All-Trans-Retinoic Acid and the Glycolipid α-Galactosylceramide Combined Reduce Breast Tumor Growth and Lung Metastasis in a 4T1 Murine Breast Tumor Model

REFERENCES

• Bray , F , McCarron , P and Parkin , D M . 2004 . The changing global patterns of female breast cancer incidence and mortality . Breast Cancer Res , 6 : 229 – 239 .
   PubMed Web of Science ®Google Scholar
• Gudas , L J and Wagner , J A . 2010 . Retinoids regulate stem cell differentiation . J Cell Physiol , 226 : 322 – 330 .
   Web of Science ®Google Scholar
• Duriancik , D M , Lackey , D E and Hoag , K A . 2010 . Vitamin A as a regulator of antigen presenting cells . J Nutr , 140 : 1395 – 1399 .
   PubMed Web of Science ®Google Scholar
• Ross , A C , Chen , Q and Ma , Y . 2009 . Augmentation of antibody responses by retinoic acid and costimulatory molecules . Semin Immunol , 21 : 42 – 50 .
   PubMed Web of Science ®Google Scholar
• Sanz , M A and Lo-Coco , F . 2011 . Modern approaches to treating acute promyelocytic leukemia . J Clin Oncol , 29 : 495 – 503 .
   PubMed Web of Science ®Google Scholar
• Ng , S C , Kamm , M A , Stagg , A J and Knight , S C . 2010 . Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation . Inflamm Bowel Dis , 16 : 1787 – 1807 .
   PubMed Web of Science ®Google Scholar
• Lee , H P , Casadesus , G , Zhu , X , Lee , H G Perry , G . 2009 . All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease . Expert Rev Neurother , 9 : 1615 – 1621 .
   PubMed Web of Science ®Google Scholar
• Tang , X H and Gudas , L J . 2011 . Retinoids, retinoic acid receptors, and cancer . Annu Rev Pathol , 6 : 345 – 364 .
   PubMed Web of Science ®Google Scholar
• Motohashi , S , Nagato , K , Kunii , N , Yamamoto , H Yamasaki , K . 2009 . A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer . J Immunol , 182 : 2492 – 2501 .
   PubMed Web of Science ®Google Scholar
• Giaccone , G , Punt , C J , Ando , Y , Ruijter , R and Nishi , N . 2002 . A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors . Clin Cancer Res , 8 : 3702 – 3709 .
   PubMed Web of Science ®Google Scholar
• Kawano , T , Cui , J , Koezuka , Y , Toura , I Kaneko , Y . 1997 . CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides . Science , 278 : 1626 – 1629 .
   PubMed Web of Science ®Google Scholar
• Van Kaer , L , Parekh , V V and Wu , L . 2011 . Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens . Immunotherapy , 3 : 59 – 75 .
   PubMed Web of Science ®Google Scholar
• Cui , J , Shin , T , Kawano , T , Sato , H Kondo , E . 1997 . Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors . Science , 278 : 1623 – 1626 .
   PubMed Web of Science ®Google Scholar
• Stewart , T J , Smyth , M J , Fernando , G J , Frazer , I H and Leggatt , G R . 2003 . Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cells . Cancer Res , 63 : 3058 – 3060 .
   PubMed Web of Science ®Google Scholar
• Crowe , N Y , Smyth , M J and Godfrey , D I . 2002 . A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas . J Exp Med , 196 : 119 – 127 .
   PubMed Web of Science ®Google Scholar
• Crowe , N Y , Coquet , J M , Berzins , S P , Kyparissoudis , K Keating , R . 2005 . Differential antitumor immunity mediated by NKT cell subsets in vivo . J Exp Med , 202 : 1279 – 1288 .
   PubMed Web of Science ®Google Scholar
• Kawano , T , Cui , J , Koezuka , Y , Toura , I Kaneko , Y . 1998 . Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells . Proc Natl Acad Sci U S A , 95 : 5690 – 5693 .
   PubMed Web of Science ®Google Scholar
• van den Heuvel , M J , Garg , N , Van Kaer , L and Haeryfar , S M . 2011 . NKT cell costimulation: experimental progress and therapeutic promise . Trends Mol Med , 17 : 65 – 77 .
   PubMed Web of Science ®Google Scholar
• Molling , J W , Moreno , M , van der Vliet , H J , van den Eertwegh , A J Scheper , R J . 2008 . Invariant natural killer T cells and immunotherapy of cancer . Clin Immunol , 129 : 182 – 194 .
   PubMed Web of Science ®Google Scholar
• Kobayashi , E , Motoki , K , Uchida , T , Fukushima , H and Koezuka , Y . 1995 . KRN7000, a novel immunomodulator, and its antitumor activities . Oncol Res , 7 : 529 – 534 .
   PubMed Web of Science ®Google Scholar
• Nakagawa , R , Motoki , K , Ueno , H , Iijima , R Nakamura , H . 1998 . Treatment of hepatic metastasis of the colon26 adenocarcinoma with an alpha-galactosylceramide, KRN7000 . Cancer Res , 58 : 1202 – 1207 .
   PubMed Web of Science ®Google Scholar
• Nakagawa , R , Motoki , K , Nakamura , H , Ueno , H Iijima , R . 1998 . Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production . Oncol Res , 10 : 561 – 568 .
   PubMed Web of Science ®Google Scholar
• Toura , I , Kawano , T , Akutsu , Y , Nakayama , T Ochiai , T . 1999 . Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide . J Immunol , 163 : 2387 – 2391 .
   PubMed Web of Science ®Google Scholar
• Ishikawa , A , Motohashi , S , Ishikawa , E , Fuchida , H Higashino , K . 2005 . A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer . Clin Cancer Res , 11 : 1910 – 1917 .
