Fisetin Inhibits Matrix Metalloproteinases and Reduces Tumor Cell Invasiveness and Endothelial Cell Tube Formation

REFERENCES

• Woessner , J F Jr . 2002 . MMPs and TIMPs: an historical perspective . Mol Biotechnol , 22 : 33 – 49 .
   PubMed Web of Science ®Google Scholar
• Nelson , A R , Fingleton , B , Rothenberg , M L and Matrisian , L M . 2000 . Matrix metalloproteinases: biologic activity and clinical implications . J Clin Oncol , 18 : 1135 – 1149 .
   PubMed Web of Science ®Google Scholar
• Coussens , L M , Fingleton , B and Matrisian , L M . 2002 . Matrix metalloproteinase inhibitors and cancer: trials and tribulations . Science , 295 : 2387 – 2392 .
   PubMed Web of Science ®Google Scholar
• Golub , L M , Sorsa , T , Lee , H M , Ciancio , S Sorbi , D . 1995 . Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva . J Clin Periodontol , 22 : 100 – 109 .
   PubMed Web of Science ®Google Scholar
• Ryan , M E , Ramamurthy , S and Golub , L M . 1996 . Matrix metalloproteinases and their inhibition in periodontal treatment . Curr Opin Periodontol , 3 : 85 – 96 .
   PubMedGoogle Scholar
• Koo , H M , Kim , J H , Hwang , I K , Lee , S J Kim , T H . 2002 . Refolding of the catalytic and hinge domains of human MT1-MMP expressed in Escherichia coli and its characterization . Mol Cells , 13 : 118 – 124 .
   PubMed Web of Science ®Google Scholar
• Kim , S Y , Park , S M and Lee , S-T . 2006 . Apolipoprotein C-II is a novel substrate for matrix metalloproteinases . Biochem Biophys Res Commun , 339 : 47 – 54 .
   PubMed Web of Science ®Google Scholar
• Choi , S-S , Ji , A-R , Yu , S-W , Cho , B-H Park , J D . 2011 . Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors . Bull Korean Chem Soc , 32 : 2032 – 2038 .
   Web of Science ®Google Scholar
• Jo , Y , Yoon , D-W , Kim , M Y , Lee , Y J Kim , H J . 1999 . Tissue inhibitor of metalloproteinases-2 inhibits the 4-aminophenylmercuric acetate-induced activation and autodegradation of the free promatrix metalloproteinase-2 . J Biolchem Mol Biol , 32 : 60 – 66 .
   Web of Science ®Google Scholar
• Park , S M , Hwang , I K , Kim , S Y , Lee , S J Park , K S . 2006 . Characterization of plasma gelsolin as a substrate for matrix metalloproteinases . Proteomics , 6 : 1192 – 1199 .
   PubMed Web of Science ®Google Scholar
• Golub , L M , Ramamurthy , N , McNamara , T F , Gomes , B Wolff , M . 1984 . Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease . J Periodontal Res , 19 : 651 – 655 .
   PubMed Web of Science ®Google Scholar
• Hurewitz , A N , Wu , C L , Mancuso , P and Zucker , S . 1993 . Tetracycline and doxycycline inhibit pleural fluid metalloproteinases. A possible mechanism for chemical pleurodesis . Chest , 103 : 1113 – 1117 .
   PubMed Web of Science ®Google Scholar
• Jaffe , E A , Nachman , R L , Becker , C G and Minick , C R . 1973 . Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria . J Clin Invest , 52 : 2745 – 2756 .
   PubMed Web of Science ®Google Scholar
• Hansen , M B , Nielsen , S E and Berg , K . 1989 . Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill . J Immunol Methods , 119 : 203 – 210 .
   PubMed Web of Science ®Google Scholar
• Shin , W S , Maeng , Y S , Jung , J W , Min , J K Kwon , Y G . 2008 . Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis . Biochem Biophys Res Commun , 371 : 793 – 798 .
   PubMed Web of Science ®Google Scholar
• Park , J H , Park , S M , Park , S H , Cho , K H and Lee , S-T . 2008 . Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14 . Proteomics , 8 : 2926 – 2935 .
   PubMed Web of Science ®Google Scholar
• Yu , M , Sato , H , Seiki , M , Spiegel , S and Thompson , E W . 1998 . Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells . Clin Exp Metastasis , 16 : 185 – 191 .
   PubMed Web of Science ®Google Scholar
• Jiang , A , Lehti , K , Wang , X , Weiss , S J Keski-Oja , J . 2001 . Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis . Proc Natl Acad Sci U S A , 98 : 13693 – 13698 .
   PubMed Web of Science ®Google Scholar
• Kessenbrock , K , Plaks , V and Werb , Z . 2010 . Matrix metalloproteinases: regulators of the tumor microenvironment . Cell , 141 : 52 – 67 .
   PubMed Web of Science ®Google Scholar
• Liotta , L A , Steeg , P S and Stetler-Stevenson , W G . 1991 . Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation . Cell , 64 : 327 – 336 .
