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Original Articles

Effects of Nobiletin on PhIP-Induced Prostate and Colon Carcinogenesis in F344 Rats

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Pages 227-233 | Received 28 Dec 2009, Accepted 08 Sep 2010, Published online: 04 Feb 2011

REFERENCES

  • Syed , D N , Khan , N , Afaq , F and Mukhtar , H . 2007 . Chemoprevention of prostate cancer through dietary agents: progress and promise . Cancer Epidemiol Biomarkers Prev , 16 : 2193 – 2203 .
  • Johnson , J J and Mukhtar , H . 2007 . Curcumin for chemoprevention of colon cancer . Cancer Lett , 255 : 170 – 181 .
  • Takayama , K , Yamashita , K , Wakabayashi , K , Sugimura , T and Nagao , M . 1989 . DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats . Jpn J Cancer Res , 80 : 1145 – 1148 .
  • Snyderwine , E G , Venugopal , M and Yu , M . 2002 . Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) . Mutat Res , 506–507 : 145 – 152 .
  • Shirai , T , Takahashi , S , Cui , L , Yamada , Y Tada , M . 1998 . Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis . Toxicol Lett , 102–103 : 441 – 446 .
  • Takahashi , S , Tamano , S , Hirose , M , Kimoto , N Ikeda , Y . 1998 . Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution . Cancer Res , 58 : 4307 – 4313 .
  • Zhu , J , Chang , P , Bondy , M L , Sahin , A A Singletary , S E . 2003 . Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer . Cancer Epidemiol Biomarkers Prev , 12 : 830 – 837 .
  • Tang , D , Liu , J J , Rundle , A , Neslund-Dudas , C Savera , A T . 2007 . Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesis . Cancer Epidemiol Biomarkers Prev , 16 : 803 – 808 .
  • Shirai , T , Sano , M , Tamano , S , Takahashi , S Hirose , M . 1997 . The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods . Cancer Res , 57 : 195 – 198 .
  • Ito , N , Hasegawa , R , Sano , M , Tamano , S Esumi , H . 1991 . A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-pheny limidazo[4,5-b]pyridine (PhIP) . Carcinogenesis , 12 : 1503 – 1506 .
  • Parkin , D M , Bray , F I and Devesa , S S . 2001 . Cancer burden in the year 2000. The global picture . Eur J Cancer , 37 ( Suppl 8 ) : S4 – 66 .
  • Sinha , R . 2002 . An epidemiologic approach to studying heterocyclic amines . Mutat Res , 506–507 : 197 – 204 .
  • Nishino , H , Tokuda , H , Satomi , Y , Masuda , M Osaka , Y . 2004 . Cancer prevention by antioxidants . Biofactors , 22 : 57 – 61 .
  • Miyata , Y , Sato , T , Imada , K , Dobashi , A Yano , M . 2008 . A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells . Biochem Biophys Res Commun , 366 : 168 – 173 .
  • Tang , M , Ogawa , K , Asamoto , M , Hokaiwado , N Seeni , A . 2007 . Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells . Cancer Sci , 98 : 471 – 477 .
  • Luo , G , Guan , X and Zhou , L . 2008 . Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo . Cancer Biol Ther , 7 : 966 – 973 .
  • Murakami , A , Nakamura , Y , Torikai , K , Tanaka , T Koshiba , T . 2000 . Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice . Cancer Res , 60 : 5059 – 5066 .
  • Minagawa , A , Otani , Y , Kubota , T , Wada , N Furukawa , T . 2001 . The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice . Jpn J Cancer Res , 92 : 1322 – 1328 .
  • Kohno , H , Yoshitani , S , Tsukio , Y , Murakami , A Koshimizu , K . 2001 . Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats . Life Sci , 69 : 901 – 913 .
  • Suzuki , R , Kohno , H , Murakami , A , Koshimizu , K Ohigashi , H . 2004 . Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats . Biofactors , 22 : 111 – 114 .
  • Miyamoto , S , Yasui , Y , Tanaka , T , Ohigashi , H and Murakami , A . 2008 . Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice . Carcinogenesis , 29 : 1057 – 1063 .
  • Wakabayashi , K , Nagao , M , Esumi , H and Sugimura , T . 1992 . Food-derived mutagens and carcinogens . Cancer Res , 52 ( Suppl ) : 2092S – 2098S .
  • Asamoto , M , Hokaiwado , N , Cho , Y M , Takahashi , S Ikeda , Y . 2001 . Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent . Cancer Res , 61 : 4693 – 4700 .
  • Kandori , H , Suzuki , S , Asamoto , M , Murasaki , T Mingxi , T . 2005 . Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats . Cancer Sci , 96 : 221 – 226 .
  • McLellan , E A and Bird , R P . 1988 . Aberrant crypts: potential preneoplastic lesions in the murine colon . Cancer Res , 48 : 6187 – 6192 .
  • Sinha , R , Rothman , N , Brown , E D , Salmon , C P Knize , M G . 1995 . High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method . Cancer Res , 55 : 4516 – 4519 .
  • Mori , H , Yamada , Y , Kuno , T and Hirose , Y . 2004 . Aberrant crypt foci and beta-catenin accumulated crypts; significance and roles for colorectal carcinogenesis . Mutat Res , 566 : 191 – 208 .
  • Morley , K L , Ferguson , P J and Koropatnick , J . 2007 . Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells . Cancer Lett , 251 : 168 – 178 .
  • Zhou , C H , Wu , X H and Wu , Y Q . 2009 . Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway . Eur J Pharmacol , 615 : 55 – 60 .
  • Suzuki , T , Fujimoto , N , Kitamura , S and Ohta , S . 2007 . Quantitative determination of lobe specificity of mRNA expression of androgen-dependent genes in the rat prostate gland . Endocr J , 54 : 123 – 132 .
  • Lin , N , Sato , T , Takayama , Y , Mimaki , Y Sashida , Y . 2003 . Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages . Biochem Pharmacol , 65 : 2065 – 2071 .

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