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Original Articles

Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus Suppresses DMH-Induced Procarcinogenic Fecal Enzymes and Preneoplastic Aberrant Crypt Foci in Early Colon Carcinogenesis in Sprague Dawley Rats

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Pages 84-91 | Received 16 Feb 2012, Accepted 01 Oct 2012, Published online: 31 Jan 2013

REFERENCES

  • Jemal , A , Bray , F , Center , M M , Ferley , J Ward , E . 2011 . Global cancer statistics . CA Cancer J Clin , 61 : 60 – 69 .
  • Chau , I and Cunningham , D . 2006 . Adjuvant therapy in colon cancer- what, when and how? . Ann Oncology , 17 : 1347 – 1359 .
  • Day , D W . 1984 . The adenoma-carcinoma sequence . Scand J Gastroenterol , 104 : 99 – 107 .
  • Goldin , B R , Gualtieri , L J and Moore , R P . 1996 . The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in rat . Nutr Cancer , 25 : 197 – 204 .
  • Kado , S , Uchida , K , Funabashi , H , Iwata , S Nagata , Y . 2001 . Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice . Cancer Res , 61 : 2395 – 2398 .
  • Reddy , S , Narisawa , T , Wright , P , Vukusich , D Weisburger , J H . 1975 . Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats . Cancer Res , 35 : 287 – 290 .
  • Gillette , J R , Kamm , J J and Sasame , H A . 1968 . Mechanism of p-nitrobenzoate reduction in liver: the possible role of cytochrome P-450 in liver microsomes . Mol. Pharmacol , 4 : 541 – 548 .
  • Kato , R , Oshima , T and Taranama , A . 1969 . Studies on the mechanism of nitro reduction by rat liver . Mol Pharmacol , 5 : 487 – 498 .
  • Bird , R P . 1981 . Role of aberrant crypt foci in understanding the pathogenesis of colon cancer . Cancer Lett , 93 : 55 – 71 .
  • Bird , R P . 1987 . Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings . Cancer Lett , 37 : 147 – 151 .
  • Thorup , I , Meyer , O and Kristiansen , E . 1984 . Influence of a dietary fiber on development of dimethylhydrazine-induced aberrant crypt foci and colon tumor incidence in Wistar rats . Nutr Cancer , 2 : 177 – 182 .
  • Bird , R P , McLellan , E A and Bruce , W R . 1989 . Aberrant crypts, putative precancerous lesions, in the study of the role of diet in the aetiology of colon cancer . Cancer Surv , 8 : 189 – 200 .
  • Demarzo , M M and Garcia , S B . 2004 . Exhaustive physical exercise increases the number of colonic pre-neoplastic lesions in untrained rats treated with a chemical carcinogen . Cancer Lett , 216 : 31 – 34 .
  • Sant , M , Capocaccia , E , Verdecchia , A , Gatta , G Micheli , A . 1995 . Comparisons of colon-cancer survival among European countries: The Eurocare Study . Intl J Cancer , 63 : 43 – 48 .
  • Fooks , L J , Fuller , R and Gibson , G R . 1999 . Prebiotics, probiotics and human gut microbiology . Int Dairy J , 9 : 53 – 61 .
  • Kubota , Y . 1990 . Fecal intestinal flora in patients with colon adenoma and colon cancer . Nippon-Shoh. Gakkai-Zasshi , 87 : 771 – 779 .
  • Wollowski , I , Rechkemmer , G and Pool-Zobel , B L . 2001 . Protective role of probiotics and prebiotics in colon cancer . Am J Clin Nutr , 73 : 451S – 455S .
  • Shukla , G , Devi , P and Sehgal , R . 2008 . Effect of Lactobacillus casei as a probiotic on modulation of giardiasis . Dig Dis Sci , 53 : 2671 – 2679 .
  • Bird , R . 1995 . Role of aberrant crypt foci in understanding the pathogenesis of colon cancer . Cancer Lett , 93 : 55 – 71 .
