PPARα Activation Sensitizes Cancer Cells to Epigallocatechin-3-Gallate (EGCG) Treatment via Suppressing Heme Oxygenase-1

REFERENCES

• Frei , B and Higdon , J V . 2003 . Antioxidant activity of tea polyphenols in vivo: evidence from animal studies . J Nutr , 133 : 3275S – 3284S .
   PubMed Web of Science ®Google Scholar
• Kuriyama , S . 2008 . The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies . J Nutr , 138 1548S–1553S
   PubMed Web of Science ®Google Scholar
• Kuriyama , S , Shimazu , T , Ohmori , K , Kikuchi , N Nakaya , N . 2006 . Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study . JAMA , 296 : 1255 – 1265 .
   PubMed Web of Science ®Google Scholar
• Khan , S G , Katiyar , S K , Agarwal , R and Mukhtar , H . 1992 . Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention . Cancer Res , 52 : 4050 – 4052 .
   PubMed Web of Science ®Google Scholar
• Gensler , H L , Timmermann , B N , Valcic , S , Wachter , G A Dorr , R . 1996 . Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea . Nutr Cancer , 26 : 325 – 335 .
   PubMed Web of Science ®Google Scholar
• Setiawan , V W , Zhang , Z F , Yu , G P , Lu , Q Y Li , Y L . 2001 . Protective effect of green tea on the risks of chronic gastritis and stomach cancer . Int J Cancer , 92 : 600 – 604 .
   PubMed Web of Science ®Google Scholar
• Inoue , M , Tajima , K , Mizutani , M , Iwata , H Iwase , T . 2001 . Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan . Cancer Lett , 167 : 175 – 182 .
   PubMed Web of Science ®Google Scholar
• Singh , B N , Shankar , S and Srivastava , R K . 2011 . Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications . Biochem Pharmacol , 82 : 1807 – 1821 .
   PubMed Web of Science ®Google Scholar
• Qiao , Y , Cao , J , Xie , L and hi , X . 2009 . Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells . Arch Pharm Res , 32 : 1309 – 1315 .
   PubMed Web of Science ®Google Scholar
• Hsieh , T C and Wu , J M . 2009 . Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin . Anticancer Res , 29 : 4025 – 4032 .
   PubMed Web of Science ®Google Scholar
• Bettuzzi , S , Brausi , M , Rizzi , F , Castagnetti , G Peracchia , G . 2006 . Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study . Cancer Res , 66 : 1234 – 1240 .
   PubMed Web of Science ®Google Scholar
• Philips , B J , Coyle , C H , Morrisroe , S N , Chancellor , M B and Yoshimura , N . 2009 . Induction of apoptosis in human bladder cancer cells by green tea catechins . Biomed Res , 30 : 207 – 215 .
   PubMed Web of Science ®Google Scholar
• Liu , T T , Liang , N S , Li , Y , Yang , F Lu , Y . 2003 . Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats . World J Gastroenterol , 9 : 2742 – 2744 .
   PubMed Web of Science ®Google Scholar
• Lambert , J D and Elias , R J . 2010 . The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention . Arch Biochem Biophys , 501 : 65 – 72 .
   PubMed Web of Science ®Google Scholar
• Lee , T S and Chau , L Y . 2002 . Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice . Nat Med , 8 : 240 – 246 .
   PubMed Web of Science ®Google Scholar
• Shan , Y , Pepe , J , Lu , T H , Elbirt , K K Lambrecht , R W . 2000 . Induction of the heme oxygenase-1 gene by metalloporphyrins . Arch Biochem Biophys , 380 : 219 – 227 .
   PubMed Web of Science ®Google Scholar
• Wu , C C , Hsu , M C , Hsieh , C W , Lin , J B Lai , P H . 2006 . Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways . Life Sci , 78 : 2889 – 2897 .
   PubMed Web of Science ®Google Scholar
• Patterson , A D , Slanar , O , Krausz , K W , Li , F Hofer , C C . 2009 . Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation . J Proteome Res , 8 : 4293 – 4300 .
   PubMed Web of Science ®Google Scholar
• Patterson , A D , Shah , Y M , Matsubara , T , Krausz , K W and Gonzalez , F J . 2012 . Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity . Hepatology , 56 : 281 – 290 .
   PubMed Web of Science ®Google Scholar
• Schoonjans , K , Staels , B and Auwerx , J . 1996 . The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation . Biochim Biophys Acta , 1302 : 93 – 109 .
