Res , 26 : 1297 – 1303 .
  • Sharma , H , Sen , S and Singh , N . 2005 . Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer . Cancer Biol Ther , 4 : 949 – 955 .
  • Huang , S L , Hsu , C L and Yen , G C . 2006 . Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells . Life Sci , 79 : 203 – 209 .
  • Djavaheri-Mergny , M , Wietzerbin , J and Besancon , F . 2003 . 2-methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production . Oncogene , 22 : 2558 – 2567 .
  • Pelicano , H , Feng , L , Zhou , Y , Carew , J S Hileman , E O . 2003 . Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism . J Biol Chem , 278 : 37832 – 37839 .
  • Zhang , Y M . 2005 . Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells . Toxicol Sci , 88 : 545 – 550 .
  • Policastro , L , Molinari , B , Larcher , F , Blanco , P Podhajcer , O L . 2004 . Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide . Mol Carcinog , 39 : 103 – 113 .
  • Blokhina , O , Virolainen , E and Fagerstedt , K V . 2003 . Antioxidants, oxidative damage and oxygen deprivation stress: a review . Ann Bot (Lond) , 91 : 179 – 194 . (Spec No)

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