714
Views
178
CrossRef citations to date
0
Altmetric
Original Articles

Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

, , , , , & show all
Pages 393-400 | Received 27 Dec 2010, Accepted 17 Nov 2011, Published online: 14 Feb 2012

REFERENCES

  • Subbaramaiah , K , Chung , W J , Michaluart , P , Telang , N and Tanabe , T . 1998 . Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells . J Biol Chem , 273 : 21875 – 21882 . et al.
  • Roberti , M , Pizzirani , D , Simoni , D , Rondanin , R and Baruchello , R . 2003 . Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents . J Med Chem , 46 : 3546 – 3554 . et al.
  • Mgbonyebi , O P , Russo , J and Russo , I H . 1998 . Antiproliferative effect of synthetic resveratrol on human breast epithelial cells . Int J Oncol , 12 : 865 – 869 .
  • Jang , M , Cai , L , Udeani , G O , Slowing , K V and Thomas , C F . 1997 . Cancer chemopreventive activity of resveratrol, a natural product derived from grapes . Science , 275 : 218 – 220 . et al.
  • Banerjee , S , Bueso-Ramos , C and Aggarwal , B B . 2002 . Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9 . Cancer Res , 62 : 4945 – 4954 .
  • Levi , F , Pasche , C , Lucchini , F , Ghidoni , R and Ferraroni , M . 2005 . Resveratrol and breast cancer risk . Eur J Cancer Prev , 14 : 139 – 142 . et al.
  • Widschwendter , M and Jones , P A . 2002 . DNA methylation and breast carcinogenesis . Oncogene , 21 : 5462 – 5482 .
  • Qin , W , Zhu , W , Shi , H , Hewett , J E and Ruhlen , R L . 2009 . Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women . Nutr Cancer , 61 : 238 – 244 . et al.
  • Bestor , T H . 2000 . The DNA methyltransferases of mammals . Hum Mol Genet , 9 : 2395 – 2402 .
  • Leu , Y W , Rahmatpanah , F , Shi , H , Wei , S H and Liu , J C . 2003 . Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation . Cancer Res , 63 : 6110 – 6115 . et al.
  • Rhee , I , Bachman , K E , Park , B H , Jair , K W and Yen , R W . 2002 . DNMT1 and DNMT3b cooperate to silence genes in human cancer cells . Nature , 416 ( 6880 ) : 552 – 556 . et al.
  • Qin , W , Zhu , W and Sauter , E R . 2005 . Resveratrol induced DNA methylation in ER+ breast cancer . Proc Am Assn Cancer Res , 96 : 2750A
  • Walle , T , Hsieh , F , DeLegge , M H and Oatis , J E Jr . 2004 . and Walle UK: High absorption but very low bioavailability of oral resveratrol in humans . Drug Metab Dispos , 32 : 1377 – 1382 .
  • de la Lastra , C A and Villegas , I . 2005 . Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications . Mol Nutr Food Res , 49 : 405 – 430 .
  • Rowland , I , Faughnan , M , Hoey , L , Wahala , K and Williamson , G . 2003 . Bioavailability of phyto-oestrogens . Br J Nutr , 89 ( Suppl 1 ) : S45 – S58 . et al.
  • Jannin , B , Menzel , M , Berlot , J P , Delmas , D and Lancon , A . 2004 . Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake . Biochem Pharmacol , 68 : 1113 – 1118 . et al.
  • Wang , L X , Heredia , A , Song , H , Zhang , Z and Yu , B . 2004 . Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity . J Pharm Sci , 93 : 2448 – 2457 . et al.
  • Santner , S J , Feil , P D and Santen , R J . 1984 . In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway . J Clin Endocrinol Metab , 59 : 29 – 33 .
  • Signorelli , P and Ghidoni , R . 2005 . Resveratrol as an anticancer nutrient: molecular basis, open questions and promises . J Nutr Biochem , 16 : 449 – 466 .
  • Colin , D , Lancon , A , Delmas , D , Lizard , G and Abrossinow , J . 2008 . Antiproliferative activities of resveratrol and related compounds in human hepatocyte derived HepG2 cells are associated with biochemical cell disturbance revealed by fluorescence analyses . Biochimie , 90 : 1674 – 1684 . et al.
  • Delmas , D , Lancon , A , Colin , D , Jannin , B and Latruffe , N . 2006 . Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer . Curr Drug Targets , 7 : 423 – 442 .
