Preventive Effects of Curcumin on the Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/db Obese Mice

REFERENCES

• Gunter , M J and Leitzmann , M F . 2006 . Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes . J Nutr Biochem , 17 : 145 – 156 .
   PubMed Web of Science ®Google Scholar
• Huang , X F and Chen , J Z . 2009 . Obesity, the PI3K/Akt signal pathway and colon cancer . Obes Rev , 10 : 610 – 616 .
   PubMed Web of Science ®Google Scholar
• Wei , E K , Giovannucci , E , Fuchs , C S , Willett , W C and Mantzoros , C S . 2005 . Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study . J Natl Cancer Inst , 97 : 1688 – 1694 .
   PubMed Web of Science ®Google Scholar
• Otake , S , Takeda , H , Suzuki , Y , Fukui , T Watanabe , S . 2005 . Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance . Clin Cancer Res , 11 : 3642 – 3646 .
   PubMed Web of Science ®Google Scholar
• Hirose , Y , Hata , K , Kuno , T , Yoshida , K Sakata , K . 2004 . Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice . Carcinogenesis , 25 : 821 – 825 .
   PubMed Web of Science ®Google Scholar
• Shimizu , M , Shirakami , Y , Sakai , H , Adachi , S Hata , K . 2008 . EGCG suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice . Cancer Prev Res , 1 : 298 – 304 .
   PubMed Web of Science ®Google Scholar
• Shimizu , M , Shirakami , Y , Iwasa , J , Shiraki , M Yasuda , Y . 2009 . Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice . Clin Cancer Res , 15 : 3068 – 3075 .
   PubMed Web of Science ®Google Scholar
• Yasuda , Y , Shimizu , M , Shirakami , Y , Sakai , H Kubota , M . 2010 . Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice . Cancer Sci , 101 : 1701 – 1707 .
   PubMed Web of Science ®Google Scholar
• Miyamoto , S , Yasui , Y , Tanaka , T , Ohigashi , H and Murakami , A . 2008 . Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice . Carcinogenesis , 29 : 1057 – 1063 .
   PubMed Web of Science ®Google Scholar
• Hotamisligil , G S , Shargill , N S and Spiegelman , B M . 1993 . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance . Science , 259 : 87 – 91 .
   PubMed Web of Science ®Google Scholar
• Szlosarek , P , Charles , K A and Balkwill , F R . 2006 . Tumour necrosis factor-alpha as a tumour promoter . Eur J Cancer , 42 : 745 – 750 .
   PubMed Web of Science ®Google Scholar
• Aggarwal , B B . 2010 . Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals . Annu Rev Nutr , 30 : 173 – 199 .
   PubMed Web of Science ®Google Scholar
• Aggarwal , B B and Harikumar , K B . 2009 . Potential therapeutic effects of curcumin, the antiinflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases . Int J Biochem Cell Biol , 41 : 40 – 59 .
   PubMed Web of Science ®Google Scholar
• Rao , C V . 2007 . Regulation of COX and LOX by curcumin . Adv Exp Med Biol , 595 : 213 – 226 .
   PubMed Web of Science ®Google Scholar
• Lee , Y K , Park , S Y , Kim , Y M and Park , O J . 2009 . Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells . Ann NY Acad Sci , 1171 : 489 – 494 .
   PubMed Web of Science ®Google Scholar
• Goel , A , Boland , C R and Chauhan , D P . 2001 . Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells . Cancer Lett , 172 : 111 – 118 .
   PubMed Web of Science ®Google Scholar
• Gupta , R A and Dubois , R N . 2001 . Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 . Nat Rev Cancer , 1 : 11 – 21 .
   PubMed Web of Science ®Google Scholar
• Hanai , H , Iida , T , Takeuchi , K , Watanabe , F Maruyama , Y . 2006 . Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial . Clin Gastroenterol Hepatol , 4 : 1502 – 1506 .
   PubMed Web of Science ®Google Scholar
• Camacho-Barquero , L , Villegas , I , Sanchez-Calvo , J M , Talero , E Sanchez-Fidalgo , S . 2007 . Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis . Int Immunopharmacol , 7 : 333 – 342 .
