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Original Articles

Quercetin Attenuates TNF-Induced Inflammation in Hepatic Cells by Inhibiting the NF-κB Pathway

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Pages 588-598 | Received 06 Jun 2011, Accepted 23 Jan 2012, Published online: 27 Mar 2012

REFERENCES

  • Ramos , S . 2008 . Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways . Mol Nutr Food Res , 52 : 507 – 526 .
  • Spencer , J , Chowrimootoo , G , Choudhury , R , Debnam , E Srai , S . 1999 . The small intestine can both absorb and glucuronidate luminal flavonoids . FEBS Lett , 458 : 224 – 230 .
  • Alía , M , Ramos , S , Mateos , R , Granado-Serrano , A Bravo , L . 2006 . Quercetin protects human hepatoma cell line (HepG2) against oxidative stress induced by tertbutyl hydroperoxide . Toxicol Appl Pharmacol , 212 : 110 – 118 .
  • Granado-Serrano , A , Martín , M , Bravo , L , Goya , L and Ramos , S . 2006 . Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-Kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2) . J Nutr , 136 : 2715 – 2721 .
  • Granado-Serrano , A , Martin , M , Bravo , L , Goya , L and Ramos , S . 2008 . Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells . Mol Nutr Food Res , 52 : 457 – 464 .
  • Granado-Serrano , A , Martin , M , Bravo , L , Goya , L and Ramos , S . 2010 . Quercetin modulates NF-κ B and AP-1/JNK pathways to induce cell death in human hepatoma cells . Nutr Cancer , 62 : 390 – 401 .
  • Garcia-Mediavilla , V , Crespo , I , Collado , P , Esteller , A Sanchez-Campos , S . 2007 . The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and relative C-protein, and downregulation of the nuclear factor-kappaB pathway in Chang liver cells . Eur J Pharmacol , 557 : 221 – 229 .
  • Hämäläinen , M , Nieminen , R , Vuorela , P , Heinonen , M and Moilanen , E . 2007 . Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages . Mediators Inflammation , doi:10.1155/2007/45673
  • Martinez-Florez , S , Gutierrez-Fernandez , B , Sanchez-Campos , S , Gonzalez-Gallego , J and Tuñon , M . 2005 . Quercetin attenuates nuclear factor-kB activation and nitric oxide production in interleukin-1b-activated rat hepatocyte . J Nutr , 135 : 1359 – 1365 .
  • Ruiz , P A , Braune , A , Hölzlwimmer , G , Quintanilla-Fend , L and Haller , D . 2007 . Quercetin inhibits TNF-induced NF-kB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . J Nutr , 137 : 1208 – 1215 .
  • Pan , M-H , Lai , C-S and Ho , C-T . 2010 . Anti-inflammatory activity of natural dietary flavonoids . Food Funct , doi: 10.1039/c0fo00103a
  • Muriel , P . 2009 . NF-kB in liver diseases: a target for drug therapy . J Appl Toxicol , 29 : 91 – 100 .
  • Naugler , W and Karin , M . 2008 . NF-kB and cancer-identifying targets and mechanisms . Curr Opin Gen Dev , 18 : 1 – 8 .
  • Guo , W , Kong , E H and Meydani , M . 2009 . Dietary polypheols, inflammation and cancer . Nutr Cancer , 61 : 807 – 810 .
  • Balkwill , F . 2006 . TNF-alpha in promotion and progression of cancer . Cancer Metastasis Rev , 25 : 409 – 416 .
  • Bishayee , A , Waghray , A , Barnes , K F , Mbimba , T Bhatia , D . 2010 . Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis . Pharm Res , 27 : 1080 – 1091 .
  • Wu , T . 2006 . Cyclooxygenase-2 in hepatocellular carcinoma . Cancer Treat Rev , 32 : 28 – 44 .
  • Gloire , G , Legrand-Poels , S and Piette , J . 2006 . NF-kB activation by reactive oxygen species: fifteen years later . Biochem Pharmacol , 72 : 1493 – 1505 .
  • Musonda , C and Chipman , J . 1998 . Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kB DNA binding activity and DNA damage in HepG2 cells . Carcinogenesis , 19 : 1583 – 1589 .
  • Ramiro , E , Franch , A , Castellote , C , Pérez-Cano , F Permanyer , J . 2005 . Flavonoids from Theobroma cacao downregulate inflammatory mediators . J Agric Food Chem , 53 : 8506 – 8511 .
  • Zafra-Stone , S , Yasmin , T , Bagchi , M , Chatterjee , A Vinson , J A . 2007 . Berry anthocyanins as novel antioxidants in human health and disease prevention . Mol Nutr Food Res , 51 : 675 – 683 .
