Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats

REFERENCES

• 2010 . Cancer Facts and Figures , Accessed October 15, 2010 at http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/most-requested-tables-figures-2010
   Google Scholar
• Henderson , B E , Kolonel , L N , Dworsky , R and Al , E . 1984 . Cancer incidence in the islands of the Pacific . Fourth Symposium on Epidemiology and Cancer Registries in the Pacific Basin , 69 : 73 – 81 .
   Google Scholar
• Tuomilehto , J , Zimmet , P , Taylor , R , Bennet , P Wolf , E . 1986 . Smoking rates in Pacific islands . Bull World Health Org , 64 : 447 – 456 .
   Web of Science ®Google Scholar
• Le Marchand , L , Hankin , J H , Bach , F , Kolonel , L N Wilkens , L R . 1995 . An ecological study of diet and lung cancer in the South Pacific . Int J Cancer , 63 : 18 – 23 .
   Web of Science ®Google Scholar
• Steiner , G G . 2000 . The correlation between cancer incidence and kava consumption . Hawaii Med J , 59 : 420 – 422 .
   PubMedGoogle Scholar
• Mathews , J M , Etheridge , A S and Black , S R . 2002 . Inhibition of human cytochrome P450 activities by kava extract and kavalactones . Drug Metab Dispos , 30 : 1153 – 1157 .
   PubMed Web of Science ®Google Scholar
• Anke , J and Ramzan , I . 2004 . Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.) . J Ethnopharmacol , 93 : 153 – 160 .
   PubMed Web of Science ®Google Scholar
• Russmann , S , Lauterburg , B H , Barguil , Y , Choblet , E Cabalion , P . 2005 . Traditional aqueous kava extracts inhibit cytochrome P450 1A2 in humans: protective effect against environmental carcinogens? . Clin Pharmacol Ther , 77 : 453 – 454 .
   PubMed Web of Science ®Google Scholar
• Wu , D , Nair , M G and DeWitt , D L . 2002 . Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme . J Agric Food Chem , 50 : 701 – 705 .
   Web of Science ®Google Scholar
• Hashimoto , T , Suganuma , M , Fujiki , H , Yamada , M Kohno , T . 2003 . Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum) . Phytomedicine , 10 : 309 – 317 .
   Web of Science ®Google Scholar
• Folmer , F , Blasius , R , Morceau , F , Tabudravu , J Dicato , M . 2006 . Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives . Biochem Pharmacol , 71 : 1206 – 1218 .
   PubMed Web of Science ®Google Scholar
• Brown , J R and DuBois , R N . 2005 . COX-2: a molecular target for colorectal cancer prevention . J Clin Oncol , 23 : 2840 – 2855 .
   PubMed Web of Science ®Google Scholar
• Sinicrope , F A . 2006 . Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer . Mol Carcinog , 45 : 447 – 454 .
   PubMed Web of Science ®Google Scholar
• Stevinson , C , Huntley , A and Ernst , E . 2002 . A systematic review of the safety of kava extract in the treatment of anxiety . Drug Saf , 25 : 251 – 261 .
   PubMed Web of Science ®Google Scholar
• Pittler , M H and Ernst , E . 2003 . Kava extract for treating anxiety . Cochrane Database Syst Rev , : CD003383
   Google Scholar
• Russmann , S , Barguil , Y , Cabalion , P , Kritsanida , M Duhet , D . 2003 . Hepatic injury due to traditional aqueous extracts of kava root in New Caledonia . Eur J Gastroenterol Hepatol , 15 : 1033 – 1036 .
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration . Consumer Advisory: Kava-Containing Dietary Supplements May Be Associated With Severe Liver Injury Accessed February 19, 2012 from http://www.fda.gov/Food/ResourcesForYou/Consumers/ucm085482.htm
   Google Scholar
• Hapke , H J , Sterner , W , Heisler , E and Brauer , H . 1971 . Toxicological studies with Kavaform . Farmaco Prat , 26 : 692 – 720 .
   Google Scholar
• Sorrentino , L , Capasso , A and Schmidt , M . 2006 . Safety of ethanolic kava extract: results of a study of chronic toxicity in rats . Phytomedicine , 13 : 542 – 549 .
   PubMed Web of Science ®Google Scholar
• Behl , M , Nyska , A , Chhabra , R S , Travlos , G S Fomby , L M . 2011 . Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava . Food Chem Toxicol , 49 : 2820 – 2829 .
   PubMed Web of Science ®Google Scholar
• Reeves , P G , Nielsen , F H and Fahey , G C Jr. 1993 . AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet . J Nutr , 123 : 1939 – 1951 .
   PubMed Web of Science ®Google Scholar
• Kule’a Farm Kava Co . Traditional Kava Kava . Accessed February 23 2006, http://www.kickbackwithkava.com/kava_recipes.htm
   Google Scholar
• Bird , R P . 1987 . Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings . Cancer Lett , 37 : 147 – 151 .
   PubMed Web of Science ®Google Scholar
• Caderni , G , Giannini , A , Lancioni , L , Luceri , C Biggeri , A . 1995 . Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis . Br J Cancer , 71 : 763 – 769 .
   PubMed Web of Science ®Google Scholar
• Filipe , M I . 1975 . Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: a morphological and histochemical study . Br J Cancer , 32 : 60 – 77 .
   PubMed Web of Science ®Google Scholar
• Jenab , M , Chen , J and Thompson , L U . 2001 . Sialomucin production in aberrant crypt foci relates to degree of dysplasia and rate of cell proliferation . Cancer Lett , 165 : 19 – 25 .