   PubMed Web of Science ®Google Scholar
• Chang , D H , Osman , K , Connolly , J , Kukreja , A Krasovsky , J . 2005 . Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients . J Exp Med , 201 : 1503 – 1517 .
   PubMed Web of Science ®Google Scholar
• Chen , Q , Mosovsky , K L and Ross , A C . 2011 . Retinoic Acid and {alpha}-galactosylceramide differentially regulate b cell activation in vitro and augment antibody production in vivo . Clin Vaccine Immunol , 18 : 1015 – 1021 .
   PubMed Web of Science ®Google Scholar
• Chen , Q and Ross , A C . 2007 . Retinoic acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells . Exp Biol Med (Maywood) , 232 : 488 – 494 .
   PubMed Web of Science ®Google Scholar
• Aslakson , C J and Miller , F R . 1992 . Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor . Cancer Res , 52 : 1399 – 1405 .
   PubMed Web of Science ®Google Scholar
• Figdor , C G , de Vries , I J , Lesterhuis , W J and Melief , C J . 2004 . Dendritic cell immunotherapy: mapping the way . Nat Med , 10 : 475 – 480 .
   PubMed Web of Science ®Google Scholar
• Kim , E J , Shin , M , Park , H , Hong , J E Shin , H K . 2009 . Oral administration of 3,3’-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice . J Nutr , 139 : 2373 – 2379 .
   PubMed Web of Science ®Google Scholar
• duPre , S A , Redelman , D and Hunter , K W Jr. 2008 . Microenvironment of the murine mammary carcinoma 4T1: endogenous IFN-gamma affects tumor phenotype, growth, and metastasis . Exp Mol Pathol , 85 : 174 – 188 .
   PubMed Web of Science ®Google Scholar
• Chen , Q and Ross , A C . 2004 . Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells . Exp Cell Res , 297 : 68 – 81 .
   PubMed Web of Science ®Google Scholar
• Kunii , N , Horiguchi , S , Motohashi , S , Yamamoto , H Ueno , N . 2009 . Combination therapy of in vitro-expanded natural killer T cells and alpha-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma . Cancer Sci , 100 : 1092 – 1098 .
   PubMed Web of Science ®Google Scholar
• Shojaei , F , Wu , X , Qu , X , Kowanetz , M Yu , L . 2009 . G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models . Proc Natl Acad Sci U S A , 106 : 6742 – 6747 .
   PubMed Web of Science ®Google Scholar
• Dolcetti , L , Peranzoni , E , Ugel , S , Marigo , I Fernandez Gomez , A . 2010 . Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF . Eur J Immunol , 40 : 22 – 35 .
   PubMed Web of Science ®Google Scholar
• Coussens , L M and Werb , Z . 1996 . Matrix metalloproteinases and the development of cancer . Chem Biol , 3 : 895 – 904 .
   PubMed Web of Science ®Google Scholar
• Gialeli , C , Theocharis , A D and Karamanos , N K . 2011 . Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting . FEBS J , 278 : 16 – 27 .
   PubMed Web of Science ®Google Scholar
• Godfrey , D I and Kronenberg , M . 2004 . Going both ways: immune regulation via CD1d-dependent NKT cells . J Clin Invest , 114 : 1379 – 1388 .
   PubMed Web of Science ®Google Scholar
• Yamasaki , K , Horiguchi , S , Kurosaki , M , Kunii , N Nagato , K . 2010 . Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy . Clin Immunol , 138 : 255 – 265 .
   PubMed Web of Science ®Google Scholar
• DuPre , S A , Redelman , D and Hunter , K W Jr. 2007 . The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci . Int J Exp Pathol , 88 : 351 – 360 .
   PubMed Web of Science ®Google Scholar
• DuPre , S A and Hunter , K W Jr . 2007 . Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factors . Exp Mol Pathol , 82 : 12 – 24 .
   PubMed Web of Science ®Google Scholar
• Solito , S , Bronte , V and Mandruzzato , S . 2011 . Antigen specificity of immune suppression by myeloid-derived suppressor cells . J Leukoc Biol , 90 : 31 – 36 .
   PubMed Web of Science ®Google Scholar
• Kusmartsev , S and Gabrilovich , D I . 2002 . Immature myeloid cells and cancer-associated immune suppression . Cancer Immunol Immunother , 51 : 293 – 298 .
   PubMed Web of Science ®Google Scholar
• Younos , I , Donkor , M , Hoke , T , Dafferner , A Samson , H . 2011 . Tumor- and organ-dependent infiltration by myeloid-derived suppressor cells . Int Immunopharmacol , 11 : 816 – 826 .
   PubMed Web of Science ®Google Scholar
• James , S Y , Williams , M A , Kelsey , S M , Newland , A C and Colston , K W . 1997 . The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells . Biochem Pharmacol , 54 : 625 – 634 .
   PubMed Web of Science ®Google Scholar
• Fujii , S , Shimizu , K , Smith , C , Bonifaz , L and Steinman , R M . 2003 . Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein . J Exp Med , 198 : 267 – 279 .
   PubMed Web of Science ®Google Scholar
• Yoshino , Y , Kageshita , T , Nakajima , M , Funakubo , M and Ihn , H . 2008 . Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma . J Dermatol , 35 : 206 – 214 .
   PubMed Web of Science ®Google Scholar
• Overall , C M and Kleifeld , O . 2006 . Tumour microenvironment—opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy . Nat Rev Cancer , 6 : 227 – 239 .
   PubMed Web of Science ®Google Scholar