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Original Articles

Plasma Fatty Acid Composition in Patients with Pancreatic Cancer: Correlations to Clinical Parameters

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Pages 946-955 | Received 15 Dec 2011, Accepted 11 Jul 2012, Published online: 12 Oct 2012

REFERENCES

  • Jemal , A , Siegel , R , Xu , J and Ward , E . 2010 . Cancer Statistics. 2010 . CA Cancer J Clin , 60, : 277 – 300 .
  • Institute of Health Information and Statistics of the Czech Republic and Council of the National Oncological Registry of the Czech Republic . 2012 . Cancer Incidence 2009 , Prague , , Czech Republic : ÚZIS CR and NOR ČR .
  • Welsch , T , Kleeff , J , Seitz , H K , Büchler , P Friess , H . 2006 . Update on pancreatic cancer and alcohol-associated risk . J Gastroenterol Hepatol , 21, : S69 – S75 .
  • Maitra , A and Hruban , R H . 2008 . Pancreatic cancer . Annu Rev Pathol , 3, : 157 – 188 .
  • Koorstra , J-BM , Hustinx , S R , Offerhaus , G JA and Maitra , A . 2008 . Pancreatic carcinogenesis . Pancreatology , 8, : 110 – 125 .
  • Klapman , J and Malafa , M P . 2008 . Early detection of pancreatic cancer: why, who, and how to screen . Cancer Control , 15, : 280 – 287 .
  • Vilamachandran , D , Ghaneh , P , Costello , E and Neoptolemos , J P . 2004 . Genetics and prevention of pancreatic cancer . Cancer Control , 11, : 6 – 14 .
  • Hassan , M M , Bondy , M L , Wolff , R A , Abbruzzese , J L Vauthey , J N . 2007 . Risk factors for pancreatic cancer: case-control study . Am J Gastroenterol , 102, : 2696 – 2707 .
  • Krechler , T , Jachymova , M , Pavlikova , M , Vecka , M Zeman , M . 2009 . Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: a pilot study . Neoplasma , 56, : 26 – 32 .
  • Fernandez-del Castillo , C and Jimenez , R E . 2002 . “ Pancreatic cancer, cystic pancreatic neoplasms, and other non-endocrine pancreatic tumors ” . In Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, , 7th ed , Edited by: Feldman , M , Friedman , L S and Sleisinger , M H . 970 – 987 . Philadelphia : WB. Saunders Company .
  • van den Brandt , P A and Goldbohm , R A . 2006 . Nutrition in the prevention of gastrointestinal cancer . Best Pract Res Clin Gastroenter , 20, : 589 – 603 .
  • Harris , D M , Champaneria , M. and Go , V LW . 2006 . “ Pancreatic Cancer ” . In Nutritional Oncology, , 2nd ed , Edited by: Heber , D , Blackburn , G L and Milner , J A . 449 – 473 . San Diego , CA : Academic Press .
  • Vigneri , P , Frasca , F , Sciacca , L , Pandini , G and Vignery , R . 2009 . Diabetes and cancer . Endocr Relat Cancer , 16, : 1103 – 1123 .
  • Riccardi , G , Giacco , R and Rivellese , A A . 2004 . Dietary fat, insulin sensitivity and the metabolic syndrome . Clin Nutr , 23, : 447 – 456 .
  • Semenkovich , C F , Coleman , T and Fiedorek , F T Jr . 1995 . Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetic decay after glucose deprivation . J Lipid Res , 36, : 1507 – 1521 .
  • Lupu , R and Menendez , J A . 2006 . Targeting fatty acid synthase in breast and endometrial cancer: an alternative to selective estrogen receptor modulators? . Endocrinology , 147, : 4056 – 4066 .
  • Flowers , M T and Ntambi , J M . 2008 . Role of Stearoyl-Coenzyme A desaturase in regulating lipid metabolism . Curr Opin Lipidol , 19, : 248 – 256 .
  • Howe , G R and Burch , J D . 1996 . Nutrition and pancreatic cancer . Cancer Causes Control , 7, : 69 – 82 .
  • Stolzenberg-Solomon , R Z , Pietinen , P , Taylor , P R , Virtamo , J and Albanes , D . 2002 . Prospective study of diet and pancreatic cancer in male smokers . Am J Epidemiol , 155, : 783 – 792 .
  • Thiebaut , A CM , Jiao , L , Silverman , D T , Gross , A J Thompson , F E . 2009 . Dietary fatty acids and pancreatic cancer in the NIH-AARP Diet and Health Study . J Natl Cancer Inst , 101, : 1001 – 1011 .
  • Nkondjock , A , Krewski , D , Johnson , K C , Ghadirian , P and the Canadian Cancer Registries Epidemiology Research Group . 2005 . Specific fatty acid intake and the risk of pancreatic cancer in Canada . Brit J Cancer , 92, : 971 – 977 .