   PubMed Web of Science ®Google Scholar
• Desvergne , B and Wahli , W . 1999 . Peroxisome proliferator-activated receptors: nuclear control of metabolism . Endocr Rev , 20 : 649 – 688 .
   PubMed Web of Science ®Google Scholar
• Evans , R M , Barish , G D and Wang , Y X . 2004 . PPARs and the complex journey to obesity . Nat Med , 10 : 355 – 361 .
   PubMed Web of Science ®Google Scholar
• Kronke , G , Kadl , A , Ikonomu , E , Bluml , S Furnkranz , A . 2007 . Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors . Arterioscler Thromb Vasc Biol , 27 : 1276 – 1282 .
   PubMed Web of Science ®Google Scholar
• Wu , K K . 2010 . Peroxisome proliferator-activated receptors protect against apoptosis via 14–3–3 . PPAR Res , 2010 : 1 – 7 .
   Web of Science ®Google Scholar
• Zhang , S , Lu , J , Zhao , X , Wu , W Wang , H . 2010 . A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer . Carcinogenesis , 31 : 1251 – 1258 .
   PubMed Web of Science ®Google Scholar
• Zhang , S , Song , C , Zhou , J , Xie , L Meng , X . 2012 . Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats . Radiat Oncol , 7 ( 4 )
   Google Scholar
• Jiang , Y J , Hatch , G M , Mymin , D , Dembinski , T Kroeger , E A . 2001 . Modulation of cytosolic phospholipase A(2) by PPAR activators in human preadipocytes . J Lipid Res , 42 : 716 – 724 .
   PubMed Web of Science ®Google Scholar
• Kim , Y I , Hirai , S , Takahashi , H , Goto , T Ohyane , C . 2011 . 9-oxo-10(E),12(E)-Octadecadienoic acid derived from tomato is a potent PPAR alpha agonist to decrease triglyceride accumulation in mouse primary hepatocytes . Mol Nutr Food Res , 55 : 585 – 593 .
   PubMed Web of Science ®Google Scholar
• Beck , K , Wu , B J , Ni , J , Santiago , F S Malabanan , K P . 2010 . Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia . Circ Res , 107 : 1490 – 1497 .
   PubMed Web of Science ®Google Scholar
• A , I J , Jeannin , E , Wahli , W and Desvergne , B . 1997 . Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element . J Biol Chem , 272 : 20108 – 20117 .
   PubMed Web of Science ®Google Scholar
• van der Meer , D L , Degenhardt , T , Vaisanen , S , de Groot , P J Heinaniemi , M . 2010 . Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis . Nucleic Acids Res , 38 : 2839 – 2850 .
   PubMed Web of Science ®Google Scholar
• Zhou , J , Zhang , S , Xue , J , Avery , J Wu , J . 2012 . Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) suppresses hypoxia-inducible factor-1alpha (HIF-1alpha) signaling in cancer cells . J Biol Chem , 287 : 35161 – 35169 .
   PubMed Web of Science ®Google Scholar
• Lin , H , Hou , C C , Cheng , C F , Chiu , T H Hsu , Y H . 2007 . Peroxisomal proliferator-activated receptor-alpha protects renal tubular cells from doxorubicin-induced apoptosis . Mol Pharmacol , 72 : 1238 – 1245 .
   PubMed Web of Science ®Google Scholar
• Chinetti , G , Griglio , S , Antonucci , M , Torra , I P Delerive , P . 1998 . Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages . J Biol Chem , 273 : 25573 – 25580 .
   PubMed Web of Science ®Google Scholar
• Zhao , W , Iskandar , S , Kooshki , M , Sharpe , J G Payne , V . 2007 . Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs . Radiat Res , 167 : 581 – 591 .
   PubMed Web of Science ®Google Scholar
• Xiao , S , Anderson , S P , Swanson , C , Bahnemann , R Voss , K A . 2006 . Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver . Toxicol Sci , 92 : 368 – 377 .
   PubMed Web of Science ®Google Scholar
• Maggiora , M , Oraldi , M , Muzio , G and Canuto , R A . 2007 . Involvement of PPARalpha and PPARgamma in apoptosis and proliferation of human hepatocarcinoma HepG2 cells . Cell Biochem Funct , 28 : 571 – 577 .
   Web of Science ®Google Scholar
• Tuller , E R , Brock , A L , Yu , H , Lou , J R Benbrook , D M . 2009 . PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells . Biochem Pharmacol , 77 : 1480 – 1486 .
   PubMed Web of Science ®Google Scholar