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Original Articles

Glucose Starvation Induces Apoptosis in a Model of Acute T Leukemia Dependent on Caspase-3 and Apoptosis-Inducing Factor: A Therapeutic Strategy

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Pages 99-109 | Received 11 Apr 2012, Accepted 31 Aug 2012, Published online: 31 Jan 2013

REFERENCES

  • Hanahan , D and Weinberg , R A . 2000 . The hallmarks of cancer . Cell , 100 : 57 – 70 .
  • Tennant , D A , Durán , R V , Boulahbel , H and Gottlieb , E . 2009 . Metabolic transformation in cancer . Carcinogenesis , 30 : 1269 – 1280 .
  • Kroemer , G , Galluzzi , L , Vandenabeele , P , Abrams , J Alnemri , E S . 2009 . Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 . Cell Death Differ , 16 : 3 – 11 .
  • Galluzzi , L , Vitale , I , Abrams , J M , Alnemri , E S Baehrecke , E H . 2012 . Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 . Cell Death Differ , 19 : 107 – 120 .
  • Nowak , D , Stewart , D and Koeffler , H P . 2009 . Differentiation therapy of leukaemia: 3 decades of development . Blood , 113 : 3655 – 3665 .
  • Pieters , R and Carroll , W L . 2010 . Biology and treatment of acute lymphoblastic leukaemia . Hematol Oncol Clin North Am , 24 : 1 – 18 .
  • Chen , W , Wang , E , Lu , Y , Gaal , K K and Huang , Q . 2010 . Therapy-related acute lymphoblastic leukaemia without 11q23 abnormality: report of six cases and a literature review . Am J Clin Pathol , 133 : 75 – 82 .
  • Szotkowski , T , Rohon , P , Zapletalova , L , Sicova , K Hubacek , J . 2010 . Secondary acute myeloid leukaemia: a single center experience . Neoplasma , 57 : 170 – 178 .
  • Annibaldi , A and Widmann , C . 2010 . Glucose metabolism in cancer cells . Curr Opin Clin Nutr. Metab Care , 13 : 466 – 470 .
  • Aykin-Burns , N , Ahmad , I M , Zhu , Y , Oberley , L W and Spitz , D R . 2009 . Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation . Biochem J , 418 : 29 – 37 .
  • Lee , Y J , Galoforo , S S , Berns , C M , Tong , W P Kim , H R . 1997 . Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death . J Cell Sci , 110 ( Pt. 5 ) : 681 – 686 .
  • Lee , Y J , Galoforo , S S , Berns , C M , Chen , J C Davis , B H . 1998 . Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells . J Biol Chem , 273 : 5294 – 5299 .
  • Blackburn , R V , Spitz , D R , Liu , X , Galoforo , S S Sim , J E . 1999 . Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells . Free Radic Biol Med , 26 : 419 – 430 .
  • Spitz , D R , Sim , J E , Ridnour , L A , Galoforo , S S and Lee , Y J . 2000 . Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? . Ann N Y Acad Sci , 899 : 349 – 362 .
  • Caro-Maldonado , A , Tait , S W , Ramírez-Peinado , S , Ricci , J E Fabregat , I . 2010 . Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells . Cell Death Differ , 17 : 1335 – 1344 .
  • Aki , T , Mizukami , Y , Oka , Y , Yamaguchi , K Uemura , K . 2003 . Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the cardiomyocyte-derived cell line H9c2 . Oncogene , 22 : 8529 – 8535 .
  • Marambio , P , Toro , B , Sanhueza , C , Troncoso , R Parra , V . 1802, 2010 . Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes . Biochim Biophys Acta , : 509 – 518 .
  • El Mjiyad , N , Caro-Maldonado , A , Ramírez-Peinado , S and Muñoz-Pinedo , C . 2010 . Sugar-free approaches to cancer cell killing . Oncogene , 30 : 253 – 264 .
