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Original Articles

Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats

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Pages 38-46 | Received 14 Dec 2012, Accepted 12 Aug 2013, Published online: 09 Dec 2013

REFERENCES

  • Jemal , A , Siegel , R , Xu , J and Ward , E . 2010 . Cancer statistics . CA Cancer J Clin , 60 : 277 – 300 .
  • Syed , D N , Khan , N , Afaq , F and Mukhtar , H . 2007 . Chemoprevention of prostate cancer through dietary agents: progress and promise . Cancer Epidemiol Biomarkers Prev , 16 : 2193 – 2203 .
  • Pollard , M and Luckert , P H . 1975 . Transplantable metastasizing prostate adenocarcinoma in rats . J Natl Cancer Inst , 54 : 643 – 649 .
  • Chiarodo , A . 1991 . National Cancer Institute roundtable on prostate cancer: future research directions . Cancer Res , 5 : 2498 – 2505 .
  • McCormick , D L and Rao , K V . 1999 . Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat . Euro Urol , 35 : 464 – 467 .
  • Arunkumar , A , Vijayababu , M R , Venkataraman , P , Senthilkumar , K and Arunakaran , J . 2006 . Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic . Biol Pharm Bull , 29 : 375 – 379 .
  • Banudevi , S , Elumalai , P , Arunkumar , R , Senthilkumar , K Sharmila , G . 2010 . Chemopreventive effects of zinc on MNU and testosterone induced prostate cancer in male SpragueDawley rats . J Clin Cancer Oncol Res , 137 : 677 – 686 .
  • Arunakaran , J , Banudevi , S and Arunkumar , A . 2012 . Chemopreventive Target for Prostate Cancer: Prostatic Intraepithelial Neoplasia, Intraepithelial Neoplasia , Edited by: Srivastava , S. InTech . http://www.intechopen. com/books/intraepithelial-neoplasia/chemopreventive-target-for-prostate-cancer-prostatic-intraepithelial-neoplasia (Accessed November 18, 2013).
  • Kelloff , G J , Higley , H R , Brawer , M K , Lucia , M S Sigman , C C . 2002 . Chemoprevention strategies in the prostate: an overview . Rev Urol , 4 : 69 – 77 .
  • Ramos , S . 2007 . Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention . J Nut. Biochem , 18 : 427 – 442 .
  • Bravo , L . 1998 . Polyphenols: chemistry, dietary sources, metabolism and nutritional significance . Nutrition Reviews , 56 : 317 – 333 .
  • Rice-Evans , C . 2001 . Flavonoid antioxidants . Current Medicinal Chemistry , 8 : 797 – 807 .
  • Aviram , M and Fuhrman , B . 2002 . Wine flavonoids protect against LDL oxidation and atherosclerosis . Ann NY Acad Sci , 957 : 146 – 161 .
  • Shaik , Y B , Castellani , M L , Perrella , A , Conti , F Salini , V . 2006 . Role of quercetin (a natural herbal compound) in allergy and inflammation . J Biol Regul Homeost Agents , 20 : 47 – 52 .
  • Choi , J A , Kim , J Y , Lee , J Y , Kang , C M Kwon , H J . 2001 . Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin . Int J Oncol , 19 : 837 – 844 .
  • Kuo , P C , Liu , H F and Chao , J I . 2004 . Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells . J Biol Chem , 279 : 55875 – 55885 .
  • Yang , C S , Tran , E , Nguyen , T T , Ong , C K Lee , S K . 2004 . Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions . Oncol Rep , 11 : 727 – 733 .
  • Vijayababu , M R , Kanagaraj , P , Arunkumar , A , Ilangovan , R Dharmarajan , A . 2006 . Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3 . Oncol Res , 16 : 67 – 74 .
  • Choi , E J , Bae , S M and Ahn , W S . 2009 . Antiproliferative effects of Quercetin through cell cycle arrest and apoptosis in human breast cancerMDA-MB-453 cells . Arch Pharm Res , 31 : 1281 – 1285 .
  • Jung , Y H , Heo , J , Lee , J Y , Kwon , K T and Kim , H K . 2010 . Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5 . Life Sci , 86 : 351 – 357 .
  • Senthilkumar , K , Elumalai , P , Arunkumar , R , Banudevi , S Gunadharini , N D . 2010 . Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3) . Mol Cell Biochem , 344 : 173 – 184 .
  • Senthilkumar , K , Arunkumar , R , Elumalai , P , Sharmila , G Gunadharini , N D . 2011 . Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3) . Cell Biochem Funct , 29 : 87 – 95 .
