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Original Articles

Inhibition of IGF-1 Signaling by Genistein: Modulation of E-Cadherin Expression and Downregulation of β-Catenin Signaling in Hormone Refractory PC-3 Prostate Cancer Cells

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Pages 153-162 | Received 09 May 2010, Accepted 25 Aug 2011, Published online: 18 Nov 2011

REFERENCES

  • Debes , J D and Tindall , D J . 2004 . Mechanisms of androgen-refractory prostate cancer . N Engl J Med , 351 : 1488 – 1490 .
  • Schröder , F H . 2008 . Progress in understanding androgen-independent prostate cancer (AIPC): a review of potential endocrine-mediated mechanisms . Eur Urol , 53 : 1129 – 1137 .
  • Miyamoto , H , Messing , E M and Chang , C . 2004 . Androgen deprivation therapy for prostate cancer: current status and future prospects . Prostate , 61 : 332 – 353 .
  • Renehan , A G , Zwahlen , M , Minder , C , O’Dwyer , S T Shalet , S M . 2004 . Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis . Lancet , 363 : 346 – 353 .
  • Mauro , L , Salerno , M , Morelli , C , Boterberg , T Bracke , M E . 2003 . Role of the IGF-I receptor in the regulation of cell–cell adhesion: implications in cancer development and progression . J Cell Physiol , 194 : 108 – 116 .
  • Nelson , W J and Nusse , R . 2004 . Convergence of Wnt, beta-catenin, and cadherin pathways . Science , 5 : 1483 – 1487 .
  • Ozawa , M and Kemler , R . 1998 . Altered cell adhesion activity by pervanadate due to the dissociation of alpha-catenin from the E-cadherin.catenin complex . J Biol Chem , 273 : 6166 – 6170 .
  • Christofori , G and Semb , H . 1999 . The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene . Trends Biochem Sci , 24 : 73 – 76 .
  • Paul , R , Ewing , C M , Jarrard , D F and Isaacs , W B . 1997 . The cadherin cell–cell adhesion pathway in prostate cancer progression . Br J Urol , 79 ( Suppl 1 ) : 37 – 43 .
  • Playford , M P , Bicknell , D , Bodmer , W F and Macaulay , V M . 2000 . Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin . Proc Natl Acad Sci USA , 97 : 12103 – 12108 .
  • MacDonald , B T , Tamai , K and He , X . 2009 . Wnt/beta-catenin signaling: components, mechanisms, and diseases . Dev Cell , 17 : 9 – 26 .
  • Aberle , H , Bauer , A , Stappert , J , Kispert , A and Kemler , R . 1997 . Beta-catenin is a target for the ubiquitin-proteasome pathway . EMBO J , 16 : 3797 – 3804 .
  • Yost , C , Torres , M , Miller , J R , Huang , E Kimelman , D . 1996 . The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3 . Genes Dev , 10 : 1443 – 1454 .
  • Pollak , M N , Schernhammer , E S and Hankinson , S E . 2004 . Insulin-like growth factors and neoplasia . Nat Rev Cancer , 4 : 505 – 518 .
  • Hellawell , G O , Turner , G D , Davies , D R , Poulsom , R Brewster , S F . 2002 . Expression of the type 1 insulin-like growth factor receptor is upregulated in primary prostate cancer and commonly persists in metastatic disease . Cancer Res , 62 : 2942 – 2950 .
  • Krueckl , S L , Sikes , R A , Edlund , N M , Bell , R H Hurtado-Coll , A . 2004 . Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model . Cancer Res , 64 : 8620 – 8629 .
  • Nickerson , T , Chang , F , Lorimer , D , Smeekens , S P Sawyers , C L . 2001 . In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) . Cancer Res , 61 : 6276 – 6280 .
  • Perabo , F G , Von Low , E C , Ellinger , J , von Rucker , A Muller , S C . 2008 . Soy isoflavone genistein in prevention and treatment of prostate cancer . Prostat Cancer Prostatic Dis , 11 : 6 – 12 .
  • Baserga , R . 1995 . The insulin-like growth factor I receptor: a key to tumor growth? . Cancer Res , 55 : 249 – 252 .