  • Avila-Gomez , I C , Velez-Pardo , C and Jimenez-Del-Rio , M . 2010 . Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in lymphocyte cells . Basic & Clinical Pharmacology & Toxicology , 106 : 53 – 61 .
  • Jimenez-Del-Rio , M and Velez-Pardo , C . 2002 . Monoamine neurotoxin-induced apoptosis in lymphocytes by a common mechanism: involvement of hydrogen peroxide (H2O2), caspase-3, and nuclear factor kappa-B (NF-κB), p53, c-Jun transcription factor . Biochem Pharmacol , 63 : 677 – 688 .
  • Liang , Z Q , Li , Y L , Zhao , X L , Han , R Wang , X X . 2007 . NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53 . Brain Res , 1145 : 190 – 203 .
  • Son , Y O , Jang , Y S , Shi , X and Lee , J C . 2009 . Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells . Mol Cells , 28 : 545 – 551 .
  • Bonilla-Porras , A R , Jimenez-Del-Rio , M and Velez-Pardo , C . 2011 . Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukaemia cells by a similar oxidative stress signalling mechanism . Cancer Cell Int , 11 : 19
  • Chaturvedi , M M , Sung , B , Yadav , V R , Kannappan , R and Aggarwal , B B . 2011 . NF-κB addiction and its role in cancer: ‘one size does not fit all’ . Oncogene , 30 : 1615 – 1630 .
  • Wang , J and Yi , J . 2008 . Cancer cell killing via ROS. To increase or decrease, that is the question . Cancer Biology & Therapy , 7 : 1875 – 1884 .
  • Susin , S A , Lorenzo , H K , Zamzami , N , Marzo , I Snow , B E . 1999 . Molecular characterization of mitochondrial apoptosis-inducing factor . Nature , 397 : 441 – 446 .
  • Jänicke , R U , Sprengart , M L , Wati , M R and Porter , A G . 1998 . Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis . J Biol Chem , 273 : 9357 – 9360 .
  • Melinn , M and McLaughlin , H . 1987 . Nitroblue tetrazolium reduction in lymphocytes . J Leukoc Biol , 41 : 325 – 329 .
  • Leite , M , Quinta-Costa , M , Leite , P S and Guimaraes , J E . 1999 . Critical valuation of techniques to detect and measure cell death- study in a model of UV radiation of the leukaemic cell line HL60 . Anal Cell Pathol , 19 : 139 – 151 .
  • Kolenko , V M , Uzzo , R G , Dulin , N , Hauzman , E Bukowski , R . 2001 . Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes . Apoptosis , 6 : 419 – 429 .
  • Li , J , Liu , R , Lei , Y , Wang , K Lau , Q C . 2010 . Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukaemia cells . Autophagy , 6 : 711 – 724 .
  • Velez-Pardo , C , Jimenez-Del-Rio , M , Lores-Arnaiz , S and Bustamante , J . 2010 . Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure . Neurochem Res , 35 : 1323 – 1332 .
  • Ahmad , I M , Aykin-Burns , N , Sim , J E , Walsh , S A Higashikubo , R . 2005 . Mitochondrial O2 − and H2O2 mediate glucose deprivation-induced stress in human cancer cells . J Biol Chem , 280 : 4254 – 4263 .
  • Murphy , M P . 2009 . How mitochondria produce reactive oxygen species . Biochem J , 417 : 1 – 13 .
  • Miramar , M D , Costantini , P , Ravagnan , L , Saraiva , L M Haouzi , D . 2001 . NADH oxidase activity of mitochondrial apoptosis-inducing factor . J Biol Chem , 276 : 16391 – 16398 .
  • Stridh , H , Kimland , M , Jones , D P , Orrenius , S and Hampton , M B . 1998 . Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis . FEBS Lett , 429 : 351 – 355 .
  • Li , G Y and Osborne , N N . 2008 . Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis inducing factor . Brain Res , 1188 : 35 – 43 .
