Advanced search
Publication Cover
Nutrition and Cancer Volume 65, 2013 - Issue 1
Submit an article Journal homepage
3,891
Views
108
CrossRef citations to date
0
Altmetric
Original Articles

Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells

Li-Shu Wang Medical College of Wisconsin, Division of Hematology and Oncology, Department of Medicine, Milwaukee, Wisconsin, USA
,
Chieh-Ti Kuo Medical College of Wisconsin, Division of Hematology and Oncology, Department of Medicine, Milwaukee, Wisconsin, USA
,
Seung-Ju Cho Medical College of Wisconsin, Division of Hematology and Oncology, Department of Medicine, Milwaukee, Wisconsin, USA
,
Claire Seguin Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, USA
,
Jibran Siddiqui Medical College of Wisconsin, Division of Hematology and Oncology, Department of Medicine, Milwaukee, Wisconsin, USA
,
Kristen Stoner Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, USA
,
Yu-I Weng Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, USA
,
Tim H.-M. Huang Department of Molecular Medicine and Cancer Therapy & Research Center, University of Texas Health Science Center, San Antonio, Texas, USA
,
Jay Tichelaar Medical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, Wisconsin, USA
,
Martha Yearsley Department of Pathology, Ohio State University, Columbus, Ohio, USA
,
Gary D. Stoner Medical College of Wisconsin, Division of Hematology and Oncology, Department of Medicine, Milwaukee, Wisconsin, USA
&
Yi-Wen Huang Medical College of Wisconsin, Department of Obstetrics and Gynecology Ohio State University, Milwaukee, Wisconsin, USA
 show all
Pages 118-125 | Received 14 Jun 2012, Accepted 01 Oct 2012, Published online: 31 Jan 2013

REFERENCES

  • Wang , L-S and Stoner , G D . 2008 . Anthocyanins and their role in cancer prevention . Cancer Lett , 269 : 281 – 290 .
  • Hertog , M GL , Hollman , P CH , Katan , M B and Kromhout , D . 1993 . Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands . Nutr Cancer , 20 : 21 – 29 .
  • Mazza , G J . 2007 . Anthocyanins and heart health . Ann Ist Supper Sanita , 43 : 369 – 374 .
  • Cao , G and Prior , R L . 1999 . Anthocyanins are detected in human plasma after oral administration of an elderberry extract . Clinical Chemistry , 45 : 574 – 576 .
  • Wang , L-S , Hecht , S S , Carmella , S G , Yu , N Larue , B . 2009 . Anthocyanins in black raspberries prevent esophageal tumors in rats . Cancer Prev Res , 2 : 84 – 93 .
  • Wang , L-S , Arnold , M , Huang , Y-W , Sardo , C Seguin , C . 2011 . Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase i pilot study . Clin Cancer Res , 17 : 598 – 610 .
  • Herman , J G and Baylin , S B . 2003 . Gene silencing in cancer in association with promoter hypermethylation . N Engl J Med , 349 : 2042 – 2054 .
  • Bestor , T H . 2000 . The DNA methyltransferases of mammals . Hum Mol Genet , 9 : 2395 – 2402 .
  • Okano , M , Xie , S and Li , E . 1998 . Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases . Nat Genet , 19 : 219 – 220 .
  • Pradhan , S , Bacolla , A , Wells , R D and Roberts , R J . 1999 . Recombinant human DNA (cytosine-5) methyltransferase . J Biol Chem , 274 : 33002 – 33010 .
  • Robertson , K D , Uzvolgyi , E , Liang , G , Talmadge , C Sumegi , J . 1999 . The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors . Nucleic Acids Res , 27 : 2291 – 2298 .
  • Rhee , I , Bachman , K E , Park , B H , Jair , K-W Yen , R-WC . 2002 . DNMT1 and DNMT3b cooperate to silence genes in human cancer cells . Nature , 416 : 552 – 556 .
  • Issa , J-PJ . 2007 . DNA Methylation as a Therapeutic Target in Cancer . Clin Cancer Res , 13 : 1634 – 1637 .
  • Huang , Y-W , Liu , J C , Deatherage , D E , Luo , J Mutch , D G . 2009 . Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer . Cancer Res , 69 : 9038 – 9046 .
  • Ernst , I MA , Wagner , A E , Lipinski , S , Skrbek , S Ruefer , C E . 2010 . Cellular uptake, stability, visualization by ‘Naturstoff reagent A’, and multidrug resistance protein 1 gene-regulatory activity of cyanidin in human keratinocytes . Pharmacol Res , 61 : 253 – 258 .
  • Shah , M Y , Vasanthakumar , A , Barnes , N Y , Figueroa , M E Kamp , A . 2010 . DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis . Cancer Res , 70 : 5840 – 5850 .
  • Whitley , A C , Stoner , G D , Darby , M V and Walle , T . 2003 . Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid—extensive binding to protein and DNA . Biochemical Pharmacology , 66 : 907 – 915 .
  • Jones , P A and Liang , G . 2009 . Rethinking how DNA methylation patterns are maintained . Nat Rev Genet , 10 : 805 – 811 .
  • Riggs , A D . 1975 . X inactivation, differentiation, and DNA methylation . Cytogenet Cell Genet , 14 : 9 – 25 .
  • Holliday , R and Pugh , J E . 1975 . DNA modification mechanisms and gene activity during development . Science , 187 : 226 – 232 .
  • Huang , Y-W , Kuo , C-T , Stoner , K , Huang , T HY and Wang , L-S . 2011 . An overview of epigenetics and chemoprevention . FEBS Lett , 585 : 2129 – 2136 .
  • Lin , R-K , Wu , C-Y , Chang , J-W , Juan , L-J Hsu , H-S . 2010 . Dysregulation of p53/Sp1 Control leads to DNA methyltransferase-1 overexpression in lung cancer . Cancer Res , 70 : 5807 – 5817 .
  • Rhee , I , Jair , K-W , Yen , R-WC , Lengauer , C Herman , J G . 2000 . CpG methylation is maintained in human cancer cells lacking DNMT1 . Nature , 404 : 1003 – 1007 .

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.