   PubMed Web of Science ®Google Scholar
• Sato , H , Takino , T , Okada , Y , Cao , J Shinagawa , A . 1994 . A matrix metalloproteinase expressed on the surface of invasive tumour cells . Nature , 370 : 61 – 51 .
   PubMed Web of Science ®Google Scholar
• Knauper , V , Will , H , Lopez-Otin , C , Smith , B Atkinson , S J . 1996 . Cellular mechanisms for human procollagenase-3 activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme . J Biol Chem , 271 : 17124 – 17131 .
   PubMed Web of Science ®Google Scholar
• Nagakawa , O , Murakami , K , Yamaura , T , Fujiuchi , Y Murata , J . 2000 . Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines . Cancer Lett , 155 : 173 – 179 .
   PubMed Web of Science ®Google Scholar
• Seiki , M and Yana , I . 2003 . Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis . Cancer Sci , 94 : 569 – 574 .
   PubMed Web of Science ®Google Scholar
• Kang , T H , Tian , Y H and Kim , Y C . 2005 . Isoliquiritigenin: a competitive tyrosinase inhibitor from the Heartwood of Dalbergia odorifera . J Appl Pharmacol , 13 : 32 – 34 .
   Google Scholar
• Arai , Y , Watanabe , S , Kimira , M , Shimoi , K Mochizuki , R . 2000 . Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration . J Nutr , 130 : 2243 – 2250 .
   PubMed Web of Science ®Google Scholar
• Williams , R J , Spencer , J P and Rice-Evans , C . 2004 . Flavonoids: antioxidants or signalling molecules? . Free Radic Biol Med , 36 : 838 – 849 .
   PubMed Web of Science ®Google Scholar
• Hanneken , A , Lin , F F , Johnson , J and Maher , P . 2006 . Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death . Invest Ophthalmol Vis Sci , 47 : 3164 – 3177 .
   PubMed Web of Science ®Google Scholar
• Lee , S E , Jeong , S I , Yang , H , Park , C S Jin , Y H . 2011 . Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells . J Cell Biochem , 112 : 2352 – 2360 .
   PubMed Web of Science ®Google Scholar
• Stephenls , C R , Conover , L H , Pasternack , R , Hochstein , F A Moreland , W T . 1954 . The structure of aureomycin . J Am Chem Soc , 76 : 3568 – 3575 .
   Web of Science ®Google Scholar
• Golub , L M , Ramamurthy , N S , McNamara , T F , Greenwald , R A and Rifkin , B R . 1991 . Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs . Crit Rev Oral Biol Med , 2 : 297 – 321 .
   PubMedGoogle Scholar
• Syed , S , Takimoto , C , Hidalgo , M , Rizzo , J Kuhn , J G . 2004 . A phase I and pharmacokinetic study of Col-3 (Metastat), an oral tetracycline derivative with potent matrix metalloproteinase and antitumor properties . Clin Cancer Res , 10 : 6512 – 6521 .
   PubMed Web of Science ®Google Scholar
• Lu , X , Jung , J , Cho , H J , Lim , D Y Lee , H S . 2005 . Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells . J Nutr , 135 : 2884 – 2890 .
   PubMed Web of Science ®Google Scholar
• Khan , N , Afaq , F , Syed , D N and Mukhtar , H . 2008 . Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells . Carcinogenesis , 29 : 1049 – 1056 .
   PubMed Web of Science ®Google Scholar
• Lim , D Y and Park , J HY . 2009 . Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin . Am J Physiol Gastrointest Liver Physiol , 296 : G1060 – G1068 .
   PubMed Web of Science ®Google Scholar
• Li , J , Cheng , Y , Qu , W , Sun , Y Wang , Z . 2011 . Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells . Basic Clin Pharmacol Toxicol , 108 : 84 – 93 .
   PubMed Web of Science ®Google Scholar
• Liotta , L A , Tryggvason , K , Garbisa , S , Hart , I Foltz , C M . 1980 . Metastatic potential correlates with enzymatic degradation of basement membrane collagen . Nature , 284 : 67 – 68 .
   PubMed Web of Science ®Google Scholar
• Karakiulakis , G , Papanikolaou , C , Jankovic , S M , Aletras , A Papakonstantinou , E . 1997 . Increased type IV collagen-degrading activity in metastases originating from primary tumors of the human colon . Invasion Metastasis , 17 : 158 – 168 .
   PubMedGoogle Scholar
• Folkman , J . 1996 . Fighting cancer by attacking its blood supply . Sci Am , 275 : 150 – 154 .
   PubMed Web of Science ®Google Scholar
• Schnaper , H W , Grant , D S , Stetler-Stevenson , W G , Fridman , R D’Orazi , G . 1993 . Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro . J Cell Physiol , 156 : 235 – 246 .
   PubMed Web of Science ®Google Scholar