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Original Articles

Stearate Preferentially Induces Apoptosis in Human Breast Cancer Cells

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Pages 746-753 | Received 18 Jul 2008, Accepted 14 Feb 2009, Published online: 03 Sep 2009

REFERENCES

  • Wickramasinghe , N S , Jo , H , McDonald , J M and Hardy , R W . 1996 . Stearate inhibition of breast cancer cell proliferation: a mechanism involving epidermal growth factor receptor and G-proteins . Am J Pathol , 148 : 987 – 995 .
  • Singh , R K , Hardy , R W , Wang , M H , Williford , J Gladson , C L . 1995 . Stearate inhibits human tumor cell invasion . Invasion Metastasis , 15 : 144 – 155 .
  • Hardy , S , El-Assaad , W , Przybytkowski , E , Joly , E Prentki , M . 2003 . Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells: a role for cardiolipin . J Biol Chem , 278 : 31861 – 31870 .
  • Tinsley , I J , Schmitz , J A and Pierce , D A . 1981 . Influence of dietary fatty acids on the incidence of mammary tumors in the C3H mouse . Cancer Res , 41 : 1460 – 1465 .
  • Bennett , A S . 1984 . Effect of dietary stearic acid on the genesis of spontaneous mammary adenocarcinomas in strain A/ST mice . Int J Cancer , 34 : 529 – 533 .
  • Saadatian-Elahi , M , Norat , T , Goudable , J and Riboli , E . 2004 . Biomarkers of dietary fatty acid intake and the risk of breast cancer: a meta-analysis . Int J Cancer , 111 : 584 – 591 .
  • Shannon , J , King , I B , Moshofsky , R , Lampe , J W Gao , D L . 2007 . Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China . Am J Clin Nutr , 85 : 1090 – 1097 .
  • Jin , Z and El-Deiry , W S . 2005 . Overview of cell death signaling pathways . Cancer Biol Ther , 4 : 139 – 163 .
  • Spector , A A and Hoak , J C . 1969 . An improved method for the addition of long-chain free fatty acid to protein solutions . Anal Biochem , 32 : 297 – 302 .
  • Rosen , A and Casciola-Rosen , L . 1997 . Macromolecular substrates for the ICE-like proteases during apoptosis . J Cell Biochem , 64 : 50 – 54 .
  • Lu , Z H , Mu , Y M , Wang , B A , Li , X L Lu , J M . 2003 . Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell . Biochem Biophys Res Commun , 303 : 1002 – 1007 .
  • Mu , Y M , Yanase , T , Nishi , Y , Tanaka , A Saito , M . 2001 . Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells . Endocrinology , 142 : 3590 – 3597 .
  • Staiger , K , Staiger , H , Weigert , C , Haas , C Haring , H U . 2006 . Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation . Diabetes , 55 : 3121 – 3126 .
  • Ulloth , J E , Casiano , C A and De Leon , M . 2003 . Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells . J Neurochem , 84 : 655 – 668 .
  • Artwohl , M , Roden , M , Waldhausl , W , Freudenthaler , A and Baumgartner-Parzer , S M . 2004 . Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells . FASEB J , 18 : 146 – 148 .
  • Beeharry , N , Chambers , J A and Green , I C . 2004 . Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition . Apoptosis , 9 : 599 – 607 .
  • Paumen , M B , Ishida , Y , Muramatsu , M , Yamamoto , M and Honjo , T . 1997 . Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis . J Biol Chem , 272 : 3324 – 3329 .
  • Mishra , R and Simonson , M S . 2005 . Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G . Cardiovasc Diabetol , 4 : 2
  • El-Assaad , W , Buteau , J , Peyot , M L , Nolan , C Roduit , R . 2003 . Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death . Endocrinology , 144 : 4154 – 4163 .
  • Eitel , K , Staiger , H , Rieger , J , Mischak , H Brandhorst , H . 2003 . Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells . Diabetes , 52 : 991 – 997 .
  • Mougios , V , Ring , S , Petridou , A and Nikolaidis , M G . 2003 . Duration of coffee- and exercise-induced changes in the fatty acid profile of human serum . J Appl Physiol , 94 : 476 – 484 .
  • Hunter , D J , Spiegelman , D , Adami , H O , Beeson , L van den Brandt , P A . 1996 . Cohort studies of fat intake and the risk of breast cancer—a pooled analysis . N Engl J Med , 334 : 356 – 361 .
  • Wicha , M S , Liotta , L A and Kidwell , W R . 1979 . Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells . Cancer Res , 39 : 426 – 435 .
  • Yu , H Y , Inoguchi , T , Kakimoto , M , Nakashima , N Imamura , M . 2001 . Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells . Diabetologia , 44 : 614 – 620 .
  • Igal , R A , Wang , P and Coleman , R A . 1997 . Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA . Biochem J , 324 : 529 – 534 . (Pt 2)
  • Coleman , R A , Lewin , T M , Van Horn , C G and Gonzalez-Baro , M R . 2002 . Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? . J Nutr , 132 : 2123 – 2126 .
  • Musashi , M , Ota , S and Shiroshita , N . 2000 . The role of protein kinase C isoforms in cell proliferation and apoptosis . Int J Hematol , 72 : 12 – 19 .
  • Wang , Q , Wang , X and Evers , B M . 2003 . Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B . J Biol Chem , 278 : 51091 – 51099 .
  • Howe , G R , Hirohata , T , Hislop , T G , Iscovich , J M Yuan , J M . 1990 . Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies . J Natl Cancer Inst , 82 : 561 – 569 .
  • Boyd , N F , Stone , J , Vogt , K N , Connelly , B S Martin , L J . 2003 . Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature . Br J Cancer , 89 : 1672 – 1685 .
  • Grundy , S M . 1994 . Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids . Am J Clin Nutr , 60 : 986S – 990S .
  • Mitropoulos , K A , Miller , G J , Martin , J C , Reeves , B E and Cooper , J . 1994 . Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration . Arterioscler Thromb , 14 : 214 – 222 .
  • Tholstrup , T . 2005 . Influence of stearic acid on hemostatic risk factors in humans . Lipids , 40 : 1229 – 1235 .
  • Kelly , F D , Sinclair , A J , Mann , N J , Turner , A H Abedin , L . 2001 . A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males . Eur J Clin Nutr , 55 : 88 – 96 .
  • Louheranta , A M , Turpeinen , A K , Schwab , U S , Vidgren , H M Parviainen , M T . 1998 . A high-stearic acid diet does not impair glucose tolerance and insulin sensitivity in healthy women . Metabolism , 47 : 529 – 534 .

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