   PubMed Web of Science ®Google Scholar
• Weisberg , S P , Leibel , R and Tortoriello , D V . 2008 . Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity . Endocrinology , 149 : 3549 – 3558 .
   PubMed Web of Science ®Google Scholar
• Jain , S K , Rains , J , Croad , J , Larson , B and Jones , K . 2009 . Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats . Antioxid Redox Signal , 11 : 241 – 249 .
   PubMed Web of Science ®Google Scholar
• Bird , R P and Good , C K . 2000 . The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer . Toxicol Lett , 112–113 : 395 – 402 .
   PubMed Web of Science ®Google Scholar
• Yamada , Y and Mori , H . 2003 . Precancerous lesions for colorectal cancers in rodents: a new concept . Carcinogenesis , 24 : 1015 – 1019 .
   PubMed Web of Science ®Google Scholar
• Perkins , S , Verschoyle , R D , Hill , K , Parveen , I Threadgill , M D . 2002 . Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis . Cancer Epidemiol Biomarkers Prev , 11 : 535 – 540 .
   PubMed Web of Science ®Google Scholar
• Larmonier , C B , Uno , J K , Lee , K M , Karrasch , T Laubitz , D . 2008 . Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection . Am J Physiol Gastrointest Liver Physiol , 295 : G1079 – G1091 .
   PubMed Web of Science ®Google Scholar
• Wu , K K . 2005 . Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators . Prostaglandins Leukot Essent Fatty Acids , 72 : 89 – 93 .
   PubMed Web of Science ®Google Scholar
• Plummer , S M , Holloway , K A , Manson , M M , Munks , R J Kaptein , A . 1999 . Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signaling complex . Oncogene , 18 : 6013 – 6020 .
   PubMed Web of Science ®Google Scholar
• Fay , J R , Steele , V and Crowell , J A . 2009 . Energy homeostasis and cancer prevention: the AMP-activated protein kinase . Cancer Prev Res , 2 : 301 – 309 .
   PubMed Web of Science ®Google Scholar
• Buzzai , M , Jones , R G , Amaravadi , R K , Lum , J J DeBerardinis , R J . 2007 . Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth . Cancer Res , 67 : 6745 – 6752 .
   PubMed Web of Science ®Google Scholar
• Zakikhani , M , Dowling , R J , Sonenberg , N and Pollak , M N . 2008 . The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase . Cancer Prev Res , 1 : 369 – 375 .
   PubMed Web of Science ®Google Scholar
• Ouchi , N and Walsh , K . 2007 . Adiponectin as an antiinflammatory factor . Clin Chim Acta , 380 : 24 – 30 .
   PubMed Web of Science ®Google Scholar
• Kim , A Y , Lee , Y S , Kim , K H , Lee , J H Lee , H K . 2010 . Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation . Mol Endocrinol , 24 : 1441 – 1452 .
   PubMed Web of Science ®Google Scholar
• Fujisawa , T , Endo , H , Tomimoto , A , Sugiyama , M Takahashi , H . 2008 . Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition . Gut , 57 : 1531 – 1538 .
   PubMed Web of Science ®Google Scholar
• Hardwick , J C , Van Den Brink , G R , Offerhaus , G J , Van Deventer , S J and Peppelenbosch , M P . 2001 . Leptin is a growth factor for colonic epithelial cells . Gastroenterology , 121 : 79 – 90 .
   PubMed Web of Science ®Google Scholar
• Jaffe , T and Schwartz , B . 2008 . Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways . Int J Cancer , 123 : 2543 – 2556 .
   PubMed Web of Science ®Google Scholar
• Sharma , R A , Euden , S A , Platton , S L , Cooke , D N Shafayat , A . 2004 . Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance . Clin Cancer Res , 10 : 6847 – 6854 .
   PubMed Web of Science ®Google Scholar
• Garcea , G , Berry , D P , Jones , D J , Singh , R Dennison , A R . 2005 . Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences . Cancer Epidemiol Biomarkers Prev , 14 : 120 – 125 .
   PubMed Web of Science ®Google Scholar