   PubMed Web of Science ®Google Scholar
• Uchida , K , Kado , S , Ando , M , Nagata , Y Takagi , A . 2001 . A mucinous histochemical study on malignancy of aberrant crypt foci (ACF) in rat colon . J Vet Med Sci , 63 : 145 – 149 .
   PubMed Web of Science ®Google Scholar
• Shaik , A A , Hermanson , D L and Xing , C . 2009 . Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity . Bioorg Med Chem Lett , 19 : 5732 – 5736 .
   Web of Science ®Google Scholar
• Johnson , T E , Kassie , F , O’Sullivan , M G , Negia , M Hanson , T E . 2008 . Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice . Cancer Prev Res , 1 : 430 – 438 .
   PubMed Web of Science ®Google Scholar
• Carter , J W , Lancaster , H K , Hardman , W E and Cameron , I L . 1994 . Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice . Cancer Res , 54 : 4304 – 4307 .
   PubMed Web of Science ®Google Scholar
• Raju , J . 2008 . Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer . World J Gastroenterol , 14 : 6632 – 6635 .
   PubMed Web of Science ®Google Scholar
• Papanikolaou , A , Wang , Q S , Papanikolaou , D , Whiteley , H E and Rosenberg , D W . 2000 . Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis . Carcinogenesis , 21 : 1567 – 1572 .
   PubMed Web of Science ®Google Scholar
• Takayama , T , Ohi , M , Hayashi , T , Miyanishi , K Nobuoka , A . 2001 . Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis . Gastroenterology , 121 : 599 – 611 .
   PubMed Web of Science ®Google Scholar
• Filipe , M I . 1975 . Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: a morphological and histochemical study . Br J Cancer , 32 : 60 – 77 .
   PubMed Web of Science ®Google Scholar
• Klurfeld , D M , Weber , M M and Kritchevsky , D . 1987 . Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat . Cancer Res , 47 : 2759 – 2762 .
   PubMed Web of Science ®Google Scholar
• Lasko , C M and Bird , R P . 1995 . Modulation of aberrant crypt foci by dietary fat and caloric restriction: the effects of delayed intervention . Cancer Epidemiol Biomarkers Prev , 4 : 49 – 55 .
   PubMed Web of Science ®Google Scholar
• Lasko , C M , Good , C K , Adam , J and Bird , R P . 1999 . Energy restriction modulates the development of advanced preneoplastic lesions depending on the level of fat in the diet . Nutr Cancer , 33 : 69 – 75 .
   PubMed Web of Science ®Google Scholar
• Yoshimi , N , Morioka , T , Kinjo , T , Inamine , M Kaneshiro , T . 2004 . Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride . Cancer Sci , 95 : 792 – 797 .
   PubMed Web of Science ®Google Scholar
• Rao , C V , Indranie , C , Simi , B , Manning , P T Connor , J R . 2002 . Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor . Cancer Res , 62 : 165 – 170 .
   PubMed Web of Science ®Google Scholar
• Kirana , C , McIntosh , G H , Record , I R and Jones , G P . 2003 . Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone . Nutr Cancer , 45 : 218 – 225 .
   PubMed Web of Science ®Google Scholar
• Li , W , Wanibuchi , H , Salim , E I , Wei , M Yamamoto , S . 2000 . Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon . Nutr Cancer , 36 : 66 – 73 .
   PubMed Web of Science ®Google Scholar
• Roncucci , L , Pedroni , M , Vaccina , F , Benatti , P Marzona , L . 2000 . Aberrant crypt foci in colorectal carcinogenesis: cell and crypt dynamics . Cell Prolif , 33 : 1 – 18 .
   Web of Science ®Google Scholar
• Caderni , G , Femia , A P , Giannini , A , Favuzza , A Luceri , C . 2003 . Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis . Cancer Res , 63 : 2388 – 2392 .
   PubMed Web of Science ®Google Scholar
• Femia , A P , Bendinelli , B , Giannini , A , Salvadori , M Pinzani , P . 2005 . Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats . Int J Cancer , 116 : 9 – 15 .
   PubMed Web of Science ®Google Scholar
• Arikawa , A Y and Gallaher , D D . 2008 . Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats . J Nutr , 138 : 526 – 532 .
   Web of Science ®Google Scholar
• Pierre , F , Freeman , A , Tache , S , Van der Meer , R and Corpet , D E . 2004 . Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons . J Nutr , 134 : 2711 – 2716 .
   PubMed Web of Science ®Google Scholar
• Sakano , K , Takahashi , M , Kitano , M , Sugimura , T and Wakabayashi , K . 2006 . Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats . Asian Pac J Cancer Prev , 7 : 599 – 603 .
   PubMedGoogle Scholar
• Sohn , O S , Ishizaki , H , Yang , C S and Fiala , E S . 1991 . Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1 . Carcinogenesis , 12 : 127 – 131 .
   PubMed Web of Science ®Google Scholar
• Sohn , O S , Fiala , E S , Requeijo , S P , Weisburger , J H and Gonzalez , F J . 2001 . Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol . Cancer Res , 61 : 8435 – 8440 .
   PubMed Web of Science ®Google Scholar
• Rizzo , A , Pallone , F , Monteleone , G and Fantini , M C . 2011 . Intestinal inflammation and colorectal cancer: a double-edged sword? . World J Gastroenterol , 17 : 3092 – 3100 .
   PubMed Web of Science ®Google Scholar