  • Berquin , I M , Edwards , I J and Chen , Y Q . 2008 . Multi-targeted therapy of cancer by omega-3 fatty acids . Cancer Letters , 269, : 363 – 377 .
  • Gerber , M , Thiébaut , A , Astorg , P , Clavel-Chapelon , F and Combe , N . 2005 . Dietary fat, fatty acid composition and risk of cancer . Eur J Lipid Sci Technol , 107, : 540 – 559 .
  • Wendel , M and Heller , A R . 2009 . Anticancer actions of omega-3 fatty acids—current state and future perspectives . Anticancer Agents Med Chem , 9, : 457 – 470 .
  • Lochman , T , Roche , A and Martorel , R . 1989 . Standardization of anthropometric measurements , Champaign , IL : Human Kinetics Publishers .
  • Durnin , J V and Womersley , J . 1974 . Body fat assessed from the total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 71 years . Br J Nutr , 32, : 7 – 97 .
  • Kunešová , M , Hainer , V , Tvrzická , E , Phinney , S D , Štich , V Pařízková , J . 2002 . Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins . Lipids , 37, : 27 – 32 .
  • McMillan , D C . 2009 . Systemic inflammation, nutritional status and in patients with cancer . Curr Opin Clin Nutr Metab Care , 12, : 223 – 226 .
  • Matthews , D R , Hosker , J P , Rudenski , A S , Naylor , B A Treacher , D F . 1985 . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man . Diabetologia , 28, : 412 – 419 .
  • Fleming , I D , Cooper , J S and Henson , D E . 1997 . AJCC: Cancer Staging Manual, . , 5th ed , New York : Lippincott-Raven, Philadephia .
  • Tvrzická , E , Vecka , M , Staňková , B and Žák , A . 2002 . Analysis of fatty acids in plasma lipoproteins by gas chromatography-flame ionisation detection: Quantitative aspects . Anal Chim Acta , 465, : 337 – 350 .
  • Warensjö , E , Rosell , M , Hellenius , M-L , Vessby , B De Faire , U . 2009 . Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance . Lipids in Health and Disease , 8, : 37 doi: 10.1186/1476–511X-8-37
  • Ahotupa , M , Ruutu , M and Mäntylä , E . 1996 . Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins . Clin Biochem , 29, : 139 – 144 .
  • Tisdale , M J . 2005 . Molecular pathways leading to cancer cachexia . Physiology , 20, : 340 – 348 .
  • Bing , C . 2011 . Lipid mobilization in cachexia: mechanism and mediators . Curr Opin Support Palliat Care , 5, : 356 – 360 .
  • Batista , M L Jr , Peres , S B , McDonald , M E , Alcantra , P SM , Olivan , M , Otoch , J P , Farmer , S R and Seelaender , M . 2012 . Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors . Cytokine , 57, : 9 – 16 .
  • Cowey , S and Hardy , R W . 2006. . The metabolic syndrome: a high-risk state for cancer? . Am J Pathol , 169, : 1505 – 1522 .
  • Calle , E E and Kaaks , R . 2004 . Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms . Nat Rev Cancer , 4, : 579 – 591 .
  • La Vecchia , C , Negri , E , Franceschi , S , D’Avanzo , B and Boyle , P . 1994 . A case control study of diabetes mellitus and cancer risk . Br J Cancer , 70, : 950 – 953 .
  • Malenfant , P , Joanisse , D R , Thériault , R , Goodpaster , B H Kelley , D E . 2001 . Fat content in individual muscle fibers of lean and obese subjects . Int J Obes , 25, : 1316 – 1321 .
  • Stephens , N A , Skipworth , R JE , MacDonald , A J , Greig , C A Ross , J A . 2011 . Intramyocellular lipid droplets increase with progression of cachexia in cancer patients . J Cachexia Sarcopenia Muscle , 2, : 111 – 117 .
  • Fouladiun , M , Körner , U , Bosaeus , I , Daneryd , P Hyltander , A . 2005 . Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care-correlations with food intake, metabolism, exercise capacity, and hormones . Cancer , 103, : 2189 – 2198 .
  • Žák , A , Tvrzická , E , Vecka , M , Jáchymová , M Duffková , L . 2007 . Severity of metabolic syndrome unfavorably influences oxidative stress and fatty acid metabolism in men . Tohoku J Exp Med , 212, : 359 – 371 .
  • Jeppesen , P B , Christensen , M S , Hoy , C E and Mortensen , P B . 1997 . Essential fatty acid deficiency in patients with servere fat malabsorption . Am J Clin Nutr , 65, : 837 – 843 .