  • Umesalma , S and Sudhandiran , G . 2010 . Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis . Basic Clin Pharmacol Toxicol , 107 : 650 – 655 .
  • Rangan , G K , Wang , Y and Harris , D C . 2002 . Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease . Nephron , 90 : 313 – 319 .
  • Granado-Serrano , A , Marin , M A , Haegeman , G , Goya , L Bravo , L . 2010 . Epicatechin induces NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells . Br J Nutr , 103 : 168 – 179 .
  • Sethi , G , Sung , B and Aggarwal , B . 2008 . Nuclear factor-kB activation: from bench to bedside . Exp Biol Med , 233 : 21 – 31 .
  • Kim , B H , Cho , S M , Reddy , A M , Kim , Y S Min , K R . 2005 . Downregulatory effect of quercitrin gallate on nuclear factor-κB-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7 . Biochem Pharmacol , 69 : 1577 – 1583 .
  • Pang , J L , Ricupero , D A , Huang , S , Fatma , N Sing , D P . 2006 . Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells . Biochem Pharmacol , 71 : 818 – 826 .
  • Balstad , T R , Paur , I , Poulsen , M , Markowski , J Kolodziejczyk , K . 2010 . Apple, cherry, and blackcurrant increases nuclear factor kappa B activation in liver of transgenic mice . Nutr Cancer , 62 : 841 – 848 .
  • Comalada , M , Camuesco , D , Sierra , S , Ballester , I Xaus , J . 2005 . In vivo quercitrin anti-inflammatory effect involves releases of quercetin, which inhibits inflammation through downregulation of NF-kappaB pathway . Eur J Immunol , 35 : 584 – 592 .
  • Murphy , A , Davis , J M , McClellan , J L and Carmichael , M D . 2011 . Quercetin's effects on intestinal polyp multiplicity and macrophage number in the ApcMin/+ mouse . Nutr Cancer , 63 : 421 – 426 .
  • Nair , M P , Mahajan , S , Reynolds , J L , Aalinkeel , R Nair , H . 2006 . The flavonoid quercetin inhibits proinflammatory cytokine (Tumor necrosis factor alpha) gene expression in normal peripheral mononuclear cells via modulation of the NF-κB system . Clin Vaccine Immunol , 13 : 319 – 328 .
  • Alia , M , Mateos , R , Ramos , S , Lecumberri , E Bravo , L . 2006 . Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2) . Eur J Nutr , 45 : 19 – 28 .
  • Trombetta , D , Cimino , F , Cristiani , M T , Mandalari , G Saija , A . 2010 . In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-alpha (TNF-alpha) . J Agric Food Chem , 58 : 8430 – 8436 .
  • Chun , K-S and Surh , Y-J . 2004 . Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention . Biochem Pharmacol , 68 : 1089 – 1100 .
  • Crespo , I , García-Mediavilla , V , Gutierrez , B , Sanchez-Campos , S Tuñon , M J . 2008 . A comparison of the effects of kaempferol and quercetin on cytokine-induced proinflammatory status of cultured human endothelial cells . Br J Nutr , 100 : 968 – 976 .
  • Lai , C-S , Lee , J-H , Ho , C-T , Liu , C B Wang , J-M . 2009 . Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through dowregulating MAPK, NF-kB, STAT3 and C/EBP signaling pathways . J Agric Food Chem , 57 : 10990 – 10998 .
  • Ying , B , Yang , T , Song , X , Hu , X Fan , H . 2009 . Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A459 through MAPK pathway . Mol Biol Rep , 36 : 1825 – 1832 .
  • Chen , F , Demers , L M , Vallyathan , V , Ding , M Lu , Y . 1999 . Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages . J Biol Chem , 274 : 20307 – 20312 .
  • Vanden Berghe , W , Plaisance , S , Boone , E , De Boscher , K Schmitz , M L . 1998 . p38 and extrcellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor . J Biol Chem , 273 : 3285 – 3290 .
  • Granado-Serrano , A B and Ramos , S . 2010 . Molecular targets of quercetin in cancer chemoprevention . CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources , 5 : 35 (doi: 10.1079/ PAVSNNR20105035)
  • Manach , C , Williamson , G , Morand , C , Scalbert , A and Rémésy , C . 2005 . Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies . Am J Clin Nutr , 81 ( Suppl ) : 230S – 242S .

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