Methylseleninic Acid Suppresses Pancreatic Cancer Growth Involving Multiple Pathways

REFERENCES

• Siegel , R , Naishadham , D and Jemal , A . 2012 . Cancer statistics, 2012 . CA: a cancer Journal for Clinicians , 62 : 10 – 29 .
   PubMed Web of Science ®Google Scholar
• Chue , B M . 2009 . Five-year survival of metastatic pancreatic carcinoma: a study of courage and hope . Gastrointestinal Cancer Research , 3 : 208 – 211 .
   PubMedGoogle Scholar
• Schneider , G , Siveke , J T , Eckel , F and Schmid , R M . 2005 . Pancreatic cancer: basic and clinical aspects . Gastroenterology , 128 : 1606 – 1625 .
   PubMed Web of Science ®Google Scholar
• Lippman , S M , Klein , E A , Goodman , P J , Lucia , M S Thompson , I M . 2009 . Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) . JAMA: The Journal of the American Medical Association , 301 : 39 – 51 .
   PubMed Web of Science ®Google Scholar
• Marshall , J R , Tangen , C M , Sakr , W A , Wood , D P Jr. Berry , D L . 2011 . Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917 . Cancer Prev Res (Phila) , 4 : 1761 – 1769 .
   PubMed Web of Science ®Google Scholar
• Ip , C . 1998 . Lessons from basic research in selenium and cancer prevention . The Journal of Nutrition , 128 : 1845 – 1854 .
   PubMed Web of Science ®Google Scholar
• Lu , J and Jiang , C . 2005 . Selenium and cancer chemoprevention: hypotheses integrating the actions of selenoproteins and selenium metabolites in epithelial and non-epithelial target cells . Antioxidants & Redox Signaling , 7 : 1715 – 1727 .
   PubMed Web of Science ®Google Scholar
• Li , G X , Lee , H J , Wang , Z , Hu , H Liao , J D . 2008 . Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite . Carcinogenesis , 29 : 1005 – 1012 .
   PubMed Web of Science ®Google Scholar
• Wang , L , Bonorden , M J , Li , G X , Lee , H J Hu , H . 2009 . Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit . Cancer Prev Res (Phila) , 2 : 484 – 495 .
   PubMed Web of Science ®Google Scholar
• Jiang , C , Wang , Z , Ganther , H and Lu , J . 2001 . Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells . Cancer Research , 61 : 3062 – 3070 .
   PubMed Web of Science ®Google Scholar
• Wang , Z , Jiang , C , Ganther , H and Lu , J . 2001 . Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling . Cancer Research , 61 : 7171 – 7178 .
   PubMed Web of Science ®Google Scholar
• Wang , Z , Jiang , C and Lu , J . 2002 . Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol . Molecular Carcinogenesis , 34 : 113 – 120 .
   PubMed Web of Science ®Google Scholar
• Hu , H , Jiang , C , Li , G and Lu , J . 2005 . PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells . Carcinogenesis , 26 : 1374 – 1381 .
   PubMed Web of Science ®Google Scholar
• Wang , Z , Lee , H J , Chai , Y , Hu , H Wang , L . 2010 . Persistent p21Cip1 induction mediates G(1) cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells . Current Cancer Drug Targets , 10 : 307 – 318 .
   PubMed Web of Science ®Google Scholar
• Wang , L , Zhang , J , Zhang , Y , Nkhata , K Quealy , E . 2011 . Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium . The Prostate , 71 : 1429 – 1440 .
   PubMed Web of Science ®Google Scholar
• Hu , H , Jiang , C , Ip , C , Rustum , Y M and Lu , J . 2005 . Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells . Clinical Cancer Research: An Official Journal of the American Association for Cancer Research , 11 : 2379 – 2388 .
   PubMed Web of Science ®Google Scholar
• Hu , H , Li , G X , Wang , L , Watts , J Combs , G F Jr. 2008 . Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin . Clinical Cancer Research: An Official Journal of the American Association for Cancer Research , 14 : 1150 – 1158 .
   PubMed Web of Science ®Google Scholar
• Birt , D F . 1986 . Update on the effects of vitamins A, C, and E and selenium on carcinogenesis . Proc Soc Exp Biol Med , 183 : 311 – 320 .
