243
Views
32
CrossRef citations to date
0
Altmetric
Original Articles

Gamma Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells

, , , , , , , , , & show all
Pages 649-662 | Received 01 Oct 2008, Accepted 02 Feb 2009, Published online: 03 Sep 2009

REFERENCES

  • Fair , W R , Fleshner , N E and Heston , W . 1997 . Cancer of the prostate: a nutritional disease? . Urology , 50 : 840 – 848 .
  • Deneo-Pellegrini , H , De Stefani , E , Ronco , A and Mendilaharsu , M . 1999 . Foods, nutrients and prostate cancer: a case-control study in Uruguay . Br J Cancer , 80 : 591 – 597 .
  • Chavarro , J E , Stampfer , M J , Campos , H , Kurth , T Willett , W C . 2008 . A prospective study of trans-fatty acid levels in blood and risk of prostate cancer . Cancer Epidemiol Biomarkers Prev , 17 : 95 – 101 .
  • Fleshner , N E , Bagnell , P , Klotz , L and Venkateswaran , V . 2004 . Dietary fat and prostate cancer . J Urol , 171 : S19 – S24 .
  • Kolonel , L N , Nomura , A MY and Cooney , R V . 1999 . Dietary fat and prostate cancer: current status . J Natl Cancer Inst , 91 : 414 – 428 .
  • De Marzo , A M , Marchi , V L , Epstein , J I and Nelson , W G . 1999 . Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis . Am J Path , 155 : 1985 – 1992 .
  • De Marzo , A M , Platz , E A , Sutcliffe , S , Xu , J Gronberg , H . 2007 . Inflammation in prostate carcinogenesis . Nat Rev Cancer , 7 : 256 – 269 .
  • Nelson , W G , De Marzo , A M , DeWeese , T L and Isaacs , W B . 2004 . The role of inflammation in the pathogenesis of prostate cancer . J Urol , 172 : S6 – S12 .
  • Nickel , J C , Roehrborn , C G , O'Leary , M P , Bostwick , D G Somerville , M C . 2008 . The relationship between prostate inflammation and lower urinary tract symptoms: examination of baseline data from the REDUCE trial . Eur Urol , 54 : 1379 – 1384 .
  • Stone , W L and Papas , A M . 1997 . Tocopherols and the etiology of colon cancer . J Natl Cancer Inst , 89 : 1006 – 1014 .
  • Barrie , M M . 1938 . Vitamin E deficiency in the rat: fertility in the female . Biochem J , 32 : 2134 – 2137 .
  • Albanes , D , Heinonen , O P , Huttunen , J K , Taylor , P R Virtamo , J E . 1995 . Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study . Am J Clin Nutr , 62 : 1427S – 1430S .
  • Lippman , S M , Goodman , P J , Klein , E A , Parnes , H L Thompson , I M . 2005 . Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . J Natl Cancer Inst , 97 : 94 – 102 .
  • Lippman , S M , Klein , E A , Goodman , P J , Lucia , M S Thompson , I M . 2009 . Effect of selenium and vitamin e on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . JAMA , 301 : 39 – 51 .
  • Nomura , A M , Ziegler , R G , Stemmermann , G N , Chyou , P H and Craft , N E . 1997 . Serum micronutrients and upper aerodigestive tract cancer . Cancer Epidemiol Biomarkers Prev , 6 : 407 – 412 .
  • Bostick , R M , Potter , J D , McKenzie , D R , Sellers , T A Kushi , L H . 1993 . Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study . Cancer Res , 53 : 4230 – 4237 .
  • Helzlsouer , K J , Huang , H Y , Alberg , A J , Hoffman , S Burke , A . 2000 . Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer . J Natl Cancer Inst , 92 : 2018 – 2022 .
  • Stone , W L , Papas , A M , LeClair , I O , Qui , M and Ponder , T . 2002 . The influence of dietary iron and tocopherols on oxidative stress and ras-p21 levels in the colon . Cancer Detect Prev , 26 : 78 – 84 .
