Vitamin D Transport Proteins Megalin and Disabled-2 Are Expressed in Prostate and Colon Epithelial Cells and Are Induced and Activated by All-Trans-Retinoic Acid

REFERENCES

• Colston , K W and Hansen , C M . 2002 . Mechanisms implicated in the growth regulatory effects of vitamin d in breast cancer . Endocrine-Related Cancer , 9 : 45 – 59 .
   PubMed Web of Science ®Google Scholar
• Colston , K W , James , S Y , Ofori-Kuragu , E A , Binderup , L and Grant , A G . 1997 . Vitamin d receptors and anti-proliferative effects of vitamin d derivatives in human pancreatic carcinoma cells in vivo and in vitro . British Journal of Cancer , 76 : 1017 – 1020 .
   PubMed Web of Science ®Google Scholar
• Garland , C F , Grant , W B , Mohr , S B , Gorham , E D and Garland , F C . 2007 . What is the dose-response relationship between vitamin d and cancer risk? . Nutr Rev , 65 : S91 – S95 .
   PubMed Web of Science ®Google Scholar
• Zinser , G , Packman , K and Welsh , J . 2002 . Vitamin d(3) receptor ablation alters mammary gland morphogenesis . Development , 129 : 3067 – 3076 .
   PubMed Web of Science ®Google Scholar
• Dackiw , A P , Ezzat , S , Huang , P , Liu , W and Asa , S L . 2004 . Vitamin d3 administration induces nuclear p27 accumulation, restores differentiation, and reduces tumor burden in a mouse model of metastatic follicular thyroid cancer . Endocrinology , 145 : 5840 – 5846 .
   PubMed Web of Science ®Google Scholar
• John , E M , Schwartz , G G , Dreon , D M and Koo , J . 1999 . Vitamin d and breast cancer risk: The nhanes i epidemiologic follow up study, 1971–1975 to 1992 . Cancer Epidemiology Biomarkers Prevention , 8 : 399 – 406 .
   PubMed Web of Science ®Google Scholar
• Ooi , L L , Zhou , H , Kalak , R , Zheng , Y Conigrave , A D . 2010 . Vitamin d deficiency promotes human breast cancer growth in a murine model of bone metastasis . Cancer Research , 70 : 1835 – 1844 .
   PubMed Web of Science ®Google Scholar
• Kawaura , A , Takahashi , A , Tanida , N , Oda , M Sawada , K . 1990 . 1 alpha-hydroxyvitamin d3 suppresses colonic tumorigenesis induced by repetitive intrarectal injection of n-methyl-n-nitrosourea in rats . Cancer Lett , 55 : 149 – 152 .
   PubMed Web of Science ®Google Scholar
• Grant , W B . 2010 . Relation between prediagnostic serum 25-hydroxyvitamin d level and incidence of breast, colorectal, and other cancers . J Photochem Photobiol B , 101 : 130 – 136 .
   PubMed Web of Science ®Google Scholar
• Antico , A , Tampoia , M , Tozzoli , R and Bizzaro , N . 2012 . Can supplementation with vitamin d reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature . Autoimmun Rev , 12 : 127 – 136 .
   PubMed Web of Science ®Google Scholar
• Garland , C F , Gorham , E D , Mohr , S B and Garland , F C . 2009 . Vitamin d for cancer prevention: Global perspective . Ann Epidemiol , 19 : 468 – 483 .
   PubMed Web of Science ®Google Scholar
• Mitri , J , Muraru , M D and Pittas , A G . 2011 . Vitamin d and type 2 diabetes: A systematic review . Eur J Clin Nutr , 65 : 1005 – 1015 .
   PubMed Web of Science ®Google Scholar
• Wang , L , Song , Y , Manson , J E , Pilz , S Marz , W . 2012 . Circulating 25-hydroxy-vitamin d and risk of cardiovascular disease: A meta-analysis of prospective studies . Circ Cardiovasc Qual Outcomes , 5 : 819 – 829 .
   PubMed Web of Science ®Google Scholar
• Wolpin , B M , Ng , K , Bao , Y , Kraft , P Stampfer , M J . 2012 . Plasma 25-hydroxyvitamin d and risk of pancreatic cancer . Cancer Epidemiol Biomarkers Prev , 21 : 82 – 91 .
   PubMed Web of Science ®Google Scholar
• Nykjaer , A , Dragun , D , Walther , D , Vorum , H Jacobsen , C . 1999 . An endocytic pathway essential for renal uptake and activation of the steroid 25(oh)hydroxyvitamin d3 . Cell , 96 : 507 – 515 .
   PubMed Web of Science ®Google Scholar
• Nykjaer , A , Fyfe , J , Kozyraki , R , Leheste , J-R Jacobsen , C . 2001 . Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(oh) vitamin d3. . Proceeding of the National Academy of Sciences USA , 98 : 13895 – 13900 .
   PubMed Web of Science ®Google Scholar
• Nagai , J , Christensen , E I , Morris , S M , Willnow , T E Cooper , J A . 2005 . Mutually dependent localization of megalin and dab2 in the renal proximal tubule . Am J Physiol Renal Physiol , 289 : F569 – F576 .
