217
Views
27
CrossRef citations to date
0
Altmetric
Articles

Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9

, , , , , , , & show all
Pages 1191-1200 | Received 11 Dec 2014, Accepted 08 Jul 2015, Published online: 11 Sep 2015

REFERENCES

  • Yachida S, Jones S, Bozic I, Antal T, Leary R, et al.: Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114–1117, 2010.
  • Valastyan S and Weinberg RA: Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275–292, 2011.
  • Kessenbrock K, Plaks V, and Werb Z: Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141, 52–67, 2010.
  • McCawley LJ and Matrisian LM: Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 6, 149–156, 2000.
  • Khasigov PZ, Podobed OV, Gracheva TS, Salbiev KD, Grachev SV, et al.: Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis. Biochemistry (Mosc) 68, 711–717, 2003.
  • Schnaeker EM, Ossig R, Ludwig T, Dreier R, Oberleithner H, et al.: Microtubule-dependent matrix metalloproteinase-2/matrix metalloproteinase-9 exocytosis: prerequisite in human melanoma cell invasion. Cancer Res 64, 8924–8931, 2004.
  • Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, et al.: Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clin Cancer Res 10, 7621–7628, 2004.
  • Kim ES, Kim MS, and Moon A: TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int J Oncol 25, 1375–1382, 2004.
  • Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, et al.: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23, 3550–3560, 2004.
  • Qi Q, Gu H, Yang Y, Lu N, Zhao J, et al.: Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. J Mol Med (Berl) 86, 1367–1377, 2008.
  • Li C, Li F, Zhao K, Yao J, Cheng Y, et al.: LFG-500 inhibits the invasion of cancer cells via down-regulation of PI3K/AKT/NF-kappaB signaling pathway. PLoS One 9, e91332, 2014.
  • Kim JE, Lee DE, Lee KW, Son JE, Seo SK, et al.: Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res 4, 582–591, 2011.
  • Li C, Yang X, Chen C, Cai SX, and Hu JB: Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway. Mol Med Rep 9, 935–940, 2014.
  • Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, et al.: Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor gamma activation pathway in gastric cancer. J Biol Chem 287, 38028–38040, 2012.
  • Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, et al.: Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic src and beta-catenin. Cancer Res 73, 5473–5484, 2013.
  • Li C, Qi Q, Lu N, Dai Q, Li F, et al.: Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells. Biochem Cell Biol 90, 718–730, 2012.
  • Li C, Lu N, Qi Q, Li F, Ling Y, et al.: Gambogic acid inhibits tumor cell adhesion by suppressing integrin beta1 and membrane lipid rafts-associated integrin signaling pathway. Biochem Pharmacol 82, 1873–1883, 2011.
  • Chen Y, Lu N, Ling Y, Gao Y, Wang L, et al.: Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology 259, 10–17, 2009.
  • Albini A: Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms. Pathol Oncol Res 4, 230–241, 1998.
  • Liu YW, Zhu X, Yang QQ, Lu Q, Wang JY, et al.: Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. Psychopharmacology (Berl) 228, 585–594, 2013.
  • Liu YW, Zhu X, Zhang L, Lu Q, Wang JY, et al.: Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Eur J Pharmacol 721, 355–364, 2013.
  • Bogenrieder T and Herlyn M: Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22, 6524–6536, 2003.
  • Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25, 9–34, 2006.
  • Duffy MJ: Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to level 1 evidence studies. Clin Chem 48, 1194–1197, 2002.
  • Hsiao YC, Kuo WH, Chen PN, Chang HR, Lin TH, et al.: Flavanone and 2′-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact 167, 193–206, 2007.
  • Adya R, Tan BK, Punn A, Chen J, and Randeva HS: Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res 78, 356–365, 2008.
  • Song Y, Qian L, Song S, Chen L, Zhang Y, et al.: Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. Mol Immunol 45, 137–143, 2008.
  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.: Global cancer statistics. CA Cancer J Clin 61, 69–90, 2011.
  • Larkins TL, Nowell M, Singh S, and Sanford GL: Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. Bmc Cancer 6, 181, 2006.
  • Jones JL, Shaw JA, Pringle JH, and Walker RA: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol 201, 562–572, 2003.
  • Lai WW, Hsu SC, Chueh FS, Chen YY, Yang JS, et al.: Quercetin Inhibits migration and invasion of sas human oral cancer cells through inhibition of NF-kappa B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res 33, 1941–1950, 2013.
  • Kong CS, Kim YA, Kim MM, Park JS, Kim SK, et al.: Antioxidant activity and inhibition of MMP-9 by isorhamnetin and quercetin 3-O-beta-D-glucopyranosides isolated from salicornia herbacea in HT1080 cells. Food Sci Biotechnol 17, 983–989, 2008.
  • Rabbani SA and Xing RH: Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies. Int J Oncol 12, 911–920, 1998.
  • Yodkeeree S, Garbisa S, and Limtrakul P: Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA. Acta Pharmacol Sin 29, 853–860, 2008.
  • Shang HS, Chang JB, Lin JH, Lin JP, Hsu SC, et al.: Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro. Molecules 19, 16588–16608, 2014.
  • Bode W, Reinemer P, Huber R, Kleine T, Schnierer S, et al.: The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J 13, 1263–1269, 1994.
  • Nagase H, Visse R and Murphy G: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69, 562–573, 2006.
  • Kajanne R, Miettinen P, Mehlem A, Leivonen SK, Birrer M, et al.: EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways. J Cell Physiol 212, 489–497, 2007.
  • Cohen M, Meisser A, Haenggeli L, and Bischof P: Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod 12, 225–232, 2006.
  • McCawley LJ, Li SN, Wattenberg EV, and Hudson LG: Sustained activation of the mitogen-activated protein kinase pathway: a mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration. J Biol Chem 274, 4347–4353, 1999.
  • Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, et al.: p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res 70, 832–841, 2010.
  • Xie TX, Wei DY, Liu MG, Gao AC, Ali-Osman F, et al.: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23, 3550–3560, 2004.
  • Dechow TN, Pedranzini L, Leitch A, Leslie K, Gerald WL, et al.: Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci U S A 101, 10602–10607, 2004.
  • Zarubin T and Han J: Activation and signaling of the p38 MAP kinase pathway. Cell Res 15, 11–18, 2005.
  • Shishodia S, Majumdar S, Banerjee S, and Aggarwal BB: Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63, 4375–4383, 2003.
  • Pani G, Galeotti T and Chiarugi P: Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29, 351–378, 2010.
  • Pengfei L, Tiansheng D, Xianglin H, and Jianguo W: Antioxidant properties of isolated isorhamnetin from the sea buckthorn marc. Plant Foods Hum Nutr 64, 141–145, 2009.
  • Hollborn M, Stathopoulos C, Steffen A, Wiedemann P, Kohen L, et al.: Positive feedback regulation between MMP-9 and VEGF in human RPE cells. Invest Ophthalmol Vis Sci 48, 4360–4367, 2007.
  • Shiomi T, Hashimoto G, Inoki I, Fujii Y, Ikeda E, et al.: Regulation of VEGF induced angiogenesis by MMPs. Wound Repair Regen 13, A11–A11, 2005.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.