Oral Caffeine During Voluntary Exercise Markedly Inhibits Skin Carcinogenesis and Decreases Inflammatory Cytokines in UVB-Treated Mice

REFERENCES

• Lu , Y-P , Lou , L-R , Lin , Y , Shih , W J Huang , M-T . 2001 . Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat . Cancer Research , 61 : 5002 – 5009 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Lou , Y R , Li , X H , Xie , J G Brash , D . 2000 . Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice . Cancer Research , 60 : 4785 – 4791 .
   PubMed Web of Science ®Google Scholar
• Michna , L , Lu , Y P , Lou , Y R , Wagner , G C and Conney , A H . 2003 . Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice . Life Sciences , 73 : 1383 – 1392 .
   PubMed Web of Science ®Google Scholar
• Lou , Y R , Lu , Y P and Xie , J G . 1999 . Huang MT, and Conney AH: Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light . Nutrition and Cancer , 33 : 146 – 153 .
   PubMed Web of Science ®Google Scholar
• Michna , L , Wagner , G C , Lou , Y R , Xie , J G Peng , Q Y . 2006 . Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice . Carcinogenesis , 27 : 2108 – 2115 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Lou , Y R , Nolan , B , Peng , Q Y Xie , J G . 2006 . Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice . Proceedings of the National Academy of Sciences of the United States of America , 103 : 16301 – 16306 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Nolan , B , Lou , Y R , Peng , Q Y Wagner , G C . 2007 . Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice . Proceedings of the National Academy of Sciences of the United States of America , 104 : 12936 – 12941 .
   PubMed Web of Science ®Google Scholar
• de Leon , J , Diaz , F J , Rogers , T , Browne , D Dinsmore , L . 2003 . A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers . Progress in Neuro-Psychopharmacology & Biological Psychiatry , 27 : 165 – 171 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Lou , Y R , Nolan , B , Peng , Q Y Xie , J G . 2006 . Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice . Proceedings of the National Academy of Sciences of the United States of America , 103 : 16301 – 16306 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Lou , Y R , Bernard , J J , Peng , Q Y Li , T . 2012 . Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet . Proc Natl Acad Sci U S A , 109 : 9065 – 9070 .
   PubMed Web of Science ®Google Scholar
• Reddy , B S and Sugie , S . 1988 . Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats . Cancer Research , 48 : 6642 – 6647 .
   PubMed Web of Science ®Google Scholar
• Lou , Y , Peng , Q , Nolan , B , Wagner , G C and Lu , Y . 2010 . Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice . Carcinogenesis , 31 : 671 – 678 .
   PubMed Web of Science ®Google Scholar
• Lu , YP. , Lou , Y R , Yen , P , Mitchell , D Huang , M T . 1999 . Time course for early adaptive responses to ultraviolet B light in the epidermis of SKH-1 mice . Cancer Research , 59 : 4591 – 4602 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Lou , Y R , Peng , Q Y , Xie , J G and Conney , A H . 2004 . Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice . Cancer Research , 64 : 5020 – 5027 .
   PubMed Web of Science ®Google Scholar
• Lu , Y P , Chang , R L , Huang , M T and Conney , A H . 1993 . Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis . Carcinogenesis , 14 : 293 – 297 .
   PubMed Web of Science ®Google Scholar
• Lou , Y R , Peng , Q Y , Li , T , Medvecky , C M Lin , Y . 2011 . Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice . Carcinogenesis , 32 : 1078 – 1084 .
   PubMed Web of Science ®Google Scholar
• Graham , T E and Spriet , L L . 1991 . Performance and metabolic responses to a high caffeine dose during prolonged exercise . Journal of Applied Physiology , 71 : 2292 – 2298 .
   PubMed Web of Science ®Google Scholar
• Bangsbo , J , Jacobsen , K , Nordberg , N , Christensen , N J and Graham , T . 1992 . Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise . Journal of Applied Physiology , 72 : 1297 – 1303 . erratum in Journal of Applied Physiology 73(2)
   PubMed Web of Science ®Google Scholar
• Van Soeren , M H , Sathasivam , P , Spriet , L L and Graham , T E . 1993 . Caffeine metabolism and epinephrine responses during exercise in users and nonusers . Journal of Applied Physiology , 75 : 805 – 812 .
   PubMed Web of Science ®Google Scholar
• Lindinger , M I , Graham , T E and Spriet , L L . 1993 . Caffeine attenuates the exercise-induced increase in plasma [K+] in humans . Journal of Applied Physiology , 74 : 1149 – 1155 .
   PubMed Web of Science ®Google Scholar
• Jackman , M , Wendling , P , Friars , D and Graham , T E . 1996 . Metabolic catecholamine, and endurance responses to caffeine during intense exercise . Journal of Applied Physiology , 81 : 1658 – 1663 .
