215
Views
30
CrossRef citations to date
0
Altmetric
Original Articles

Genistein Induces G2/M Arrest in Gastric Cancer Cells by Increasing the Tumor Suppressor PTEN Expression

, , , , &
Pages 1034-1041 | Received 24 Apr 2012, Accepted 22 May 2013, Published online: 20 Sep 2013

REFERENCES

  • Messina , M , Nagata , C and Wu , A H . 2006 . Estimated Asian adult soy protein and isoflavone intakes . Nutr Cancer , 55 : 1 – 12 .
  • Banerjee , S , Li , Y , Wang , Z and Sarkar , F H . 2008 . Multi-targeted therapy of cancer by genistein . Cancer Lett , 269 : 226 – 242 .
  • Li , Y and Sarkar , F H . 2002 . Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway . Clin Cancer Res , 8 : 2369 – 2377 .
  • Yuan-Jing , F , Nan-Shan , H and Lian , X . 2009 . Genistein synergizes with RNA interference inhibiting survivin for inducing DU-145 of prostate cancer cells to apoptosis . Cancer Lett , 284 : 189 – 197 .
  • Frey , R S , Li , J and Singletary , K W . 2001 . Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression . Biochem Pharmacol , 61 : 979 – 989 .
  • Chang , K L , Kung , M L , Chow , N H and Su , S J . 2004 . Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1 . Biochem Pharmacol , 67 : 717 – 726 .
  • Ouyang , G , Yao , L , Ruan , K , Song , G and Mao , Y . 2009 . Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways . Cell Biol Int , 33 : 1237 – 1244 .
  • Zhao , R , Xiang , N , Domann , F E and Zhong , W . 2009 . Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells . Nutr Cancer , 61 : 397 – 407 .
  • Park , C E , Yun , H , Lee , E B , Min , B I and Bae , H . 2010 . The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells . J Med Food , 13 : 815 – 820 .
  • Rahal , O M and Simmen , R C . 2010 . PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation . Carcinogenesis , 31 : 1491 – 1500 .
  • Elledge , S J . 1996 . Cell cycle checkpoints: preventing an identity crisis . Science , 274 : 1664 – 1672 .
  • Nigg , E A . 2001 . Mitotic kinases as regulators of cell division and its checkpoints . Nat Rev Mol Cell Biol , 2 : 21 – 32 .
  • Okumura , E , Fukuhara , T , Yoshida , H , Hanada Si , S and Kozutsumi , R . 2002 . Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition . Nat Cell Biol , 4 : 111 – 116 .
  • McGowan , C H and Russell , P . 1995 . Cell cycle regulation of human WEE1 . EMBO J , 14 : 2166 – 2175 .
  • Gautier , J , Solomon , M J , Booher , R N , Bazan , J F and Kirschner , M W . 1991 . cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2 . Cell , 67 : 197 – 211 .
  • Chu , E C and Tarnawski , A S . 2004 . PTEN regulatory functions in tumor suppression and cell biology . Med Sci Monit , 10 : RA235 – RA241 .
  • Xu , X , Zhang , Y , Qu , D , Jiang , T and Li , S . 2011 . Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway . J Exp Clin Cancer Res , 30 : 33
  • Lim , W T , Zhang , W H , Miller , C R , Watters , J W and Gao , F . 2007 . PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer . Oncol Rep , 17 : 853 – 857 .
  • Sawai , H , Yasuda , A , Ochi , N , Ma , J and Matsuo , Y . 2008 . Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival . BMC Gastroenterol , 8 : 56
  • Pandolfi , P P . 2004 . Breast cancer—loss of PTEN predicts resistance to treatment . N Engl J Med , 351 : 2337 – 2338 .
  • Warde , N . 2011 . Prostate cancer: loss of PTEN promotes progression of prostate cancer in an androgen-independent manner . Nat Rev Urol , 8 : 412
  • Chow , L M and Baker , S J . 2006 . PTEN function in normal and neoplastic growth . Cancer Lett , 241 : 184 – 196 .
  • Kandel , E S , Skeen , J , Majewski , N , Di Cristofano , A and Pandolfi , P P . 2002 . Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage . Mol Cell Biol , 22 : 7831 – 7841 .
  • Arafa el , S A , Zhu , Q , Shah , Z I , Wani , G and Barakat , B M . 2011 . Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells . Mutat Res , 706 : 28 – 35 .
  • Saito , Y , Swanson , X , Mhashilkar , A M , Oida , Y and Schrock , R . 2003 . Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo . Gene Ther , 10 : 1961 – 1969 .
  • Hang , Y , Zheng , Y C , Cao , Y , Li , Q S and Sui , Y J . 2005 . Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene . World J Gastroenterol , 11 : 2224 – 2229 .
  • Zhang , Y , Chen , L H , Wang , L , Wang , H M and Zhang , Y W . 2010 . Radiation-inducible PTEN expression radiosensitises hepatocellular carcinoma cells . Int J Radiat Biol , 86 : 964 – 974 .
  • Katayama , K , Fujita , N and Tsuruo , T . 2005 . Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition . Mol Cell Biol , 25 : 5725 – 5737 .