  • Zhu , W , Qin , W , Hewett , J E and Sauter , E R . 2010 . Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids . Int J Cancer , 126 : 474 – 482 .
  • Van der Auwera , I , Van Laere , S J , Van den Bosch , S M , Van den Eynden , G G and Trinh , B X . 2008 . Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype . Br J Cancer , 99 : 1735 – 1742 . et al.
  • Sheng , H , Shao , J , Morrow , J D , Beauchamp , R D and DuBois , R N . 1998 . Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells . Cancer Res , 58 : 362 – 366 .
  • Masferrer , J L , Leahy , K M , Koki , A T , Zweifel , B S and Settle , S L . 2000 . Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors . Cancer Res , 60 : 1306 – 1311 . et al.
  • Fulton , A M , Gimotty , P , Alonsozana , E , Dorsey , R and Kundu , N . 2000 . Elevated prostaglandin E2 (PGE2) levels in human breast cancer are associated with poor long-term survival . Proc Am Assn Cancer Res , 41 : 3660A
  • Chachay , V S , Kirkpatrick , C M , Hickman , I J , Ferguson , M and Prins , J B . 2011 . Resveratrol: pills to replace a healthy diet? . Br J Clin Pharmacol , 72 : 27 – 38 . et al.
  • Sauter , E R , Daly , M , Linahan , K , Ehya , H and Engstrom , P F . 1996 . Prostate-specific antigen levels in nipple aspirate fluid correlate with breast cancer risk . Cancer Epidemiol Biomarkers Prev , 5 : 967 – 970 . et al.
  • Sauter , E R , Ehya , H , Klein-Szanto , A J , Wagner-Mann , C and MacGibbon , B . 2005 . Fiberoptic ductoscopy findings in women with and without spontaneous nipple discharge . Cancer , 103 : 914 – 921 .
  • Gustafson , K S , Furth , E E , Heitjan , D F , Fansler , Z B and Clark , D P . 2004 . DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis . Cancer , 102 : 259 – 268 .
  • House , M G , Guo , M , Iacobuzio-Donahue , C and Herman , J G . 2003 . Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas . Carcinogenesis , 24 : 193 – 198 .
  • Fackler , M J , McVeigh , M , Mehrotra , J , Blum , M A and Lange , J . 2004 . Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer . Cancer Res , 64 : 4442 – 4452 . et al.
  • Wang , D , Hang , T , Wu , C and Liu , W . 2005 . Identification of the major metabolites of resveratrol in rat urine by HPLC-MS/MS . J Chromatogr B Analyt Technol Biomed Life Sci , 829 : 97 – 106 .
  • Yu , C , Shin , Y G , Chow , A , Li , Y and Kosmeder , J W . 2002 . Human, rat, and mouse metabolism of resveratrol . Pharm Res , 19 : 1907 – 1914 . et al.
  • Sauter , E R , Qin , W , Schlatter , L , Hewett , J E and Flynn , J T . 2006 . Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer . BMC Cancer ,
  • Delmas , D , Aires , V , Limagne , E , Dutartre , P and Mazue , F . 2011 . Transport, stability, and biological activity of resveratrol . Ann NY Acad Sci , 1215 : 48 – 59 . et al.
  • Patel , K R , Brown , V A , Jones , D J , Britton , R G and Hemingway , D . 2010 . Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients . Cancer Res , 70 : 7392 – 7399 . et al.
  • Rodrigo , R , Miranda , A and Vergara , L . 2011 . Modulation of endogenous antioxidant system by wine polyphenols in human disease . Clin Chim Acta , 412 : 410 – 424 .
  • Murias , M , Handler , N , Erker , T , Pleban , K and Ecker , G . 2004 . Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship . Bioorg Med Chem , 12 : 5571 – 5578 . et al.
  • Dave , M , Attur , M , Palmer , G , Al-Mussawir , H E and Kennish , L . 2008 . The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production . Arthritis Rheum , 58 : 2786 – 2797 . et al.
  • Juan , M E , Maijo , M and Planas , J M . 2010 . Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC . J Pharm Biomed Anal , 51 : 391 – 398 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.