  • Pandini , G , Mineo , R , Frasca , F , Roberts , C T Jr. Marcelli , M . 2005 . Androgens upregulate the insulin-like growth factor-I receptor in prostate cancer cells . Cancer Res , 65 : 1849 – 1857 .
  • Lee , L F , Guan , J , Qiu , Y and Kung , H J . 2001 . Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase . Mol Cell Biol , 21 : 8385 – 8397 .
  • Lee , L F , Louie , M C , Desai , S J , Yang , J Chen , H W . 2004 . Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK . Oncogene , 23 : 2197 – 2205 .
  • Unni , E , Sun , S , Nan , B , McPhaul , M J Cheskis , B . 2004 . Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence . Cancer Res , 64 : 7156 – 7168 .
  • Grimberg , A . 2003 . Mechanisms by which IGF-I may promote cancer . Cancer Biol Ther , 2 : 630 – 635 .
  • Bahr , C and Groner , B . 2005 . The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function . Growth Factors , 23 : 1 – 14 .
  • Jaggi , M , Johansson , S L , Baker , J J , Smith , L M Galich , A . 2005 . Aberrant expression of E-cadherin and beta-catenin in human prostate cancer . Urol Oncol , 23 : 402 – 406 .
  • Morita , N , Uemura , H , Tsumatani , K , Cho , M Hirao , Y . 1999 . E-cadherin and alpha-, beta-, and gamma-catenin expression in prostate cancers: correlation with tumour invasion . Br J Cancer , 79 : 1879 – 1883 .
  • Patriarca , C , Petrella , D , Campo , B , Colombo , P Giunta , P . 2003 . Elevated E-cadherin and alpha/beta-catenin expression after androgen deprivation therapy in prostate adenocarcinoma . Pathol Res Pract , 199 : 659 – 665 .
  • Nam , S , Kim , D , Cheng , J Q , Zhang , S Lee , J H . 2005 . Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells . Cancer Res , 65 : 9185 – 9199 .
  • Lilien , J , Balsamo , J , Arregui , C and Xu , G . 2002 . Turn-off, drop-out: functional state switching of cadherins . Dev Dyn , 224 : 18 – 29 .
  • Jamora , C and Fuchs , E . 2002 . Intercellular adhesion, signaling and the cytoskeleton . Nat Cell Biol , 4 : E101 – E108 .
  • Chen , H C , Chu , R Y , Hsu , P N , Hsu , P I Lu , J Y . 2003 . Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas . Cancer Lett , 201 : 97 – 106 .
  • Chesire , D R and Isaacs , W B . 2003 . Beta-catenin signaling in prostate cancer: an early perspective . Endocr Relat Cancer , 10 : 537 – 560 .
  • Umbas , R , Schalken , J A , Aalders , T W , Carter , B S Karthaus , H F . 1992 . Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer . Cancer Res , 52 : 5104 – 5109 .
  • Verras , M and Sun , Z . 2006 . Roles and regulation of Wnt signaling and beta-catenin in prostate cancer . Cancer Lett , 237 : 22 – 32 .
  • El Touny , L H and Banerjee , P P . 2007 . Akt–GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype . Carcinogenesis , 28 : 1710 – 1717 .
  • Wang , Y , Kreisberg , J I and Ghosh , P M . 2007 . Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer . Curr Cancer Drug Targets , 7 : 591 – 604 .
  • Adlercreutz , H , Markkanen , H and Watanabe , S . 1993 . Plasma concentrations of phyto-oestrogens in Japanese men . Lancet , 13 : 1209 – 1210 .
  • Uehar , M , Arai , Y , Watanabe , S and Adlercreutz , H . 2000 . Comparison of plasma and urinary phytoestrogens in Japanese and Finnish women by time-resolved fluoroimmunoassay . Biofactors , 12 : 217 – 225 .
  • Limer , J L , Parkes , A T and Speirs , V . 2006 . Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro . Int J Cancer , 119 : 515 – 521 .
  • Moore , A B , Castro , L , Yu , L , Zheng , X Di , X . 2007 . Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration . Hum Reprod , 22 : 2623 – 2631 .

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