  • Liao , Z , Boileau , T WM , Erdman , J W and Clinton , S K . 2002 . Interrelationships among angiogenesis, proliferation, and apoptosis in the tumor microenvironment during N-methyl-N-nitrosourea androgen-induced prostate carcinogenesis in rats . Carcinogenesis , 23 : 1701 – 1712 .
  • Seufi , A M , Ibrahim , S S , Elmaghraby , T K and Hafez , E E . 2009 . Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences . J Exp Clin Cancer Res , 28 ( 80 )
  • Lowry , O H , Rosenbrough , N J , Farr , A L and Randall , R J . 1951 . Protein measurement with the Folin phenol reagent . J Biol Chem , 193 : 256 – 75 .
  • Devasagayam , T P and Tarachand , U . 1987 . Decreased lipid peroxidation in the rat kidneys during gestation . Biochem Biophys Res Commun , 145 : 134 – 138 .
  • Pick , E and Keisari , Y . 1981 . Superoxide anion and H2O2 production by chemically elicited peritoneal macrophages-induced by multiple nonphagocytic stimuli . Cell Immunol , 59 : 301 – 318 .
  • Moron , M S , Depierre , J W and Mannervik , B . 1979 . Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver . Biochim Biophys Acta , 582 : 67 – 78 .
  • Jesik , C J , Holland , J M and Lee , C . 1982 . An anatomic and histologic study of the rat prostate . Prostate , 3 : 81 – 97 .
  • Shureiqi , I , Reddy , P and Brenner , D E . 2000 . Chemoprevention: general perspective . Crit Rev Oncol/Hematol , 33 : 157 – 167 .
  • Senthilkumar , K , Arunkumar , A , Sridevi , N , Vijayababu , M R Kanagaraj , P . 2006 . Chemoprevention of MNU and testosterone induced prostate carcinogenesis by calcitriol (vitamin D3) in adult male albino Wistar rats . Ann Cancer Res Therap , 14 : 12 – 18 .
  • Bartsch , H and Nair , J . 2002 . Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adduct as stable oxidative stress markers . Cancer Detect Prev , 26 : 308 – 312 .
  • Kang , D H . 2002 . Oxidative stress, DNA damage and breast cancer . AACN Clin , 13 : 540 – 549 .
  • Ahmed , M I , Fayed , S T , Hossein , H and Tash , F M . 1999 . Lipid peroxidation and antioxidant status in human cervical carcinoma . Dis Markers , 15 : 283 – 291 .
  • Tampa , Y and Tsukamoto , M . 1998 . The antioxidant action of 2-methyl- 6-(pmethoxyphenyl3, 7- dihydroimidazo [1,2-alpha] pyrazin-3-one (MCLA), a chemiluminescence probe to detect superoxide anions . FEBS Lett , 430 : 348 – 352 .
  • Halliwell , B and Gutteridge , M C . 1999 . Free radicals in biology and medicine (3rd ed.) Oxford, London , , UK
  • Diplock , A T , Rice-Evans , A C and Burton , R H . 1994 . Is there a significant role for lipid peroxidation in the of free causation of malignancy and for antioxidants in cancer prevention? . Cancer Res , 54 : 19525 – 19526 .
  • Otamiri , T and Sjodahl , R . 1989 . Increased lipidperoxidation in malignant tissues of patients with colorectal cancer . Cancer , 61 : 122 – 125 .
  • Sakanashi , Y , Oyama , K , Matsui , H , Oyama , T B Oyama , T M . 2008 . Possible use of quercetin, an antioxidant, for the protection of cells suffering from an overload of intracellular Ca2+: a model experiment . Life Sciences , 83 : 164 – 169 .
  • Gupta , C , Vikram , A , Tripathi , D N , Ramarao , P and Jena , G B . 2009 . Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat . Phytother Res , 24 : 119 – 128 .
  • Reddy , N S , Nirmala , P , Chidambaram , N and Kumar , P A . 2012 . Quercetin in dimethyl benzanthracene induced breast cancer in rats . Am J Pharmacol Toxicol , 7 : 68 – 72 .
  • Bostwick , D G . 1995 . High-grade prostatic intraepithelial neoplasia: the most likely precursor of prostate cancer . Cancer , 75 : 1823 – 1836 .
  • Manach , C , Morand , C , Crespy , V , Demigné , C Texier , O . 1998 . Quercetin is recovered in human plasma as conjugated derivatives which retainantioxidant properties . FEBS Lett , 426 : 331 – 336 .
  • Heijnen , C G , Haenen , G R , Vekemans , J A and Bast , A . 2001 . Peroxynitrite scavenging of flavonoids: structure activity relationship . Environ Toxicol Pharmacol , 10 : 199 – 206 .

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