   PubMed Web of Science ®Google Scholar
• Rowling , M J , Kemmis , C M , Taffany , D A and Welsh , J . 2006 . Megalin-mediated endocytosis of vitamin d binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells . J Nutr , 136 : 2754 – 2759 .
   PubMed Web of Science ®Google Scholar
• Chlon , T M , Taffany , D A , Welsh , J and Rowling , M J . 2008 . Retinoids modulate expression of the endocytic partners megalin, cubilin, and disabled-2 and uptake of vitamin d-binding protein in human mammary cells . J Nutr , 138 : 1323 – 1328 .
   PubMed Web of Science ®Google Scholar
• Marino , M , Zheng , G , Chiovato , L , Pinchera , A Brown , D . 2000 . Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release . J Biol Chem , 275 : 7125 – 7137 .
   PubMed Web of Science ®Google Scholar
• Cui , S , Verroust , P J , Moestrup , S K and Christensen , E I . 1996 . Megalin/gp330 mediates uptake of albumin in renal proximal tubule . Am J Physiol , 271 : F900 – F907 .
   PubMed Web of Science ®Google Scholar
• Barth , J L and Argraves , W S . 2001 . Cubilin and megalin: Partners in lipoprotein and vitamin metabolism . Trends Cardiovasc Med , 11 : 26 – 31 .
   PubMed Web of Science ®Google Scholar
• Christensen , E I and Willnow , T E . 1999 . Essential role of megalin in renal proximal tubule for vitamin homeostasis . J Am Soc Nephrol , 10 : 2224 – 2236 .
   PubMed Web of Science ®Google Scholar
• Kemmis , C M , Salvador , S M , Smith , K M and Welsh , J . 2006 . Human mammary epithelial cells express cyp27b1 and are growth inhibited by 25-hydroxyvitamin d-3, the major circulating form of vitamin d-3 . J Nutr , 136 : 887 – 892 .
   PubMed Web of Science ®Google Scholar
• Wang , L , Persons , K S , Jamieson , D , Flanagan , J N Hsu , H H . 2008 . Prostate 25-hydroxyvitamin d-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (saha), a histone deacetylase inhibitor . Anticancer Res , 28 : 2009 – 2013 .
   PubMed Web of Science ®Google Scholar
• Hsu , J Y , Feldman , D , McNeal , J E and Peehl , D M . 2001 . Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin d3-induced growth inhibition . Cancer Res , 61 : 2852 – 2856 .
   PubMed Web of Science ®Google Scholar
• Welsh , J , Wietzke , J A , Zinser , G M , Byrne , B Smith , K . 2003 . Vitamin d-3 receptor as a target for breast cancer prevention . The Journal of Nutrition , 133 : 2425S – 2433S .
   PubMed Web of Science ®Google Scholar
• Welsh , J , Simboli-Campbell , M , Narvaez , C J and Tenniswood , M . 1995 . Role of apoptosis in the growth inhibitory effects of vitamin d in mcf-7 cells . Adv Exp Med Biol , 375 : 45 – 52 .
   PubMedGoogle Scholar
• Rashid , S F , Moore , J S , Walker , E , Driver , P M Engel , J . 2001 . Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 dihydroxyvitamin d(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin a . Oncogene , 20 : 1860 – 1872 .
   PubMed Web of Science ®Google Scholar
• Cross , H S , Pavelka , M , Slavik , J and Peterlik , M . 1992 . Growth control of human colon cancer cells by vitamin d and calcium in vitro . J Natl Cancer Inst , 84 : 1355 – 1357 .
   PubMed Web of Science ®Google Scholar
• Krill , D , Stoner , J , Konety , B R , Becich , M J and Getzenberg , R H . 1999 . Differential effects of vitamin d on normal human prostate epithelial and stromal cells in primary culture . Urology , 54 : 171 – 177 .
   PubMed Web of Science ®Google Scholar
• Lappe , J M , Travers-Gustafson , D , Davies , K M , Recker , R R and Heaney , R P . 2007 . Vitamin d and calcium supplementation reduces cancer risk: Results of a randomized trial . Am J Clin Nutr , 85 : 1586 – 1591 .
   PubMed Web of Science ®Google Scholar
• Garland , C , Shekelle , R B , Barrett-Connor , E , Criqui , M H Rossof , A H . 1985 . Dietary vitamin d and calcium and risk of colorectal cancer: A 19-year prospective study in men . Lancet , 1 : 307 – 309 .
   PubMed Web of Science ®Google Scholar
• Adamson , P C . 1996 . All-trans-retinoic acid pharmacology and its impact on the treatment of acute promyelocytic leukemia . Oncologist , 1 : 305 – 314 .
   PubMedGoogle Scholar
• http://www.ncbi.nlm.nih.gov/pubmed/17143048.
   Google Scholar
• Grant , W B . 2012 . An ecological study of cancer mortality rates in California, 1950–64, with respect to solar uvb and smoking indices . Dermatoendocrinol , 4 : 176 – 182 .