   PubMed Web of Science ®Google Scholar
• Graham , T E , Helge , J W , MacLean , D A , Kiens , B and Richter , E A . 2000 . Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise . Journal of Physiology , 529 ( 3 ) : 837 – 847 . (Pt
   PubMed Web of Science ®Google Scholar
• Tarnopolsky , M A , Atkinson , S A , MacDougall , J D , Sale , D G and Sutton , J R . 1989 . Physiological responses to caffeine during endurance running in habitual caffeine users . Medicine & Science in Sports & Exercise , 21 : 418 – 424 .
   PubMed Web of Science ®Google Scholar
• Van Soeren , M H and Graham , T E . 1998 . Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal . Journal of Applied Physiology , 85 : 1493 – 1501 .
   PubMed Web of Science ®Google Scholar
• Poehlman , E T , LaChance , P , Tremblay , A , Nadeau , A Dussault , J . 1989 . The effect of prior exercise and caffeine ingestion on metabolic rate and hormones in young adult males . Canadian Journal of Physiology & Pharmacology , 67 : 10 – 16 .
   PubMed Web of Science ®Google Scholar
• Graham , T E and Spriet , L L . 1995 . Metabolic, catecholamine, and exercise performance responses to various doses of caffeine . Journal of Applied Physiology , 78 : 867 – 874 .
   PubMed Web of Science ®Google Scholar
• Bell , D G , Jacobs , I and Zamecnik , J . 1998 . Effects of caffeine, ephedrine and their combination on time to exhaustion during high-intensity exercise . European Journal of Applied Physiology & Occupational Physiology , 77 : 427 – 433 .
   PubMed Web of Science ®Google Scholar
• Kovacs , E M , Stegen , J and Brouns , F . 1998 . Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance . Journal of Applied Physiology , 85 : 709 – 715 .
   PubMed Web of Science ®Google Scholar
• Chesley , A , Howlett , R A , Heigenhauser , G J , Hultman , E and Spriet , L L . 1998 . Regulation of muscle glycogenolytic flux during intense aerobic exercise after caffeine ingestion . American Journal of Physiology , 275 : R596 – R603 .
   PubMed Web of Science ®Google Scholar
• Bruce , C R , Anderson , M E , Fraser , S F , Stepto , N K Klein , R . 2000 . Enhancement of 2000-m rowing performance after caffeine ingestion . Medicine & Science in Sports & Exercise , 32 : 1958 – 1963 .
   PubMed Web of Science ®Google Scholar
• Graham , T E , Sathasivam , P , Rowland , M , Marko , N Greer , F . 2001 . Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test . Canadian Journal of Physiology & Pharmacology , 79 : 559 – 565 .
   PubMed Web of Science ®Google Scholar
• Graham , T E . 2001 . Caffeine and exercise: metabolism, endurance and performance . Sports Medicine , 31 : 785 – 807 .
   PubMed Web of Science ®Google Scholar
• Bell , D G , Jacobs , I and Ellerington , K . 2001 . Effect of caffeine and ephedrine ingestion on anaerobic exercise performance . Medicine & Science in Sports & Exercise , 33 : 1399 – 1403 .
   PubMed Web of Science ®Google Scholar
• Collomp , K , Candau , R , Millet , G , Mucci , P Borrani , F . 2002 . Effects of salbutamol and caffeine ingestion on exercise metabolism and performance . International Journal of Sports Medicine , 23 : 549 – 554 .
   PubMed Web of Science ®Google Scholar
• Lu , Y-P , Lou , Y-R , Li , X-H , Xie , J-G Brash , D . 2000 . Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice . Cancer Res , 60 : 4785 – 4791 .
   PubMed Web of Science ®Google Scholar
• Chandrasekar , B , Smith , J B and Freeman , G L . 2001 . Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine . Circulation , 103 : 2296 – 2302 .
   PubMed Web of Science ®Google Scholar
• Balkwill , F . 2002 . Tumor necrosis factor or tumor promoting factor? . Cytokine & growth Factor Reviews , 13 : 135 – 141 .
   PubMed Web of Science ®Google Scholar
• Chirco , R , Liu , X W , Jung , K K and Kim , H R . 2006 . Novel functions of TIMPs in cell signaling . Cancer Metastasis Reviews , 25 : 99 – 113 .
   PubMed Web of Science ®Google Scholar
• Stamenkovic , I . 2003 . Extracellular matrix remodelling: the role of matrix metalloproteinases . The Journal of Pathology , 200 : 448 – 464 .
   PubMed Web of Science ®Google Scholar
• O’Grady , A , Dunne , C , O’Kelly , P , Murphy , G M Leader , M . 2007 . Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression . Histopathology , 51 : 793 – 804 .
   PubMed Web of Science ®Google Scholar
• Cao , L and During , M J . 2012 . What is the brain-cancer connection . Annual Review of Neuroscience , 35 : 331 – 345 .
   PubMed Web of Science ®Google Scholar