  • Simon , J A , Fong , J , Bernert , J T and Browner , W S . 1996 . Relation of smoking and alcohol consumption to serum fatty acids . Am J Epidemiol , 144, : 325 – 334 .
  • Pratt , V C , Watanabe , S , Bruera , E , Mackey , J Clandinin , M T . 2002 . Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation . Br J Cancer , 87, : 1370 – 1378 .
  • Žák , A , Jáchymová , M , Tvrzická , E , Vecka , M Duffková , L . 2008 . The influence of polymorphisms of –493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress . J Nutr Biochem , 19, : 634 – 641 .
  • Zeman , M , Vecka , M , Jáchymová , M , Jirák , R Tvrzická , E . 2009 . Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression . Tohoku J Exp Med , 217, : 287 – 293 .
  • Neoptolemos , J P , Clayton , H , Heagerty , A M , Nicholson , M J Johnson , B . 1988 . Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer . Br J Cancer , 58, : 575 – 579 .
  • Lissner , L , Kroon , U B , Björntorp , P , Blosk , S Wilhelmsen , L . 1993 . Adipose tissue fatty acids and dietary fat sources in relation to endometrial cancer: a retrospective study of cases in remission, and population-based controls . Acta Obstet Gynecol Scand , 72, : 481 – 487 .
  • Paillard , F , Catheline , D , Le Duff , F , Bouriel , M Deugnier , Y . 2008 . Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity . Nutr Metab Cardiovasc Dis , 18, : 436 – 440 .
  • Scaglia , N , Chisholm , J W and Igal , R A . 2009 . Inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK . PLoS One , 4, : e6812
  • Zuijdgeest-van Leeuwen , S D , van der Heijden , M S , Rietveld , T , van den Berg , J W Tilanus , H W . 2002 . Fatty acid composition of plasma lipids in patients with pancreatic, lung and oesophageal cancer in comparison with healthy subjects . Clin Nutr , 21, : 225 – 230 .
  • Falvella , S F , Pascale , R M , Gariboldi , M , Manenti , G DeMiglio , M R . 2002 . Stearoyl-CoA desaturase 1 (SCD1) gene overexpression i associated with genetic predisposition to hepatocarcinogenesis in mice and rats . Carcinogenesis , 23, : 1933 – 1936 .
  • Morgan-Lappe , S E , Tucker , L A , Huang , X , Zhang , Q Sarthy , A V . 2007 . Identification of Ras-related nuclear protein, targeting protein for Xenopus kinesis-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from and RNAi-based screen . Cancer Res , 67, : 4390 – 4398 .
  • Chajes , V , Hulten , K , van Kappel , A L , Winkvist , A Kaaks , R . 1999 . Fatty acid composition in serum phospholipids and risk of breast cancer: an incident case–control study in Sweden . Int J Cancer , 83, : 585 – 590 .
  • Murphy , R A , Wilke , M S , Perrine , M , Pawlowicz , M Mourtzakis , M . 2010 . Loss of adipose tissue and plasma phospholipids: Relationship to survival in advanced cancer patients . Clin Nutr , 29, : 482 – 487 .
  • Krechler , T , Zeman , M , Vecka , M , Macasek , J Jachymova , M . 2011 . Leptin and adiponectin in pancreatic cancer: connection with diabetes mellitus . Neoplasma , 58, : 58 – 64 .
  • Brown , J M and Lawrence , L . 2010 . Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery . Curr Opin Lipidol , 21, : 192 – 197 .
  • Clarke , S D . 2001 . Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome . J Nutr , 131, : 1129 – 1132 .
  • Larsson , S C , Kumlin , M , Ingelman-Sundberg , M and Wolk , A . 2004 . Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms . Am J Clin Nutr , 79, : 935 – 945 .
  • Murphy , R A , Yeung , E , Mazurak , V C and Mourtzakis , M . 2011 . Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia . Br J Cancer , doi: 10.1038/bjc.2011.391
  • Fearon , K CH , von Meyenfeldt , M F , Moses , A GW , van Geenen , R Roy , A . 2003 . Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial . Gut , 52, : 1479 – 1486 .
  • Dodesini , A R , Benedini , S , Terruzzi , I , Sereni , L P and Luzi , L . 2007 . Protein, glucose and lipid metabolism in the cancer cachexia: a preliminary report . Acta Oncol , 46, : 118 – 120 .

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