  • Cooney , R V , Franke , A A , Harwood , P J , Hatch-Pigott , V Custer , L J . 1993 . Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol . Proc Natl Acad Sci USA , 90 : 1771 – 1775 .
  • Jiang , Q , Elson-Schwab , I , Courtemanche , C and Ames , B N . 2000 . Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells . Proc Natl Acad Sci USA , 97 : 11494 – 11499 .
  • Gysin , R , Azzi , A and Visarius , T . 2002 . Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins . FASEB J , 16 : 1952 – 1954 .
  • Jiang , Q and Ames , B N . 2003 . Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats . FASEB J , 17 : 816 – 822 .
  • Jiang , Q , Moreland , M , Ames , B N and Yin , X . 2008 . A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects . J Nutr Biochem ,
  • Himmelfarb , J , Kane , J , McMonagle , E , Zaltas , E Bobzin , S . 2005 . Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease . Kidney Int , 64 : 978 – 991 .
  • Campbell , S , Stone , W , Whaley , S and Krishnan , K . 2003 . Development of gamma-tocopherol as a colorectal cancer chemopreventive agent . Crit Rev Oncol Hematol , 47 : 249 – 259 .
  • Campbell , S E , Stone , W L , Lee , S , Whaley , S Yang , H . 2006 . Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines . BMC Cancer , 6 : 13
  • Campbell , S E , Stone , W L , Whaley , S G , Qui , M and Krishnan , K . 2003 . Gamma tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma expression in SW 480 human colon cancer cell lines . BMC Cancer , 3
  • Murphy , G J and Holder , J C . 2000 . PPAR gamma agonists: therapeutic role in diabetes, inflammation, and cancer . Trends Pharmacol Sci , 21 : 469 – 474 .
  • Gurnell , M , Savage , D B , Chatterjee , V K and O'Rahilly , S . 2003 . The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation . J Clin Endocrinol Metab , 88 : 2412 – 2421 .
  • Gurnell , M , Wentworth , J M , Agostini , M , Adams , M Collingwood , T N . 2000 . A dominant-negative peroxisome proliferator-activated receptor gamma (PPAR gamma) mutant is a constitutive repressor and inhibits PPAR gamma-mediated adipogenesis . J Biol Chem , 275 : 5754 – 5759 .
  • Nichols , J S , Parks , D J , Consler , T G and Blanchard , S G . 1998 . Development of a scintillation proximity assay for peroxisome proliferator-activated receptor ligand binding domain . Anal Biochem , 257 : 112 – 119 .
  • Subbarayan , V , Xu , X C , Kim , J , Yang , P Hoque , A . 2005 . Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia . Neoplasia , 7 : 280 – 293 .
  • Lee , C J , Han , J S , Seo , C Y , Park , T H Kwon , H C . 2006 . Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells . Apoptosis , 11 : 401 – 411 .
  • Huang , J T , Welch , J S , Ricote , M , Binder , C J Willson , T M . 1999 . Interleukin-4-dependent production of PPAR-[gamma] ligands in macrophages by 12/15-lipoxygenase . Nature , 400 : 378 – 382 .
  • Shappell , S B , Gupta , R A , Manning , S , Whitehead , R Boeglin , W E . 2001 . S15S-hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in pc3 prostate carcinoma cells . Cancer Res , 61 : 497 – 503 .
  • Hsi , L C , Wilson , L C and Eling , T E . 2002 . Opposing effects of 15-lipoxygenase-1 and -2 metabolites on mapk signaling in prostate. alteration in peroxisome proliferator-activated receptor gamma . J Biol Chem , 277 : 40549
  • Chen , G G , Lee , J F , Wang , S H , Chan , U P Ip , P C . 2002 . Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer . Life Sci , 70 : 2631 – 2646 .
  • Li , M , Lee , T W , Mok , T S , Warner , T D Yim , A P . 2005 . Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth . J Cell Biochem , 96 : 760 – 774 .
  • Pham , H , Banerjee , T , Nalbandian , G M and Ziboh , V A . 2003 . Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells . Cancer Lett , 189 : 17 – 25 .
