162
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats

, , , , &
Pages 713-720 | Received 07 Mar 2014, Accepted 11 Feb 2015, Published online: 16 Apr 2015

REFERENCES

  • von Haehling S and Anker SD: Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle 1, 1–5, 2010.
  • Burckart K, Beca S, Urban RJ, and Sheffield-Moore M: Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies. Curr Opin Clin Nutr Metab Care 13, 410–416, 2010.
  • Wu G and Morris SM Jr.: Arginine metabolism: nitric oxide and beyond. Biochem J 336, 1–17, 1998.
  • Peranzoni E, Marigo I, Dolcettie L, Ugel S, Sonda N, et al.: Role of arginine metabolism in immunity and immunopathology. Immunobiology 212, 795–812, 2007.
  • Deignan JL, Livesay JC, Yoo PK, Goodman SI, O'Brien WE, et al.: Ornithine deficiency in the arginase double knockout mouse. Mol Genet Metab 89, 87–96, 2006.
  • Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, et al.: Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 65, 3044–3048, 2005.
  • Vermeulen MA, van de Poll MC, Ligthart-Melis GC, Dejong CH, van den Tol MP, et al.: Specific amino acids in the critically ill patient—exogenous glutamine/arginine: a common denominator? Crit Care Med 35, S568–S576, 2007.
  • van de Poll MC, Ligthart-Melis GC, Boelens PG, Deutz NE, van Leeuwen PA, et al.: Intestinal and hepatic metabolism of glutamine and citrulline in humans. J Physiol 581, 819–827, 2007.
  • de Blaauw I, Deutz NE, van der Hulst RR, and von Meyenfeldt MF: Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats. Gastroenterology 112, 118–126, 1997.
  • Souba WW, Strebel FR, Bull JM, Copeland EM, Teagtmeyer H, et al.: Interorgan glutamine metabolism in the tumor-bearing rat. J Surg Res 44, 720–726, 1988.
  • Hartman WJ and Prior RL. Dietary arginine deficiency alters flux of glutamine and urea cycle intermediates across the portal-drained viscera and liver of rats. J Nutr 122, 1472–1482, 1992.
  • Vissers YL, von Meyenfeldt MF, Luiking YC, Dejong CH, Buurman WA, et al.: Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice. Clin Sci (Lond) 112, 527–532, 2007.
  • Vissers YL, von Meyenfeldt MF, Luiking YC, Dejong CH, and Deutz NE: Interorgan synthesis of arginine is down-regulated in tumor-bearing mice undergoing surgical trauma. Metabolism 57, 896–902, 2008.
  • de Blaauw I, Heeneman S, Deutz NE, and von Meyenfeldt MF: Increased whole-body protein and glutamine turnover in advanced cancer is not matched by an increased muscle protein and glutamine turnover. J Surg Res 68, 44–55, 1997.
  • Buijs N, Luttikhold J, Houdijk AP, and van Leeuwen PA. The role of a disturbed arginine/NO metabolism in the onset of cancer cachexia: a working hypothesis. Curr Med Chem 19, 5278–5286, 2012.
  • Noe JE: L-glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective. Integr Cancer Ther 8, 409–415, 2009.
  • Bansal V, Rodriguez P, Wu G, Eichler DC, Sabaleta J, et al.: Citrulline can preserve proliferation and prevent the loss of CD3 zeta chain under conditions of low arginine. JPEN J Parenter Enteral Nutr 28, 423–430, 2004.
  • Wijnands KA, Vink H, Briede JJ, van Faassen EE, Lamers WH, et al.: Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. PLoS One 7, e37439, 2012.
  • Wu GY and Brosnan JT:Macrophages can convert citrulline into arginine. Biochem J 281(Pt 1), 45–48, 1992.
  • Houdijk AP, van Leeuwen PA, Teerlink T, Flinkerbusch EL, Boermeester MA, et al.: Glutamine-enriched enteral diet increases renal arginine production. JPEN 18, 422–426, 1994.
  • Younes RN, Rogatko A, Vydelingum NA, and Brennan MF: Effects of hypovolemia and transfusion on tumor growth in MCA-tumor-bearing rats. Surgery 109, 307–312, 1991.
  • Welbourne TC, Phromphetcharat V, Givens G, and Joshi S: Regulation of interorganal glutamine flow in metabolic acidosis. Am J Physiol 250, E457–E463, 1986.
  • Teerlink T, Van Leeuwen PA, and Houdijk A: Plasma amino acids determined by liquid chromatography within 17 minutes. Clin Chem 40, 245–249, 1994.
  • Boelens PG, Houdijk AP, de Thouars HN, Teerlink T, van Engeland MI, et al. Plasma taurine concentrations increase after enteral glutamine supplementation in trauma patients and stressed rats. Am J Clin Nutr 77, 250–256, 2003.
  • Vermeulen MA, Ligthart-Melis GC, Buijsman R, Siroen MP, van de Poll MC, et al.: Accurate perioperative flow measurement of the portal vein and hepatic and renal artery: a role for preoperative MRI? Eur J Radiol 81, 2042–2048, 2012.
  • Hallemeesch MM, Soeters PB, and Deutz NE: Tracer methodology in whole body and organ balance metabolic studies: plasma sampling is required. A study in post-absorptive rats using isotopically labeled arginine, phenylalanine, valine and leucine. Clin Nutr 19, 157–163, 2000.
  • Van CE and Arends J: The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 9(Suppl 2), S51–S63, 2005.
  • Popovic PJ, Zeh HJ 3rd, and Ochoa JB: Arginine and immunity. J Nutr 137, 1681S–1686S, 2007.
  • Raber P, Ochoa AC, and Rodriguez PC: Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives. Immunol Invest 41, 614–634, 2012.
  • Bansal V and Ochoa JB: Arginine availability, arginase, and the immune response. Curr Opin Clin Nutr Metab Care 6, 223–228, 2003.
  • Souba WW: Glutamine and cancer. Ann Surg 218, 715–728, 1993.
  • Chen MK, Espat NJ, Bland KI, Copeland EM 3rd, and Souba WW: Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney. Ann Surg 217, 655–667, 1993.
  • Mowat AM, Millington OR, and Chirdo FG. Anatomical and cellular basis of immunity and tolerance in the intestine. J Pediatr Gastroenterol Nutr 39(Suppl 3), S723–S724, 2004.
  • Rabinovich GA, Gabrilovich D, and Sotomayor EM: Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25, 267–296, 2007.
  • Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, et al.: The mechanisms of cancer immunoescape and development of overcoming strategies. Int J Hematol 93, 294–300, 2011.
  • Fan J, Meng Q, Guo G, Xie Y, Xiu Y, et al.: Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice. Nutrition 25, 233–239, 2009.
  • Fernandes LC, Marques-da-Costa MM, and Curi R: Metabolism of glucose, glutamine and pyruvate in lymphocytes from Walker 256 tumor-bearing rats. Braz J Med Biol Res 27, 2539–2543, 1994.
  • Hulsewe KW, Deutz NE, de BI, van der Hulst RR, von Meyenfeldt MM, et al.: Liver protein and glutamine metabolism during cachexia. Proc Nutr Soc 56, 801–806, 1997.
  • Wernerman J: Glutamine supplementation. Ann Intensive Care 1, 25, 2011.
  • Boutry C, Matsumoto H, Bos C, Moinard C, Cynober L, et al.: Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect? Amino Acids 43, 1485–1498, 2012.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.