  • Son , Y O , Jang , Y S , Heo , J S , Chung , W T Choi , K C . 2009 . Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide exposed cells . Apoptosis , 14 : 796 – 808 .
  • Barbouti , A , Amorgianiotis , C , Kolettas , E , Kanavaros , P and Galaris , D . 2007 . Hydrogen peroxide inhibits caspase-dependent apoptosis by inactivating procaspase-9 in an iron-dependent manner . Free Radic Biol Med , 43 : 1377 – 1387 .
  • Brigelius-Flohé , R and Flohé , L . 2011 . Basic principles and emerging concepts in the redox control of transcription factors . Antioxid Redox Signal , 15 : 2335 – 2381 .
  • Takada , Y , Mukhopadhyay , A , Kundu , G C , Mahabeleshwar , G H Singh , S . 2003 . Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase . J Biol Chem , 278 : 24233 – 24241 .
  • Kamata , H , Manabe , T , Oka , S , Kamata , K and Hirata , H . 2002 . Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops . FEBS Lett , 519 : 231 – 237 .
  • Tobiume , K , Saitoh , M and Ichijo , H . 2002 . Activation of apoptosis signal regulating kinase 1 by stress-induced activating phosphorylation of pre-formed oligomer . J Cell Physiol , 191 : 95 – 104 .
  • Ichijo , H , Nishida , E and Irie , K . 1997 . Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways . Science , 275 : 90 – 94 .
  • Radhakrishnan , S K and Kamalakaran , S . 2006 . Pro-apoptotic role of NF-kappaB: implications for cancer therapy . Biochim Biophys Acta , 1766 : 53 – 62 .
  • Aleyasin , H , Cregan , S P , Iyirhiaro , G , O’Hare , M J Callaghan , S M . 2004 . Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage . J Neurosci , 24 : 2963 – 2973 .
  • McNeill-Blue , C , Wetmore , B A , Sanchez , J F , Freed , W J and Merrick , B A . 2006 . Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine . Brain Res , 1112 : 1 – 15 .
  • Daugas , E , Susin , S A , Zamzami , N , Ferri , K F Irinopoulou , T . 2000 . Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis . FASEB J , 14 : 729 – 739 .
  • Circu , M L and Aw , T Y . 2008 . Glutathione and apoptosis . Free Radic Res , 42 : 689 – 706 .
  • Sakahira , H , Enari , M and Nagata , S . 1998 . Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis . Nature , 391 : 96 – 99 .
  • Mattes , M J . 2007 . Apoptosis assays with lymphoma cell lines: problems and pitfalls . Br J Cancer , 96 : 928 – 936 .
  • Galluzzi , L , Aaronson , S A , Abrams , J , Alnemri , E S Andrews , D W . 2009 . Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes . Cell Death Differ , 16 : 1093 – 1107 .
  • Simons , A L , Mattson , D M , Dornfeld , K and Spitz , D R . 2009 . Glucose deprivation-induced metabolic oxidative stress and cancer therapy . J Cancer Res Ther , 5 ( Suppl 1 ) : S2 – S6 .
  • Lee , C , Raffaghello , L , Brandhorst , S , Safdie , F M Bianchi , G . 2012 . Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy . Sci Transl Med , 4 : 124 – 127 .
  • Sandulache , V C , Skinner , H D , Wang , Y , Chen , Y , Dodge , C T , Ow , T J , Bankson , J A , Myers , J N and Lai , S Y . 2012 . Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation . Mol Cancer Ther , 11 : 1373 – 1380 .
  • Cardaci , S , Desideri , E and Ciriolo , M R . 2012 . Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug . J Bioenerg Biomembr , 44 : 17 – 29 .
  • Wang , F , Ogasawara , M A and Huang , P . 2010 . Small mitochondria-targeting molecules as anti-cancer agents . Mol Aspects Med , 31 : 75 – 92 .

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