  • Brash , A R , Boeglin , W E and Chang , M S . 1997 . Discovery of a second 15S-lipoxygenase in humans . Proc Natl Acad Sci USA , 94 : 6148 – 6152 .
  • Shappell , S B , Boeglin , W E , Olson , S J , Kasper , S and Brash , A R . 1999 . 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma . Am J Pathol , 155 : 235 – 245 .
  • Tang , D G , Bhatia , B , Tang , S and Schneider-Broussard , R . 2007 . 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size) . Prostaglandins Other Lipid Mediat , 82 : 135 – 146 .
  • Tang , S , Bhatia , B , Maldonado , C J , Yang , P Newman , R A . 2002 . Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells . J Biol Chem , 277 : 16189 – 16201 .
  • Shankaranarayanan , P and Nigam , S . 2003 . IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor . J Immunol , 170 : 887 – 894 .
  • Rossi , A , Kapahi , P , Natoli , G , Takahashi , T Chen , Y . 2000 . Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I[kappa]B kinase . Nature , 403 : 103 – 118 .
  • Wang , C , Fu , M , D'Amico , M , Albanese , C Zhou , J N . 2001 . Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin d1 . Mol Cell Biol , 21 : 3057 – 3070 .
  • Chen , F , Wang , M , O'Connor , J P , He , M Tripathi , T . 2003 . Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta . J Cell Biochem , 90 : 732 – 744 .
  • Kim , E K , Kwon , K B , Koo , B S , Han , M J Song , M Y . 2007 . Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway . Int J Biochem Cell Biol , 39 : 1260 – 1275 .
  • Legrand , A B , Lawson , J A , Meyrick , B O , Blair , I A and Oates , J A . 1991 . Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway . J Biol Chem , 266 : 7570 – 7577 .
  • Wallukat , G , Nemecz , G , Farkas , T , Kuehn , H and Wollenberger , A . 1991 . Modulation of the beta-adrenergic response in cultured rat heart cells: I. beta-adrenergic supersensitivity is induced by lactate via a phospholipase A2 and 15-lipoxygenase involving pathway . Mol Cell Biochem , 102 : 35 – 47 .
  • Bazan , H EP . 2005 . Cellular and molecular events in corneal wound healing: significance of lipid signalling . Exp Eye Res , 80 : 453 – 463 .
  • Nony , P A , Kennett , S B , Glasgow , W C , Olden , K and Roberts , J D . 2005 . 15(S)-lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK . J Biol Chem , 280 : 31413 – 31419 .
  • Profita , M , Sala , A , Riccobono , L , Pace , E Paterno , A . 2000 . 15(S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis . Am J Physiol Cell Physiol , 279 : C1249 – C1258 .
  • Subbarayan , V , Krieg , P , Hsi , L C , Kim , J Yang , P . 2006 . 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma . Oncogene , 25 : 6015 – 6025 .
  • Spector , A A , Gordon , J A and Moore , S A . 1988 . Hydroxyeicosatetraenoic acids (HETEs) . Prog Lipid Res , 27 : 271 – 323 .
  • Yang , X , Downes , M , Yu , R T , Bookout , A L He , W . 2006 . Nuclear receptor expression links the circadian clock to metabolism . Cell , 126 : 801 – 810 .
  • Canaple , L , Rambaud , J , Dkhissi-Benyahya , O , Rayet , B Tan , N S . 2006 . Reciprocal regulation of brain and muscle arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock . Mol Endocrinol , 20 : 1715 – 1727 .
  • Kaeffer , B and Pardini , L . 2005 . Clock genes of mammalian cells: practical implications in tissue culture . In Vitro Cell Dev Biol Anim , 41 : 311 – 320 .
  • Limor , R , Sharon , O , Knoll , E , Many , A Weisinger , G . 2008 . Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells . Am J Hypertens , 21 : 219 – 223 .
  • Adams , M , Reginato , M J , Shao , D , Lazar , M A and Chatterjee , V K . 1997 . Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site . J Biol Chem , 272 : 5128 – 5132 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.