   PubMed Web of Science ®Google Scholar
• Birt , D F , Julius , A D , Runice , C E , White , L T and Lawson , T . 1988 . Enhancement of BOP-induced pancreatic carcinogenesis in selenium-fed Syrian golden hamsters under specific dietary conditions . Nutrition and Cancer , 11 : 21 – 33 .
   PubMed Web of Science ®Google Scholar
• Woutersen , R A , Appel , M J and Van Garderen-Hoetmer , A . 1999 . Modulation of pancreatic carcinogenesis by antioxidants . Food Chem Toxicol , 37 : 981 – 984 .
   PubMed Web of Science ®Google Scholar
• Aichler , M , Algul , H , Behne , D , Holzlwimmer , G Michalke , B . 2007 . Selenium status alters tumour differentiation but not incidence or latency of pancreatic adenocarcinomas in Ela-TGF-alpha p53+/ mice . Carcinogenesis , 28 : 2002 – 2007 .
   PubMed Web of Science ®Google Scholar
• Jiang , C , Wang , Z , Ganther , H and Lu , J . 2002 . Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells . Molecular Cancer Therapeutics , 1 : 1059 – 1066 .
   PubMed Web of Science ®Google Scholar
• Li , G X , Hu , H , Jiang , C , Schuster , T and Lu , J . 2007 . Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells . International Journal of Cancer , 120 : 2034 – 2043 .
   PubMed Web of Science ®Google Scholar
• Sandgren , E P , Quaife , C J , Paulovich , A G , Palmiter , R D and Brinster , R L . 1991 . Pancreatic tumor pathogenesis reflects the causative genetic lesion . Proceedings of the National Academy of Sciences of the United States of America , 88 : 93 – 97 .
   PubMed Web of Science ®Google Scholar
• Biliran , H Jr. , Wang , Y , Banerjee , S , Xu , H Heng , H . 2005 . Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line . Clinical Cancer Research: An Official Journal of the American Association for Cancer Research , 11 : 6075 – 6086 .
   PubMed Web of Science ®Google Scholar
• Krishan , A . 1975 . Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining . The Journal of Cell Biology , 66 : 188 – 193 .
   PubMed Web of Science ®Google Scholar
• Jiang , C , Hu , H , Malewicz , B , Wang , Z and Lu , J . 2004 . Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells . Molecular Cancer Therapeutics , 3 : 877 – 884 .
   PubMed Web of Science ®Google Scholar
• Cho , S D , Jiang , C , Malewicz , B , Dong , Y Young , C Y . 2004 . Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription . Molecular Cancer Therapeutics , 3 : 605 – 611 .
   PubMed Web of Science ®Google Scholar
• Guo , X W , Th’ng , J P , Swank , R A , Anderson , H J Tudan , C . 1995 . Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation . The EMBO Journal , 14 : 976 – 985 .
   PubMed Web of Science ®Google Scholar
• Redston , M S , Caldas , C , Seymour , A B , Hruban , R H da Costa , L . 1994 . p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions . Cancer Research , 54 : 3025 – 3033 .
   PubMed Web of Science ®Google Scholar
• Widrow , R J , Rabinovitch , P S , Cho , K and Laird , C D . 1997 . Separation of cells at different times within G2 and mitosis by cyclin B1 flow cytometry . Cytometry , 27 : 250 – 254 .
   PubMedGoogle Scholar
• Levine , B and Klionsky , D J . 2004 . Development by self-digestion: molecular mechanisms and biological functions of autophagy . Developmental Cell , 6 : 463 – 477 .
   PubMed Web of Science ®Google Scholar
• Kabeya , Y , Mizushima , N , Yamamoto , A , Oshitani-Okamoto , S Ohsumi , Y . 2004 . LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation . Journal of Cell Science , 117 : 2805 – 2812 .
   PubMed Web of Science ®Google Scholar
• Kametaka , S , Okano , T , Ohsumi , M and Ohsumi , Y . 1998 . Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae . The Journal of Biological Chemistry , 273 : 22284 – 22291 .
   PubMed Web of Science ®Google Scholar
• Clark , L C , Combs , G F Jr. , Turnbull , B W Slate , E H . 1996 . Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group . JAMA: The Journal of the American Medical Association , 276 : 1957 – 1963 .