  • Lowry , O H , Rosebrough , N J , Farr , A L and Randall , R J . 1951 . Protein measurement with folin phenol reagent . J Agric Food Chem , 47 : 2697 – 2704 .
  • Goldin , B R and Gorbasch , S L . 1976 . The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer . J Natl Cancer Inst , 57 : 371 – 375 .
  • World Cancer Research Fund/American Institute for Cancer Research . 2007 . Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective , Washington , DC : American Institute for Cancer Research .
  • Cross , M L . 2002 . Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens . FEMS Immunol Med Microbiol , 34 : 245 – 253 .
  • Teitelbaum , J E and Walker , W A . 2002 . Nutritional impact of pre- and probiotics as protective gastrointestinal organisms . Annu Rev Nutr , 22 : 107 – 138 .
  • Lee , S M and Lee , W K . 2000 . Inhibitory effects of lactic acid bacteria (LAB) on the azoxymethane-induced colonic preneoplastic lesions . J Microbiol , 38 : 169 – 175 .
  • Arimochi , H , Kinouchi , T , Kataoka , K , Kuwahara , T and Ohnishi , Y . 1997 . Effect of intestinal bacteria on formation of azoxymethane-induced aberrant crypt foci in the rat colon . Biochem Biophys Res Commun , 238 : 753 – 757 .
  • Pool-Zobel , B L , Neudecker , C , Domizlaff , J S , Schillinger , U Rumney , C . 1996 . Lactobacillus- and bifidobacterium-mediated antigenotoxicity in the colon of rats . Nutr Cancer , 26 : 365 – 380 .
  • Ling , W H , Korpela , R , Mykkanen , H , Salminen , S and Hanninen , O . 1994 . Lactobacillus strain GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults . J Nutr , 124 : 18 – 23 .
  • Spanhaak , S , Havenaar , R and Schaafsma , G . 1998 . The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans . Eur J Clin Nutr , 52 : 899 – 907 .
  • Goldin , B R . 1990 . Intestinal microflora: metabolism of drugs and carcinogens . Ann Med , 22 : 43 – 48 .
  • Rowland , I R and Gangolli , S D . 1999 . “ Role of gastrointestinal flora in the metabolic and toxicological activities of xenobiotics ” . In General and Applied Toxicology, , 2nd ed. , Edited by: Ballantyne , B , Marrs , T C and Syverson , T . 561 – 576 . London : Macmillan Publishers Ltd .
  • Stein , K , Borowicki , A , Scharlau , D , Schettler , A Scheu , K . 2011 . Effects of synbiotic fermentation products on primary chemoprevention in human colon cells . J Nutr Biochem , 20 : 1 – 8 .
  • Hawkswotith , G , Draser , B S and Hill , M J . 1971 . Intestinal bacteria and the hydrolysis of glycosidic bonds . J Med Microbiol , 14 : 451 – 459 .
  • Benno , Y and Mitsuoka , T . 1992 . Impact of Bifidobacterium longum on fecal human microflora . Microbiol Immunol , 36 : 683 – 694 .
  • Kinouchi , T and Ohnishi , Y . 1986 . Metabolic activation of 1-nitropyrene and 1,6-dinitropyrene by nitroreductases from Bacteroides fragilis and distribution of nitroreductase activity in rats . Microbiol Immunol , 30 : 979 – 992 .
  • Otieno , D O , Ashton , J F and Shah , N P . 2005 . Stability of β-glucosidase activity produced by Bifidobacterium and Lactobacillus spp. in fermented soymilk during processing and storage . J Food Sci , 70 : M236 – M241 .
  • Marteau , P , de Vrese , M , Cellier , C J and Schrezenmeir , J . 2001 . Protection from gastrointestinal diseases with the use of probiotics . Am J Clin Nutr , 73 : 430S – 436S .

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