   PubMedGoogle Scholar
• Grant , W B . 2012 . Ecological studies of the UVB-vitamin d–cancer hypothesis . Anticancer Res , 32 : 223 – 236 .
   PubMed Web of Science ®Google Scholar
• Karam , J A , Shariat , S F , Huang , H Y , Pong , R C Ashfaq , R . 2007 . Decreased doc-2/dab2 expression in urothelial carcinoma of the bladder . Clin Cancer Res , 13 : 4400 – 4406 .
   PubMed Web of Science ®Google Scholar
• Anupam , K , Tusharkant , C , Gupta , S D and Ranju , R . 2006 . Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis . World J Gastroenterol , 12 : 6041 – 6045 .
   PubMed Web of Science ®Google Scholar
• Roland , I H , Yang , W L , Yang , D H , Daly , M B Ozols , R F . 2003 . Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies . Cancer , 98 : 2607 – 2623 .
   PubMed Web of Science ®Google Scholar
• Fazili , Z , Sun , W , Mittelstaedt , S , Cohen , C and Xu , X X . 1999 . Disabled-2 inactivation is an early step in ovarian tumorigenicity . Oncogene , 18 : 3104 – 3113 .
   PubMed Web of Science ®Google Scholar
• Boscoe , F P and Schymura , M J . 2006 . Solar ultraviolet-b exposure and cancer incidence and mortality in the united states, 1993–2002 . BMC Cancer , 6 : 264
   PubMed Web of Science ®Google Scholar
• Chen , W , Clements , M , Rahman , B , Zhang , S Qiao , Y . 2010 . Relationship between cancer mortality/incidence and ambient ultraviolet b irradiance in china . Cancer Causes Control , 21 : 1701 – 1709 .
   PubMed Web of Science ®Google Scholar
• Gugatschka , M , Kiesler , K , Obermayer-Pietsch , B , Groselj-Strele , A Griesbacher , A . 2011 . Vitamin d status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract . Eur Arch Otorhinolaryngol , 268 : 1201 – 1204 .
   PubMed Web of Science ®Google Scholar
• Ng , K , Wolpin , B M , Meyerhardt , J A , Wu , K Chan , A T . 2009 . Prospective study of predictors of vitamin d status and survival in patients with colorectal cancer . Br J Cancer , 101 : 916 – 923 .
   PubMed Web of Science ®Google Scholar
• Tretli , S , Schwartz , G G , Torjesen , P A and Robsahm , T E . 2012 . Serum levels of 25-hydroxyvitamin d and survival in norwegian patients with cancer of breast, colon, lung, and lymphoma: A population-based study . Cancer Causes Control , 23 : 363 – 370 .
   PubMed Web of Science ®Google Scholar
• Vrieling , A , Hein , R , Abbas , S , Schneeweiss , A Flesch-Janys , D . 2011 . Serum 25-hydroxyvitamin d and postmenopausal breast cancer survival: A prospective patient cohort study . Breast Cancer Res , 13 : R74
   PubMed Web of Science ®Google Scholar
• Hathcock , J N , Shao , A , Vieth , R and Heaney , R . 2007 . Risk assessment for vitamin d . Am J Clin Nutr , 85 : 6 – 18 .
   PubMed Web of Science ®Google Scholar
• Zehnder , D , Bland , R , Williams , M C , McNinch , R W Howie , A J . 2001 . Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase . J Clin Endocrinol Metab , 86 : 888 – 894 .
   PubMed Web of Science ®Google Scholar
• Albanes , D , Mondul , A M , Yu , K , Parisi , D Horst , R L . 2011 . Serum 25-hydroxy vitamin d and prostate cancer risk in a large nested case-control study . Cancer Epidemiol Biomarkers Prev , 20 : 1850 – 1860 .
   PubMed Web of Science ®Google Scholar
• Ma , Y , Zhang , P , Wang , F , Yang , J Liu , Z . 2011 . Association between vitamin d and risk of colorectal cancer: A systematic review of prospective studies . J Clin Oncol , 29 : 3775 – 3782 .
   PubMed Web of Science ®Google Scholar
• Shui , I M , Mucci , L A , Kraft , P , Tamimi , R M Lindstrom , S . 2012 . Vitamin d-related genetic variation, plasma vitamin d, and risk of lethal prostate cancer: A prospective nested case-control study . J Natl Cancer Inst , 104 : 690 – 699 .
   PubMed Web of Science ®Google Scholar
• Grant , W B . 2011 . Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin d level: Implications for meta-analyses and setting vitamin d guidelines . Dermatoendocrinol , 3 : 199 – 204 .
   PubMedGoogle Scholar
• Grant , W B . 2012 . Effect of follow-up time on the relation between prediagnostic serum 25-hydroxyvitamin d and all-cause mortality rate . Dermatoendocrinol , 4 : 198 – 202 .
   PubMedGoogle Scholar
• Lim , U , Freedman , D M , Hollis , B W , Horst , R L Purdue , M P . 2009 . A prospective investigation of serum 25-hydroxyvitamin d and risk of lymphoid cancers . Int J Cancer , 124 : 979 – 986 .
   PubMed Web of Science ®Google Scholar