   PubMed Web of Science ®Google Scholar
• Marshall , J R , Ip , C , Romano , K , Fetterly , G Fakih , M . 2011 . Methyl selenocysteine: single-dose pharmacokinetics in men . Cancer Prev Res (Phila) , 4 : 1938 – 1944 .
   PubMed Web of Science ®Google Scholar
• Wu , M , Kang , M M , Schoene , N W and Cheng , W H . 2010 . Selenium compounds activate early barriers of tumorigenesis . The Journal of Biological Chemistry , 285 : 12055 – 12062 .
   PubMed Web of Science ®Google Scholar
• Wu , M , Wu , R T , Wang , T T and Cheng , W H . 2011 . Role for p53 in selenium-induced senescence . Journal of Agricultural and Food Chemistry , 59 : 11882 – 11887 .
   PubMed Web of Science ®Google Scholar
• Kim , E H and Choi , K S . 2008 . A critical role of superoxide anion in selenite-induced mitophagic cell death . Autophagy , 4 : 76 – 78 .
   PubMed Web of Science ®Google Scholar
• Park , S H , Kim , J H , Chi , G Y , Kim , G Y Chang , Y C . 2012 . Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species . Toxicology Letters , 212 : 252 – 261 .
   PubMed Web of Science ®Google Scholar
• Jiang , Q , Li , F , Shi , K , Yang , Y and Xu , C . 2012 . Sodium selenite-induced activation of DAPK promotes autophagy in human leukemia HL60 cells . BMB Reports , 45 : 194 – 199 .
   PubMed Web of Science ®Google Scholar
• Kralova , V , Benesova , S , Cervinka , M and Rudolf , E . 2012 . Selenite-induced apoptosis and autophagy in colon cancer cells . Toxicology In Vitro , 26 : 258 – 268 .
   PubMed Web of Science ®Google Scholar
• Jiang , Q , Wang , Y , Li , T , Shi , K , Li , Z Ma , Y . 2011 . Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells . Molecular Biology of the Cell , 22 : 1167 – 1180 .
   PubMed Web of Science ®Google Scholar
• Ren , Y , Huang , F , Liu , Y , Yang , Y Jiang , Q . 2009 . Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells . BMB Reports , 42 : 599 – 604 .
   PubMed Web of Science ®Google Scholar
• Castedo , M , Roumier , T , Blanco , J , Ferri , K F Barretina , J . 2002 . Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope . The EMBO Journal , 21 : 4070 – 4080 .
   PubMed Web of Science ®Google Scholar
• Castedo , M , Ferri , K F and Kroemer , G . 2002 . Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic . Cell Death and Differentiation , 9 : 99 – 100 .
   PubMed Web of Science ®Google Scholar
• Fang , Y , Vilella-Bach , M , Bachmann , R , Flanigan , A and Chen , J . 2001 . Phosphatidic acid-mediated mitogenic activation of mTOR signaling . Science , 294 : 1942 – 1945 .
   PubMed Web of Science ®Google Scholar
• Burnett , P E and Barrow , R K . Cohen NA, Snyder SH, and Sabatini DM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 . Proceedings of the National Academy of Sciences of the United States of America , Vol. 95 , pp. 1432 – 1437 .
   Google Scholar
• Sonenberg , N and Gingras , A C . 1998 . The mRNA 5’ cap-binding protein eIF4E and control of cell growth . Current Opinion in Cell Biology , 10 : 268 – 275 .
   PubMed Web of Science ®Google Scholar
• Ambrosini , G , Adida , C and Altieri , D C . 1997 . A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma . Nature Medicine , 3 : 917 – 921 .
   PubMed Web of Science ®Google Scholar
• Li , F , Ackermann , E J , Bennett , C F , Rothermel , A L Plescia , J . 1999 . Pleiotropic cell-division defects and apoptosis induced by interference with survivin function . Nature Cell Biology , 1 : 461 – 466 .
   PubMed Web of Science ®Google Scholar
• Minn , A J , Kettlun , C S , Liang , H , Kelekar , A Vander Heiden , M G . 1999 . Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms . The EMBO Journal , 18 : 632 – 643 .
   PubMed Web of Science ®Google Scholar
• Jiang , C , Jiang , W , Ip , C , Ganther , H and Lu , J . 1999 . Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake . Molecular Carcinogenesis , 26 : 213 – 225 .
   PubMed Web of Science ®Google Scholar