  • Weir , N M , Selvendiran , K , Kutala , V K , Tong , L and Vishwanath , S . 2007 . Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK . Cancer Biol Ther , 6 : 178 – 184 .
  • Du , H P , Shen , J K , Yang , M , Wang , Y Q and Yuan , X Q . 2010 . 4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-kappaB signal pathway in lymphoma cells . Oncol Rep , 23 : 709 – 716 .
  • Huang , S M , Yang , J S , Tsai , S C , Chen , M H and Hsu , M H . 2011 . The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells . Int J Oncol , 38 : 1357 – 1364 .
  • Zhou , H B , Chen , J J , Wang , W X , Cai , J T and Du , Q . 2004 . Apoptosis of human primary gastric carcinoma cells induced by genistein . World J Gastroenterol , 10 : 1822 – 1825 .
  • Cui , H B , Na , X L , Song , D F and Liu , Y . 2005 . Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma . World J Gastroenterol , 11 : 69 – 72 .
  • Zhou , H B , Chen , J M , Cai , J T , Du , Q and Wu , C N . 2008 . Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice . World J Gastroenterol , 14 : 627 – 631 .
  • Kim , H J , Chang , W K , Kim , M K , Lee , S S and Choi , B Y . 2002 . Dietary factors and gastric cancer in Korea: a case-control study . Int J Cancer , 97 : 531 – 535 .
  • Wu , A H , Yang , D and Pike , M C . 2000 . A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders . Cancer Epidemiol Biomarkers Prev , 9 : 1051 – 1058 .
  • Nagata , C , Takatsuka , N , Kawakami , N and Shimizu , H . 2002 . A prospective cohort study of soy product intake and stomach cancer death . Br J Cancer , 87 : 31 – 36 .
  • Ito , L S , Inoue , M , Tajima , K , Yamamura , Y and Kodera , Y . 2003 . Dietary factors and the risk of gastric cancer among Japanese women: a comparison between the differentiated and non-differentiated subtypes . Ann Epidemiol , 13 : 24 – 31 .
  • Sauvaget , C , Lagarde , F , Nagano , J , Soda , M and Koyama , K . 2005 . Lifestyle factors, radiation and gastric cancer in atomic-bomb survivors (Japan) . Cancer Causes Control , 16 : 773 – 780 .
  • Bowey , E , Adlercreutz , H and Rowland , I . 2003 . Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats . Food Chem Toxicol , 41 : 631 – 636 .
  • Ko , K P , Park , S K , Park , B , Yang , J J and Cho , L Y . 2010 . Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort . Cancer Epidemiol Biomarkers Prev , 19 : 1292 – 1300 .
  • Touny , L H and Banerjee , P P . 2006 . Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein . Prostate , 66 : 1542 – 1555 .
  • Li , Z , Li , J , Mo , B , Hu , C and Liu , H . 2008 . Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells . Cell Biol Toxicol , 24 : 401 – 409 .
  • Mukherjee , S , Acharya , B R , Bhattacharyya , B and Chakrabarti , G . 2010 . Genistein arrests cell cycle progression of A549 cells at the G(2)/M phase and depolymerizes interphase microtubules through binding to a unique site of tubulin . Biochemistry , 49 : 1702 – 1712 .
  • Han , H , Zhong , C , Zhang , X , Liu , R and Pan , M . 2010 . Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells . Nutr Cancer , 62 : 641 – 647 .
  • Selvendiran , K , Tong , L , Vishwanath , S , Bratasz , A and Trigg , N J . 2007 . EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression . J Biol Chem , 282 : 28609 – 28618 .
  • Cao , F , Jin , T Y and Zhou , Y F . 2006 . Inhibitory effect of isoflavones on prostate cancer cells and PTEN gene . Biomed Environ Sci , 19 : 35 – 41 .
  • Wu , D D , Feng , C , Xu , X Y , Xiao , J Y and Liu , C . 2011 . Protein kinase B/Akt may regulate G2/M transition in the fertilized mouse egg by changing the localization of p21(Cip1/WAF1) . Cell Biochem Funct , 29 : 265 – 271 .
  • Tonic , I , Yu , W N , Park , Y , Chen , C C and Hay , N . 2010 . Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci . J Biol Chem , 285 : 23790 – 23798 .
  • McGowan , C H and Russell , P . 1993 . Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15 . EMBO J , 12 : 75 – 85 .
  • Taylor , W R and Stark , G R . 2001 . Regulation of the G2/M transition by p53 . Oncogene , 20 : 1803 – 1815 .
  • Ismail , I A , Kang , K S , Lee , H A , Kim , J W and Sohn , Y K . 2007 . Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation . Eur J Pharmacol , 575 : 12 – 20 .
  • Raffoul , J J , Wang , Y , Kucuk , O , Forman , J D and Sarkar , F H . 2006 . Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest . BMC Cancer , 6 : 107
  • Kikuno , N , Shiina , H , Urakami , S , Kawamoto , K and Hirata , H . 2008 . Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells . Int J Cancer , 123 : 552 – 560 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.