423
Views
19
CrossRef citations to date
0
Altmetric
Original Articles

Zyflamend Reduces the Expression of Androgen Receptor in a Model of Castrate-Resistant Prostate Cancer

, , , , , , & show all
Pages 1287-1296 | Received 30 Mar 2011, Accepted 18 Jul 2011, Published online: 29 Sep 2011

REFERENCES

  • Jemal , A , Siegel , R , Ward , E , Hao , Y Xu , J . 2008 . Cancer statistics, 2008 . CA Cancer J Clin , 58 : 71 – 96 .
  • Hsing , A W , Tsao , L and Devesa , S S . 2000 . International trends and patterns of prostate cancer incidence and mortality . Int J Cancer , 85 : 60 – 67 .
  • Schulze , H and Senge , T . 1990 . Influence of different types of antiandrogens on luteinizing hormone-releasing hormone analogue-induced testosterone surge in patients with metastatic carcinoma of the prostate . J Urol , 144 : 934 – 941 .
  • Montironi , R , Mazzucchelli , R , Lopez-Beltran , A , Cheng , L and Scarpelli , M . 2007 . Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate . Nat Clin Pract Urol , 4 : 321 – 332 .
  • Capodice , J L , Gorroochurn , P , Cammack , A S , Eric , G McKiernan , J M . 2009 . Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial . J Soc Integr Oncol , 7 : 43 – 51 .
  • Yang , P , Cartwright , C , Chan , D , Vijjeswarapu , M Ding , J . 2007 . Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation . Cancer Biol Ther , 6 : 228 – 236 .
  • Bemis , D L , Capodice , J L , Anastasiadis , A G , Katz , A E and Buttyan , R . 2005 . Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression . Nutr Cancer , 52 : 202 – 212 .
  • Taplin , M E , Bubley , G J , Shuster , T D , Frantz , M E Spooner , A E . 1995 . Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer . N Engl J Med , 332 : 1393 – 1398 .
  • Gregory , C W , Johnson , R T Jr. , Mohler , J L , French , F S and Wilson , E M . 2001 . Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen . Cancer Res , 61 : 2892 – 2898 .
  • Pienta , K J and Bradley , D . 2006 . Mechanisms underlying the development of androgen-independent prostate cancer . Clin Cancer Res , 12 : 1665 – 1671 .
  • Feldman , B J and Feldman , D . 2001 . The development of androgen-independent prostate cancer . Nat Rev Cancer , 1 : 34 – 45 .
  • Stattin , P , Bylund , A , Rinaldi , S , Biessy , C Dechaud , H . 2000 . Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study . J Natl Cancer Inst , 92 : 1910 – 1917 .
  • Culig , Z , Hobisch , A , Cronauer , M V , Radmayr , C Trapman , J . 1994 . Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor . Cancer Res , 54 : 5474 – 5478 .
  • Liao , Y , Abel , U , Grobholz , R , Hermani , A Trojan , L . 2005 . Upregulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor grade . Hum Pathol , 36 : 1186 – 1196 .
  • Paliouras , M and Diamandis , E P . 2008 . An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines . Biol Chem , 389 : 773 – 780 .
  • Fan , W , Yanase , T , Morinaga , H , Okabe , T Nomura , M . 2007 . Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor . J Biol Chem , 282 : 7329 – 7338 .
  • Yanase , T and Fan , W . 2009 . Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma . Vitam Horm , 80 : 649 – 666 .
  • Wu , Y , Zhao , W , Zhao , J , Pan , J Wu , Q . 2007 . Identification of androgen response elements in the insulin-like growth factor I upstream promoter . Endocrinology , 148 : 2984 – 2993 .
  • Fujio , Y , Guo , K , Mano , T , Mitsuuchi , Y Testa , J R . 1999 . Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival . Mol Cell Biol , 19 : 5073 – 5082 .
  • Donovan , M J , Osman , I , Khan , F M , Vengrenyuk , Y Capodieci , P . 2010 . Androgen receptor expression is associated with prostate cancer-specific survival in castrate patients with metastatic disease . BJU Int , 105 : 462 – 467 .
  • Kojima , S , Inahara , M , Suzuki , H , Ichikawa , T and Furuya , Y . 2009 . Implications of insulin-like growth factor-I for prostate cancer therapies . Int J Urol , 16 : 161 – 167 .
  • Ghosh , P M , Malik , S , Bedolla , R and Kreisberg , J I . 2003 . Akt in prostate cancer: possible role in androgen-independence . Curr Drug Metab , 4 : 487 – 496 .
  • Plymate , S R , Tennant , M K , Culp , S H , Woodke , L Marcelli , M . 2004 . Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors . Prostate , 61 : 276 – 290 .
  • Lin , H K , Wang , L , Hu , Y C , Altuwaijri , S and Chang , C . 2002 . Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase . EMBO J , 21 : 4037 – 4048 .
  • Mikhailova , M , Wang , Y , Bedolla , R , Lu , X H Kreisberg , J I . 2008 . AKT regulates androgen receptor-dependent growth and PSA expression in prostate cancer . Adv Exp Med Biol , 617 : 397 – 405 .
  • Shi , X B , Ma , A H , Xia , L , Kung , H J and de Vere White , R W . 2002 . Functional analysis of 44 mutant androgen receptors from human prostate cancer . Cancer Res , 62 : 1496 – 1502 .
  • Zhao , X Y , Malloy , P J , Krishnan , A V , Swami , S Navone , N M . 2000 . Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor . Nat Med , 6 : 703 – 706 .
  • McDonald , S , Brive , L , Agus , D B , Scher , H I and Ely , K R . 2000 . Ligand responsiveness in human prostate cancer: structural analysis of mutant androgen recep- tors from LNCaP and CWR22 tumors . Cancer Res , 60 : 2317 – 2322 .
  • Tepper , C G , Boucher , D L , Ryan , P E , Ma , A H Xia , L . 2002 . Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line . Cancer Res , 62 : 6606 – 6614 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.